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Hwangryunhaedoktang exerts anti-inflammation on LPS-induced nO production by suppressing mAPK and nF-κB activation in RAW264.7 macrophages

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Journal of Integrative medicine 2017年第4期15卷 326-336页

作者： Byung Hyuk Han Yun jung Lee jung Joo Yoon Eun Sik Choi Seung namgung Xian Jun Jin Da Hye Jeong Dae Gill Kang Ho Sub Lee College of Oriental medicine and Professional Graduate School of Oriental medicine Wonkwang University Hanbang Body-fluid Research Center Wonkwang University

OBJECTIVE： This study aimed to evaluate whether Hwangryunhaedoktang （HHT）, a herbal compound, has an inhibitory effect on lipopolysaccharide （LPS）-induced inflammation in RAW264.7 macrophages. mETHODS： The effects of HHT were evaluated by confirm.ng nitric oxide （nO） production and expression of inducible nO synthase （inOS） and mitogen-activated protein kinases （mAPKs） in LPS-stimulated RAW264.7 macrophages via the Griess assay, Western blotting, and real-time reverse transcription quantitative polymerase chain reaction. Western blot analyses and luciferase assays were used to evaluate whether HHT has an effect on the phosphorylation and translocation of nuclear factor-κB （nF-κB）. The secretion and expression of tumor necrosis factor-α （TnF-α） and interleukin-6 （IL-6） were determ.ned via enzyme-linked imm.nosorbent assay and Western blot analyses. RESULTS： HHT suppressed LPS-induced nO production and expression of inOS in a dose-dependent m.nner. Additionally, mAPKs activation was also attenuated via inhibition of phosphorylation of extracellular signal-regulated kinases 1/2, c-Jun n-term.nal kinase and p38 which were related to inflammatory pathway. Furthermore, HHT also effectively attenuated nF-κB activation and its translocation to the nucleus, a process that is closely linked to inflammation. LPS normally induced the expression of inflammatory cytokines such as TnF-α and IL-6, but the secretion and expression of TnF-α and IL-6 were significantly attenuated by pretreating the cells with HHT. COnCLUSIOn： HHT suppressed LPS-induced nO production by blocking the activation of nF-κB and mAPK signaling pathways in RAW264.7 macrophages. Furthermore, HHT may have an anti-inflammatory effect by suppressing the LPS-induced secretion of TnF-α and IL-6. Therefore, the traditional herbal formula HHT might be a useful potential therapeutic agent for inflammation.

关键词： medicine, Chinese traditional lipopolysaccharide nitric oxide nuclear factor-κB mitogen-activatedprotein kinases tumor necrosis factor-a inflammation

Impregnation approach for poly(vinylidene fluoride)/tin oxide nanotube composites with high tribological perform.nce

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Journal of materials Science & Technology 2020年第2期37卷 19-25页

作者： m.n Su Park Jin Kyu Kim Tong-Seok Han jung Tae Park Jong Hak Kim Departm.nt of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul03722Korea Departm.nt of Civil and Environm.ntal Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul03722Korea Departm.nt of Chemical Engineering Konkuk University120 Neungdong-roGwangjin-guSeoul05029Korea

We report a composite material with the high tribological perform.nce,which consists of onedim.nsional SnO2 nanotubes(ST)and a high molecular weight poly(vinylidene fluoride)(PVDF)matrix in terms of *** of PVDF in n,n-dimethylformamide(DmF)resulted in a facile penetration of PVDF into the inner hollow voids of ST,leading to the close *** between PVDF and ST results in a beneficial effect on the chain arrangem.nt of PVDF,providing anα-phase with better tribological *** ST incorporation,the friction coefficient decreased by 85.0%to 0.408,and the specific wear rate decreased by 69.1%to 0.412,dem.nstrating the pivotal role of ST as a self-lubricating material due to a large interactive area and PVDF chain rearrangem.nt.

关键词： SnO2 nanotube Composite Friction coefficient Wear rate

Low-intensity treadmill exercise and/or bright light promote neurogenesis in adult rat brain

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neural Regeneration Research 2013年第10期8卷 922-929页

作者： Sung Jin Kwon Jeongsook Park So Yun Park Kwang Seop Song Sun Tae jung So Bong jung Ik Ryeul Park Wan Sung Choi Sun Ok Kwon Departm.nt of Physical Education Gyeongsang National University Departm.nt of Anatomy and neurobiology Medical Research Center for Neural DysfunctionInstitute of Health ScienceSchool of MedicineGyeongsang National University Departm.nt of Liberal Arts Gyeongnam National University of Science and Technology

The hippocampus is a brain region responsible for learning and memory functions. The purpose of this study was to investigate the effects of low-intensity exercise and bright light exposure on neurogenesis and brain-derived neurotrophic factor expression in adult rat hippocampus. male Sprague-Dawley rats were randomly assigned to control, exercise, light, or exercise ＋ light groups （n = 9 per group）. The rats in the exercise group were subjected to treadmill exercise （5 days per week, 30 m.nutes per day, over a 4-week period）, the light group rats were irradiated （5 days per week, 30 m.nutes per day, 10 000 Ix, over a 4-week period）, the exercise ＋ light group rats were subjected to treadmill exercise in combination with bright light exposure, and the control group rats remained sedentary over a 4-week period. Compared with the control group, there was a significant increase in neurogenesis in the hippocampal dentate gyrus of rats in the exercise, light, and exercise ＋ light groups. moreover, the expression level of brain-derived neurotrophic factor in the rat hippocampal dentate gyrus was significantly higher in the exercise group and light group than that in the control group. Interestingly, there was no significant difference in brain-derived neurotrophic factor expression between the control group and exercise ＋ light group. These results indicate that low-intensity treadmill exercise （first 5 m.nutes at a speed of 2 m/m.n, second 5 m.nutes at a speed of 5 m/m.n, and the last 20 m.nutes at a speed of 8 m/m.n） or bright-light exposure therapy induces positive biochemical changes in the brain. In view of these findings, we propose that moderate exercise or exposure to sunlight during childhood can be beneficial for neural developm.nt.

关键词： neural regeneration neurogenesis neurorehabilitation exercise bright light brain-derivedneurotrophic factor hippocampus childhood grants-supported paper neuroregeneration

Trends of Regional Precipitation and Their Control mechanisms during 1979–2013

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Advances in Atmospheric Sciences 2016年第2期33卷 164-174页

作者： Run LIU Shaw Chen LIU Chein-jung SHIU Jun LI Yuanhang ZHAnG State Key Joint Laboratory of Environm.ntal Simulation and Pollution Control College of Environmental Sciences and Engineering Peking University Research Center for Environm.ntal Changes Academia Sinica Departm.nt of Atmospheric Science NCU

Trends in precipitation are critical to water resources. Considerable uncertainty remains concerning the trends of regional precipitation in response to global warm.ng and their controlling mechanisms. Here, we use an interannual difference method to derive trends of regional precipitation from GPCP （Global Precipitation Climatology Project） data and mERRA （modern- Era Retrospective Analysis for Research and Applications） reanalysis in the near-global domain of 60~ S-60~n during a major global warm.ng period of 1979-2013. We find that trends of regional annual precipitation are primarily driven by changes in the top 30% heavy precipitation events, which in turn are controlled by changes in precipitable water in response to global warm.ng, i.e., by thermodynamic processes. Significant drying trends are found in most parts of the U.S. and eastern Canada, the middle East, and eastern South America, while significant increases in precipitation occur in northern Australia, southern Africa, western India and western China. In addition, as the climate warms there are extensive enhancem.nts and expansions of the three major tropical precipitation centers-the maritime Continent, Central America, and tropical Africa-leading to the observed widening of Hadley cells and a significant strengthening of the global hydrological cycle.

关键词： regional precipitation global warm.ng water resources

Hyperpolarization caused by serotonin contributes to endothelium-dependent relaxations in the porcine coronary artery

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中国药理学报 1999年第12期20卷 1093-1096页

作者： Seung-jung PARK mikio nAKASHImA Tetsuhiko nAGAO Paul m VAnHOUTTE Center for Experim.ntal Therapeutics Department of MedicineBaylor College of MedicineOne Baylor PlazaHoustonTX 77030USA

AIm:The present study was designed to investigate the contribution of membrane hyperpolarization to endothelium-dependent relaxations induced by serotonin in the porcine coronary ***:Rings with and without endothelium of porcine coronary arteries were suspended in conventional organ chambers for the measurem.nt of isometric *** cell membrane potential of the vascular smooth muscle cells was measured using glass microelectrodes,in the presence of indometacin,ketanserin,and/or n^(ω)-***:Serotonin induced a transient endothelium-,and concentration-dependent relaxation in rings contracted with prostaglandin F_(2α)in the presence of n^(ω)-nitro-L-arginine(maximal relaxation;19%).The n^(ω)-nitro-L-arginine resistant relaxation was abolished by high K^(+)and tetrabutylamm.nium *** also caused an endothelium-,concentration-dependent membrane hyperpolarizations with a maximal amplitude *** nitro-L-arginine resistant relaxations and hyperpolarizations were abolished by methiothepin,but not by *** time course of the endothelium-dependent relaxations and hyperpolarizations was ***:These results suggest a contribution of cell membrane hyperpolarization to theendothelium-dependent relaxations induced by serotonin in the porcine coronary artery.

关键词： indomethacin ketanserin membrane potentials methiothepin nitric oxide potassium channels serotonin vascular endothelium

Bubble and Heat Transfer Phenom.na in Viscous Slurry Bubble Column

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Advances in Chemical Engineering and Science 2014年第4期4卷 417-429页

作者： Hyo Sik Kim Jin Ho Kim Chan Gi Lee Suk Hwan Kang Kwang Jae Woo Ho Jin jung Dong wook Kim Plant Engineering Center Institute for Advanced Engineering (IAE) Gyongki-do Korea DAEWOOnG E & S Daejeon Korea Departm.nt of Environm.ntal Engineering Kongju National University Cheonan Korea

Heat transfer and bubble phenom.na were investigated by adopting the drift flux model in a viscous slurry bubble column reactor (SBCR), having a diameter of 0.0508 m(ID) and height 1.5 m. The effects of superficial gas velocity (0.002 -0.164 m/s), solid concentration (0 - 20 wt%) and liquid viscosity (paraffin oil;16.9 mPa•s and squalane;25.9 mPa•s) on the gas holdup and heat transfer characteristics were exam.ned. It was observed that the gas holdup increased with increasing superficial gas velocity (UG), but decreased with increasing solid concentration (SC) or slurry viscosity. The degree of non-uniformity in a SBCR could be determ.ned by the modified drift flux model at the heterogeneous flow regime. The local heat transfer coefficient (h) between the immersed heater and the bed decreased with increasing liquid viscosity and SC, but it increased with increasing UG. The modified nusselt number including the gas holdup and local heat transfer coefficient was well correlated in terms of dim.nsionless groups such as Reynolds and Prandtl numbers.

关键词： Gas Holdup Slurry Bubble Column Heat Transfer Drift Flux model

LED照射光催化剂用于苯、甲苯、乙苯和二甲苯分解(英文)

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催化学报 2012年第10期33卷 1672-1680页

作者： JO Wan-Kuen KAnG Hyun-jung Departm.nt of Environm.ntal Engineering Kyungpook National University

Studies on the use of gas phase applications of light emitting diodes(LEDs) in photocatalysis are scarce although their photocatalytic decomposition kinetics of environm.ntal pollutants are likely different from those in aqueous *** present study evaluated the use of chips of visible light LEDs to irradiate nitrogen doped titania(n-TiO2) prepared by hydrolysis to decompose gaseous benzene,toluene,ethyl benzene,m-xylene,p-xylene,and *** calcined at different temperatures were characterized by various analytical *** degradation efficiency of benzene was close to zero for all *** the other compounds,a conventional 8 W daylight lamp/n-TiO2 unit gave a higher photocatalytic degradation efficiency as compared with that of visible-LED/n-TiO2 ***,the ratios of degradation efficiency to electric power consumption were higher for the photocatalytic units that used two types of visible-LED lamps(blue and white LEDs).The highest degradation efficiency was observed with the use of a calcination temperature of 350 *** average degradation efficiencies for toluene,ethyl benzene,m-xylene,p-xylene,and o-xylene were 35%,68%,94%,and 93%,*** use of blue-and white-LEDs,high light intensity,and low initial concentrations gave high photocatalytic activities for the photocatalytic units using *** morphological and optical properties of the photocatalysts were correlated to explain the dependence of photocatalytic activity on calcination *** results suggest that visible-LEDs are energy efficient light source for photocatalytic gas phase applications,but the activity depends on the operational conditions.

关键词： light emitting diode energy efficiency gas phase degradation photocatalyst characterization calcination temperature

熔融结晶器保护渣喂入技术对TWIP钢连铸坯可浇性能及其表面质量的改进

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钢铁译文集 2018年第1期 47-56页

作者： jung-wook CHO 韦菁(译) 郭俊波(校对) 韩国浦项工科大学不详

为了提高连铸生产效率，改善铸坯的表面质量，韩国浦项钢铁公司基于熔融保护渣的喂入技术，开发了一种全新的连铸工艺-PCAST工艺，熔融结晶器保护渣该工艺中，熔融结晶器保护渣用喂线的方式喂入结晶器中，从而提高了弯月面的保温性，由... 详细信息

为了提高连铸生产效率，改善铸坯的表面质量，韩国浦项钢铁公司基于熔融保护渣的喂入技术，开发了一种全新的连铸工艺-PCAST工艺，熔融结晶器保护渣该工艺中，熔融结晶器保护渣用喂线的方式喂入结晶器中，从而提高了弯月面的保温性，由此改善了凝固坯壳与铜结晶器之间的润滑性。先进高Al高强度钢（AHSS）板坯的可浇性与表面质量同时提高是该工艺应用于工业化连铸工艺后的最重要优点之一。在10t试验连铸机和100t、250t工业连铸机上进行TWIP钢的试生产试验。新工艺中的熔融保护渣消耗量超过了0．2kg／m2，远远高于传统工艺的消耗量。在试验连铸机与工厂连铸机的TWIP试浇铸中，结晶器性能（如结晶器传热）均很稳定。另外，连铸板坯显现出周期性／完整的振痕，但几乎没有缺陷。TWIP钢的成功浇铸得益于POCAST的以下特性：熔渣池深度的增加稀释了反应物；渣圈的去除扩大了弯月面处的渣膜的渗透渣道；提高保护渣的温度降低了弯月面处结晶器渣的黏度。

关键词：韩国浦项钢铁公司结晶器保护渣表面质量连铸坯熔融喂入性能技术

Suppression of laser-induced choroidal neovascularization by intravitreal injection of tristetraprolin

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 952-958页

作者： Yong Wun Cho Yong Seop Han In Young Chung Seong Jae Kim Seong wook Seo Ji myong Yoo Jong moon Park Departm.nt of Ophthalmology Gyeongsang National University School of Medicine Gyeongsang Institute of Health Science Gyeongsang National University

AIm: To exam.ne the effect of intravitreal adenoviral vector-mediated tristetraprolin(Ad-TTP) on VEGF m RnA expression in a rat model of laser-induced choroidal ***: Ad-TTP was prepared using a commercial kit. Retinal laser-induced photocoagulation(10 spots per eye) was performed on rats in this experim.ntal choroidal neovascularization(CnV) model. Rats were divided into four groups: control(single intravitreal injection of balanced salt solution, n =10), laser-induced CnV(photocoagulation only, n =20), laser-induced CnV plus Ad-TTP injection(photocoagulation plus a single intravitreal Ad-TTP injection, n =20) and Ad-TTP injection only(n =10). Changes in choroidal morphology were evaluated in ten rats in the laser only and the laser plus Ad-TTP groups. Two weeks after laser injury, the size of CnV was calculated by perfusion with high-molecular-weight fluorescein isothiocyanate(FITC)-dextran. VEGF m RnA expression in retina-choroid tissue from ten rats in each group was measured by reverse transcription polymerase chain reaction(RT-PCR). RESULTS: Two weeks after treatm.nt, the area of laser-induced CnV was reduced by approximately 60% in the rats given the Ad-TTP injection compared with that in the laser-only group. There was a tendency toward decreased VEGF m RnA expression in the Ad-TTP injection ***: A single intravitreal injection of Ad-TTP significantly suppressed CnV size in this experim.ntal laser-induced CnV model. Ad-TTP injection also decreased VEGF m RnA expression compared with that inthe laser-induced CnV group. The present study is meaningful as the first study to investigate the effect of tristetraprolin delivered via intravitreal injection.

关键词： laser-induced choroidal neovascularization tristetraprolin adenoviral vectors