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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian Li Jie Miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li Qiang Su junhong guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

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Effective property of piezoelectric composites containing coated nano-elliptical fibers with interfacial debonding

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Applied Mathematics and Mechanics(English Edition) 2022年第11期43卷 1701-1716页

作者： Yu Chen junhong guo Department of Mechanics Inner Mongolia University of TechnologyHohhot010051China School of Aeronautics Inner Mongolia University of TechnologyHohhot010051China

Based on both the spring layer interface model and the Gurtin-Murdoch surface/interface model,the anti-plane shear problem is studied for piezoelectric composites containing coated nano-elliptical fibers with imperfect *** using the complex function method and the technique of conformal mapping,the exact solutions of the electroelastic fields in fiber,coating,and matrix of piezoelectric nanocomposites are derived under far-field anti-plane mechanical and in-plane electrical ***,the generalized self-consistent method is used to accurately predict the effective electroelastic moduli of the piezoelectric nanocomposites containing coated nano-elliptical fibers with imperfect *** examples are illustrated to show the effects of the material constants of the imperfect interface layers,the aspect ratio of the fiber section,and the fiber volume fraction on the effective electroelastic moduli of the piezoelectric *** results indicate that the effective electroelastic moduli of the piezoelectric nanocomposites can be significantly reduced by the interfacial debonding,but it can be improved by the surface/interface stresses at the small scale,which provides important theoretical reference for the design and optimization of piezoelectric nanodevices and nanostructures.

关键词： piezoelectric composite coated nano-elliptical fiber effective property exact solution

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Surface effects on a mode-III reinforced nano-elliptical hole embedded in one-dimensional hexagonal piezoelectric quasicrystals

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Applied Mathematics and Mechanics(English Edition) 2021年第5期42卷 625-640页

作者： Zhina ZHAO junhong guo Department of Mechanics Inner Mongolia University of TechnologyHohhot 010051China School of Aeronautics Inner Mongolia University of TechnologyHohhot 010051China

To effectively reduce the field concentration around a hole or crack,an anti-plane shear problem of a nano-elliptical hole or a nano-crack pasting a reinforcement layer in a one-dimensional(1D)hexagonal piezoelectric quasicrystal(PQC)is investigated subject to remotely mechanical and electrical *** surface effect and dielectric characteristics inside the hole are considered for *** utilizing the technique of conformal mapping and the complex variable method,the phonon stresses,phason stresses,and electric displacements in the matrix and reinforcement layer are exactly derived under both electrically permeable and impermeable boundary *** size-dependent field intensity factors near the nano-crack tip are further obtained when the nano-elliptical hole is reduced to the *** examples are illustrated to show the effects of material properties of the surface layer and reinforced layer,the aspect ratio of the hole,and the thickness of the reinforcing layer on the field concentration of the nano-elliptical hole and the field intensity factors near the nano-crack *** results indicate that the properties of the surface layer and reinforcement layer and the electrical boundary conditions have great effects on the field concentration of the nano-hole and nano-crack,which are useful for optimizing and designing the microdevices by PQC nanocomposites in engineering practice.

关键词： surface effect reinforcement layer exact solution piezoelectric quasicrystal(PQC) nano-hole/crack

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Static response of a layered magneto-electro-elastic half-space structure under circular surface loading

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Acta Mechanica Solida Sinica 2017年第2期30卷 145-153页

作者： Jiangyi Chen junhong guo School of Mechanical Engineering Zhengzhou University Department of Mechanics Inner Mongolia University of Technology

A cylindrical system of vector functions, the stiffness matrix method and the corresponding recursive algorithm are proposed to investigate the static response of transversely isotropic,layered magneto-electro-elastic（MEE） structures over a homogeneous half-space substrate subjected to circular surface loading. In terms of the system of vector functions, we expand the extended displacements and stresses, and deduce two sets of ordinary differential equations, which are related to the expansion coeficients. The solution to one of the two sets of these ordinary differential equations can be evaluated by using the stiffness matrix method and the corresponding recursive algorithm. These expansion coeficients are then integrated by adaptive Gaussian quadrature to obtain the displacements and stresses in the physical domain. Two types of surface loads, mechanical pressure and electric loading,are considered in the numerical examples. The calculated results show that the proposed technique is stable and effective in analyzing the layered half-space MEE structures under surface loading.

关键词： Magneto-electro-elastic material Layered and half-space structure Stiffness matrix method System of vector functions Surface loading

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Effective electroelastic constants for three-phase confocal elliptical cylinder model in piezoelectric quasicrystal composites

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Applied Mathematics and Mechanics(English Edition) 2018年第6期39卷 797-812页

作者： Yongbin WANG junhong guo Department of Mechanics Inner Mongolia University of Technology

A three-phase confocal elliptical cylinder model is proposed to analyze micromechanics of one-dimensional hexagonal piezoelectric quasicrystal （PQC） compos- ites. Exact solutions of the phonon, phason, and electric fields are obtained by using the conformal mapping combined with the Laurent expansion technique when the model is subject to far-field anti-plane mechanical and in-plane electric loadings. The effective elec- troelastic constants of several different composites made up of PQC, quasicrystal （QC）, and piezoelectric （PE） materials are predicted by the generalized self-consistent method. Numerical examples are conducted to show the effects of the volume fraction and the cross-sectional shape of inclusion （or fiber） on the effective electroelastic constants of these composites. Compared with other micromechanical methods, the generalized self- consistent and Mori-Tanaka methods can predict the effective electroelastic constants of the composites consistently.

关键词： piezoelectric quasicrystal (PQC) three-phase elliptical cylinder model effective constant generalized self-consistent method

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Interaction between a screw dislocation and an elliptical hole with two asymmetrical cracks in a one-dimensional hexagonal quasicrystal with piezoelectric effect

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Applied Mathematics and Mechanics(English Edition) 2020年第6期41卷 899-908页

作者： Lianhe LI Xiaowei CUI junhong guo College of Mathematics Science Inner Mongolia Normal UniversityHohhot 010022China Department of Mechanics Inner Mongolia University of TechnologyHohhot 010051China

The interaction between a screw dislocation and an elliptical hole with two asymmetrical cracks in a one-dimensional(1 D) hexagonal quasicrystal with piezoelectric effect is considered. A general formula of the generalized stress field, the field intensity factor, and the image force is derived, and the special cases are discussed. Several numerical examples are given to show the effects of the material properties and the dislocation position on the field intensity factors and the image forces.

关键词： screw dislocation elliptical hole conformal mapping stress field onedimensional(1D)hexagonal quasicrystal with piezoelectric effect

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Bending Analysis of Functionally Graded One-Dimensional Hexagonal Piezoelectric Quasicrystal Multilayered Simply Supported Nanoplates Based on Nonlocal Strain Gradient Theory

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Acta Mechanica Solida Sinica 2021年第2期34卷 237-251页

作者： Li Zhang junhong guo Yongming Xing Department of Mechanics Inner Mongolia University of TechnologyHohhot 010051China School of Aeronautics Inner Mongolia University of TechnologyHohhot 010051China

In this study,the nonlocal strain gradient theory is adopted to investigate the static bending deformation of a functionally graded(FG)multilayered nanoplate made of onedimensional hexagonal piezoelectric quasicrystal(PQC)materials subjected to mechanical and electrical surface *** FG materials are assumed to be exponential distribution along the thickness *** closed-form solutions of an FG PQC nanoplate including nonlocality and strain gradient micro-size dependency are derived by utilizing the pseudo-Stroh *** propagator matrix method is further used to solve the multilayered case by assuming that the layer interfaces are perfectly *** examples for two FG sandwich nanoplates made of piezoelectric crystals and PQC are provided to show the influences of nonlocal parameter,strain gradient parameter,exponential factor,length-to-width ratio,loading form,and stacking sequence on the static deformation of two FG sandwich nanoplates,which play an important role in designing new smart composite structures in engineering.

关键词： Nonlocal strain gradient theory Functionally graded material.Quasicrystal.Multilayered nanoplates Propagator matrix method

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Line field analysis and complex variable method for solving elastic-plastic fields around an anti-plane elliptic hole

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Science China(Physics,Mechanics & Astronomy) 2011年第8期54卷 1495-1501页

作者： guo junhong LU ZiXing Institute of Solid Mechanics Beihang University Beijing 100191 China

A new approach is proposed to solve the elastic-plastic fields near the major-axis line of an elliptical hole. The complex variable method is used to determine the elastic fields near the major-axis line of the elliptical hole. Then, by using the line field analysis method, the exact and new solutions of the stresses, strains in the plastic zone, the size of the plastic region and the unit normal vector of the elastic-plastic boundary near the major-axis line of the elliptical hole are obtained for an anti-plane elliptical hole in a perfectly elastic-plastic solid. The usual small scale yielding assumptions are not adopted in the analysis. The present method is simple, easy and efficient. The influences of applied mechanical loading on the size of plastic zone are discussed.

关键词： complex variable method line field analysis method elliptical hole elastic-plastic solid

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Bending and vibration of two-dimensional decagonal quasicrystal nanoplates via modified couple-stress theory

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Applied Mathematics and Mechanics(English Edition) 2022年第3期43卷 371-388页

作者： Miao ZHANG junhong guo Yansong LI Department of Mechanics Inner Mongolia University of TechnologyHohhot 010051China School of Aeronautics Inner Mongolia University of TechnologyHohhot 010051China College of Architecture and Civil Engineering Guangdong University of Petrochemical TechnologyMaoming 525000Guangdong ProvinceChina

Based on the modified couple-stress theory,the three-dimensional(3D)bending deformation and vibration responses of simply-supported and multilayered twodimensional(2D)decagonal quasicrystal(QC)nanoplates are *** surface loading is assumed to be applied on the top surface in the bending analysis,the tractionfree boundary conditions on both the top and bottom surfaces of the nanoplates are used in the free vibration analysis,and a harmonic concentrated point loading is applied on the top surfaces of the nanoplates in the harmonic response *** general solutions of the extended displacement and traction vectors for the homogeneous QC nanoplates are derived by solving the eigenvalue problem reduced from the final governing equations of motion with the modified couple-stress *** utilizing the propagator matrix method,the analytical solutions of the displacements of bending deformation for the phonon and phason fields,the natural frequency of free vibration,and the displacements of the harmonic responses of the phonon and phason fields are *** examples are illustrated to show the effects of the quasiperiodic direction,the material length scale parameter,and the the stacking sequence of the nanoplates on the bending deformation and vibration responses of two sandwich nanoplates made of QC and crystal materials.

关键词： quasicrystal(QC) bending vibration layered nanoplate

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Static deformation of a multilayered one-dimensional hexagonal quasicrystal plate with piezoelectric effect

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Applied Mathematics and Mechanics(English Edition) 2018年第3期39卷 335-352页

作者： Tuoya SUN junhong guo Xiaoyan ZHANG Department of Mechanics Inner Mongolia University of Technology

Quasicrystals （QCs） are sensitive to the piezoelectric （PE） effect. This paper studies static deformation of a multilayered one-dimensional （1D） hexagonal QC plate with the PE effect. The exact closed-form solutions of the extended displacement and traction for a homogeneous piezoelectric quasicrystal （PQC）plate are derived from an eigensystem. The general solutions for multilayered PQC plates are then obtained using the propagator matrix method when mechanical and electrical loads are applied on the top surface of the plate. Numerical examples for several sandwich plates made up of PQC, PE, and QC materials are provided to show the effect of stacking sequence on phonon, phason, and electric fields under mechanical and electrical loads, which is useful in designing new composites for engineering structures.

关键词： quasicrystal (QC) piezoelectric (PE) effect multilayered plate exactsolution static deformation

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