检索结果-南通市图书馆

Covalent organic framework nanomedicines:Biocompatibility for advanced nanocarriers and cancer theranostics applications

引用

Bioactive Materials 2023年第3期21卷 358-380页

作者： Nem Singh jungryun kim Jaewon kim Kyungwoo Lee Zehra Zunbul Injun Lee Eunji kim Sung-Gil Chi Jong Seung kim Department of Chemistry Korea UniversitySeoul02841South Korea Department of Life Science Korea UniversitySeoul02841South Korea

Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research *** unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cancer drugs,such as poor localization at the tumor site,high drug doses and toxicity,recurrence,and poor immune ***,inadequate biocompatibility restricts their potential in clinical ***,advanced nanomaterials with high biocompat-ibility and enhanced therapeutic efficiency are highly desired to fast-track the clinical translation of *** properties of nanoscale covalent organic frameworks(nCOFs),such as suitable size,modular pore geometry and porosity,and straightforward post-synthetic modification via simple organic transformations,make them incredibly attractive for future *** ability of COFs to disintegrate in a slightly acidic tumor microenvironment also gives them a competitive advantage in targeted *** review summarizes recently published applications of COFs in drug delivery,photo-immuno therapy,sonodynamic therapy,photothermal therapy,chemotherapy,pyroptosis,and combination *** we mainly focused on modifications of COFs to enhance their biocompatibility,efficacy and potential clinical *** review will provide the fundamental knowledge in designing biocompatible nCOFs-based nano-medicines and will help in the rapid development of cancer drug carriers and theranostics.

关键词： doses medicines compatibility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

韩国大学初级汉语教材中文化因素分析 ——以《THE汉语Step1,2》与《汉语的神Step1,2》两套教材为例

韩国大学初级汉语教材中文化因素分析 ...

引用

作者：金正伦（kim jungryun）华东师范大学

学位级别：硕士

在第二语言学习的过程中,对目的语文化的理解是文化学习的一个重要分支。随着现在语言文化综合教育重要性的日益凸显,很多学者表示语言教材中必须要适当地融入文化因素。目前韩国的大学与韩国的小学、初中、高中教育部制定的教科书的方... 详细信息

在第二语言学习的过程中,对目的语文化的理解是文化学习的一个重要分支。随着现在语言文化综合教育重要性的日益凸显,很多学者表示语言教材中必须要适当地融入文化因素。目前韩国的大学与韩国的小学、初中、高中教育部制定的教科书的方式不同,各课程的教材都根据各课程计划或教授的选择自行使用,因此语言教学中的文化教学很大程度上需要依靠教师的个人的兴趣和知识来取舍。即使不上另外专门讲解文化的课程,在语言课程内也要开展一部分的文化教学,这不能只依赖于教师的个人兴趣和知识。在实际教育的场景中,教材是教授和学习最核心的资料,是教学体系、教育内容、教育方法的重要呈现。因此,笔者对目前在韩国大学使用的初级汉语教材展示的中国文化因素进行研究。笔者选取了韩国大学最具代表性的两套大学初级汉语教材,即《THE汉语Step1,2》与《汉语的神Step1,2》作为研究对象。这两套教材目前分别在韩国首尔大学和梨花女子大学使用,是其他学校或基础汉语学习者经常使用的教材。由于各学校的中文文学学院教授都是以各学校的课程为基础开发的,或直接由教学团队独立开发,因此可以说是以大学生为学习对象教材的典范。本论文参考韩国和中国的汉语教学中文化教学目标。把两套教材里的文化因素进行归纳,并分析包含文化内容的方式。笔者希望指出目前韩国大学初级汉语教材中存在的文化内容选定和文化内容表现方式存在的问题,并反映使用者对教材使用的意见,希望提出有价值的建议。该研究的目的在于,通过教材分析及对使用者的调查问卷和访谈研究,更好地完善本土教材,尤其是有关文化方面的内容。

关键词：韩国大学汉语教材文化因素初级汉语教材

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

引用

Bioactive Materials 2024年第4期34卷 164-180页

作者： Sungkyu Lee Jounghyun Yoo Gunhyu Bae Ramar Thangam Jeongyun Heo Jung Yeon Park Honghwan Choi Chowon kim Jusung An jungryun kim Kwang Rok Mun Seungyong Shin Kunyu Zhang Pengchao Zhao Yuri kim Nayeon Kang Seong-Beom Han Dahee kim Jiwon Yoon Misun Kang Jihwan kim Letao Yang Solmaz Karamikamkar Jinjoo kim Yangzhi Zhu Alireza Hassani Najafabadi Guosheng Song Dong-Hwee kim Ki-Bum Lee Soong Ju Oh Hyun-Do Jung Hyun-Cheol Song Woo Young Jang Liming Bian Zhiqin Chu Juyoung Yoon Jong Seung kim Yu Shrike Zhang Yongju kim Ho Seong Jang Sehoon kim Heemin Kang Department of Materials Science and Engineering Korea UniversitySeoul02841Republic of Korea Chemical and Biological Integrative Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea Department of Chemistry Korea UniversitySeoul02841Republic of Korea Materials Architecturing Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou511442China Department of Chemistry and Chemical Biology Rutgers UniversityPiscatawayNJ08854USA Terasaki Institute for Biomedical Innovation Los AngelesCA90064USA State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082China Department of Biomedical-Chemical Engineering The Catholic University of KoreaGyeonggi-do14662Republic of Korea Electronic Materials Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea KIST-SKKU Carbon-Neutral Research Center Sungkyunkwan University(SKKU)Suwon16419Republic of Korea Department of Orthopedic Surgery Korea University Anam HospitalSeoul02841Republic of Korea Department of Electrical and Electronic Engineering and Joint Appointment with School of Biomedical Sciences The University of Hong KongHong Kong518057China Department of Chemistry and Nanoscience Ewha Womans UniversitySeoul03760Republic of Korea Division of Engineering in Medicine Department of MedicineBrigham and Women’s Hospital Harvard Medical SchoolCambridgeMA02139USA Division of Nano&Information Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792Republic of Korea College of Medicine Korea UniversitySeoul02841Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul04763Republic of Korea

Extracellular matrix(ECM)undergoes dynamic inflation that dynamically changes ligand nanospacing but has not been *** we utilize ECM-mimicking photocontrolled supramolecular ligand-tunable Azo^(+)self-assembly composed of azobenzene derivatives(Azo^(+))stacked via cation-πinteractions and stabilized with RGD ligand-bearing poly(acrylic acid).Near-infrared-upconverted-ultraviolet light induces cis-Azo^(+)-mediated inflation that suppresses cation-πinteractions,thereby inflating liganded *** inflation increases nanospacing of“closely nanospaced”ligands from 1.8 nm to 2.6 nm and the surface area of liganded selfassembly that facilitate stem cell adhesion,mechanosensing,and differentiation both in vitro and in vivo,including the release of loaded molecules by destabilizing water bridges and hydrogen bonds between the Azo^(+)molecules and loaded ***,visible light induces trans-Azo^(+)formation that facilitates cation-πinteractions,thereby deflating self-assembly with“closely nanospaced”ligands that inhibits stem cell adhesion,mechanosensing,and *** stark contrast,when ligand nanospacing increases from 8.7 nm to 12.2 nm via the inflation of self-assembly,the surface area of“distantly nanospaced”ligands increases,thereby suppressing stem cell adhesion,mechanosensing,and ***-term in vivo stability of self-assembly via real-time tracking and upconversion are *** tuning of ligand nanospacing can unravel dynamic ligand-cell interactions for stem cell-regulated tissue regeneration.

关键词： Dynamic self-assembly Ligand nanospacing In vivo tracking Stem cell adhesion Stem cell fate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：