检索结果-南通市图书馆

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum Jun kim Seungyon Koh Hyo jin Cho Xuelian jin Byung Gon kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Chemical control of receptor kinase signaling by rapamycin-induced dimerization

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2021年第8期14卷 1379-1390页

作者： Sara kim jeonghyang Park Byeong Wook jeon Geonhee Hwang Na Young Kang Yeim We Won-Young Park Eunkyoo Oh jungmook kim Department of Life Sciences Korea UniversitySeoulKorea Department of Bioenergy Science and Technology Chonnam National UniversityGwangjuKorea Kumho Life Science Laboratory Chonnam National UniversityGwangjuKorea Department of Integrative Food Bioscienee and BiotechnologyChonnam National UniversityGwangjuKorea

Membrane-localized leucine-rich repeat receptor kinases(LRR-RKs)sense diverse extracellular signals,and coordinate and specify cellular functions in ***,functional understanding and identification of the cellular signaling of most LRR-RKs remain a major challenge owing to their genetic redundancy,the lack of ligand information,and subtle phenotypes of LRR-RK ***,we report an engineered rapamycin-inducible dimerization(RiD)receptor system that triggers a receptor-specific LRR-RK signaling independent of their cognate ligands or endogenous *** the RiD-receptors,we demonstrated that the rapamycin-mediated association of chimeric cytosolic kinase domains from the BRI1/BAK1 receptor/co-receptor,but not the BRI1/BRI1 or BAK1/BAK1 homodimer,is sufficient to activate downstream brassinosteroid signaling and physiological ***,we showed that the engineered RiD-FLS2/BAK1 could activate flagellin-22-mediated immune signaling and *** the RiD system,we also identified the potential function of an unkmown orphan receptor in immune signaling and revealed the differential activities of SERK co-receptors of *** results indicate that the RiD method can serve as a synthetic biology tool for precise temporal manipulation of LRR-RK signaling and for understanding LRR-RK biology.

关键词： leucine-rich repeat receptor kinase brassinosteroids BRI1 BAK1 FLS2

Super-resolution localization photoacoustic microscopy using intrinsic red blood cells as contrast absorbers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2019年第1期8卷 212-222页

作者： Jongbeom kim jin Young kim Seungwan jeon jin Woo BAIK Seong Hee Cho Chulhong kim Departments of Creative IT Engineering Electrical EngineeringMechanical Engineeringand Interdisciplinary Bioscience and BioengineeringPohang University of Science and Technology(POSTECH)77 Cheongam-roNam-guPohangGyeongbuk 37673Republic of Korea

Photoacoustic microscopy(PAM)has become a premier microscopy tool that can provide the anatomical,functional,and molecular information of animals and humans in ***,conventional PAM systems suffer from limited temporal and/or spatial ***,we present a fast PAM system and an agent-free localization method based on a stable and commercial galvanometer scanner with a custom-made scanning mirror(L-PAM-GS).This novel hardware implementation enhances the temporal resolution significantly while maintaining a high signal-to-noise ratio(SNR).These improvements allow us to photoacoustically and noninvasively observe the microvasculatures of small animals and humans in ***,the functional hemodynamics,namely,the blood flow rate in the microvasculature,is successfully monitored and quantified in *** importantly,thanks to the high SNR and fast B-mode rate(500 Hz),by localizing photoacoustic signals from captured red blood cells without any contrast agent,unresolved microvessels are clearly distinguished,and the spatial resolution is improved by a factor of 2.5 in ***-GS has great potential in various fields,such as neurology,oncology,and pathology.

关键词： resolution absorber scanner

Role of glutathione transferase in phase separation of FUS and TAF15 in neurons

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1999-2000页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord,leading to muscle weakness,paralysis,and ultimately death(Cleveland and Rothstein,2001).Frontotemporal lobar degeneration(FTLD)is a neurodegenerative disease affecting the frontal and temporal lobes of the brain,leading to changes in behavior,personality,and language(Van Langenhove et al.,2012).Both ALS and FTLD are classified as proteinopathies in which abnormal protein aggregation and accumulation in neurons contribute to the disease *** in sarcoma(FUS)is a DNA/RNA-binding protein involved in various cellular processes,including transcriptional regulation,RNA splicing,and DNA *** in the FUS gene have been linked to familial ALS,highlighting the importance of FUS in the disease pathogenesis(Vance et al.,2009).In ALS and FTLD,aberrant post-translational modifications(PTMs)of FUS,such as phosphorylation,acetylation,and methylation,have been implicated in the promotion of FUS aggregation and neurotoxicity(Choi et al.,2023).Therefore,understanding the regulatory mechanisms of FUS PTMs is crucial for developing targeted therapies against these diseases.

关键词： degeneration FUS aggregation

Carboplatin restores neuronal toxicity in FUS-linked amyotrophic lateral sclerosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2319-2320页

作者： Kiyoung kim Department of Medical Science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALS),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal *** leads to muscle weakness,paralysis,and ultimate... 详细信息

关键词： paralysis sclerosis respiratory

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal Sharma Sehwan kim Hyemi Eo Sang Ryong kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

Flow Visualization and Performance Measurements of a Flagellar Propeller

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2012年第3期9卷 322-329页

作者： Hyejin jeon Yoon-Cheol kim Dongwook Yim Jung Yui Yoo Songwan jin School of Mechanical and Aerospace Engineering Seoul National University Seoul 151-744 Korea Department of Mechanical Engineering Korea Polytechnic University Siheung-si Gyeonggi-do 429-793 Korea

A new type of propeller that is optimized for low Reynolds numbers is required to propel a small object in a medium where the flow is dominated by viscous rather than inertial forces. A propeller in the shape of a bacterial flagellum seems an appro- priate choice for driving a small object. Accordingly, in this study, we visualized the velocity field induced by a spring-like propeller inspired by the Escherichia coli flagellum, using a macroscopic model and applying stereoscopic particle image velocimetry. We also experimentally evaluated the effect of pitch and rotational speed on the performance of this flagellar propeller. Silicone oil, which has a kinematic viscosity 100,000 times that of water, was used as the working fluid to generate a low Reynolds number for the macroscopic model. Thrust, torque, and velocity were measured as functions of pitch and rota- tional speed, and the efficiency of the propeller was calculated from the measured results. We found that the flagellar propeller reached a max!mum efficiency when the pitch angle was approximately 53°. Compared to pitch, rotational speed had a relatively small effect on the efficiency, and the pitch altered the flow pattern behind the rotating propeller.

关键词： flagellar propeller stereoscopic PIV bacterial flagellum small swimming object

A New Encryption Mechanism Supporting the Update of Encrypted Data for Secure and Efficient Collaboration in the Cloud Environment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2025年第1期142卷 813-834页

作者： Chanhyeong Cho Byeori kim Haehyun Cho Taek-Young Youn Department of Cyber Security Dankook UniversityYongin16890Republic of Korea Department of Software Soongsil UniversitySeoul07027Republic of Korea

With the rise of remote collaboration,the demand for advanced storage and collaboration tools has rapidly ***,traditional collaboration tools primarily rely on access control,leaving data stored on cloud servers vulnerable due to insufficient *** paper introduces a novel mechanism that encrypts data in‘bundle’units,designed to meet the dual requirements of efficiency and security for frequently updated collaborative *** bundle includes updated information,allowing only the updated portions to be reencrypted when changes *** encryption method proposed in this paper addresses the inefficiencies of traditional encryption modes,such as Cipher Block Chaining(CBC)and Counter(CTR),which require decrypting and re-encrypting the entire dataset whenever updates *** proposed method leverages update-specific information embedded within data bundles and metadata that maps the relationship between these bundles and the plaintext *** utilizing this information,the method accurately identifies the modified portions and applies algorithms to selectively re-encrypt only those *** approach significantly enhances the efficiency of data updates while maintaining high performance,particularly in large-scale data *** validate this approach,we conducted experiments measuring execution time as both the size of the modified data and the total dataset size *** show that the proposed method significantly outperforms CBC and CTR modes in execution speed,with greater performance gains as data size ***,our security evaluation confirms that this method provides robust protection against both passive and active attacks.

关键词： Cloud collaboration mode of operation data update efficiency

Effect of Korea red ginseng on cerebral blood flow and superoxide production

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2002年第12期23卷 99-103页

作者： CukSeong kim,jin Bong PARK,Kwang-jin kim,Seok Jong CHANG,Sung-Woo RYOO,Byeong Hwa jeon Department of Physiology College of Medicine Chungnam National University Taejon KOREA Department of Physiology College of Medicine Chungnam National University Taejon KOREA Department of Physiology College of Medicine Chungnam National University Taejon KOREA Department of Physiology College of Medicine Seonam University Namwon KOREA Division of Genomics ＆ Proteomics Korea Research Institute of Bioscience and Biotechnology(KRIBB) Yusong Taejon Korea Correspondence to Byeong Hwa jeon MD PhD.Department of Physiology College of Medicine Chungnam National University 6 Munhwa-dong Jung-gu Taejon South Korea 301131

AIM: To investigate the effects of Korea red ginseng (KRG) on the cerebral perfusion rate in the rats and the generation of superoxide anion in the endothelial cells. METHODS: The cerebral perfusion rate was measured using laser-doppler flowmetry before and after the administration of crude saponin (CS) and saponin-free fraction (SFF) of KRG in the anesthetized rats. The superoxide generation was measured by the method based on lucigenin-enhanced chemiluminescence in the cultured endothelial cells. RESULTS: The relative cerebral perfusion rate (rCBF) was significantly increased by the intraperitoneal injection of CS (100 mg/kg) in the rats, but SFF had no effect on the rCBF. Chronic treatment with CS for 7 d significantly inhibited the decrease of forebrain cerebral blood flow induced by clamping both carotid arteries in the rats. Furthermore, CS (0.1 g/L) significantly sup-pressed NADPH-induced superoxide generation in the human umbilical vein endothelial cells (P<0.01). CONCLUSION: The present study d

关键词： Korean red ginseng cerebral blood flow superoxides vascular endothelium