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Phenol-based endoscopic ultrasound-guided celiac plexus neurolysis for East Asian alcohol-intolerant upper gastrointestinal cancer patients:A pilot study

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World Journal of Gastroenterology 2014年第30期20卷 10512-10517页

作者： Hirotoshi Ishiwatari Tsuyoshi Hayashi Makoto yoshida Michihiro Ono Hiroyuki Masuko Tsutomu Sato Koji Miyanishi Yasushi Sato Rishu Takimoto Masayoshi Kobune Atsushi Miyamoto Tomoko Sonoda junji Kato Department of Medical Oncology and Hematology Sapporo Medical University School of MedicineSapporo 0600061Japan Department of Hospital Pharmacy Sapporo Medical University School of MedicineSapporo 0600061Japan Department of Public Health Sapporo Medical University School of MedicineSapporo 0600061Japan

AIM: To investigate the effectiveness of phenol for the relief of cancer pain by endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN).

关键词： Celiac plexus neurolysis Celiac plexus blockade Endoscopic ultrasound Phenol Pain management Upper gastrointestinal cancer

Circulating tumor cells in gastric cancer

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 380-390页

作者： Kenichi Nakamura Masaaki Iwatsuki junji Kurashige Takatsugu Ishimoto Yoshifumi Baba Yuji Miyamoto Naoya yoshida Masayuki Watanabe Hideo Baba Division of Gastric Surgery Shizuoka Cancer CenterShizuoka 411-8777Japan Department of Gastroenterological Surgery Graduate School of Medical SciencesKumamoto UniversityKumamoto 860-8556Japan Esophageal Cancer Division Gastroenterological SurgeryCancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyo 135-8550Japan

Circulating tumor cells(CTCs)have received a lot of attention as a novel biomarker for cancer research in past *** infiltrate the bloodstream derived from the primary tumor,and are significantly involved in cancer metastasis and *** clinical applications have been challenging owing to the difficulties of CTC identification,recent development of technology for specific enrichment and detection of CTCs contributes to diagnosis and ***,CTC analyses will shed new light on the biological mechanisms of cancer progression and metastasis.A number of clinical studies have already been carried out on the basis of CTC ***,the clinical utility of CTCs is still unknown in gastric *** this review,we elaborate on the latest advances of CTC research in gastric cancer.

关键词： Circulating tumor cells gastric cancer cancer progression and metastasis tumor heterogeneity epithelial mesenchymal transition cancer stem cells immune check point blockade

Preoperative liver functional volumetry performed by 3D-99mTc-GSA scintigraphy/vascular fusion imaging using SYNAPSE VINCENT: a preliminary study

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Hepatoma Research 2016年第1期2卷 187-192页

作者： Hiroshi yoshida Hiroshi Makino Tadashi Yokoyama Hiroshi Maruyama Atsushi Hirakata junji Ueda Yasuhiro Mamada Nobuhiko Taniai Eiji Uchida Department of Surgery Nippon Medical School Tama Nagayama HospitalTokyo 206-8512Japan Department of Surgery Nippon Medical SchoolTokyo 113-8603Japan

Aim:The present study was designed to evaluate the feasibility of preoperative liver functional volumetry performed by 3D-technetium-99m-diethylenetriaminepentaacetic acid-galactosyl-human serum albumin(99mTc-GSA)scintigraphy/vascular fusion imaging using SYNAPSE VINCENT and to examine the discrepancy between conventional and functional ***:The study group comprised 15 patients who underwent preoperative 3-dimensional(3D)-99mTc-GSA scintigraphy/vascular fusion imaging using SYNAPSE VINCENT software before hepatectomy between July 2014 and August *** diagnosis was hepatocellular carcinoma(n=4),metastatic liver tumor(n=10),or intrahepatic cholangiocarcinoma(n=1).Right hepatectomy was performed in 2 patients,left hepatectomy in 3 patients,right posterior sectionectomy in 3 patients,segmentectomy in 2 patients,and partial hepatectomy in 4 patients.99mTc-GSA scintigraphy and computed tomography(CT)were performed to construct 3D-99mTc-GSA scintigraphy/vascular fused *** conventional volume ratio of the planned resection region without tumor(%CT),and the functional volume ratio of the planned resection region without tumor(%GSA)were *** discrepancy ratio was calculated as follows:discrepancy ratio=100-%GSA/%CT×100(%).Results:The%GSA(17.9±16.7%)was significantly lower than the%CT(21.5±17.6%)(P<0.036).In all except 2 patients,the%GSA was lower than the%*** discrepancy ratio ranged from-4%to 75%(median,20.7%).Conclusion:3D-99mTc-GSA scintigraphy/vascular fused images constructed using SYNAPSE VINCENT were useful for noninvasively performing functional liver volumetry in patients scheduled to undergo various patterns of *** planned resection regions without tumor,the functional volume ratio was about 20%lower than the conventional volume ratio.

关键词： Functional volumetry 99m-diethylenetriaminepentaacetic acid-galactosyl-human serum albumin SYNAPSE VINCENT fusion image 3-dimensional computed tomography

Surgical resection of a solitary para-aortic lymph node metastasis from hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第23期18卷 3027-3031页

作者： junji Ueda Hiroshi yoshida Yasuhiro Mamada Nobuhiko Taniai Sho Mineta Masato Yoshioka Youichi Kawano Tetsuya Shimizu Etsuko Hara Chiaki Kawamoto Keiko Kaneko Eiji Uchida Department of Surgery Nippon Medical School Tokyo 113-8603 Japan Divisions of Cardiology Hepatology Geriatrics and Integrated Medicine Department of Internal Medicine Nippon Medical School Tokyo 113-8603 Japan

Lymph node (LN) metastases from hepatocellular carcinoma (HCC) are considered uncommon. We describe the surgical resection of a solitary para-aortic LN metastasis from HCC. A 65-year-old Japanese man with B-type liver cirrhosis was admitted for the evaluation of a liver tumor. He had already undergone radiofrequency ablation, transcatheter arterial chemoembolization, and percutaneous ethanol injection therapy for HCC. Despite treatment, viable regions remained in segments 4 and 8. We performed a right paramedian sectionectomy with partial resection of the left paramedian section of the liver. Six months later, serum concentrations of alpha-fetoprotein (189 ng/mL) and PIVKA-2 (507 mAU/mL) increased. Enhanced com- puted tomography of the abdomen revealed a tumor (20 mm in diameter) on the right side of the abdominal aorta. Fluorine-18 fluorodeoxyglucose positron emission tomography revealed an increased standard uptake value. There was no evidence of recurrence in other regions. Esophagogastroduodenoscopy and colonoscopy revealed no malignant tumor in the gastrointestinal tract. Para-aortic LN metastasis from HCC was thus diagnosed. We performed lymphadenectomy. Histopathological examination revealed that the tumor was largely necrotic, with poorly differentiated HCC on its surface, which confirmed the suspected diagnosis. After 6 mo tumor marker levels were normal, with no evidence of recurrence. Our experience suggests that a solitary para-aortic LN metastasis from HCC can be treated surgically.

关键词： Surgical resection Lymph node metasta-sis Hepatocellular carcinoma Hepatectomy Positronemission tomography

The clinical signifi cance of circulating tumor cells in gastrointestinal cancer

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Journal of Cancer Metastasis and Treatment 2015年第1期1卷 130-137页

作者： Masaaki Iwatsuki junji Kurashige Takatsugu Ishimoto Keisuke Kosumi Yoshifumi Baba Yasuo Sakamoto Yuji Miyamoto Naoya yoshida Masayuki Watanabe Hideo Baba Department of Gastroenterological Surgery Graduate School of Medical SciencesKumamoto University1-1-1 HonjoChuo-kuKumamoto 860-8556Japan Department of Gastroenterological Surgery Esophageal Cancer DivisionCancer Institute Hospital of Japanese Foundation for Cancer Research3-8-31 AriakeKoto-kuTokyo 135-8550Japan

Circulating tumor cells(CTCs)are originated from the primary tumor lesion into the blood *** could lead to recurrence of gastrointestinal(GI)cancers,even after a curative resection and colonizing in the distant organs to facilitate tumor distant metastasis;however,it has been challenging in clinic to detect CTCs for a long time,such as detection methodology or molecular markers for identifi cation of *** review discussed the recent technical advances and biomarkers in the detection of CTCs and the molecular mechanism of CTC in cancer progression and ***,novel concepts,such as cancer stem cells and epithelial-mesenchymal transition,could lead to CTCs and tumor progression and ***,the involvement of CTCs varies greatly among cancer types in the GI and much remains to be ***,further study will provide more insightful information from a clinical and translational viewpoint to use CTCs for cancer early diagnosis or prediction of tumor recurrence and investigation of tumor progression and metastasis as well.

关键词： Cancer stem cells circulating tumor cells epithelial-mesenchymal transition gastrointestinal cancer tumor progression and metastasis

Combined Effects of Temperature and Nutrient Enrichment on Palatability of the Brown Alga Sargassum yezoense (Yamada) yoshida &T. Konno

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American Journal of Plant Sciences 2015年第2期6卷 275-282页

作者： Hikaru Endo Kentaro Suehiro junji Kinoshita Yukio Agatsuma Graduate School of Agricultural Science Tohoku University Sendai Japan

Global warming is predicted to strengthen marine plant-herbivore interactions. However, little is known about the effect of temperature on palatability and the associated chemical composition of marine macroalgae. To study the effects of physiological stress caused by the warm water temperatures and nutrient-poor conditions that occur during summer, we cultured the brown alga Sargassum yezoense at three different temperatures (16°C, 22°C, and 28°C) in both nutrient-enriched and non-enriched media. We then compared phlorotannin (i.e., defensive compounds) and nitrogen concentrations of S. yezoense as well as consumption rate by the sea urchin Hemicetrotus pulcherrimus among the treatment groups. No effect of culture temperature on phlorotannin and ni-trogen concentrations or consumption rate was detected. Nutrient enrichment resulted in decreased phlorotannin concentration and increased nitrogen concentration. Although nutrient enrichment did not affect consumption rate, a positive correlation between nitrogen concentration and consumption rate was detected. In contrast, there was no correlation between phlorotannin concentration and consumption rate. These results suggested that palatability of S. yezoense to H. pulcherrimus might not be affected by elevated temperature but that it could increase with nutrient enrichment.

关键词： Climate Change Plant-Herbivore Interaction Defensive Compound Marine Macroalgae Sea Urchin Grazing

Combined Effects of Extremely Low Frequency Electromagnetic Fields （ELFMFs） and X-rays or H2O2 on Mutation in pTN89 Plasmids

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Combined Effects of Extremely Low Frequency Electromagnetic ...

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作者： Shin Koyama Takehisa Nakahara Hideki Hirose Yoshio Takashima Yasuhito Isozumi junji Miyakoshi Department of Radiological Technology School of Health Sciences Faculty of Medicine Hirosaki University 66-1 Hon-cho Hirosaki 036-8564 Japan Department of Molecular Environment of Life and Nature Graduate School of Human and Environmental Studies Kyoto University Yoshida-Konoe-cho Sakyo-ku Kyoto 606-8501 Japan Department of Radiological Technology School of Health Sciences Faculty of Medicine Hirosaki University 66-1 Hon-cho Hirosaki 036-8564 Japan Laboratory of Radiation Biology Graduate School of Science Kyoto University Kitashirakawa-Oiwake-cho Sakyo-ku Kyoto 606-8502 Japan Department of Radiological Technology School of Health Sciences Faculty of Medicine Hirosaki University 66-1 Hon-cho Hirosaki 036-8564 Japan Department of Molecular Environment of Life and Nature Graduate School of Human and Environmental Studies Kyoto University Yoshida-Konoe-cho Sakyo-ku Kyoto 606-8501 Japan Department of Radiological Technology School of Health Sciences Faculty of Medicine Hirosaki University 66-1 Hon-cho Hirosaki 036-8564 Japan

We detected mutations that occurred in the supF gene carried by pTN89 plasmids in Escherichia coli (E. coli) to examine the effects of extremely low frequency electromagnetic fields (ELFMFs) and

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胆道肿瘤临床实践指南(英文第三版)

中华消化外科杂志 2021年第4期20卷 359-375页

作者： Masato Nagino Satoshi Hirano Hideyuki Yoshitomi Taku Aoki Katsuhiko Uesaka Michiaki Unno Tomoki Ebata Masaru Konishi Keiji Sano Kazuaki Shimada Hiroaki Shimizu Ryota Higuchi Toshifumi Wakai Hiroyuki Isayama Takuji Okusaka Toshio Tsuyuguchi Yoshiki Hirooka junji Furuse Hiroyuki Maguchi Kojiro Suzuki Hideya Yamazaki Hiroshi Kijima Akio Yanagisawa Masahiro yoshida Yukihiro Yokoyama Takashi Mizuno Itaru Endo 杨翼飞(译) 仇毓东(译) 赵梦珂(译) 伏旭(译) 蔡正华(译) 毛凉(审校) 爱知癌症中心日本名古屋北海道大学医学院胃肠外二科日本札幌独协医科大学琦玉医学中心普通外科日本越谷独协医科大学普通外二科日本米布静冈癌症中心肝胆胰外科日本长崎东北大学医学院外科系日本仙台名古屋大学医学院外科系日本名古屋国立癌症中心医院东院区肝胆胰外科日本柏市京都大学医学院外科系日本东京国立癌症中心医院日本东京帝京大学千叶医学中心外科系日本市原东京女子医科大学胃肠病研究所普通外科日本东京新泻大学医学与牙科研究生院消化与普通外科日本新泻均天道大学医学研究生院消化内科日本东京国立癌症中心医院肝胆胰肿瘤科日本东京千叶县锯原医院消化内科日本锯原藤田医科大学消化内科及消化肿瘤科日本丰明杏林大学医学院肿瘤内科日本三鹰泰恩金凯医院教育研究中心日本札幌爱知医科大学放射科日本长谷京都府立医科大学医学研究生院放射科日本京都广崎大学医学研究部病理学与生物科学系日本广崎日本红十字会京都第二医院病理科日本京都国际医疗福利大学肝胆胰胃肠外科日本一川横滨市立大学医学研究生院消化外科日本横滨南京大学医学院附属鼓楼医院肝胆胰中心

日本肝胆胰外科学会(JSHBPS)于2007年出版第一版胆道肿瘤(胆管癌、胆囊癌及壶腹癌)临床实践指南,于2014年更新第二版,2021年英文第三版胆道肿瘤临床实践指南围绕6个主题提出若干临床问题,基于相关循证医学证据并组织专家讨论后,最终确... 详细信息

日本肝胆胰外科学会(JSHBPS)于2007年出版第一版胆道肿瘤(胆管癌、胆囊癌及壶腹癌)临床实践指南,于2014年更新第二版,2021年英文第三版胆道肿瘤临床实践指南围绕6个主题提出若干临床问题,基于相关循证医学证据并组织专家讨论后,最终确定推荐意见、推荐强度以及推荐说明。根据证据推荐分级的评估、制订与评价(GRADE)系统,推荐强度被分为1级(强)或者2级(弱)。英文第三版胆道肿瘤临床实践指南中提出的31个临床问题涵盖:(1)预防性治疗;(2)诊断;(3)胆道引流;(4)外科治疗;(5)化疗;(6)放疗。31个临床问题中,14个问题给予推荐强度为强的推荐意见,14个问题给予推荐强度为弱的推荐意见,剩余的3个问题未给予推荐意见。每条推荐意见都进行推荐强度说明。最新版指南基于循证医学证据,为临床提供了重要建议。未来与癌症登记数据库协作将是评估指南和建立新证据的关键。

关键词：胆道肿瘤临床实践指南预防性治疗循证医学证据肝胆胰外科胆道引流推荐意见壶腹癌