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Controllable fabrication of FeCoS_(4) nanoparticles/S-doped bowl-shaped hollow carbon as efficient lithium storage anode

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Chinese Journal of Chemical Engineering 2024年第3期67卷 78-88页

作者： Ming Zhou Mengrong Wu Haiwei Yu Xiangjun zheng Kuan Shen Xingmei Guo Yuanjun Liu Fu Cao Hongxing Gu Qinghong Kong junhao Zhang School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Jiangsu Hengshen Co. LtdZhenjiang 212314China School of the Environment and Safety Engineering Jiangsu UniversityZhenjiang 212013China

To address the low conductivity and easy agglomeration of transition metal sulfide nanoparticles,FeCoS_(4) nanoparticles embedded in S-doped hollow carbon(FeCoS_(4)@S-HC)composites were successfully fabricated through a combination of hydrothermal processes and sulfidation treatment.The unique bowlshaped FeCoS_(4)/S-HC composites exhibit excellent structural stability with a high specific surface area of 303.7 m^(2)·g^(-1) and a pore volume of 0.93 cm^(3)·g^(-1).When applied as anode material for lithium-ion batteries,the FeCoS_(4)@S-HC anode exhibits efficient lithium storage with high reversible specific capacity(970.2 mA·h·g^(-1) at 100 mA·g^(-1))and enhanced cycling stability(574 mA·h·g^(-1) at 0.2 A·g^(-1) after 350 cycles,a capacity retention of 84%).The excellent lithium storage is attributed to the fact that the bimetallic FeCoS_(4) nanoparticles with abundant active sites can accelerate the electrochemical reaction kinetics,and the bowl-shaped S-HC structure can provide a stable mechanical structure to suppress volume expansion.

关键词： Bimetallic sulfides Bowl-shaped hollow carbon S doping Buffering volume expand Lithium-ion batteries

Repeated laparoscopic liver resection using ICG fluorescent imaging for recurrent liver cancer

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第1期5卷 19-24页

作者： Zheyong Li Jingwei Cai junhao zheng Xiao Liang Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

Objective:Liver cancer is very common in China,with cumulative five-year tumor recurrence rate after a microscopically margin-negative resection of hepatocellular carcinoma up to 70%.Postoperative recurrent hepatocellular carcinoma presents a challenge for surgeons because of the complexity of postoperative adhesion and the difficulty in of recognizing recurrent lesions.This study aims to introduce a method using an indocyanine green(ICG)fluorescent imaging technique to do repeated laparoscopic liver resection.Method:Patients received repeated laparoscopic liver resection using ICG fluorescent imaging between January 2017 and December 2019 in the Department of General Surgery of Sir Run Run Shaw Hospital were analyzed retrospectively.Basic information,intraoperative information,complications,and followup time were collected and analyzed.Results:Totally,35 patients with a median age of 59 years(ranged 38-82 years)were included.All of the patients received minimally invasive surgery.One case was performed robotically,and only two cases were converted to open surgery due to severe adhesion.The median operating time was 174 minutes,and the median blood loss during surgery was 100 mL.The median hospital stay after surgery was 5 days,with a range of 3e55 days.In total,32(91.4%)patients showed staining by ICG fluorescent imaging,and lesions were visible on fluorescent camera.The median follow-up time was 19.7 months,with a range of 1e40.2 months.The median relapse-free survival time was 18.5 months.Conclusion:Repeated laparoscopic liver resection using ICG fluorescent imaging is a safe and promising approach in the treatment of recurrent liver tumors in selected patients.

关键词： Recurrence Liver cancer Laparoscopic hepatectomy Fluorescent imaging

Accurate and efficient planar near-field measurements: a new perspective from electromagnetic information theory

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Science China(Information Sciences) 2023年第10期66卷 321-322页

作者： junhao zheng Xiaoming CHEN zhengpeng WANG Jianxing LI Juan CHEN Wei E.I.SHA Lixin GUO School of Information and Communications Engineering Xi'an Jiaotong University School of Electronic Information Engineering Beihang University College of Information Science and Electronic Engineering Zhejiang University School of Physics Xidian University

Near-field measurement can obtain the far-field radiation pattern of the antenna under test(AUT) by performing near-field-to-far-field transformation(NFT) [1]. Generally,the minimum bounding for AUTs with different fo... 详细信息

关键词： Information theory

激光雷达与惯性测量单元同步融合下的园区三维建图

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光学精密工程 2024年第3期32卷 422-434页

作者：马庆禄汪军豪张杰邹政重庆交通大学交通运输学院重庆400074 同济大学道路与交通工程教育部重点实验室上海201804

针对自动驾驶三维建图中存在的建图不准确以及位姿飘移的问题,利用激光雷达里程计消除惯性测量单元(Iner-tial Measurement Unit,nIMU)累计误差并通过IMU预积分去除激光雷达点云畸变,形成激光雷达与IMU的紧耦合建图系统;通过增加回环检... 详细信息

针对自动驾驶三维建图中存在的建图不准确以及位姿飘移的问题,利用激光雷达里程计消除惯性测量单元(Iner-tial Measurement Unit,nIMU)累计误差并通过IMU预积分去除激光雷达点云畸变,形成激光雷达与IMU的紧耦合建图系统;通过增加回环检测因子、激光雷达里程计因子以及IMU预积分因子进行后端图优化,旨在提升定位建图的全局一致性,减小位姿估计误差,降低累计漂移误差。最后,在学校园区实地场景以及利用开源数据集KITTI进行实验验证,实验表明,在选取的学校园区实地场景下,改进算法APE误差均值相较于原算法降低了11.04%,APE均方根误差较于原算法降低了17.35%;改进算法在KITTI数据集场景下平均APE误差下降了10.04%,均方误差方面相较于原算法平均下降了12.04%。研究结果表明,改进的建图方法能够有效提高建图的位姿估计精度与地图构建精度。

关键词：激光雷达自动驾驶同步定位与建图传感器融合

数字孪生技术在土木工程中的应用:综述与展望

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哈尔滨工业大学学报 2024年第1期56卷 1-16页

作者：林楷奇郑俊浩陆新征福州大学土木工程学院福州350116 土木工程安全与耐久教育部重点试验室(清华大学) 北京100084

随着工业4.0概念的发展,数字孪生技术(digital twin)已经成为智能制造和产品全寿命周期管理相关领域的主要数字化解决手段。在工程建设领域,提升土木工程结构数字化防灾能力和管理水平是未来智慧城市建设的重要环节。建立精确可靠的数... 详细信息

随着工业4.0概念的发展,数字孪生技术(digital twin)已经成为智能制造和产品全寿命周期管理相关领域的主要数字化解决手段。在工程建设领域,提升土木工程结构数字化防灾能力和管理水平是未来智慧城市建设的重要环节。建立精确可靠的数字孪生模型,一方面,可以帮助实现工程灾害的精准防控和重大灾害事故的风险识别预警;另一方面,数字孪生也为未来城市的数字化建设和管理提供了技术基础。本文首先对数字孪生技术的基本概念和阶段性发展成果进行梳理,总结了在土木工程领域里孪生数据获取和构建数字孪生体的技术手段。最后,从结构运营评估、灾害仿真推演和数字孪生城市建设三个领域来回顾与展望数字孪生技术在土木工程领域的应用进展。

关键词：数字孪生数字化防灾运营评估灾害仿真推演数字孪生城市

UBQLN1 mediates sorafenib resistance through regulating mitochondrial biogenesis and ROS homeostasis by targeting PGCip in hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1856-1868页

作者： Junjie Xu Lin Ji Yeling Ruan Zhe Wan Zhongjie Lin Shunjie Xia Liye Tao junhao zheng Liuxin Cai Yifan Wang Xiao Liang Xiujun Cai Key Laboratory of Laparoscopic Technology of Zhejiang Province Department of General SurgerySir Run-Run Shaw HospitalZhejiang University School of MedicineHangzhouChina Zhejiang Minimal Invasive Diagnosis and Treatment Technology Research Center of Severe Hepatobiliary Disease Zhejiang Research and Development Engineering Laboratory of Minimally Invasive Technology and EquipmentHangzhouChina Zhejiang University Cancer Center HangzhouChina Liangzhu Laboratory Zhejiang University Medical CenterHangzhouChina

The treatment for hepatocellular carcinoma(HCC)is promising in recent years,but still facing critical challenges.The first targeted therapy,sorafenib,prolonged the overall survival by months.However,resistance often occurs,largely limits its efficacy.Sorafenib was found to target the electron transport chain complexes,which results in the generation of reactive oxygen species(ROS).To maintain sorafenib resistance and further facilitate tumor progression,cancer cells develop strategies to overcome excessive ROS production and obtain resistance to oxidative stress-induced cell death.In the present study,we investigated the roles of ROS in sorafenib resistance,and found suppressed ROS levels and reductive redox states in sorafenib-resistant HCC cells.Mitochondria in sorafenib-resistant cells maintained greater functional and morphological integrity under the treatment of sorafenib.However,cellular oxygen consumption rate and mitochondria DNA content analyses revealed fewer numbers of mitochondria in sorafenib-resistant cells.Further investigation attributed this finding to decreased mitochondrial biogenesis,likely caused by the accelerated degradation of peroxisome proliferator-activated receptor y coactivator ip(PGC1P).Mechanistic dissection showed that upregulated UBQLN1 induced PGCip degradation in a ubiquitination-independent manner to attenuate mitochondrial biogenesis and ROS production in sorafenib-resistant cells under sorafenib treatment.Furthermore,clinical investigations further indicated that the patients with higher UBQLN1 levels experienced worse recurrence-free survival.In conclusion,we propose a novel mechanism involving mitochondrial biogenesis and ROS homeostasis in sorafenib resistance,which may offer new therapeutic targets and strategies for HCC patients.

关键词： homeostasis resistance overcome

基于《第一批罕见病目录》的我国罕见病药物上市情况分析

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中国药房 2024年第11期35卷 1291-1295页

作者：彭菲菲蒋君好鲍宇健郑航重庆医科大学药学院重庆400016

目的考察我国罕见病药物的上市现状、一般特征以及时间发展趋势。方法基于《第一批罕见病目录》收纳的121种罕见病,从国家药品监督管理局药品审评中心和药智网数据库中获取相应适应证药物的名称和批准上市信息,提取相关特征变量进行... 详细信息

目的考察我国罕见病药物的上市现状、一般特征以及时间发展趋势。方法基于《第一批罕见病目录》收纳的121种罕见病,从国家药品监督管理局药品审评中心和药智网数据库中获取相应适应证药物的名称和批准上市信息,提取相关特征变量进行描述性统计分析。结果截至2022年12月31日,该目录收纳的121种罕见病中,有治疗药物上市的仅有32种,共涉及79个罕见病药物。其中,46.84%的药物是国产药,有88.61%的药物被批准成人和儿童都可用;化药占比为67.09%,注射剂占比为59.49%;按解剖学、治疗学及化学分类系统(ATC)分类,A类(消化系统用药)是最多的,占比为20.25%。每年上市的罕见病药物数量在2021年最多,2018-2021年总体呈上升趋势,2022年呈下降趋势。每年上市的罕见病药物中,按ATC分类,L类(抗肿瘤药及免疫用药)在2021年上市的数量最多,为5个;按剂型分类,口服制剂在2022年上市的数量最多,注射剂在2021年上市的数量最多。结论近年来我国罕见病药物上市数量不断增长,但是还远不能满足患者需求,并且上市的国产罕见病药物还非常缺乏。应进一步加快罕见病药物的研发,促进罕见病药物的进口与仿制。

关键词：罕见病罕见病药物第一批罕见病目录上市情况发展趋势

有机硅烷对介孔Y型分子筛理化特性及费托性能影响研究

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广西大学学报（自然科学版） 2024年第1期49卷 178-192页

作者：白净林溢琦何正胡俊豪李攀常春郑州大学机械与动力工程学院河南郑州450001 中国科学院可再生能源重点实验室广东广州510640 郑州大学化工学院河南郑州450001 河南省杰出外籍科学家工作室河南郑州450001

为了合成对汽油段、柴油段产物有高选择性的催化剂载体,以多种有机硅烷为模板剂原位合成了高结晶度介孔Y型分子筛,考察了硅烷剂浓度以及有机硅烷剂中的取代基对Y型分子筛性能的影响,并以合成的介孔分子筛为载体通过浸渍法负载钴制备了... 详细信息

为了合成对汽油段、柴油段产物有高选择性的催化剂载体,以多种有机硅烷为模板剂原位合成了高结晶度介孔Y型分子筛,考察了硅烷剂浓度以及有机硅烷剂中的取代基对Y型分子筛性能的影响,并以合成的介孔分子筛为载体通过浸渍法负载钴制备了催化剂,考察了催化剂的费托反应性能;采用X射线衍射、比表面积测试、扫描电子显微镜等测试手段分析了介孔分子筛及催化剂的物性特征,分别使用气相色谱质谱联用仪、气相色谱对反应产物进行了定性和定量分析。结果表明:有机硅烷剂中的硅与硅凝胶中的硅摩尔比为1∶30时达到饱和,继续提高硅烷剂浓度将导致分子筛结晶度下降,且大量的微孔损失,粒径明显减小。通过改变有机硅烷剂的取代基链长,分子筛的平均介孔尺寸可在4.9~9.0 nm进行调控。极性有机硅烷剂更有利于合成高结晶度与大比表面积的介孔分子筛,其中最大比表面积达到683.7 m^(2)/g,且相较于相同链长的非极性有机硅烷剂合成的分子筛其微孔孔容增加了约30%,而介孔孔容几乎相同。在以合成气为原料气的费托合成实验中,极性有机硅烷剂合成的分子筛催化剂对柴油段C_(10-20)产物具有较高选择性,最高达31.1%;非极性有机硅烷剂合成的分子筛催化剂对汽油段C_(5-12)产物具有较高选择性,最高达39.7%。

关键词：有机硅烷介孔分子筛费托合成钴基催化剂

Robotic single-incision left hemihepatectomy for intrahepatic bile duct stones by Da Vinci single-site surgical system: A case report with video

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Laparoscopic, Endoscopic and Robotic Surgery 2021年第3期4卷 90-92页

作者： Xiao Liang junhao zheng Jiaqi Gao Yubin Sheng Tianyu Lin Xiujun Cai Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Key Laboratory of Laparoscopic Technology of Zhejiang Province Hangzhou 310016China Zhejiang Minimal Invasive Diagnosis and Treatment Technology Research Center of Severe Hepatobiliary Disease Hangzhou 310016China Zhejiang Research and Development Engineering Laboratory of Minimally Invasive Technology and Equipment Hangzhou 310016China Zhejiang University Cancer Center Hangzhou 310058China

Minimally invasive surgery is a trend in hepatobiliary surgery.A 56-year-old female patient was admitted to our institution for intrahepatic lithiasis.The CT scan showed multiple calculi in the left liver,dilation of the left intrahepatic bile duct and liver atrophy of the left lobe.Robotic single-incision left hemihepatectomy by the single-site systemwas successfully applied.With the idea of enhanced recovery after surgery,the patient was discharged on the third day after the operation without any morbidity.Robotic single-incision surgery is more frequent in gynecologic and urological surgery.As far as we know,this is the first robotic single-incision left hemihepatectomy report in the world.

关键词： Robotic liver resection Single-incision surgery Video case