检索结果-南通市图书馆

生物质资源与工程(英文) 2023年第3期8卷 224-234页

作者： Peifu Kong junichi peter abe Shunsuke Masuo Toshiharu Enomae Degree Programs in Life and Earth Sciences University of TsukubaIbaraki 305-8572Japan Faculty of Life and Environmental Sciences University of TsukubaIbaraki305-8572Japan

This study aimed to prepare tea tree oil-β-cyclodextrin microcapsules using an optimized co-precipitated *** impact of the volume fraction of ethanol in the solvent system for microencapsulation on encapsulation efficiency was investigated and analyzed ***-high encapsulation efficiency was achieved when a 40%volume fraction of ethanol was used for the microencapsulation procedure,where the recovery yield of microcapsules and the embedding fraction of tea tree oil in microcapsules were as high as 88.3%and 94.3%,***,considering the operation cost,including time and energy consumption,an economical preparation was validated so that it would be viable for large-scale *** on the results of morphological and X-ray diffraction analysis,the crystal structure appeared to differ before and after *** results of gas chromatography-mass spectrometry and Fourier transform infrared spectroscopy confirmed the successful formation of ***,the antibacterial activity of the fabricated microcapsules was assessed by a simple growth inhibition test using Bacillus subtilis as the study object,and the hydrophilic property was proved by a water contact angle measurement.

关键词： β-cyclodextrin Co-precipitation Encapsulation efficiency Microcapsule Tea tree oil

Early effects of Lansoprazole orally disintegrating tablets on intragastric pH in CYP2C19 extensive metabolizers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第13期14卷 2049-2054页

作者： Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Toru Horii Ryousuke Kikuchi Shigeyuki Kobayashi Yasuhiko abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma junichi Goto Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine 1-1 Seiryou-Machi Aobaku Sendai 9808574 Japan Division of Clinical Pharmacy Tohoku University Graduate School of Pharmaceutical Sciences 1-1 Seiryou-Machi Aobaku Sendai 9808574 Japan Division of Pharmacotherapy Tohoku University Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Sciences Tohoku University Hospital 1-1 Seiryou-Machi Aobaku Sendai 9808574 Japan

AIM: To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose. METHODS: Eight H pylori-negative cytochrome P450 (CYP) 2C19 extensive metabolizers were assigned to receive a single oral dose of RPZ 10 mg or LPZ 30 mg OD. Twelve hour intragastric pH monitoring was perform- ed on the day of treatment. Blood samples were also collected after the administration of each drug. RESULTS: LPZ 30 mg OD induced a significantly earlier rise in blood drug concentration than RPZ 10 mg; consequently, LPZ 30 mg OD induced a significantly earlier rise in median pH in the third and fourth hours of the study. CONCLUSION: In H pylori-negative CYP2C19 extensive metabolizers, LPZ 30 mg OD induced a significantly faster inhibition of gastric acid secretion than RPZ 10 mg.

关键词： LPZ 30 mg orally disintegrating tablets Intragastric pH Blood drug concentration Cytochrome P450 2C19 extensive metabolizers H pylori-negative

Stronger inhibition of gastric acid secretion by lafutidine, a novel H_2 receptor antagonist, than by the proton pump inhibitor lansoprazole

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第15期14卷 2406-2410页

作者： Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Toru Horii Ryousuke Kikuchi Shigeyuki Kobayashi Yasuhiko abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma junichi Goto Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai 9808574 Japan Division of Clinical Pharmacy Tohoku University Graduate School of Pharmaceutical Sciences Sendai 9808574 Japan Division of Pharmacotherapy Tohoku University Graduate School of Pharmaceutical Sciences and Department of Pharmaceutical Sciences Tohoku University Hospital Sendai 9808574 Japan

AIM: To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg. METHODS: Ten volunteers without H pylori infection participated in this crossover study comparing lafutidine 10 mg with LPZ 30 mg. Intragastric pH was monitored for 6 h in all participants, and blood samples were collected from four randomly selected individuals after single-dose administration of each drug. RESULTS: The median intragastric pH was significantly higher in individuals who received lafutidine 10 mg than in those who received LPZ 30 mg 2, 3, 4, 5, and 6 h after administration. Maximal plasma drug concentration was reached more promptly with lafutidine 10 mg than with LPZ 30 mg. CONCLUSION: In H pylori-negative individuals, gastric acid secretion is more markedly inhibited by lafutidinethan by LPZ.

关键词： Lafutidine Lansoprazole H2 receptor antagonists Proton pump inhibitors Antisecretory activity

Etodolac Attenuates Hippocampal Blood Flow Responses Induced by Tooth Pulp Stimulation in Rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience & Medicine 2011年第3期2卷 295-298页

作者： Makoto Hasegawa junichi Hada Tetsuya abe Nao Ohtsu Kousuke Honda Masahiro Urade 不详

In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (MABP) and HBF in urethane-anesthetized rats using laser Doppler flowmetry and examined the effects of etodolac, a specific COX-2 inhibitor, on TPS-induced MABP and HBF responses. The MABP response was not attenuated by the intraperitoneal (i.p.) administration of etodolac (10 mg/kg);however, the HBF response was significantly attenuated by etodolac administration. These results suggest that COX-2 may be involved in the mechanisms regulating TPS-induced HBF responses.

关键词： Cyclooxygenase-2 (COX-2) Etodolac Fear Memory Hippocampal Blood Flow Mean Arterial Blood Pressure Tooth Pulp Stimulation

The Reliability of Assessment of Ki-67 Expression on Core Needle Biopsy and the Surgical Specimens of Invasive Breast Cancer: Comparison of Local Pathologists’ Assessment and Central Review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2012年第5期3卷 841-845页

作者： Yoshio Mizuno Tsuneo Natori Naoko Takeda junichi Yamada Hiroaki abe Yuko Inoue Hiroshi Seto Kazuhiko Sato Clinical Testing Business Testing Division Special Reference Laboratories Inc. Tokyo Japan Department of Breast Oncology Tokyo-West Tokushukai Hospital Tokyo Japan Department of Clinical Pathology Tokyo-West Tokushukai Hospital Tokyo Japan Inoue Ladies Clinic Tokyo Japan Seto Hospital Saitama Japan

Purpose: The aim of this study was to assess the reliability of Ki-67 expression on core needle biopsy (CNB) and the surgical specimens of invasive breast cancer. We examined the concordance rate of Ki-67 expressions, hormone receptors, and human epidermal growth factor receptor 2 (HER2) status from a CNB with from a surgery in invasive breast cancer. Methods: A retrospective study was conducted on a clinical database of patients who underwent surgery for early breast cancer. Of these, 193 patients who underwent CNB before the surgery were enrolled. A cut-off value of 20% was used for Ki-67-positive criteria. Expression of estrogen receptor (ER), progesterone receptor (PgR), and HER2 were examined and compared with that of Ki-67. To evaluate discordance between the pathologists’ earlier assessments, we re-examined Ki-67 expression among the Ki-67 discordant group in a central laboratory. Results: The concordance rate for Ki-67 expression between the two specimen types was 77.7%, which was significantly lower than that for ER, PgR, and HER2 expression (95.9%, 88.1%, and 91.6%, respectively). The concordance rate for re-examined Ki-67 expression among the Ki-67 discordant group improved to 93.8% and was not significantly different from that for the other receptors. Conclusion: The concordance rate for Ki-67 expression between biopsy and surgical specimens was significantly lower than that for ER, PgR, and HER2 expressions, but re-examination of Ki-67 expression in a central laboratory revealed no significant difference among the receptors, suggesting the need for standard pathological assessment of Ki-67 expression for clinical use as a predictive marker of breast cancer.

关键词： Ki-67 CNB Concordance Rate Standard Assessment

Standardized Assessment of Ki-67 in Breast Cancer Patients Using Virtual Slides and an Automated Analyzer in Comparison to Central/Local Pathological Assessments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2014年第2期5卷 141-146页

作者： Yoshio Mizuno Hiromi Fuchikami Tsuneo Natori Naoko Takeda Yuko Inoue junichi Yamada Hiroaki abe Hiroshi Seto Kazuhiko Sato Clinical Testing Business Testing Division SRL Inc. Tokyo Japan Department of Breast Oncology Tokyo-West Tokushukai Hospital Tokyo Japan Department of Clinical Pathology Tokyo-West Tokushukai Hospital Tokyo Japan Inoue Ladies Clinic Tokyo Japan Seto Hospital Tokorozawa Japan

Purpose: To standardize the methods to measure Ki-67, there is an interest in automating the assessment of Ki-67. Therefore, we reviewed the possibility of introducing an automated analyzer to standardize the Ki-67 evaluation method. Methods: We retrospectively reviewed a clinical database of patients who underwent surgery for early breast cancer at Tokyo-West Tokushukai Hospital. Among them, those who underwent preoperative core needle biopsy (CNB) were enrolled. The concordance rates of estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2), and Ki-67 by local pathologists were reviewed (valuations made by local pathologists), and nonmatching cases (from August 2008 to October 2011) were reassessed both by central review and using an automated analyzer with virtual slides. The results were compared with the evaluations made by local pathologists, and we reexamined the concordance rate by using central review and the automated analyzer. Results: The concordance rate of Ki-67 evaluations made by local pathologists in the preoperative CNB and surgical specimens was 78.7% in 287 cases pathologically assessed from October 2008 to March 2013. This rate was significantly lower (p < 0.01) than that of ER (95.6%), PgR (88.5%), and HER2 (91.6%). Reassessment of the 37 cases of nonmatching Ki-67 values from 2008 to October 2011 using central review and an automated analyzer resulted in clear improvement in matching of 22 (92.1%) and 24 (93.1%) of 37 cases, respectively. Conclusion: The concordance rate of Ki-67 in preoperative CNB and surgical specimens was lower than that of other biological markers;however, they were nearly equal by reassessment using central review and an automated analyzer.

关键词： Ki-67 Core Needle Biopsy Concordance Rate Virtual Slides Automated Analyzer Standardized Assessment

Congratulatory Letter from the Kazankai Foundation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Understanding 2021年第3期 56-56页

作者： junichi abe the Kazankai Foundation

Chinese Association for International Understanding,On the occasion of the 40th anniversary of the establishment of Chinese Association for International Understanding(CAFIU),the Kazankai Foundation would like to exte... 详细信息

关键词： since Letter anniversary

Thyroid hormone alterations in trauma patients requiring massive transfusion: An observational study

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2014年第4期5卷 270-274页

作者： Toru Hifumi Ichiro Okada Nobuaki Kiriu Eiju Hasegawa Tomoko Ogasawara Hiroshi Kato Yuichi Koido junichi Inoue Yuko abe Kenya Kawakita Masanobu Hagiike Yasuhiro Kuroda Emergency Medical Center Kagawa University Hospital Division of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical Center Division of Critical Care Medicine and Trauma Yamanashi Prefectural Central Hospital

BACKGROUND: Although non-thyroidal illness syndrome(NTIS) is considered a negative prognostic factor, the alterations in free triiodothyronine(f T3) levels in trauma patients requiring massive transfusion have not been ***: A prospective observational study comparing 2 groups of trauma patients was conducted. Group M comprised trauma patients requiring massive transfusions(>10 units of packed red blood cells) within 24 hours of emergency admission. Group C comprised patients with an injury severity score >9 but not requiring massive transfusions. Levels of f T3, free thyroxine(f T4), and thyroidstimulating hormone(TSH) were evaluated on admission and on days 1, 2, and 7 after admission. The clinical backgrounds and variables measured including total transfusion amounts were compared and the inter-group prognosis was evaluated. Results are presented as mean±standard ***: Nineteen patients were enrolled in each group. In both groups, 32 were men, and the mean age was 50±24 years. In group C one patient died from respiratory failure. The initial f T3 levels in group M(1.95±0.37 pg/m L) were signifi cantly lower than those in group C(2.49±0.72 pg/m L; P<0.01) and remained low until 1 week after admission. Initial inter-group f T4 and TSH levels were not significantly different. TSH levels at 1 week(1.99±1.64 μIU/m L) were higher than at admission(1.48±0.5 μIU/m L) in group C(P<0.05).CONCLUSION: Typical NTIS was observed in trauma patients requiring massive transfusions. When initial resuscitation achieved circulatory stabilization, prognosis was not strongly associated with NTIS.

关键词： Non-thyroidal illness syndrome Massive transfusion Trauma Freetriiodothyronine Thyroid hormone

A Study on Microstructural and Mechanical Properties of a Stir Cast Al(SiC-Mg-TiFe)Composite

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2019年第1期15卷 15-26页

作者： Samuel Olukayode Akinwamide Serge Mudinga Lemika Babatunde Abiodun Obadele Ojo Jeremiah Akinribide Bolanle Tolulope abe peter Apata Olubambi Centre for Nanomechanics and Tribocorrosion University of JohannesburgJohannesburg 2028South Africa Department of Electrical and Electronics Engineering Tshwane University of TechnologyPretoria 0182South Africa Department of Chemical Material and Chemical EngineeringBotswana International University of Science and TechnologyPalapyeBotswana

Development of metal matrix composite is becoming widespread in most engineering applications where excellent mechanical properties are *** and microstructural properties of aluminium reinforced with silicon carbide was *** of aluminium was melted in a furnace at temperature ranging between 650-700℃.Ferrotitanium and silicon carbide were preheated in a muffle furnace before addition to molten aluminium in a crucible *** proportions of magnesium,ferrotitanium and varying proportions of silicon carbide were utilized as *** was carried out manually for a minimum of 10 mins after the addition of each weight percent of silicon *** as-cast samples were sectioned for various mechanical and microstructural *** studies from optical microscopy and scanning electron microscopy(SEM)showed the dispersion of reinforcements in the aluminium *** properties which includes hardness and tensile strength of fabricated composites were observed to increase,while XRD analysis showed various phases formed from reaction between the matrix and reinforcements.

关键词： Aluminium ferrotitanium silicon carbide microscopy

abe-induced PDGFD start codon silencing unveils new insights into the genetic architecture of sheep fat tails

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2023年第12期50卷 1022-1025页

作者： peter Kalds Shuhong Huang Shiwei Zhou Siyuan Xi Yumeng Fang Yawei Gao Kexin Sun Chao Li Bei Cai Yao Liu Yige Ding Qifang Kou Tad Sonstegard Bjöm petersen Stephen Kemp Baohua Ma Jian-Lin Han Yulin Chen Xiaolong Wang International Joint Agriculture Research Center for Animal Bio-breeding Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal GeneticsBreeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Department of Animal and Poultry Production Faculty of Environmental Agricultural SciencesArish UniversityEl-Arish 45511Egypt College of Veterinary Medicine Northwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Ruminant Molecular and Cellular Breeding School of AgricultureNingxia UniversityYinchuanNingxia 750000China Ningxia Tianyuan Tan Sheep Farm HongsibuNingxia 751999China Acceligen Inc. St.PaulMN 55104United States International Livestock Research Institute(ILRI) Nairobi 30709-00100Kenya International Livestock Research Institute(ILRI) Nairobi 30709-00100Kenya CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic ResourcesInstitute of Animal ScienceChinese Academy of Agricultural Sciences(CAAS)Beijing 100193China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China Institute of Farm Animal Genetics Friedrich-Loeffler-lnstitutMarienseeNeustadt am Rubenberge 31535Germany

Sheep is an important livestock species raised globally to produce meat,milk,wool,and other *** the Neolithic Revolution,sheep were domesticated in the Fertile Crescent of Southwest Asia around 10,000 years ago(Chessa... 详细信息

关键词： products. globally raised