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IgG Anti-Body Titers among Patients with Amoebic Liver Abscess in Bangui, Central African Republic

Open Journal of Immunology 2022年第4期12卷 77-85页

作者： Wilfrid Sylvain Nambei Edwige Régina Kodia-Lenguetama junior nguerenam-ouefio Department of Biomedical Sciences Faculty of Health Sciences Bangui Central African Republic (CAR) National Center of Blood Donors’ Ministry of Public Health Bangui Central African Republic (CAR)

Entamoeba histolytica (Eh) is a protozoan parasite that causes amoebiasis characterized by intestinal damage and amoebic liver development and is an important cause of hospitalization in low-middle income countries. The aims of this study were to determine the prevalence and the titer of IgG anti Eh in ALA (Amoebic Liver Abscess) patients’ in Bangui according sex, age and other risk factors. This was a cross sectional study where data was collected between January 2018 and October 2020. The diagnosis of ALA was suspected based on clinical symptoms of;fever, abdominal pain (usually in the right hypochondrium or epigastrium) and clinical signs of hepatomegaly and/or tender liver with or without jaundice and abdominal ultra-sonography. ALA patients’ IgG antibody titers were measured by Indirect Hemmaglutination Assay and Chi-square test was used. A total of 1249 ALA patients were included, among whom 570 (45.64%) were positive. Of these, 244 (42.08%) had titer 1:160 or less, 223 patients’ (39.13%) had titer ranging from 1:320 to 1:640 and 103 patients (18.07%) had strong titer ranging from 1:1280 to 1:2560. The association between antibody titer results, age and sex was no significant (p = 1.0000). Our findings indicate a high prevalence of ALA and show no significant difference between the sex and age ALA patients.

关键词： Amoebic Liver Abscess Antibody Sex Difference Central African Republic

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Rubella Immunity among Pregnant Women in Bangui, Central African Republic

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Open Journal of Immunology 2022年第4期12卷 130-136页

作者： Wilfrid Sylvain Nambei junior nguerenam-ouefio Arsène Gbamonza Edwige Régine Kodia-Lenguetama Department of Biomedical Sciences Faculty of Health Sciences University of Bangui Bangui Central African Republic Communautaire Hospital of Bangui Bangui Central African Republic National Center of Blood Donors’ Ministry of Public Health Bangui Central African Republic

Sero-positivity rates of the rubella virus among pregnant women vary from country to country widely throughout the world. In the Central African Republic, rubella vaccination is not included in the national immunization schedule. Thus, we propose to evaluate the immune status of pregnant women. This was an analytical retrospective study that consulted the records of pregnant women received in prenatal consultations at the Bangui Community Hospital maternity ward from January to December 2020. Socio-demographic and laboratory data (IgM, IgG) were collected from January to June 2021. Chi2 test was used. A total of 289 pregnant women were analyzed. Women with an IgM+ response accounted for 4.15%. Those with an IgG+ were 14.87%. The distribution by age group shows that patients aged 20 - 24 and those aged 25 - 29 had a rubella profile suggesting persistent infection (p = 0.010). The average age of women included was 28 (±6) years. The average parity for the entire sample was 2.18 (1.93). At any age pregnant women were not significantly exposed to rubella infection (p = 0.96), (ORbrut = 1.03;CI95% = [0.32 - 3.34]). Both immunized and non-immunized individuals are similarly exposed [OR = 0.86;95% IC95% = 0.44 - 1.68] with no difference (p = 0.96). Rubella infection remains particularly severe when it occurs during pregnancy. It would be wise to seek immunity in all girls of childbearing age in order to rule out any risk of rubella embryopathy.

关键词： Rubella Immunity Pregnant Women Central African Republic

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Humoral Response to Toxoplasma gondii in Pregnant Women in Bangui Central African Republic

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Open Journal of Immunology 2022年第4期12卷 122-129页

作者： Wilfrid Sylvain Nambei junior ouefio nguerenam Edwige Régina Kodia-Lenguetama Arsène Gbamonza Department of Science Biomedical Faculty of Health Science University of Bangui Bangui Central African Republic National Center of Blood Donor’s Ministry of Public Health Bangui Central African Republic Community Hospital of Bangui Bangui Central African Republic

Toxoplasmosis is a cosmopolitan antrhropozoonosis widespread in mammals and birds. Normally asymptomatic in the subject health, it can have serious consequences for the fetus in the first trimester of pregnancy in the pregnant woman. It is in this context that we propose to assess the immune response to T. gondii in pregnant women in Bangui. This was a retrospective analytical study that consulted the records of pregnant women received in prenatal consultations at the Bangui Community Hospital Maternity ward from January 2019 to December 2019. Socio-demographic and laboratory data (IgM, IgG response to T. gondii) and results of HIV serology were collected from January to June 2021. Chi2 test was used. A total of 307 pregnant women were analyzed. The average age of the women included was 28 (±6) years. The average parity of the entire sample was 2.18 (±1.93). Toxoplasmosis infectious was 14.65%. Women with a positive IgM response accounted for 17.58% and those with an IgG-positive response for 42.99%. Patients with a positive HIV were 5.86%. Patients aged 20 - 29 had a serological profile suggesting a probable ongoing infection (p = 0.010). The paucipares were more represented with no statistically significant difference (p = 0.23). Pregnant women were not significantly exposed to toxoplasmosis infectious (p = 0.96). Immunized and non-immunized subjects were similarly exposed [OR = 0.97;CI 95% 0.4 = 6 - 2.05]. Toxoplasmosis remains particularly serious during pregnancy. Seroprevalence was significantly higher in the 20 - 24 year age group. Women were similarly exposed depending on whether they were immunized or not. This requires the establishment of a specific prevention program against this disease.

关键词： T. gondii Humoral Response HIV Pregnant Women Central African Republic

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