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Respiratory failure after scoliosis correction surgery in patients with Prader-Willi syndrome: Two case reports

World Journal of Clinical Cases 2021年第32期9卷 9960-9969页

作者： Ju-Yul yoon Sung-hee Park Yu Hui Won Department of Physical Medicine and Rehabilitation Jeonbuk National University Medical SchoolJeonju 54907JeonbukSouth Korea Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital Jeonju 54907JeonbukSouth Korea

BACKGROUND Sleep-disordered breathing,including hypoventilation and obstructive sleep apnea,is often observed in Prader-Willi syndrome(PWS).Particularly in adolescence,scoliosis causes a progressive restrictive pulmonary pattern,leading to hypoventilation,so timely corrective surgery is ***,the effect is *** addition,since mental retardation of PWS,patient effort-based respiratory tests may be less *** far,no studies have accurately reported on the comparison of respiratory function before and after corrective surgery,and appropriate respiratory function measurement method in *** SUMMARY We present two cases of adolescent PWS with typical characteristics,including obesity,mental retardation,and *** boys,aged 12 and 13,diagnosed with PWS,both underwent scoliosis correction *** and immediately after surgery,arterial blood tests showed no abnormalities and no respiratory symptoms ***,after 6-7 mo,both patients complained of daytime sleepiness,difficulty sleeping at night,dyspnea on exertion,and showed *** and hypoxia were confirmed by polysomnography and transcutaneous CO2 monitoring during sleep and were diagnosed with obstructive sleep apnea and alveolar *** was corrected by nighttime noninvasive ventilation application and normal findings of arterial blood gas were maintained after 6-8 mo *** Even after scoliosis surgery,“periodic”monitoring of respiratory failure with an“objective”test method is needed for timely respiratory support.

关键词： Prader-Willi syndrome Respiratory failure Noninvasive ventilation Obstructive sleep apnea Scoliosis Case report

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SMARCA4-deficient undifferentiated thoracic tumor:A case report

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World Journal of Clinical Cases 2023年第11期11卷 2521-2527页

作者： hee jung Kwon Min Hye Jang Department of Pathology Yeungnam University Medical CenterDaegu 42415South Korea

BACKGROUND SMARCA4-deficient undifferentiated tumors(SMARCA4-DUTs)present with diverse clinical manifestations and progress to metastasis and even cause death within a few *** novel subset of undifferentiated tumors occurs in the middle-aged population and is strongly associated with a smoking ***-guishing it from other malignancies is *** SUMMARY A 62-year-old man presented with chest pain for 7 *** patient had no respiratory symptoms and normal pulmonary function test *** patient had been a smoker for 8 years and quit smoking 2 years *** computed tomography revealed a huge mass involving the left upper and lower lung lobes with pericardial invasion and multiple *** samples were obtained using open frozen biopsy,after several unsuccessful *** tumor was composed of sheets of undifferentiated disclosive cells with vesicular nuclei and prominent *** differential diagnosis included high-grade lymphoma,germ cell tumor,NUT carcinoma,undifferentiated carcinoma,and *** tumor cells were large,arranged in sheets,and did not exhibit glandular or squamous *** foci of necrosis were *** was no evidence of epithelial differentiation on immunohistochemical *** SMARCA4 stain showed complete loss of expression of SMARCA4,which is *** In the present case,thoracic SMARCA4-DUT was diagnosed based on clinical features,absence of epithelial differentiation,and negative SMARCA4 expression.

关键词： SMARCA4 BRG1 Deficient Undifferentiated tumor Thoracic Case report

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Fournier’s gangrene after insertion of thermo-expandable prostatic stent for benign prostatic hyperplasia:A case report

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世界临床病例杂志 2023年第27期11卷 6498-6504页

作者： hee Chang jung Yeong Uk Kim Department of Urology Yeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND Thermo-expandable urethral stent(Memokath 028)implantation is an alternative treatment for older patients with lower urinary tract symptoms and benign prostatic *** prostatic urethral stent implantation,minor complications such as urinary tract infection,irritative symptoms,gross hematuria,and urethral pain have been observed;however,there are no reports of life-threatening ***,we report a critical case of Fournier’s gangrene that occurred 7 years after prostatic *** SUMMARY An 81-years-old man with benign prostatic hyperplasia(volume,126 ccs;as measured by transrectal ultrasound)had undergone insertion of a thermoexpandable urethral stent(Memokath 028)as he was unfit for surgery under general ***,the patient had undergone a suprapubic cystostomy for recurrent acute urinary retention 4 years after the insertion of prostatic stent(Memokath 028).We had planned to remove the Memokath 028;however,the patient was lost to *** patient presented to the emergency department 3 years after the suprapubic cystostomy with necrotic changes from the right scrotum to the right inguinal *** digital rectal examination,tenderness and heat of prostate was ***,the black skin color change with foulsmelling from right scrotum to right inguinal area was *** computed tomography finding,subcutaneous emphysema was identified to same *** was diagnosed with Fournier’s gangrene based on the physical examination and computed tomography *** emergency room,Fournier’s gangrene severity index value is seven ***,he underwent emergent extended surgical debridement and removal of the Memokath ***-spectrum intravenous antibiotics were administered and additional necrotic tissue debridement was ***,the patient died 14 days after surgery due to multiorgan *** If Memokath 028 for benign prostatic hyperplasia is not working in older patients,its rapid

关键词： Urethral stents Minimally invasive surgery Complication Fournier’s gangrene Benign prostatic hyperplasia Case report

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Development of tool-path generation module for 5-axis control machining of impellers

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Journal of Central South University 2012年第12期19卷 3424-3429页

作者： jung Hyoun-chul SON Hwang-jin jung yoon-gyo School of Mechatronics Changwon National UniversityChangwon 641-773Korea

An impeller is difficult to machine because of severe collision due to the complex shape,overlapping and twisted shape of the impeller ***,most computer aided manufacturing(CAM)software companies have developed CAM module for manufacturing impeller according to their CAM *** these dedicated modules are difficult to use for inexperienced *** purpose of this work is to develop a tool-path generation module for *** this purpose,it is based on Visual Basic language and used CATIA graphical *** result of simulation for generated tool-path by the module is *** it has slow processing speed compared to other commercial modules,but it is easy to use.

关键词： impeller computer aided manufacturing 5-axis control machining tool path module

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Intraoperative photodynamic therapy for tracheal mass in non-small cell lung cancer:A case report

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World Journal of Clinical Cases 2023年第16期11卷 3915-3920页

作者： hee Suk jung Hyun jung Kim Kwan Wook Kim Department of Thoracic and Cardiovascular Surgery CHA Bundang Medical CenterSeongnam-si 13496South Korea

BACKGROUND Tracheal neoplasms represent less than 0.1%of all malignancies and have no established treatment *** resection with reconstruction is the primary *** study demonstrates successful treatment of concurrent lung and tracheal tumors using surgical excision and intraoperative photodynamic therapy(PDT),highlighting the effectiveness and safety of this *** SUMMARY A 74-year-old male with a history of smoking and chronic obstructive pulmonary disease was diagnosed with tracheal squamous cell carcinoma and right lower lobe adenocarcinoma.A multidisciplinary team created a treatment plan involving tumor resection and *** tracheal tumor was removed through a tracheal incision and this was followed by intraluminal *** trachea was repaired and a right lower lobectomy was *** patient received a second PDT treatment postoperatively and was discharged 10 d after the tracheal surgery,without *** then underwent platinum-based chemotherapy for lymphovascular invasion of lung ***-month postoperative bronchoscopy revealed normal tracheal mucosa with a scar at the resection site and no evidence of tumor recurrence in the trachea or *** Our case of concurrent tracheal and lung cancers was successfully treated with surgical excision and intraoperative PDT which proved safe and effective in this patient.

关键词： Tracheal neoplasm Non-small cell lung carcinoma Pulmonary surgical procedure Photochemotherapy Prognosis Case report

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Production of germline chimeric quails following spermatogonial cell transplantation in busulfan-treated testis

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Asian Journal of Andrology 2018年第4期20卷 414-416页

作者： Young Min Kim Jin Se Park Jong Won yoon hee jung Choi Kyung Je Park Tamao Ono Jae Yong Han Department of Agricultural Biotechnology Research Institute of Agriculture and Life Sciences College of Agriculture and Life Sciences Seoul National University Seou108826 Korea Division of Animal Science Faculty of Agriculture Shinshu University Minamiminowa Nagano 399-4598 Japan Institute for Biomedical Sciences Shinshu University Minamiminowa Nagano 399-4598 Japan

Dear Editor, The merits of using quaff as an avian experimental model include high egg production, low maintenance cost, small body size, and short generation period （approximately 6-8 weeks）. Indeed, these characteristics make quail an ideal species for many biological areas including transgenic research. Methods of primordial germ cell （PGC）-mediated germline chimera production are considered very reliable and have been used in avian transgenesis.

关键词： COTURNIX-JAPONICA TRANSGENIC QUAIL TESTICULAR CELLS JAPANESE-QUAIL STEM-CELLS SPERMATOGENESIS TRANSMISSION CHICKEN

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^(27)Al MAS-NMR study of inorganic polymer formation at ambient temperature

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 182-187页

作者： Sang-Wook AHN hee-Soo LEE Wan-hee YANG jung-Woo LEE Young-Keun JEONG National Core Research Center for Hybrid Materials Solution Pusan National University School of Material Science and Engineering Pusan National University INTChem Co. Ltd.

Inorganic polymers are a novel class of materials formed by the polymerization of silicon, aluminium and oxygen species to form an amorphous three-dimensional framework structure. The basis of this process is the alkaline solutions to induce a certain amount of Si and AI atoms to dissolve from a feedstock such as aluminosilicate. A study of 27A1 MAS-NMR was carried out in an attempt to understand the reaction mechanism of the inorganic polymerization at ambient temperature. Scanning electron microscopy （SEM） and X-ray diflYactometry （XRD） were also employed to establish the composition and microstructure of the inorganic polymerization. Specimens were prepared with different A1/Si mole ratios from the starting materials. The higher the AI content, the more sufficient the AI atoms that can combine with SiO4, and the longer the reaction time, the more the bonded Si--O--A1--O polymer structure, and then the higher the A1 content, the fewer the octahedral A1 with a uniform Si--O--A1--O structure in four directions, because four AI atoms are combined with SiO4, resulting in a uniform Si--O--AI--O structure in four directions. The results show that they have an amorphous microstructure.

关键词： inorganic polymer amorphous tetrahedral

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High resolution impedance manometric findings in dysphagia of Huntington's disease

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World Journal of Gastroenterology 2012年第14期18卷 1695-1699页

作者： Tae hee Lee Joon Seong Lee Wan jung Kim Institute for Digestive Research Soon Chun Hyang College of MedicineSeoul 140-743South Korea

Conventional manometry presents significant challenges,especially in assessment of pharyngeal swallowing,because of the asymmetry and deglutitive movements of oropharyngeal *** only provides information about intraluminal pressure and thus it is difficult to study functional details of esophageal motility *** technology of solid high resolution impedance manometry(HRIM),with 32 pressure sensors and 6 impedance sensors,is likely to provide better assessment of pharyngeal swallowing as well as more information about esophageal motility ***,the clinical usefulness of application of HRIM in patients with oropharyngeal dysphagia or esophageal dysphagia is not *** experienced a case of Huntington's disease presenting with both oropharyngeal and esophageal dysphagia,in which HRIM revealed the mechanism of oropharyngeal dysphagia and provided comprehensive information about esophageal dysphagia.

关键词： Dysphagia Esophagus High resolution impedance manometry Huntington's disease Oropharynx

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LAME:Layout-Aware Metadata Extraction Approach for Research Articles

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Computers, Materials & Continua 2022年第8期72卷 4019-4037页

作者： Jongyun Choi Hyesoo Kong Hwamook yoon Heungseon Oh Yuchul jung Department of Computer Engineering Kumoh National Institute of Technology(KIT)GumiKorea Korea Institute of Science and Technology Information(KISTI) DaejeonKorea School of Computer Science and Engineering Korea University of Technology and Education(KOREATECH)CheonanKorea

The volume of academic literature,such as academic conference papers and journals,has increased rapidly worldwide,and research on metadata extraction is ***,high-performing metadata extraction is still challenging due to diverse layout formats according to journal *** accommodate the diversity of the layouts of academic journals,we propose a novel LAyout-aware Metadata Extraction(LAME)framework equipped with the three characteristics(e.g.,design of automatic layout analysis,construction of a large meta-data training set,and implementation of metadata extractor).In the framework,we designed an automatic layout analysis using PDF *** on the layout analysis,a large volume of metadata-separated training data,including the title,abstract,author name,author affiliated organization,and keywords,were automatically ***,we constructed a pre-trainedmodel,Layout-Meta BERT,to extract the metadata from academic journals with varying layout *** experimental results with our metadata extractor exhibited robust performance(Macro-F1,93.27%)in metadata extraction for unseen journals with different layout formats.

关键词： Automatic layout analysis layout-MetaBERT metadata extraction research article

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Regeneration-associated macrophages： a novel approach to boost intrinsic regenerative capacity for axon regeneration

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Neural Regeneration Research 2016年第9期11卷 1368-1371页

作者： Min jung Kwon Hyuk Jun yoon Byung Gon Kim Department of Brain Science Ajou University School of Medicine Suwon Republic of Korea Department of Neurology Ajou University School of Medicine Suwon Republic of Korea Neuroscience Graduate Program Department of Biomedical Sciences Ajou University Graduate School of Medicine Suwon Republic of Korea

Axons in central nervous system （CNS） do not regenerate spontaneously after injuries such as stroke and traumatic spinal cord iniury. Both intrinsic and extrinsic factors are responsible for the regeneration fail- ure, Although intensive research efforts have been invested on extrinsic regeneration inhibitors, the extent to which glial inhibitors contribute to the regeneration failure in viva still remains elusive. Recent exper- imental evidence has rekindled interests in intrinsic factors for the regulation of regeneration capacity in adult mammals. In this review, we propose that activating macrophages with pro-regenerative molecular signatures could be a novel approach for boosting intrinsic regenerative capacity of CNS neurons. Using a conditioning injury model in which regeneration of central branches of dorsal root ganglia sensory neu- rons is enhanced by a preceding injury to the peripheral branches, we have demonstrated that perineuronal macrophages surrounding dorsal root ganglia neurons are critically involved in the maintenance of en- hanced regeneration capacity. Neuron-derived chemokine （C-C motif） ligand 2 （CCL2） seems to mediate neuron-macrophage interactions conveying injury signals to perineuronal macrophages taking on a soley pro-regenerative phenotype, which we designate as regeneration-associated macrophages （RAMs）. Ma- nipulation of the CCL2 signaling could boost regeneration potential mimicking the conditioning injury, suggesting that the chemokine-mediated RAM activation could be utilized as a regenerative therapeutic strategy for CNS injuries.

关键词： axon regeneration conditioning injury neuron-macrophage interaction regeneration-associatedmacrophage cAMP CCL2 M2 polarization spinal cord injury

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