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Gene-like Precise Construction of Functional DNA Materials

Accounts of Materials Research 2022年第1期3卷 42-53页

作者： Chi Yao Yuwei Xu Pin Hu junhan ou Dayong Yang Frontiers Science Center for Synthetic Biology Key Laboratory of Systems Bioengineering(MOE)Institute of Biomolecular and Biomedical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350P.R.China

CONSPECTUS:Developing a new system of material chemistry is an important molecular foundation for the design and preparation of functional materials,which resembles the preparation of raw materials such as bricks for constructing a building that determines the quality of the ***,precisely controlling the synthesis processes and structures of functional materials always remains a grand *** is expected to propose a paradigm of“gene-like”precise construction to realize the rational synthesis of functional materials,i.e.,a“structure-function-application”principle for the precise *** the core genetic material of life,the DNA molecule is a bioactive macromolecule that can accurately encode genetic information and also can act as the generic molecular building block for the precise construction of functional *** this Account,we describe our work on the design and construction of functional DNA materials,to illustrate the principle of“gene-like”construction of functional DNA *** DNA molecule shows the unique advantages in the“gene-like”construction of functional materials,mainly including the precise arrangement of bases(monomers),the controllable design and assembly of structure,the precise transmission of sequence information,and customization of ***,the number and sequence of four deoxynucleotide monomers that constitute the DNA strand can be rationally designed and accurately ***,the sequence information on DNA endows the precise and efficient assembly of DNA molecules and ensures the precise regulation on the specific biological functions of functional DNA ***,the functions of DNA materials can couple with the biological environments,so as to achieve the predetermined *** on the scale of the constructed DNA materials,we categorize DNA materials into three classes:molecular scale,nanoscale,and *** the molecular scale,the representative material is branched

关键词： materials. precise synthesis

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