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畜禽业 2007年第7期18卷 48-48页

作者： K.jung J.Kim Y.ha 李春华（译）魏晓锋（译）

***等报道了经胎盘感染猪圆环病毒2型对猪流行性腹泻病毒引起新生仔猪肠炎的影响。6头怀孕母猪被随机分为感染组和对照组，每组3头。感染纰3头怀孕母猪在分娩前3周鼻内接种6mL PCV2组织培养毒（病毒含量为1.2×105 TCID50／ml，毒株为SN... 详细信息

***等报道了经胎盘感染猪圆环病毒2型对猪流行性腹泻病毒引起新生仔猪肠炎的影响。6头怀孕母猪被随机分为感染组和对照组，每组3头。感染纰3头怀孕母猪在分娩前3周鼻内接种6mL PCV2组织培养毒（病毒含量为1.2×105 TCID50／ml，毒株为SNUVR000470）；对照组3头怀孕母猪同时接种正常细胞培养上清液．

关键词：胎盘感染 PCV2 PEDV 猪流行性腹泻病毒猪圆环病毒2型进程临床疾病

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Heavy metal chemistry in soils received long-term application of organic wastes

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Journal of Agricultural Chemistry and Environment 2012年第1期1卷 1-9页

作者： Soon-Ik Kwon Yeon-Ah Jang Kye-Hoon Kim Goo-Bok jung Min-Kyeong Kim hae Hwang Mi-Jin Chae Seung-Chang Hong Kyu-Ho So Sun-Gang Yun Kwon-Rae Kim Gyeongnam National University of Science and Technology Jinju South Korea National Academy of Agricultural Science (NAAS) RDA Suwon South Korea The University of Seoul Seoul South Korea

This study was carried out to understand the long-term effect of organic waste treatment on the fate of heavy metals originated from the organic wastes, together with examination of changes in soil properties. For this, the soils received three different organic wastes (municipal sewage sludge, alcohol fermentation processing sludge, pig manure compost) in three different rates (12.5, 25, 50 ton/ha/yr) for 7 years (1994 - 2000) were used. To see the long-term effect, plant growth study and soil examination were conducted twice in 2000 and 2010, respectively. There was no additional treatment of organic wastes for post ten years after ceasing organic waste treatment for seven years. Soil examination conducted in 2010 showed decreases in soil pH, EC, total nitrogen, organic matter, available phosphorus, exchangeable cations and heavy metal contents in all soils received organic wastes compared to the results obtained in 2000. Speciation of heavy metals in soil through sequential extraction showed that organically bound Cu was the dominant species in all treatment and exchangeable Cu was increased in the plots treated with municipal sewage sludge and alcohol fermentation processing sludge. organically bound Ni increased from 25% - 30% to 32% - 45% in 2010 inall treatment while Pb showed increase in carbonate form in all treatments. Zn existed mainly as sulfide and residual forms, showing increases in organically bound form in all treatment during post ten years.

关键词： Heavy Metal Long-Term Application Organic Wastes Sequential Extraction

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来自一项艾日布林联合吉西他滨对比紫杉醇联合吉西他滨作为HER2阴性转移性乳腺癌的一线化疗的Ⅱ期、多中心、随机试验的包含神经病变相关量表的生活质量结果：韩国癌症研究组试验(KCSG BR13-11)

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癌症 2019年第8期38卷 368-376页

作者： Ji‑Yeon Kim Seri Park Seock‑Ah Im Sung‑Bae Kim Joohyuk Sohn Keun Seok Lee Yee Soo Chae Ki Hyeong Lee Jee Hyun Kim Young‑Hyuck Im Tae‑Yong Kim Kyung‑Hun Lee Jin‑Hee Ahn Gun Min Kim In hae Park Soo jung Lee Hye Sook han Se Hyun Kim Kyung hae jung Yeon Hee Park Korean Cancer Study Group Division of Hematology‑Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of Medicine81 Irwon‑roGangnam‑guSeoul 06351South Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and TechnologySungkyunkwan UniversitySeoul 06351South Korea Department of Internal Medicine Seoul National University HospitalCancer Research InstituteCollege of MedicineSeoul National UniversitySeoul 03080South Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Division of Medical Oncology Department of Internal MedicineYonsei University College of MedicineSeoul 03722South Korea Center for Breast Cancer National Cancer CenterGoyang 10408South Korea Department of Internal Medicine Kyungpook National University HospitalDaegu 41944South Korea Deparment of Internal Medicine Chungbuk National University HospitalCheongju 28644South Korea Department of Internal Medicine Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam 13620South Korea 不详

背景与目的一项比较艾日布林联合吉西他滨(eribulin plus gemcitabine,EG)或紫杉醇联合吉西他滨(paclitaxel plus gemcitabine,PG)作为转移性乳腺癌(metastatic breast cancer,MBC)患者一线化疗方案的II期临床试验发现,EG方案的神经毒性较低,但疗效与PG方案相似。在本研究中,我们分析了该临床实验中的癌症患者生命质量测评量表–紫杉烷(functional assessment of cancer therapy-taxane,FACT-Taxane)问卷评分以确定他们的生活质量(quality of life,QoL)。方法使用韩国版的FACT-Taxane问卷评估QoL。在评估基线之后,前12个疗程中每2个疗程评估1次QoL,之后每3个疗程评估1次QoL。使用线性混合模型评估EG组和PG组QoL的差异。结果在118例入组患者中,117例在基线时回复了FACT-Taxane问卷,PG组中有1例患者没有回复。EG组和PG组之间的基线QoL评分没有差异。在治疗期间,除了第11个疗程外,在第2–13个化疗疗程后,PG组紫杉烷亚量表评分显著高于EG组(均P<0.05)。神经病变特异性分析显示PG组患者的神经病症状比EG组患者更早出现且更严重(P<0.001)。结论在我们的QoL分析中,与PG方案相比,EG方案延迟并减少神经病变的发生。因此,艾日布林是MBC一线化疗药物紫杉醇的合理替代品。

关键词：转移性乳腺癌艾日布林紫杉醇神经病生活质量癌症患者生命质量测评量表–紫杉烷问卷

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A型流感病毒血凝素蛋白S-棕榈酰化修饰的质谱分析

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分析化学 2016年第10期44卷 1521-1527页

作者：王子健高祥杨静波孙万春吴东林彭其胜刘宁吉林大学第二医院吉林大学人兽共患病研究所人兽共患病研究教育部重点实验室吉林省疾病预防与控制中心

蛋白质S-棕榈酰化修饰是指棕榈酸分子通过硫酯键共价结合在蛋白质分子的半胱氨酸（S）的巯基侧链上,是蛋白质脂类修饰的重要形式之一,在细胞信号转导、代谢等过程中起着重要作用。本实验首先利用酰基-生物素置换反应,将A型流感病毒血凝... 详细信息

蛋白质S-棕榈酰化修饰是指棕榈酸分子通过硫酯键共价结合在蛋白质分子的半胱氨酸（S）的巯基侧链上,是蛋白质脂类修饰的重要形式之一,在细胞信号转导、代谢等过程中起着重要作用。本实验首先利用酰基-生物素置换反应,将A型流感病毒血凝素蛋白上的S-棕榈酸分子转换为含有生物素（Biotin）分子的标签。生物素标记蛋白经特异性富集、电泳分离纯化后,进行胶内水解。再利用质谱技术对水解混合物进行分析。结果表明,经酰基-生物素置换方法处理A型流感病毒裂解产物后,蛋白质耦联生物素的浓度（羟胺处理,+Hydroxylamine）与空白对照组（未加羟胺处理,-Hydroxylamine）的比值大于3;对经富集后的流感病毒血凝素蛋白进行了质谱分析,鉴定了A型的两个S-棕榈酰化修饰位点,分别位于蛋白羧基末端的Cys;和Cys;。本研究为大规模研究S-棕榈酰化修饰蛋白提供了一种特异、有效的分析方法。

关键词：流感病毒血凝素蛋白酰基-生物素置换 S-棕榈酰化

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应用320层CT评价自由呼吸下CCTA的初步随机研究

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国际医学放射学杂志 2013年第4期 387-388页

作者： E.J. Kang J. Lee K.N. Lee H. Kown D.H. ha R.B. Kim 董龙春 Department of Radiology Kyungpook National University & Hospital50 Sam-Duk 2Ga Jung GuDaegu 700-721 Republic of Korea

目的应用320层CT(MDCT)评估成人自由呼吸状态下冠状动脉CT血管成像(CCTA)的可行性。方法在74例接受CCTA检查的病人中,37例在自由呼吸状态下进行,另外37例在标准的屏气状态下完成。分别对所有冠状动脉的16段质量评分进行分析,并将其定义... 详细信息

目的应用320层CT(MDCT)评估成人自由呼吸状态下冠状动脉CT血管成像(CCTA)的可行性。方法在74例接受CCTA检查的病人中,37例在自由呼吸状态下进行,另外37例在标准的屏气状态下完成。分别对所有冠状动脉的16段质量评分进行分析,并将其定义为:1极好,2良好,3不良。比较2种检查方法下每幅影像的信噪比(SNR)、对比噪声比(CNR)和有效辐射剂量。结果屏气和自由呼吸两种检查方法的影像质量评分差异无统计学意义[(1.10±0.31)∶(1.12±0.33);P=0.443]。两种检查方法间的SNR和CNR差异无统计学意义,有效剂量的总均数差异亦无统计学意义(P=0.585)。结论应用320层MDCT自由呼吸下CCTA与标准屏气CCTA影像质量之间差异无统计学意义。对于那些屏气困难或因不可忽视的呼吸暂停导致的心率不稳的病人,自由呼吸CCTA可作为评估冠状动脉的替代方法。要点①心脏CT的应用越来越广泛,不可避免地会面对一些屏气不足的病人。②MDCT(如320层)为这些屏气不足的病人带来了新的机会。③自由呼吸状态下与屏气状态下所获得的影像质量相当。④较高的辐射剂量限制了它的临床应用。

关键词：冠状动脉CT血管成像 CT 辐射剂量屏气自由呼吸

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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