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Abrupt visual loss during anti-vascular endothelial growth factor treatment for type 3 neovascularization

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 480-487页

作者： Jae Hui Kim Young Suk Chang Jong Woo Kim Chul Gu Kim Dong Won lee Department of Ophthalmology Kim's Eye Hospital Konyang University College of Medicine Department of Ophthalmology Konyang University College of Medicine

AIM: To investigate the incidence of abrupt visual loss and its associated factors, during anti-vascular endothelial growth factor(VEGF) treatment for type 3 ***: This retrospective study included 137 eyes that were newly diagnosed with type 3 neovascularization. All eyes were treated with anti-VEGF therapy. Abrupt visual loss was defined as loss of 5 or more lines in best-corrected visual acuity(BCVA) in comparison to the previous visit. The incidence and timing of abrupt visual loss as well as the factors associated with it, were determined. In addition, the BCVA at the final follow-up was compared between the eyes with and those without abrupt visual ***: The mean follow-up period was 42.4±18.9 mo after diagnosis, and abrupt visual loss was noted in 22 eyes(16.1%) at a mean of 19.6±13.9 mo. Abrupt visual loss was found to be associated with subretinal hemorrhage in 11 eyes(50.0%), development of or increase in the height of pigment epithelial detachment with fluid in 8 eyes(36.4%), and tears in the retinal pigment epithelium in 3 eyes(13.6%). The logarithm of minimum angle of resolution(logMAR) mean BCVA at the final follow-up was 2.07±0.67(Snellen equivalents: 20/2349) and 1.00±0.55(20/200) in eyes with and without abrupt visual loss, respectively. BCVA was significantly worse in the eyes with abrupt visual loss(P<0.001).CONCLUSION: Abrupt visual loss is noted in 16.1% of patients with type 3 neovascularization and is associated with poor visual outcome. Additional studies are needed to determine how abrupt visual loss can be prevented.

关键词： age-related macular degeneration type 3 neovascularization retinal angiomatous proliferation hemorrhage tear in retinal pigment epithelium pigment epithelial detachment

Identification of quantitative trait loci for the dead leaf rate and the seedling dead rate under alkaline stress in rice

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Journal of Genetics and Genomics 2008年第5期35卷 299-305页

作者： Dongling Qi Guizhen Guo Myung-chul lee junguo Zhang Guilan Cao Sanyuan Zhang Seok-cheol Suh Qingyang Zhou Longzhi Han Institute of Crop Science Chinese Academy of Agricultural Sciences/The National Key Facility for Crop Gene Resources and Genetic Improvement NFCR1/Key Laboratory of Crop Germplasm Resources and Biotechnology Ministry of Agriculture Beijing 100081 China Rubber Research Institute of China Chinese Academy of Tropical Agricultural Sciences/Key laboratory of Physiology for Tropical Crops Ministry of Agriculture Hainan 571737 China Institute of Rice Research Jilin Academy of Agricultural Sciences Gongzhuling 136100 China National Institute of Agricultural Biotechnology Rural Development Administration Suwon 441-707 Korea Horticultural Department Sichuan Agricultural University Ya＇an 625014 China

The quantitative trait loci （QTLs） for the dead leaf rate （DLR） and the dead seedling rate （DSR） at the different rice growing periods after transplanting under alkaline stress were identified using an F2：3 population, which included 200 individuals and lines derived from a cross between two japonica rice cultivars Gaochan 106 and Changbai 9 with microsatellite markers. The DLR detected at 20 days to 62 days after transplanting under alkaline stress showed continuous normal or near normal distributions in F3 lines, which was the quantitative trait controlled by multiple genes. The DSR showed a continuous distribution with 3 or 4 peaks and was the quantitative trait controlled by main and multiple genes when rice was grown for 62 days after transplanting under alkaline stress. Thirteen QTLs associated with DLR were detected at 20 days to 62 days after transplanting under alkaline stress. Among these, qDLR9-2 located in RM5786-RM160 on chromosome 9 was detected at 34 days, 41 days, 48 days, 55 days, and 62 days, respectively; qDLR4 located in RM3524-RM3866 on chromosome 4 was detected at 34 days, 41 days, and 48 days, respectively; qDLR7-1 located in RM3859-RM320 on chromosome 7 was detected at 20 days and 27 days; and qDLR6-2 in RM1340-RM5957 on chromosome 6 was detected at 55 days and 62 days, respectively. The alleles of both qDLR9-2 and qDLR4 were derived from alkaline sensitive parent ＂Gaochanl06＂. The alleles of both qDLR7-1 and qDLR6-2 were from alkaline tolerant parent Changbai 9. These gene actions showed dominance and over dominance primarily. Six QTLs associated with DSR were detected at 62 days after transplanting under alkaline stress. Among these, qDSR6-2 and qDSR8 were located in RM1340-RM5957 on chromosome 6 and in RM3752-RM404 on chromosome 8, respectively, which were associated with DSR and accounted for 20.32% and 18.86% of the observed phenotypic variation, respectively; qDSR11-2 and qDSR11-3 were located in RM536-RM479 and RM2596-RM286 on chromoso

关键词： rice alkaline stress dead leaf rate dead seedling rate microsatellite marker quantitative trait locus (QTL)

Biological and Functional Properties of Wedelolactone in Human Chronic Diseases

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Phyton-International Journal of Experimental Botany 2021年第1期90卷 1-15页

作者： Ramachandran Vinyagam Pradeep Kumar Kyung Eun lee Baojun Xu Muhammad Nurul Matin Sang Gu Kang Department of Biotechnology Institute of BiotechnologyCollege of Life and Applied ScienceYeungnam UniversityGyeongsanGyeongbuk38541Korea Department of Forestry North Eastern Regional Institute of Science and TechnologyNirjuli791109India Stemforce 313 Institute of Industrial TechnologyYeungnam UniversityGyeongsanGyeongbuk38541Korea Food Science and Technology Program Beijing Normal University-Hong Kong Baptist UniversityUnited International CollegeZhuhai519000China Department of Genetic Engineering and Biotechnology University of RajshahiRajshahi6205Bangladesh

Medicinal herbs are well known and studied over the past millennia in most of the developing countries as a rational means of treatment against various diseases and ***(WDL),a major bioactive compound in Eclipta prostrata L(Eclipta alba L),has been reported with potential benefits in human health against chronic ***,a comprehensive study on WDL pharmacological benefits in various ailments,to the best of our knowledge,is not yet ***,the present review provides the recent therapeutic applications in reference to biological and functional activities against major human chronic diseases,including cardiovascular,cancer,diabetes mellitus,liver disease,Alzheimer’s disease,and androgenetic *** this study,we collected all the relevant experimental information on WDL from Scientific databases such as PubMed,Web of Science,Science Direct,and Google ***,WDL is recognized as a key anti-oxidant with both specific regulator and inhibitor of major drug targetable proteins in human chronic diseases and ***,WDL as a novel therapeutic bioactive molecule is advised to explore further for relevant pharmacological activities.

关键词： Wedelolactone Eclipta alba L Ecliptaprostrata L bioactivity bioavailability

Extraction and purification of ustiloxin A from rice false smut balls by a combination of macroporous resin and high-speed countercurrent chromatography

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Food Production, Processing and Nutrition 2020年第1期2卷 287-299页

作者： Gang Wang Dan He Fengchun Zhao Junqiang Hu Yin-Won lee Jianrong Shi Jianhong Xu Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base Ministry of Science and Technology/Key Laboratory for Control Technology and Standard for Agro-product Safety and QualityMinistry of Agriculture and Rural Affairs/Key Laboratory for Agro-product Safety Risk Evaluation(Nanjing)Ministry of Agriculture and Rural Affairs/Collaborative Innovation Center for Modern Grain Circulation and Safety/Institute of Food Safety and NutritionJiangsu Academy of Agricultural SciencesNanjingPeople’s Republic of China School of Food and Biological Engineering Jiangsu UniversityZhenjiangPeople’s Republic of China Department of Microbiology College of Life ScienceKey Laboratory for Agriculture MicrobiologyShandong Agricultural UniversityTai’anPeople’s Republic of China School of Agricultural Biotechnology Seoul National UniversitySeoul 08826Republic of Korea

Rice false smut is an emerging plant disease *** A(UstA)is the major mycotoxin found in rice false smut balls,which are fungal colonies in rice *** this study,a new method consisting of macroporous resin column chromatography and high-speed countercurrent chromatography(HSCCC)was developed for UstA *** was extracted by a 3.81%HCOOH solution and adsorbed by XAD-4 *** was then eluted by a 40%methanol solution supplemented with 0.1%trifluoroacetic acid(TFA).Further purification was achieved by HSCCC using a two-phase solvent system consisting of n-butanol/TFA/H_(2)O(1/0.05/1,v/v/v).Under the optimized conditions,225 mg of UstA was obtained with a purity of 97.39%in a single run,with a final recovery of 65.2%.An inhibitory effect on seed germination of wheat and maize caused by UstA was observed in a preliminary phytotoxicity assay.

关键词： Ustiloxin A Rice false smut Preparative purification Macroporous resin High-speed counter-current chromatography Phytotoxicity assay

Recent research progress on magnesium alloys in Korea:A review

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Journal of Magnesium and Alloys 2023年第10期11卷 3545-3584页

作者： Sung Hyuk Park Ye Jin Kim Hyun Ji Kim Sang-Cheol Jin Jong Un lee Alexander Komissarov Kwang Seon Shin School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Laboratory of Hybrid Nanostructured Materials National University of Science and TechnologyMoscow 119049Russia Laboratory of Medical Bioresorption and Bioresistance Moscow State University of Medicine and DentistryMoscow 127473Russia Magnesium Technology Innovation Center School of Materials Science and EngineeringSeoul National UniversitySeoul 08826Republic of Korea

This review highlights the recent advancements in Mg research in South Korea with a prime focus on high-speed-extrudable Mg–Bi-based alloys for high productivity and strength,innovative techniques utilizing{10–12}twinning for improved mechanical properties,and alloying and processing methods for enhanced corrosion ***-alloyed Mg–Bi-based alloys possess thermally stableα-Mg matrix and secondary phase,which ensures high-speed extrusion of these alloys at elevated temperatures without hot ***,they exhibit outstanding extrudability with a maximum extrusion speed of up to 70 m/***,their high alloying contents offer excellent strength even after high-speed extrusion through strong solid solution hardening and particle hardening effects,making them suitable for high-performance extruded Mg *** pre-twinning process utilizing{10–12}twinning and the combined process of pre-twinning and subsequent annealing have shown promise in controlling microstructure and texture of wrought Mg alloys and thus enhancing their mechanical *** pre-twinning process enhances tensile strength,fatigue properties,and age-hardening rate of Mg ***,the combined processes of pre-twinning and subsequent annealing considerably improve their ductility,stretch formability,bending formability,and damping *** have been made to improve the corrosion resistance of Mg alloys through alloying additions,process treatments,and surface *** elements like Ca,Sc,and Sm alter the microstructural features(such as secondary phases and grain size)that affect the corrosion *** treatments such as multidirectional forging,screw rolling,and pulse electron beam can also improve the corrosion resistance by refining the ***,advanced surface coating technologies can create durable and corrosion-resistant layers for effectively protecting the Mg *** these research activities conducted

关键词： South Korea Mg–Bi alloys {10–12}twinning Corrosion Mechanical properties

Cancer-associated fibroblasts of colorectal cancer: Translationalprospects in liquid biopsy and targeted therapy

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BIOCELL 2023年第10期47卷 2233-2244页

作者： ELYN AMIELA SALLEH YEONG YEH lee ANDEE DZULKARNAEN ZAKARIA NUR ASYILLA CHE JALIL MARAHAINI MUSA Human Genome Centre School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia Department of Internal Medicine School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia Department of Surgery School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia Department of Pathology School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia

Colorectal cancer (CRC) is a major global health concern. Accumulation of cancer-associated fibroblasts(CAFs) in CRC is associated with poor prognosis and disease recurrence. CAFs are the main cellular component ofthe tumor microenvironment. CAF-tumor cell interplay, which is facilitated by various secretomes, drives colorectalcarcinogenesis. The complexity of CAF populations contributes to the heterogeneity of CRC and influences patientsurvival and treatment response. Due to their significant roles in colorectal carcinogenesis, different clinicalapplications utilizing or targeting CAFs have been suggested. Circulating CAFs (cCAFs) which can be detected inblood samples, have been proposed to help in determining patient prognosis and enables the detection of cancerthrough liquid biopsy. Liquid biopsy is gaining traction as it is non-invasive, allows frequent and easy sampling, andshows concordance to tissue biopsy analysis. In addition, CAF-targeted therapy is currently being studied extensivelyto be used as one of the treatment avenues for CRC. Various mechanisms of CAF-targeted therapy have beenreported, including blocking the signaling pathways involving CAFs and cancer cells, thus abolishing the CAF-tumorcell crosstalk and subsequently hindering tumorigenesis. These translational applications of cCAFs and utilization ofCAFs as key targets for CRC therapy, although still in the early phases of development, will potentially improve CRCpatient management in the future.

关键词： Activated fibroblast Colon cancer Liquid biopsy Precision medicine

The effects of probiotics administration on the milk production,milk components and fecal bacteria microbiota of dairy cows

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Science Bulletin 2017年第11期62卷 767-774页

作者： Haiyan Xu Weiqiang Huang Qiangchuan Hou Lai-yu Kwok Zhihong Sun Huimin Ma Feiyan Zhao Yuan-Kun lee Heping Zhang Key Laboratory of Dairy Biotechnology and Engineering Ministry of EducationInner Mongolia Agricultural University Department of Microbiology National University of Singapore

Probiotics administration can improve host health. This study aims to determine the effects of probiotics （Lactobacillus casei Zhang and Lactobacillus plantarum P-8） administration on milk production, milk func- tional components, milk composition, and fecal microbiota of dairy cows. Variations in the fecal bacteria microbiota between treatments were assessed based on 16S rRNA profiles determined by PacBio single molecule real-time sequencing technology. The probiotics supplementation significantly increased the milk production and the contents of milk immunoglobulin C （IgG）, lactoferrin （LTF）, lysozyme （LYS） and lactoperoxidase （LP）, while the somatic cell counts （SCC） significantly decreased （P〈0.01）. However, no significant difference was found in the milk fat, protein and lactose contents （P 〉 0.05）. Although the probiotics supplementation did not change the fecal bacteria richness and diversity, significantly more rumen fermentative bacteria （ Bacteroides, Roseburia, Ruminococcus, CIostridium, Coprococcus and Dorea） and beneficial bacteria （Faecalibacterium prausnitzii） were found in the probiotics treatment group. Meanwhile, some opportunistic pathogens e.g. Bacillus cereus, Cronobacter sakazakii and Alkaliphilus oremlandii, were suppressed. Additionally, we found some correlations between the milk production, milk components and fecal bacteria. To sum up, our study demonstrated the beneficial effects of probiotics application in improving the quality and quantity of cow milk production.

关键词： Milk production Milk components Fecal bacteria Prnbintics Dairy cow PacBio single molecule real-time sequencing technology

Ensemble Model for Spindle Thermal Displacement Prediction of Machine Tools

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Computer Modeling in Engineering & Sciences 2023年第10期137卷 319-343页

作者： Ping-Huan Kuo Ssu-Chi Chen Chia-Ho lee Po-Chien Luan Her-Terng Yau Department of Mechanical Engineering National Chung Cheng UniversityChiayi62102Taiwan Advanced Institute of Manufacturing with High-Tech Innovations(AIM-HI) National Chung Cheng UniversityChiayi62102Taiwan

Numerous factors affect the increased temperature of a machine tool, including prolonged and high-intensity usage,tool-workpiece interaction, mechanical friction, and elevated ambient temperatures, among others. Consequently,spindle thermal displacement occurs, and machining precision suffers. To prevent the errors caused by thetemperature rise of the Spindle fromaffecting the accuracy during themachining process, typically, the factory willwarm up themachine before themanufacturing ***, if there is noway to understand the tool spindle’sthermal deformation, the machining quality will be greatly affected. In order to solve the above problem, thisstudy aims to predict the thermal displacement of the machine tool by using intelligent algorithms. In the practicalapplication, only a few temperature sensors are used to input the information into the prediction model for realtimethermal displacement prediction. This approach has greatly improved the quality of tool ***,each algorithm has different performances in different environments. In this study, an ensemble model is used tointegrate Long Short-TermMemory (LSTM) with Support VectorMachine (SVM). The experimental results showthat the prediction performance of LSTM-SVM is higher than that of other machine learning algorithms.

关键词： Thermal displacement ensemble model LSTM milling machine spindle

Segmental artery injury during transforaminal percutaneous endoscopic lumbar discectomy:Two case reports

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World Journal of Clinical Cases 2022年第33期10卷 12345-12351页

作者： Wan-Jae Cho Ki-Won Kim Hyung-Youl Park Bo-Hyoung Kim Jun-Seok lee Department of Orthopedic Surgery Yeouido St.Mary’s HospitalCollege of MedicineCatholic University of KoreaSeoul 07345South Korea Department of Orthopedic Surgery Eunpyeong St.Mary’s HospitalCollege of MedicineCatholic University of KoreaSeoul 03312South Korea

BACKGROUND Since Kambin experimentally induced arthroscopy to treat herniated nucleus pulposus,percutaneous endoscopic lumbar discectomy(PELD)has been *** branch of the segmental artery around the neural foramen may be damaged during PELD using the transforaminal *** report 2 rare cases in which segmental artery injury that occurred during PELD was treated with emergency *** SUMMARY In case 1,a 31-year-old man was transferred to our emergency department with left lower quadrant abdominal pain after PELD at a local *** spine magnetic resonance imaging after the surgery showed a hematoma of the left retroperitoneal area and the psoas muscle *** suspicion of vascular injury,arteriography was *** and blood leakage from the left 4th lumbar segmental artery into the abdominal cavity were *** transarterial embolization was performed using fibered microcoils for bleeding of the segmental *** case 2,a 75-year-old woman was transferred to our emergency department with low blood pressure,right flank pain,and drowsy mental status after PELD at a local *** the patient arrived at the emergency room,the blood pressure decreased from 107/55 mmHg to 72/47 *** blood pressure *** suspicion of vessel injury,arteriography was performed,and the right 4th lumbar segmental artery rupture was *** transarterial embolization was performed for bleeding of segmental *** We were able to find the bleeding focus by angiography and treat the injury of the segmental artery successfully through emergency transarterial embolization.

关键词： Percutaneous endoscopic lumbar discectomy Segmental artery injury Transarterial embolization Angiography Case report