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Activity and bioavailability of tepotinib for leptomeningeal metastasis of NSCLC with MET exon 14 skipping mutation

Cancer Communications 2021年第1期41卷 83-87页

作者： Hisashi Tanaka Kageaki Taima Tomonori Makiguchi junichi nakagawa Takenori Niioka Sadatomo Tasaka Department of Respiratory Medicine Hirosaki University Graduate School of MedicineAomori 036-8562Japan Department of Pharmacy Hirosaki University HospitalAomori 036-8562Japan

Tepotinib is a key drug for cancer patients with mesenchymal-epithelial transition receptor tyrosine kinase proto-oncogene(MET)exon 14 skipping ***,its bioavailability in the cerebrospinal fluid(CSF)in humans has not been fully ***,information about the efficacy of tepotinib in patients with leptomeningeal metastasis is ***,we present the case of a 56-year-old man who was diagnosed with lung adenocarcinoma with MET exon 14 skipping *** was urgently hospitalized due to leptomeningeal *** administered tepotinib 500 mg/day as the second-line therapy and observed improvement in leptomeningeal metastasis and performance *** tepotinib concentrations reached 1,648 ng/mL in the plasma and 30.6 ng/mL in the CSF,with a penetration rate(CSF/plasma)of 1.83%.These demonstrate tepotinib could achieve a high rate of central nervous system transition and could be effective against leptomeningeal metastasis.

关键词： cerebrospinal fluid IC50 leptomeningeal metastasis MET exon 14 skipping mutation non-small cell lung carcinoma performance status pharmacokinetics tepotinib

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Injuries and illness of athletes at the Tokyo 2020 Olympic and Paralympic summer games visiting outside facilities

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Sports Medicine and Health Science 2024年第1期6卷 48-53页

作者： Shuji Sakanashi Hideharu Tanaka Hiroyuki Yokota Yasuhiro Otomo Tomohiko Masuno Kousuke Nakano junichi Inoue Manabu Sugita Takahiko Tokunaga Nagisa Kato Tomoya Kinoshi Hironori Inoue Hiroto Numata Koshi nakagawa Ryo Sagisaka Shota Tanaka Tetsuya Miyamoto Takao Akama The Tokyo Organising Committee of the Olympic and Paralympic Games TokyoJapan Department of Sports Medicine Kokushikan University TokyoJapan Graduate School of Emergency Medical System Kokushikan UniversityTokyoJapan Research Institute of Disaster Management and EMS Kokushikan University TokyoJapan Graduate School of Health and Medical Science Nippon Sports Science UniversityJapan Tokyo Medical and Dental University Hospital Trauma and Acute Critical Care CenterTokyoJapan Graduate School of Medicine Nippon Medical UniversityTokyoJapan Saitama City Hospital Emergency DepartmentSaitamaJapan Graduate School of Medicine Juntendo UniversityTokyoJapan Emergency Lifesaving Academy Tokyo TokyoJapan Nippon Medical School Musashikosugi Hospital Emergency and Critical Care CenterKnagawaJapan Department of Integrated Science and Engineering for Sustaiable Society Chuo UniversityJapan Faculty of Sport Sciences Waseda UniversitySaitamaJapan National Hospital Organization Disaster Medical Center TokyoJapan

This study aimed to identify the reasons for transferring athletes to local medical facilities during the Olympic and Paralympic *** on 567 injuries and other illnesses of athletes treated at the on-site clinics were collected from the Tokyo 2020 Organizing *** these,84 athletes who required outpatient care during the Games were registered for this *** the Olympic and Paralympic Games,66(8.3/1000)and 18(7.2/1000)athletes,respectively,consulted external medical *** the Olympic Games,the reasons for these visits included 48 cases(72.7%)of injuries,13(19.7%)cases of illnesses,and 5(7.6%)cases of heat stroke illness(HSI).Of these patients,56(84.9%)were treated as outpatients and 10(15.1%)were hospitalized,while three of these patients required hospitalization for>7 *** the other hand,in the Paralympics Games,there were 7(38.8%)cases of injuries,9(50.0%)other illnesses,1(5.6%)case of HSI,and 1(5.6%)other cases,of which 11(61.1%)were treated as outpatients and 7(38.9%)were hospitalized,but none was hospitalized for>7 *** accounted for 70%of the total cases at the 2021 Olympic Games,but only three(0.05%)were severe cases that required hospitalization for more than 1 *** contrast,in the Paralympic Games,other illnesses accounted for approximately half of the total *** study provides details on the extent of injuries and other illnesses that were transferred to outside facilities,which has not been documented in previous games.

关键词： Olympic games Paralympic games Sports injuries Illness Heat-related illness 2020 Tokyo

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