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大气NO2对33例慢性阻塞性肺疾病患者肺功能和呼出气NO的短期影响

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中华预防医学杂志 2017年第6期51卷 527-532页

作者：单娇倪洋董伟许珺辉潘璐李宏宇杨玄吴少伟陈亚红邓芙蓉郭新彪北京大学公共卫生学院劳动卫生与环境卫生学系 100191

目的探讨大气NO2对慢性阻塞性肺疾病患者肺功能和呼出气NO水平的短期影响.方法采用定组研究的设计,在北京招募稳定期慢性阻塞性肺疾病患者,纳入标准为在北京居住时间超过1年,年龄在60~85岁之间的患者,排除患有哮喘、支气管扩张、肺癌... 详细信息

目的探讨大气NO2对慢性阻塞性肺疾病患者肺功能和呼出气NO水平的短期影响.方法采用定组研究的设计,在北京招募稳定期慢性阻塞性肺疾病患者,纳入标准为在北京居住时间超过1年,年龄在60~85岁之间的患者,排除患有哮喘、支气管扩张、肺癌等除慢阻肺以外的其他呼吸系统疾病以及有职业暴露和胸部创伤手术史的患者,共招募研究对象33例.于2013年12月至2014年10月期间,对患者肺功能和呼出气NO进行重复测量,由于研究对象到医院就诊的频次不同,本研究共采集患者肺功能数据170人次,采集呼出气NO数据215人次.同时收集测量前累积滞后（lag）1 d至7 d研究对象住所附近的北京市环境监测站点大气NO2数据;采用线性混合效应模型评价大气NO2对研究对象肺功能和呼出气NO的短期影响.结果研究对象的用力肺活量（FVC）、第一秒用力呼气肺容量（FEV1）、最大呼气峰流速（PEF）及呼出气NO值分别为（3.26±0.83）L、（1.66±0.61）L、（4.13±1.77）L/s和（48.99±14.30）μg/m^3.大气NO2暴露浓度为（70.3±34.2）μg/m^3,四分位数间距（IQR）为39.0μg/m^3.大气NO2短期暴露可引起患者FVC水平的下降,其效应在lag 2 d时最大,大气NO2浓度每增加一个IQR（39μg/m^3）,可引起研究对象FVC水平下降1.84%（95%CI：-3.20%^-0.48%）;分层分析发现,较高浓度大气NO2（≥58.0μg/m^3）暴露对FVC影响的效应估计值为-2.32%（95%CI：-4.15%^-0.48%）;本研究未发现大气NO2对患者呼出气NO水平有影响.结论大气NO2短期暴露可使慢性阻塞性肺疾病患者肺功能降低.

关键词：二氧化氮肺疾病,慢性阻塞性肺功能呼出气NO

Identification of Potential Zinc Deficiency Responsive Genes and Regulatory Pathways in Rice by Weighted Gene Co-expression Network Analysis

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Rice science 2022年第6期29卷 545-558页

作者： Blaise Pascal MUVUNYI lu Xiang ZHAN junhui HE Sang YE Guoyou CAAS-IRRI Joint Laboratory for Genomics-Assisted Germplasm Enhancement Agricultural Genomics Institute in ShenzhenChinese Academy of Agricultural Sciences(CAAS)Shenzhen 518120China Rice Breeding Innovations Platform International Rice Research Institute(IRRI)Metro Manila 1301the Philippines

Zinc(Zn)malnutrition is a major public health *** biofortification of Zn in rice grain can alleviate global Zn ***,elucidating the genetic mechanisms regulating Zn deprivation response in rice is essential to identify elite genes useful for breeding high grain Zn rice ***,a meta-analysis of previous RNA-Seq studies involving Zn deficient conditions was conducted using the weighted gene co-expression network analysis(WGCNA)and other in silico prediction tools to identify modules(denoting cluster of genes with related expression pattern)of co-expressed genes,modular genes which are conserved differentially expressed genes(DEGs)across independent RNA-Seq studies,and the molecular pathways of the conserved modular *** identified 16 modules of co-expressed ***-eight and five modular DEGs were conserved in leaf and crown,and root tissues across two independent RNA-Seq *** enrichment analysis showed that 24 of the 28 conserved modular DEGs from leaf and crown tissues significantly up-regulated 2 Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways and 15 Gene Ontology(GO)terms,including the substrate-specific transmembrane transporter and the small molecule metabolic ***,the well-studied transcription factors(OsWOX11 and OsbHLH120),protein kinase(OsCDPK20 and OsMPK17),and miRNAs(OSA-MIR397A and OSA-MIR397B)were predicted to target some of the identified conserved modular *** of the 24 conserved and up-regulated modular DEGs,19 were yet to be experimentally validated as Zn deficiency responsive *** from this study provide a comprehensive insight on the molecular mechanisms of Zn deficiency response and may facilitate gene and pathway prioritization for improving Zn use efficiency and Zn biofortification in rice.

关键词： rice biofortification zinc deficiency gene expression weighted gene co-expression network analysis

Secondary control fusion in inverter intensive dynamic microgrids for distribution system resiliency enhancement

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iEnergy

iEnergy 2023年第1期2卷 9-13页

作者： Yuxi Men Lizhi Ding junhui Zhang Xiaonan lu School of Engineering Technology Purdue UniversityWest LafayetteIN 47907USA

Microgrids(MGs)dominated by power electronics interface inverters can augment distribution system *** interactions among neighboring MGs and the requirements for flexible system network reconfiguration motivate the development of dynamic *** improve the distribution system resiliency in the context of dynamic MGs,this paper proposes the concept of functional fusion of secondary control levels across neighboring dynamic MGs with the integration of multiple compensation terms into the secondary controller in each distributed generator(DG).Moreover,two kinds of consensus-based algorithms with the consideration of communication delays are encompassed to calculate the average values of static and dynamic variables and thereby build an effective communications network among DGs in dynamic ***,the effectiveness of the proposed secondary controller is validated using a 9-bus test distribution feeder.

关键词： Communication delay consensus algorithm dynamic microgrids(MGs) secondary control

A stability locomotion-control strategy for quadruped robots with center-of-mass dynamic planning

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第6期24卷 516-530页

作者： Yangyang HAN Guoping LIU Zhenyu lu Huaizhi ZONG junhui ZHANG Feifei ZHONG Liyu GAO School of Advanced Manufacturing Nanchang UniversityNanchang 330031China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310058China

Locomotion stability is essential for controlling quadruped robots and adapting them to unstructured *** propose a control strategy with center-of-mass(CoM)dynamic planning for the stable locomotion of these *** motion trajectories of the swing legs are synchronized with the CoM of the *** implement the synchronous control scheme,we adjusted the swing legs to form a support *** strategy is applicable to both static walk gait and dynamic trot *** the motion control processes of the robot legs,the distribution of the ground reaction forces is optimized to minimize joint torque and locomotion energy *** also used an improved joint-torque controller with varied controller coefficients in the stance and swing *** simulation and experimental results demonstrate that the robot can complete omnidirectional locomotion in both walk and trot *** a given locomotion speed,the stability margins for the robot during walking and trotting were 27.25%and 37.25%higher,respectively,than in the scheme without CoM *** control strategy with energy consumption optimization(ECO)reduced the energy consumption of the robot in walk and trot gaits by 11.25%and 13.83%,respectively,from those of the control scheme without ECO.

关键词： Center-of-mass(CoM)planning Quadruped robot Cooperative scheme Ground reaction forces Stability margin

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声波法在直埋供热管道泄漏检测中的工程应用

暖通空调 2024年第5期54卷 160-165页

作者：郭帅杰张立申李成穆连波王随林鲁军辉北京建筑大学北京北京市煤气热力工程设计院有限公司北京北京市热力集团有限责任公司北京

利用声波法对城市内2段直埋供热管道的泄漏情况进行非开挖式工程实测,分析了不同工程条件下的泄漏声波信号特征,并采用傅里叶滤波进行声波振动信号的降噪处理。研究表明,傅里叶滤波可有效提升泄漏定位精度,实测漏点定位误差小于2%,基于... 详细信息

利用声波法对城市内2段直埋供热管道的泄漏情况进行非开挖式工程实测,分析了不同工程条件下的泄漏声波信号特征,并采用傅里叶滤波进行声波振动信号的降噪处理。研究表明,傅里叶滤波可有效提升泄漏定位精度,实测漏点定位误差小于2%,基于傅里叶滤波降噪的声波法直埋供热管道泄漏检测技术具有较好的工程应用价值。

关键词：供热管道声波法泄漏检测定位直埋

基于单片机产生参数可调PWM微网雾化器的设计

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信息与电脑 2022年第16期34卷 210-212页

作者：卢俊晖罗晰嘉唐明枝雷炳阳何浩淼新乡医学院三全学院河南新乡453003

不同雾化程度的药物可用于治疗不同种类的上下呼吸道疾病,而通过单片机与Keil和Proteus软件的联合调控可产生不同占空比的脉冲宽度调制(Pulse Width Modulation,PWM)信号,调节雾化片的振动频率,最终达到控制微网雾化器雾化程度的目的。... 详细信息

不同雾化程度的药物可用于治疗不同种类的上下呼吸道疾病,而通过单片机与Keil和Proteus软件的联合调控可产生不同占空比的脉冲宽度调制(Pulse Width Modulation,PWM)信号,调节雾化片的振动频率,最终达到控制微网雾化器雾化程度的目的。结果表明,基于单片机参数可调PWM的微网雾化器可以克服自身作用效果单一、超声波雾化器有效雾化颗粒少以及压缩式雾化器噪声大等缺点。

关键词：微网雾化器脉冲宽度调制(PWM) 单片机

原发性干燥综合征相关间质性肺病危险因素分析

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徐州医学院学报 2017年第2期37卷 88-90页

作者：蒋培培殷寒秋刘春梅周瑾卢俊慧徐浩徐州医科大学附属医院风湿免疫科江苏徐州221002

目的分析影响原发性干燥综合征（pSS）相关间质性肺病（ILD）的危险因素。方法回顾性分析2010-2015年于我科住院确诊的pSS患者214例，根据HRCT结果将患者分为ILD组（86例）和与无ILD组（128例），分析生化及免疫学指标等因素与ILD的相... 详细信息

目的分析影响原发性干燥综合征（pSS）相关间质性肺病（ILD）的危险因素。方法回顾性分析2010-2015年于我科住院确诊的pSS患者214例，根据HRCT结果将患者分为ILD组（86例）和与无ILD组（128例），分析生化及免疫学指标等因素与ILD的相关性。结果pSS患者ILD发生率为40．2％，与无ILD组比较，ILD组发病年龄较大，病程较长，差异有统计学意义（P〈0．05）；与无ILD组比较，ILD组血沉（ESR）、C反应蛋白（CRP）、类风湿因子（RF）、IgG、IgA水平升高，补体3（C3）水平降低（P〈0．05），抗核抗体（ANA）、SSA、抗心磷脂抗体（ACA）阳性率升高（P〈0．05）；Logistic回归分析显示血SSA抗体阳性率、IgG水平升高为pSS患者出现ILD的危险因素。结论发病年龄大、病程长的pSS患者继发ILD几率更高，SSA抗体阳性及IgG水平升高是pSS患者出现ILD的危险因素。

关键词：原发性干燥综合征间质性肺病危险因素

Classification and Facies Sequence Model of Subaqueous Debris Flows

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Acta Geologica Sinica(English Edition) 2017年第2期91卷 751-752页

作者： XIAN Benzhong LIU Jianping DONG Yanlei lu Zhiyong HE Yanxin WANG junhui State Key Laboratory of Petroleum Resources and Prospecting Beijing 102200China College of Geosciences China University of Petroleum(Beijing)Beijing 102200China Dongxin Oil Production Plant Shengli Oilfield CompanySinopecDongying 207015ShandongChina

Objective Debris flows are cohesive sediment gravity flows which occur in both subaerial and subaqueous settings. Compared to subaerial debris flows which have been well studied as a geological hazard, subaqueous debris flows showing complicated sediment composition and sedimentary processes were poorly understood. The main objective of this work is to establish a classification scheme and facies sequence models of subaqueous debris flows for well understanding their sedimentary processes and depositional characteristics.

关键词： Classification and Facies Sequence Model of Subaqueous Debris Flows

Research and Design of Electric Vehicle Controller Based on Brushless DC Motor 36

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Research and Design of Electric Vehicle Controller Based on ...