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Cardiac regeneration: Pre-existing cardiomyocyte as the hub of novel signaling pathway

Genes & Diseases 2024年第2期11卷 747-759页

作者： Tao Wang Xinzhe Chen Kai Wang Jie ju Xue Yu Wanpeng Yu Cuiyun Liu Yin Wang Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityCollege of MedicineQingdao UniversityQingdaoShandong 266023China College of Medicine Qingdao UniversityQingdaoShandong 266023China

In the mammalian heart,cardiomyocytes are forced to withdraw from the cell cycle shortly after birth,limiting the ability of the heart to regenerate and *** development of multimodal regulation of cardiac proliferation has verified that pre-existing cardiomyocyte proliferation is an essential driver of cardiac *** the continuous development of genetic lineage tracking technology,it has been revealed that cell cycle activity produces polyploid cardiomyocytes during the embryonic,juvenile,and adult stages of cardiogenesis,but newly formed mononucleated diploid cardiomyocytes also elevated sporadically during myocardial *** implied that adult cardiomyocytes have a weak regenerative capacity under the condition of ischemia injury,which offers hope for the clinical treatment of myocardial ***,the regeneration frequency and source of cardiomyocytes are still low,and the mechanism of regulating cardiomyocyte proliferation remains further *** is noteworthy to explore what force triggers endogenous cardiomyocyte proliferation and heart ***,we focused on summarizing the recent research progress of emerging endogenous key modulators and crosstalk with other signaling pathways and furnished valuable insights into the internal mechanism of heart *** addition,myocardial transcription factors,non-coding RNAs,cyclins,and cell cycle-dependent kinases are involved in the multimodal regulation of pre-existing cardiomyocyte ***,awakening the myocardial proliferation endogenous modulator and regeneration pathways may be the final battlefield for the regenerative therapy of cardiovascular diseases.

关键词： Cardiac regeneration Cell cycle re-enter Myocardial infarction Pre-existing cardiomyocyte proliferation Regenerative therapy of cardiovascular diseases

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Multifunctional nanoparticle-mediated combining therapy for human diseases

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Signal Transduction and Targeted Therapy 2024年第2期9卷 343-375页

作者： Xiaotong Li Xiuju Peng Makhloufi Zoulikha George Frimpong Boafo Kosheli Thapa Magar Yanmin ju Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 2111198PR China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013PR China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Combining existing drug therapy is essential in developing new therapeutic agents in disease prevention and *** preclinical investigations,combined effect of certain known drugs has been well established in treating extensive human *** to synergistic effects by targeting various disease pathways and advantages,such as reduced administration dose,decreased toxicity,and alleviated drug resistance,combinatorial treatment is now being pursued by delivering therapeutic agents to combat major clinical illnesses,such as cancer,atherosclerosis,pulmonary hypertension,myocarditis,rheumatoid arthritis,inflammatory bowel disease,metabolic disorders and neurodegenerative *** therapy involves combining or co-delivering two or more drugs for treating a specific ***(NP)-mediated drug delivery systems,i.e.,liposomal NPs,polymeric NPs and nanocrystals,are of great interest in combinatorial therapy for a wide range of disorders due to targeted drug delivery,extended drug release,and higher drug stability to avoid rapid clearance at infected *** review summarizes various targets of diseases,preclinical or clinically approved drug combinations and the development of multifunctional NPs for combining therapy and emphasizes combinatorial therapeutic strategies based on drug delivery for treating severe clinical ***,we discuss the challenging of developing NP-codelivery and translation and provide potential approaches to address the *** review offers a comprehensive overview for recent cutting-edge and challenging in developing NP-mediated combination therapy for human diseases.

关键词： drugs diseases prevention

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dECM restores macrophage immune homeostasis and alleviates iron overload to promote DTPI healing

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Regenerative Biomaterials 2024年第2期3卷 100-113页

作者： ju Zhang Ruijuan Si Yu Gao Hui Shan Qi Su Zujian Feng Pingsheng Huang Deling Kong Weiwei Wang Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China School of Nursing Qingdao UniversityNingde RoadShinan DistrictQingdaoShandong266071China Cancer Hospital of Tianjin Medical University North Huanhu West RoadTianjinChina The Affliated Hospital of Qingdao University 16 Jjiangsu RoadShinan DistrictQingdaoChina 5NankaiUniver aniin300071.China

Due to its highly insidious and rapid progression,deep tissue pressure injury(DTPI)is a clinical *** previous study found that DTPI may be a skeletal muscle injury dominated by macrophage immune dysfunction due to excessive iron *** extracellular matrix(dECM)hydrogel promotes skeletal muscle injury ***,its role in po-larizing macrophages and regulating iron metabolism in DTPI remains ***,porcine dECM hydrogel was prepared,and its therapeutic function and mechanism in repairing DTPI were *** stimulus of dECM hydrogel toward RAW264.7 cells resulted in a significantly higher percentage of CD2o6+macrophages and notably decreased intracellular divalent iron *** mice DTPI model,dECM hydrogel treatment promoted M1 to M2 macrophage conversion,improved iron metabolism and reduced oxidative stress in the early stage of *** the remodeling phase,the dECM hydrogel remarkably enhanced revascularization and accelerated skeletal muscle ***,the immunomodulation of dEcM hydrogels in vivo was mainly involved in the P13k/Akt signaling pathway,as revealed by GO and KEGG pathway analysis,which may ameliorate the iron deposition and promote the healing of *** findings indicate that dECM hydrogel is promising in skeletal muscle repair,inflammation resolution and tissue injury healing by effectively restoring macrophage immune homeostasis and normalizing iron metabolism.

关键词： Deep tissue pressure injury hydrogel immunomodulation tissue repair

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Intense and Superflat White Laser with 700-nm 3-dB Bandwidth and 1-mJ Pulse Energy Enabling Single-Shot Subpicosecond Pulse Laser Spectroscopy

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Research 2024年第2期6卷 319-327页

作者： Lihong Hong Haiyao Yang Liqiang Liu Mingzhou Li Yuanyuan Liu Baoqin Chen Huakang Yu Wenbo ju Zhi-Yuan Li School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510641China State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640China

An optical spectrometer is a basic spectral instrument that probes microscopic physical and chemical properties of macroscopic objects but generally suffers from difficulty in broadband time-resolved *** this work,we report the creation of ultrabroadband white-light laser with a 3-dB bandwidth covering 385 to 1,080 nm,pulse energy of 1.07 mJ,and pulse duration of several hundred femtoseconds by passing 3-mJ pulse energy,50-fs pulse duration Ti:Sapphire pulse laser through a cascaded fused silica plate and chirped periodically poled lithium niobate *** utilize this unprecedented superflat,ultrabroadband,and intense femtosecond laser light source to build a single-shot(i.e.,single-pulse)subpicosecond pulse laser ultraviolet-visible-near-infrared spectrometer and successfully measure various atomic and molecular absorption *** single-shot ultrafast spectrometer may open up a frontier to monitor simultaneously the ultrafast dynamics of multiple physical and chemical processes in various microscopic systems.

关键词： Pulse utilize frontier

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Effect of Ti_(p) Content on the Work Hardening and Softening Behavior of Mg-Zn-Ca Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 551-560页

作者： Jin-Kai Zhang Cui-ju Wang Yi-Dan Fan Chao Xu Kai-Bo Nie Kun-Kun Deng Shanxi Key Laboratory of Advanced Magnesium-Based Materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China

The Ti_(p)/ZX60 composites with different Ti_(p) contents were prepared by semi-solid stirring *** extrusion,the microstructure,work hardening and softening behavior of the Ti_(p)/ZX60 composites were analyzed compared with the ZX60(Mg-6Zn-0.2Ca)*** results showed that the addition of Ti_(p) could not only promote the nucleation of dynamic recrystallized(DRXed)grains,but also be propitious to the refinement of DRXed *** increasing Ti_(p) content,the size of DRXed grains decreased accompanied with increasing volume fraction of DRXed *** the Ti_(p) content increased to 15 vol.%,the average size and volume fraction of DRXed grains reached to~0.32μm and 93.2%,***,both the strength and elongation were improved by the addition of Ti_(p).With increasing content of Ti_(p),a substantial increase in the strength was achieved with little change in the ***,the elongation decreased sharply when the Ti_(p) content further increased to 15 vol.%.The addition of Ti_(p) led to an increase in the work hardening rate,which gradually increased with increasing Ti_(p) ***,the softening rate did not demonstrate the same tendency with increasing Ti_(p) *** the conventional ceramic particles,the Ti_(p) can be deformed in coordination with the matrix alloy,which imparted a higher softening rate to the matrix *** though the softening rate improved as the Ti_(p) content increased from 5 to 10 vol.%,it dropped deeply as the Ti_(p) content increased to 15 vol.%owing to the fracture of Ti_(p) during extrusion.

关键词： Titanium particle content Particle reinforced magnesium matrix composites Work hardening Softening behavior Mechanical properties

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Integrated neural tracing and in-situ barcoded sequencing reveals the logic of SCN efferent circuits in regulating circadian behaviors

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Science China(Life Sciences) 2024年第3期67卷 518-528页

作者： Meimei Liao Xinwei Gao Chen Chen Qi Li Qingchun Guo He Huang Erquan Zhang Dapeng ju College of Biological Sciences China Agriculture UniversityBeijing 100193China National Institute of Biological Sciences(NIBS) Beijing 102206China Chinese Institute for Brain Research Beijing 102206China School of Biomedical Engineering Capital Medical UniversityBeijing 100069China Department of Anesthesiology The Second Affiliated HospitalChongqing Medical UniversityChongqing 401336China Tsinghua Institute of Multidisciplinary Biomedical Research Tsinghua UniversityBeijing 102206China

The circadian clock coordinates rhythms in numerous physiological processes to maintain organismal homeostasis. Since the suprachiasmatic nucleus(SCN) is widely accepted as the circadian pacemaker, it is critical to understand the neural mechanisms by which rhythmic information is transferred from the SCN to peripheral clocks. Here, we present the first comprehensive map of SCN efferent connections and suggest a molecular logic underlying these projections. The SCN projects broadly to most major regions of the brain, rather than solely to the hypothalamus and thalamus. The efferent projections from different subtypes of SCN neurons vary in distance and intensity, and blocking synaptic transmission of these circuits affects circadian rhythms in locomotion and feeding to different extents. We also developed a barcoding system to integrate retrograde tracing with in-situ sequencing, allowing us to link circuit anatomy and spatial patterns of gene expression. Analyses using this system revealed that brain regions functioning downstream of the SCN receive input from multiple neuropeptidergic cell types within the SCN, and that individual SCN neurons generally project to a single downstream brain *** map of SCN efferent connections provides a critical foundation for future investigations into the neural circuits underlying SCNmediated rhythms in physiology. Further, our new barcoded tracing method provides a tool for revealing the molecular logic of neuronal circuits within heterogeneous brain regions.

关键词： circadian rhythms SCN output circuit neural tracing barcoded GFP in situ sequencing

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OsWRKY65 enhances immunity against fungal and bacterial pathogens in rice

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The Crop Journal 2024年第2期12卷 470-481页

作者： Seungmin Son Giha Song Suhyeon Nam Jinjeong Lee Duk-ju Hwang Eun-jung Suh Sang Ryeol Park National Institute of Agricultural Sciences Rural Development AdministrationJeonju 54874Republic of Korea Department of Agriculture Forestry and BioresourcesPlant Genomics and Breeding InstituteResearch Institute of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Department of Crop Science and Biotechnology Jeonbuk National UniversityJeonju 54896Republic of Korea

Diverse bacterial and fungal pathogens attack plants,causing biotic stress and severe yield losses *** losses are expected to become more serious as climate change improves conditions for many ***,identifying genes conferring broad-spectrum disease resistance and elucidating their underlying mechanisms provides important resources for plant *** transcription factors affect plant growth and stress ***,the functions of many WRKY proteins remain to be ***,we demonstrated the role of rice(Oryza sativa)WRKY groupⅢtranscription factor OsWRKY65 in ***65 localized to the nucleus and acted as transcriptional *** and molecular functional analyses showed that OsWRKY65 increases resistance to the fungal pathogen Fusarium fujikuroi through downregulation of GA signaling and upregulation of JA ***,OsWRKY65 modulated the expression of the key genes that confer susceptibility or resistance to Xanthomonas oryzae *** to enhance immunity against the *** particular,OsWRKY65directly bound to the promoter region of OsSWEET13 and repressed its *** together,our findings demonstrate that the OsWRKY65 enhances resistance to fungal and bacterial pathogens in rice.

关键词： Bacterial blight Bakanae disease Broad-spectrum disease resistance Oriza sativa OsWRKY65 Rice

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Surface Topological Glycosylation-Mediated Mucoadhesion of Bacteria

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Chinese Journal of Chemistry 2024年第13期42卷 1447-1455页

作者： Xiao Kuang Xiaobing Liu ju Chen Wenyan Lv Mengmeng Zhang Huan Chen Feng Wu Jinyao Liu School of Life Sciences Shanghai UniversityShanghai 200444China Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine Institute of Molecular MedicineState Key Laboratory of Systems Medicine for CancerRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Materials Science Shanghai Normal UniversityShanghai 200234China

Sugar moieties present on bacterial surface serve as pivotal regulators of bacterial *** adjusting the abundance and distribution of surface sugar moieties can offer an important approach to manipulating bacterial behavior,but has been proven to be ***,surface topological glycosylation is reported to mediate the interaction of bacteria with mucous *** functionalized by sugar moieties with different branching are synthesized through iterative Michael addition and amide condensation *** a copper-catalyzed azide-alkyne cycloaddition,the resulting compounds with different branching structures can be attached onto bacterial surface that is modified with azido *** a proof-of-concept study,a set of topologically glycosylated probiotics(TGPs)is prepared using linear,two-branched,and tetra-branched compounds,*** interaction between mucin and TGPs was studied and the results demonstrate that,compared to unmodified bacteria,TGPs exhibit an enhanced adhesive capacity to mucin,which increases with the branching *** binding trend is observed in ex vivo colonic mucus adhesion experiments and bacteria glycosylated with tetra-branched compounds display the highest binding *** work proposes a chemical method to tune the abundance and distribution of sugar moieties on bacteria,providing unique significant insights into the manipulation of bacterial behavior through surface modification.

关键词： Topochemistry Bacteria Glycosylation Surface modification Mucoadhesion Click chemistry

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Spherical cationic polymer networks with porphyrin photosensitizer for sustainable and efficient photocatalysis

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Nano Research 2024年第5期17卷 3934-3941页

作者： Lingling Zhang Liwei Wu junhui Bao Longhui Li Zejun Liu Feng Bai Jie ju Xi Yao Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and EngineeringHenan UniversityKaifeng 475004China Department of Chemistry City University of Hong KongKowloonHong Kong 999077China

The continuous and sustainable photo-activity on micro-or nano-carriers has always been a key stepping stone in the industrialization of photo-catalysis,photo-synthesis,and ***,we report a new series of positively charged hollow microspheres carrying porphyrin *** hollow spheres are formed through crosslinking of well-ordered porous thin laminates,initiated by co-assembly of regular monomers and those decorated with porphyrin *** the surface of an individual sphere,densely distributed positive sites attract anionic *** superficial porphyrin decomposes the accumulated reactants under 1 *** degradation and release of products,the photoactive sites are thereby *** demonstrate that polymer network(1:10)exhibited superior sustainable photocatalytic performance with complete degradation of methyl orange(MO)in 40 min with no observable performance deterioration after six *** established close loop of adsorption-reaction-release cycle makes possible many efficient and continuous photo-catalytic processes.

关键词： hydrogen bonding assembly porphyrin sustainable photo-activity anionic pollutant

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SIRT1 inhibits apoptosis of human lens epithelial cells through suppressing endoplasmic reticulum stress in vitro and in vivo

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1205-1216页

作者： Hui Cui Di Sun Sheng Meng Tian-ju Ma Zi Ye Zhao-Hui Li Medical School of Chinese PLA Beijing 100089China Senior Department of Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China

AIM:To explore the effect of silent information regulator factor 2-related enzyme 1(SIRT1)on modulating apoptosis of human lens epithelial cells(HLECs)and alleviating lens opacification of rats through suppressing endoplasmic reticulum(ER)***:HLECs(SRA01/04)were treated with varying concentrations of tunicamycin(TM)for 24h,and the expression of SIRT1 and C/EBP homologous protein(CHOP)was assessed using real-time quantitative polymerase chain reaction(RT-PCR),Western blotting,and *** morphology and proliferation was evaluated using an inverted microscope and cell counting kit-8(CCK-8)assay,*** the SRA01/04 cell apoptosis model,which underwent siRNA transfection for SIRT1 knockdown and SRT1720 treatment for its activation,the expression levels of SIRT1,CHOP,glucose regulated protein 78(GRP78),and activating transcription factor 4(ATF4)were *** potential reversal of SIRT1 knockdown effects by 4-phenyl butyric acid(4-PBA;an ER stress inhibitor)was *** vivo,age-related cataract(ARC)rat models were induced by sodium selenite injection,and the protective role of SIRT1,activated by SRT1720 intraperitoneal injections,was evaluated through morphology observation,hematoxylin and eosin(H&E)staining,Western blotting,and ***:SIRT1 expression was downregulated in TMinduced SRA01/04 ***,in SRA01/04 cells,both cell apoptosis and CHOP expression increased with the rising doses of *** stress was stimulated by TM,as evidenced by the increased GRP78 and ATF4 in the SRA01/04 cell apoptosis *** of SIRT1 by siRNA knockdown increased ER stress activation,whereas SRT1720 treatment had opposite results.4-PBA partly reverse the adverse effect of SIRT1 knockdown on *** vivo,SRT1720 attenuated the lens opacification and weakened the ER stress activation in ARC rat ***:SIRT1 plays a protective role against TM-induced apoptosis in HLECs and slows the progression of cataract in

关键词： silent information regulator factor 2-related enzyme 1 endoplasmic reticulum stress apoptosis human lens epithelial cells cataract

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