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Effect of probiotics on growth performance, development of small intestinal tract and microbial populations in broilers

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Journal of Agricultural Science and Technology 2009年第4期3卷 24-31,39页

作者： LEI Yan ZHANG Ke-ying DING Xue-mei BAI Shi-ping jung sik Choi Animal Nutrition Institute Sichuan Agricultural University Ya ＇an 625014 China Engineering Research Center of Animal Disease-Resistance Nutrition of China Ministry of Education Sichuan Agricultural University Ya ＇an 625014 China JSC Bio-teek Company Korea 4490205 Korea

The experiment was conducted using a total of 1392 one-day-old, Cobb commercial male broilers to investigate the effects of a commercial probiotic addition in diet on growth, the development of the small intestine and microbial populations of broilers. Broilers were randomly allotted by BW to 1 of 6 replicate cages （29 chicks per cage） for each of 8 treatments in a randomized block design involving one factorial arrangement of treatments. Dietary treatments included the basal diet （including corn, soybean, rapeseed, cottonseed meal） added with 100 mg/kg antibiotic, 0%, 0.05%, 0.1%, 0.15%, 0.2%, 0.25% or 0.3%. The experiment last 42 d and divided into the starter period （1-21 d） and the finisher period （22-42 d）. The results showed that there were significant differences in broiler body weight （BW）（P〈0.001）, average daily feed intake （ADFI）（P=0.033）, relative length of the duodenum （P〈0.001）, jejunum （P=0.008）, ileum （P〈0.001） and the populations of lactobacillus （P〈0.001） and coliform （P〈0.001） in the rectum between the probiotics treatments and the control treatment only in the starter period of the trails. No significant differences were observed in intestinal morphology parameters in two periods of the experiment. Our results indicated that the probiotic was able to improve the performance of broiler chickens, and it was better in the starter period to be used than in the finisher period.

关键词： probiotic broiler chickens performance intestine development microbial population

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Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B

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World Journal of Gastroenterology 2012年第47期18卷 6987-6995页

作者： Tae jung Yun Jin Yong jung Chang Ha Kim Soon Ho Um Hyonggin An Yeon Seok Seo Jin Dong Kim Hyung Joon Yim Bora Keum Yong sik Kim Yoon Tae Jeen Hong sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu Department of Internal Medicine Korea University College of MedicineSeoul 136-705South Korea Department of Biostatistics Korea University College of MedicineSeoul 136-705South Korea

AIM:To investigate retrospectively the long-term efficacy of various treatment strategies using adefovir dipivoxil(adefovir) in patients with lamivudine-resistant chronic hepatitis ***:We included 154 consecutive patients in two treatment groups:the "add-on" group(n = 79),in which adefovir was added to ongoing lamivudine treatment due to lamivudine resistance,and the "switch/combination" group(n = 75),in which lamivudine was first switched to adefovir and then re-added later as *** "switch/combination" group was then divided into two subgroups depending on whether participants followed(group A,n = 30) or violated(group B,n = 45) a proposed treatment strategy that determined whether to add lamivudine based on the serum hepatitis B virus(HBV) DNA levels(< 60 IU/mL or not) after 6 mo of treatment(roadmap concept).RESULTS:The cumulative probability of virologic response(HBV DNA < 60 IU/mL) was higher in group A than in the "add-on" group and in group B(P < 0.001).In contrast,the cumulative probability of virologic breakthrough was lower in the "add-on" group than in group B(P = 0.002).Furthermore,the risk of virologic breakthrough in the multivariate analysis was significantly lower in the "add-on" group than in group A(hazard ratio = 0.096;95%CI,0.015-0.629;P = 0.015).CONCLUSION:The selective combination of adefovir with lamivudine based upon early treatment responses increased the odds of virologic breakthrough relative to the use of uniform combination therapy from the beginning of treatment.

关键词： Chronic hepatitis B Lamivudine-resistant Adefovir Combination therapy Roadmap concept

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中韩河流沉积物微量元素地球化学研究

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海洋地质与第四纪地质 2003年第2期23卷 19-24页

作者：杨守业李从先 jung Hoi-soo LI M Dong-il CHOI Man-sik 同济大学海洋地质教育部重点实验室上海200092 韩国海洋研究院(KORDI) 韩国基础科学研究院(KBSI)

长江和黄河以及韩国的Keum和Yeongsan江,具有不同的微量元素地球化学特征。韩国河流沉积物中微量元素含量多介于长江和黄河之间,以Li、Rb和Th较高为特征,粒级效应明显。长江富铁族和铜族元素,黄河则Sr最高,其他元素均低于其他3条河流;... 详细信息

长江和黄河以及韩国的Keum和Yeongsan江,具有不同的微量元素地球化学特征。韩国河流沉积物中微量元素含量多介于长江和黄河之间,以Li、Rb和Th较高为特征,粒级效应明显。长江富铁族和铜族元素,黄河则Sr最高,其他元素均低于其他3条河流;韩国河流中Sr主要赋存于长石中,而长江和黄河中则主要赋存于碳酸盐矿物中。根据沉积物中元素的赋存相态及含量,我们认为Ti、Cr/Th、Ti/Nb和Zr/Nb等可以作为判别西太平洋边缘海,尤其是黄海中长江、黄河与韩国河流物质贡献的可靠地球化学参数,但在运用中必须注意粒级效应影响。

关键词：河流沉积物微量元素地球化学粒级效应物源判别

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Effect of Farnesyl Caffeate-Induced Apoptosis of Lung Carcinoma Cell Line from Damage to DNA

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Pharmacology & Pharmacy 2013年第9期4卷 689-695页

作者： Kyu sik Kim Akemi Umeyama Toshihiro Hashimoto Hyun-Ju Cho Je-jung Lee Masao Takei Department of Pulmonary Medicine Chonnam National University Medical School Gwangiu South Korea Department of Pulmonary Medicine Chonnam National University Medical School Gwangiu South Korea Faculty of Pharmaceutical Sciences Tokushima University Tokushima Japan Research Center for Cancer Immunotherapy Chonnam National University Hwasun Hospital Hwasun-eup Hwasun-gun South Korea Research Center for Cancer Immunotherapy Chonnam National University Hwasun Hospital Hwasun-eup Hwasun-gun South Korea Department of Hematology-Oncology Chonnam National University Medical School Gwangiu South Korea.

Farnesyl caffeate, synthesis of propolis and polar bud excretion, has been reported to exhibit anti-allergic effects in mice. However, little is known about anti-tumor effects. In this study, we investigated the effect of Farnesyl caffeate in cell proliferation of lung carcinoma cell line (H157). Antiproliferative effect and apoptosis on H157 cell were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay (MTT) and DNA fragmentation assay, respectively. Farnesyl caffeate inhibited the growth of H157 cell in dose-dependent manner. Morphological changes of nuclei by staining Hoechst 33258 and DNA fragmentation suggested that Farnesyl caffeate induced death involved in a mechanism of apoptosis. Moreover, caspase-3, caspase-7 and caspase-9 were activated by Farnesyl caffeate on H157 cell. The protein expressions of Bax and Bcl-2 were down-regulated by Farnesyl caffeate, resulting in cytochrome c release from the mitochondria. Farnesyl caffeate significantly increased the expression of p53 proteins which indicates that p53 plays a pivotal role in the initiation phase of Farnesyl caffeate-induced HepG2 cell apoptosis. These results demonstrated Farnesyl caffeate-induced apoptosis in human lung carcinoma cell line. More detailed mechanism of ?Farnesyl caffeate-induced H157 apoptosis remains to be elucidated.

关键词： Apoptosis Propolis Farnesyl Caffeate DNA Fragmentation Lung Cancer

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Functionally graded structure of a nitride-strengthened Mg_(2)Si-based hybrid composite

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Journal of Magnesium and Alloys 2024年第3期12卷 1239-1256页

作者： Jeongho Yang Woongbeom Heogh Hogi Ju Sukhyun Kang Tae-sik Jang Hyun-Do jung Mohammad Jahazi Seung Chul Han Seong Je Park Hyoung Seop Kim Susmita Bose Amit Bandyopadhyay Martin Byung-Guk Jun Young Won Kim Dae-kyeom Kim Rigoberto CAdvincula Clodualdo Aranas Jr Sang Hoon Kim School of Mechanical Engineering Pusan National UniversityBusan 46241Republic of Korea Department of Mechanical Design Engineering Hanyang UniversitySeoul 04763Republic of Korea Process Research 3 Team LG Display Co.Ltd.PajuGyeonggi-do 10845Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea Institute of Well-Aging Medicare&Chosun University LAMP Center Chosun UniversityGwangju 61452Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea Department of Mechanical Engineering École de Technologie SupérieureMontrealQuebec H3C 1K3Canada Material&Component Convergence R&D Center Korea Construction Equipment Technology InstituteGunsanJeollabuk-do 54002Republic of Korea School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Graduate Institute of Ferrous&Eco Materials Technology Pohang University of Science and TechnologyPohangGyeongsangbuk-do 37673Republic of Korea Advanced Institute for Materials Research Tohoku UniversitySendai 980-8577Japan Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoul 03722Republic of Korea School of Mechanical and Materials Engineering Washington State UniversityPullmanWashington 99164USA School of Mechanical Engineering Purdue UniversityWest LafayetteIndiana 47907USA Research Institute of Advanced Manufacturing Technology Korea Institute of Industrial TechnologyIncheon 21999Republic of Korea Department of Macromolecular Science and Engineering Case Western Reserve UniversityClevelandOhio 44106USA Department of Chemical and Biomolecular Engineering and Joint Institute for Advanced Materials University of TennesseeKnoxvilleTennessee 37996USA Center for Nanophase Materials and Sciences Oak Ridge National LaboratoryOak RidgeTennessee 37830USA Department of Mechanical Engineering University of New BrunswickFrederictonNew Brunswick E3B 5A3Cana

The ex-situ incorporation of the secondary SiC reinforcement,along with the in-situ incorporation of the tertiary and quaternary Mg_(3)N_(2) and Si_(3)N_(4) phases,in the primary matrix of Mg_(2)Si is employed in order to provide ultimate wear resistance based on the laser-irradiation-induced inclusion of N_(2) gas during laser powder bed *** is substantialized based on both the thermal diffusion-and chemical reactionbased metallurgy of the Mg_(2)Si–SiC/nitride hybrid *** study also proposes a functional platform for systematically modulating a functionally graded structure and modeling build-direction-dependent architectonics during additive *** strategy enables the development of a compositional gradient from the center to the edge of each melt pool of the Mg_(2)Si–SiC/nitride hybrid ***,the coefficient of friction of the hybrid composite exhibits a 309.3%decrease to–1.67 compared to–0.54 for the conventional nonreinforced Mg_(2)Si structure,while the tensile strength exhibits a 171.3%increase to 831.5 MPa compared to 485.3 MPa for the conventional *** outstanding mechanical behavior is due to the(1)the complementary and synergistic reinforcement effects of the SiC and nitride compounds,each of which possesses an intrinsically high hardness,and(2)the strong adhesion of these compounds to the Mg_(2)Si matrix despite their small sizes and low concentrations.

关键词： Laser powder bed fusion Mg_(2)Si-SiC/nitride hybrid composite Both the thermal diffusion-and chemical reaction-based metallurgy Functionally graded structure Compositional gradient Wear resistance.

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Dipsacussaponin C from <i>Dipsacus asper</i>Reduces the Risk of Gastritis and Gastric Ulcer in Rats

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Food and Nutrition Sciences 2012年第7期3卷 931-941页

作者： Seon A. Hwang In Young Hwang Joohee jung Hye Kyung Kang Kun Ho Son Choon sik Jeong College of Pharmacy Duksung Women’s University Seoul 132-714 South Korea College of Pharmacy Duksung Women’s University Seoul Korea Department of Food Science and Nutrition Andong National University Gyeongbuk 760-749 South Korea

The roots of Dipsacus asper (DA) have been used as a tonic and analgesic agent in traditional Chinese medicine for the treatment of osteoporosis, low back pain, knee pain, and as an anti-inflammatory agent. Few studies have reported pharmacological gastric activities. In this study, we investigated the effects of dipsacussaponin C (DSC) and 70% ethanol and water extracts of DA on gastritis and gastric ulcer in rat. First, we examined the free radical scavenging effect by the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay. Second, we examined the Helicobacter pylori (H. pylori) colonization inhibitory effect and found that DSC has a mild anti-H. pylori effect. Third, the cytotoxicity was assessed by measuring the cell viability of human gastric cancer cells (SNU638 and AGS). Also, we observed the acid-neutralizing capacity by measuring NaOH consumption volume and found that DSC is effective as an antacid agent. For these reasons, we observed the effect of DSC on HCl?ethanol-induced gastritis and indomethacin-induced gastric ulcer in rat. In pylorus-ligated rats, DSC (200 mg/kg) also decreased the volume of gastric secretion (approximately 2.2 mL) and gastric acid output (0.16 mEq/4 hrs). From these results, we suggest that DSC isolated from DA may be useful for the treatment and/or protection of gastritis and gastric ulcer.

关键词： Dipsacussaponin C Dipsacusasper Antioxidants Gastritis Gastric Ulcer

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Mirizzi syndrome in an anomalous cystic duct:A case report

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World Journal of Gastroenterology 2007年第41期13卷 5527-5529页

作者： Cheol Woong jung Byung Wook Min Tae Jin Song Gil Soo Son Hong sik Lee Seung Joo Kim Jun Won Um Department of Surgery Korea University College of Medicine126-15-Ga Anam-DongSungbuk-GuSeoul 136-705Korea Department of Internal Medicine Korea University College of Medicine126-15-Ga Anam-DongSungbuk-GuSeoul 136-705Korea

Mirizzi syndrome is a rare complication of gallstone disease,and results in partial obstruction of the common bile duct or a cholecystobiliary fistula. Moreover,congenital anatomical variants of the cystic duct are common,occurring in 18%-23% of cases,but Mirizzi syndrome underlying an anomalous cystic duct is an important clinical consideration. Here,we present an unusual case of typeⅠMirizzi syndrome with an uncommon anomalous cystic duct,namely,a low lateral insertion of the cystic duct with a common sheath of cystic duct and common bile duct.

关键词： Bile duct diseases and surgery Cholelithiasis Cholelithiasis and surgery, Cystic duct Cholangiography

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Foldable three dimensional neural electrode arrays for simultaneous brain interfacing of cortical surface and intracortical multilayers

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npj Flexible Electronics 2022年第1期6卷 840-853页

作者： Ju Young Lee Sang Hoon Park Yujin Kim Young Uk Cho Jaejin Park jung-Hoon Hong Kyubeen Kim Jongwoon Shin Jeong Eun Ju In sik Min Mingyu Sang Hyogeun Shin Ui-Jin Jeong Yuyan Gao Bowen Li Aizhan Zhumbayeva Kyung Yeun Kim Eun-Bin Hong Min-Ho Nam Hojeong Jeon Youngmee jung Huanyu Cheng Il-Joo Cho Ki Jun Yu School of Electrical and Electronic Engineering Yonsei University50 Yonsei-roSeodaemunguSeoul 03722Republic of Korea Department of Biomedical Sciences College of MedicineKorea UniversitySeoul 02841Republic of Korea Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Biotechnology College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of KHU-KIST Convergence Science and Technology Kyung Hee UniversitySeoul 02447Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea School of Electrical and Electronic Engineering YU-KIST InstituteYonsei UniversitySeoul 03722Republic of Korea Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Anatomy College of MedicineKorea UniversitySeoul 02841Republic of Korea Department of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Korea

Challenges in the understanding of three-dimensional(3D)brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted ***,we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical *** device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated *** demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological *** also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker *** platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface.

关键词： neural electrode simultaneous

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Evaluation of esophageal function in patients with esophageal motor abnormalities using multichannel intraluminal impedance esophageal manometry

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World Journal of Gastroenterology 2006年第39期12卷 6349-6354页

作者： Yu Kyung Cho Myung-Gyu Choi Jae Myung Park jung Hwan Oh Chang Nyol Paik Joon Wook Lee In Seok Lee Sang Woo Kim In-sik Chung Division of Gastroenterology Department of Internal Medicine The Catholic University of Korea Seoul Korea

AIM: To evaluate the functional aspect of esophageal motility in healthy subjects and in patients who were referred for esophageal function testing using multichannel intraluminal impedance-esophageal manometry (MII-EM), and to assess the clinical utility of MII-EM. METHODS: From September 2003 to January 2004, we performed the MII-EM on healthy volunteers and all the patients who were referred for esophageal function testing. Each patient received 10 liquid and 10 viscous swallows. We analyzed the results, the impedance and the manometric findings. Some of the subjects had additional ambulatory 24-h pH study performed to diagnose gastroesophageal reflux disease (GERD). RESULTS: Among 89 studied subjects, the MII-EM findings showed normal esophageal motility in 50 (56.17%), ineffective esophageal motility (IEM) in 17 (19.10%), nutcracker esophagus in 7 (7.86%), achalasia in 4 (4.49%), and scleroderma esophagus in 11 (12.35%) cases. The completeness and the speed of bolus transit were in the order of nutcracker esophagus, normal manometry and IEM. Some of the swallows showing normal manometry and IEM had incomplete transit. In the achalasia and scleroderma esophagus, almost all the swallows had incomplete transit. The body amplitudes were higher for the swallows with complete transit than for the swallows with incomplete transit. There was not a significant difference in the manometric and impedance findings between the subjects with and without GERD. CONCLUSION: MII-EM is a useful tool in assessing theesophageal function in the patients having esophageal motility abnormality. The primary factors influencing the bolus transit are the amplitude of the esophageal body and normal peristalsis.

关键词： Impedance manometry Esophageal function Motility Bolus transit

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Usefulness of the BRAF(V600E) mutation to the suspicious papillary thyroid carcinoma result from the Cytology

Usefulness of the BRAF(V600E) mutation to the suspicious pap...

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2010中华医学会影像技术分会第十八次全国学术大会

作者： Yoo Min-a Kim Yun-min Ahn jung-hyun Ahn Mi-sub Park Won-sik Department of Radiology Samsung medical centerSeoulKorea

Objective:Thyroid cancers account for about 1%of all human malignancies,with papillary thyroid carcinoma(PTC) occupies more than 80%of thyroid cancer in *** BRAF (V600E) mutation is the most common genetic disorder found

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