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Repair of a large patellar cartilage defect using human umbilical cord blood-derived mesenchymal stem cells:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12665-12670页

作者： Jun-Seob Song Ki-taek Hong Ki Jeon Song Seok jung Kim Department of Orthopedic Surgery Gangnam JS HospitalSeoul 06053South Korea Department of Orthopedic Surgery Uijeongbu Street Mary’s HospitalCollege of MedicineThe Catholic University of KoreaUijeongbu 11765GyeonggidoSouth Korea

BACKGROUND Patellar dislocation may cause cartilage defects of various *** defects commonly require surgical treatment;however,conventional treatments are *** SUMMARY A 15-year-old male with a large patellar cartilage defect due to patellar dislocation was treated via human umbilical cord blood-derived mesenchymal stem cell(hUCB-MSC)*** our knowledge,this is the first report of this treatment for this *** patient recovered well as indicated by good visual analog scale,International Knee Documentation Committee and McMaster Universities Osteoarthritis Index *** resonance imaging showed cartilage regeneration 18 mo *** Umbilical cord blood-derived hUCB-MSCs may be a useful treatment option for the repair of large patellar cartilage defects.

关键词： Cartilage defect Umbilical cord Mesenchymal stem cells Patellar dislocation Magnetic resonance imaging Case report

The interplay between direct-acting antivirals and hepatocellular carcinoma in chronic hepatitis C

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Hepatoma Research 2020年第3期6卷 15-23页

作者： Sun Hong Yoo jung Hyun kwon Department of Internal Medicine Catholic University Liver Research CenterThe Catholic University of KoreaSeoul 06591Korea

Direct-acting antivirals(DAAs)have been introduced for the treatment of hepatitis C virus,and the sustained virological response rate after DAAs was reported to be over 95%.Because of the high sustained virological response rate,the risk of hepatocellular carcinoma(HCC)was expected to be ***,an unexpected high risk of HCC recurrence after DAA treatment was reported,and thus the dispute about the association of DAA and HCC *** present article reviews the interplay between DAAs and HCC.

关键词： Chronic hepatitis C hepatocellular carcinoma direct-acting antivirals

Adoption of wide-bandgap microcrystalline silicon oxide and dual buffers for semitransparent solar cells in building-integrated photovoltaic window system

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Journal of Materials Science & Technology 2019年第8期35卷 1563-1569页

作者： Johwa Yang Hyunjin Jo Soo-Won Choi Dong-Won Kang jung-Dae kwon Surface Technology Division Korea Institute of Materials ScienceChangwon 641-831 Republic of Korea School of Energy Systems Engineering Chung-Ang UniversitySeoul 06974 Republic of Korea

We focused on developing penetration-type semitransparent thin-film solar cells(STSCs) using hydrogenated amorphous Si(a-Si:H) for a building-integrated photovoltaic(BIPV) window system. Instead of conventional p-type a-Si:H, p-type hydrogenated microcrystalline Si oxide(p-μc-SiOx:H) was introduced for a wide-bandgap and conductive window layer. For these purposes, we tuned the CO2/SiH4 flow ratio(R) during p-μc-SiOx:H deposition. The film crystallinity decreased from 50% to 13% as R increased from 0.2 to 1.2. At the optimized R of 0.6, the quantum efficiency was improved under short wavelengths by the suppression of p-type layer parasitic absorption. The series resistance was well controlled to avoid fill factor loss at R = 0.6. Furthermore, we introduced dual buffers comprising p-a-SiOx:H/i-a-Si:H at the p/i interface to alleviate interfacial energy-band mismatch. The a-Si:H STSCs with the suggested window and dual buffers showed improvements in transmittance and efficiency from 22.9% to 29.3% and from 4.62% to 6.41%, respectively, compared to the STSC using a pristine p-a-Si:H window.

关键词： Microcrystalline silicon oxide Building-integrated photovoltaics Semitransparent Thin film Solar cells

Macroscopic Ag nanostructure array patterns with high-density hotspots for reliable and ultra-sensitive SERS substrates

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Nano Research 2019年第10期12卷 2554-2558页

作者： taeksu Lee Soongeun kwon San ghee jung Hyungjun Lim Jae-Jong Lee Department of Nano Manufacturing Technology Korea Institute of Machinery and Materials(KIMM)156 Gajeongbuk-RoYuseong-GuDaejeon 34103Republic of Korea

Syn thesis of metal nano structures arrays with large amounts of small nano-gaps on a homoge nous macroscale is of significant in terest and importa nee in chemistry,biotech no logy,physics,and nan otech no logy because of their enhan ced ***,the fabricatio n of uncovered nano-gaps with high-density and uniformity is rather difficult due to the complex and multiple synthetic *** this research,a facile and low-cost approach is demonstraind for the synthesis of high-density small nano-gaps(about 3.4 nm)between silver nanostructure array patter ns(SNAPs)over a large *** nan o?hole patter ns were periodically gen erated over an entire substrate using nano-impri nt *** reacti on at the high over-potential produced multiple silver nano crystals inside the nano-hole patter ns,gen erati ng a high-de nsity of small and un covered ***,we fully dem on strate their applicati on in the rapid detectio n of rhodamine 6G(R6G)molecules by surface-enhaneed Raman scattering(SERS)spectroscopy with a very low detection limit(1 fM)as well as excellent signal uniformity(RSD<8.0%±2.5%),i ndicati ng an extra ordinary capability for single-molecule detecti on.

关键词： nanoImprint lithography surface-enhanced Raman scattering(SERS)spectroscopy electrodeposition nano patterning gold silver

Diel vertical migration of the copepod Calanus sinicus before and during formation of the Yellow Sea Cold Bottom Water in the Yellow Sea

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Acta Oceanologica Sinica 2013年第9期32卷 99-106页

作者： KANG jung-Hoon SEO MinHo kwon Oh Youn KIM Woong-Seo South Sea Environment Research Division Korea Institute of Ocean Science&Technology (KIOST) Deep-sea and Seabed Resources Research Division

To understand the effects of the Yellow Sea Cold Bottom Water （YSCBW） on the diel vertical migration （D- VM） of the copepod Calanus sinicus, we surveyed vertical distribution of C. sinicus at a fixed station in the Yellow Sea before （spring） and during （summer） formation of the YSCBW. Cold water （〈10℃） was observed in the bottom layer when the water column was thermally stratified in summer, but the water column was thermally well-mixed in spring 2010. Samples were collected from five different layers at 3-h intervals using an opening-closing net. Adult females （1-155 ind./m3） showed a clear normal DVM pattern throughout the entire water column in spring, whereas adult males did not migrate. DVM of copepodite V （CV） individuals was not clear, but the maximum abundance of CI-CIV occurred consistently in the upper 10-20 m layer, where there was a high concentration of chlorophyll-a （Chl-a）（0.49-1.19μg/L）. In summer, weak DVM was limited to cold waters beneath the thermocline for adult females （〈30 ind./m3）, but not for adult males. The maximum abundance of CI-CIV also occurred consistently in the subsurface layer （20-40 m） together with high concentrations of Chl-a （0.81-2.36 μg/L）. CV individuals （1-272 ind./m3） moved slightly upward noc- turnally to the near-surface layer （10-20 m）, where the average temperature was 25.74℃, but they were not found in the surface layer （0-10 m; 28.31℃）. These results indicate that the existence of the YSBCW affected food availability at depth and the vertical temperature distribution, leading to variation in the amplitude and shape of stage-specific vertical distributions （CI to adults） in C. sinicus before and during the formation of cold waters in the Yellow Sea during the study period.

关键词： Yellow Sea Cold Bottom Water (YSCBW) copepod Calanus sinicus developmental stages,diel vertical migration (DVM)

Identification of Rice Accessions Associated with K+/Na+ Ratio and Salt Tolerance Based on Physiological and Molecular Responses

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Rice science 2017年第6期24卷 360-364页

作者： Inja Naga Bheema Lingeswara REDDY Sung-Mi KIM Beom-Ki KIM In-Sun YOON taek-Ryoun kwon Genetic Engineering Division Department of Agricultural Biotechnology National Institute of Agricultural Sciences Rural Development Administration Jeonju 54874 South Korea

The key for rice plant survival under Na Cl salt stress is maintaining a high K^+/Na^+ ratio in its cells. Selection for salt tolerance rice genotypes based on phenotypic performance alone will delay in progress in breeding. Use of molecular markers in tandem with physiological studies will help in better identification of salt tolerant rice accessions. Eight rice accessions along with the check Dongjin were screened using 1/2 Yoshida solution with 50 mmol/L NaCl at the seedling stage. The accessions IT001158, IT246674, IT260533 and IT291341 were classified as salt tolerant based on their K^+/Na^+ ratios. Seventeen SSR markers reported to be associated with K^+/Na^+ ratio were used to screen the accessions. Five SSR markers(RM8053, RM345, RM318, RM253 and RM7075) could differentiate accessions classified based on their K^+/Na^+ ratios. Banding pattern of the accessions was scored compared to the banding pattern of Dongjin. The study differentiated accessions based on their association of K^+/Na^+ ratio with molecular markers which are very reliable. These markers can play a significant role in screening large set of rice germplasms for salt tolerance and also help in identification of high-yielding varieties with better salt tolerance. The salt tolerant accessions can be taken forward into developing better varieties by conventional breeding and exploring genes for salt tolerance.

关键词： rice salinity K+/Na+ ratio simple sequence repeat salt tolerance

Identifying and Verifying Vulnerabilities through PLC Network Protocol and Memory Structure Analysis

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Computers, Materials & Continua 2020年第10期65卷 53-67页

作者： Joo-Chan Lee Hyun-Pyo Choi Jang-Hoon Kim Jun-Won Kim Da-Un jung Ji-Ho Shin jung-taek Seo Department of Information Security Engineering Soonchunhyang UniversityAsan31538Korea

Cyberattacks on the Industrial Control System(ICS)have recently been increasing,made more intelligent by advancing *** such,cybersecurity for such systems is attracting *** a core element of control devices,the Programmable Logic Controller(PLC)in an ICS carries out on-site control over the ICS.A cyberattack on the PLC will cause damages on the overall ICS,with Stuxnet and Duqu as the most representative ***,cybersecurity for PLCs is considered essential,and many researchers carry out a variety of analyses on the vulnerabilities of PLCs as part of preemptive efforts against *** this study,a vulnerability analysis was conducted on the XGB *** vulnerabilities were identified by analyzing the network protocols and memory structure of PLCs and were utilized to launch replay attack,memory modulation attack,and FTP/Web service account theft for the verification of the *** on the results,the attacks were proven to be able to cause the PLC to malfunction and disable it,and the identified vulnerabilities were defined.

关键词： Industrial control system programmable logic controller cybersecurity network protocol vulnerability

Characterization of particulate matter from diesel passenger cars tested on chassis dynamometers

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Journal of Environmental Sciences 2017年第4期29卷 21-32页

作者： Sungwoon jung Jaehyun Lim Sangil kwon Sangwoo Jeon Jeongsoo Kim Jongtae Lee Sunmoon Kim Transportation Pollution Research Center National Institute of Environmental Research Incheon Republic of Korea Division of Global Environment Research National Institute of Environmental Research Incheon Republic of Korea Compliance & Defects Investigation Office Korea Automobile Testing & Research Institute Hwasung Republic of Korea

Emission characterization of particle number as well as particle mass from three diesel passenger cars equipped with diesel particulate filter（DPF）, diesel oxidation catalyst（DOC）and exhaust gas recirculation（EGR） under the vehicle driving cycles and regulatory *** particle number emissions（PNEs） decreased gradually during speed-up of vehicle from 17.3 to 97.3 km/hr. As the average vehicle speed increases, the size-segregated peak of particle number concentration shifts to smaller size ranges of particles. The correlation analysis with various particulate components such as particle number concentration（PNC）,ultrafine particle number concentration（UFPNC） and particulate matter（PM） mass was conducted to compare gaseous compounds（CO, CO2, HC and NOx）. The UFPNC and PM were not only emitted highly in Seoul during severe traffic jam conditions, but also have good correlation with hydrocarbons and NOxinfluencing high potential on secondary aerosol generation. The effect of the dilution temperature on total PNC under the New European Driving Cycle（NEDC）, was slightly higher than the dilution ratio. In addition, the nuclei mode（DP： ≤ 13 nm） was confirmed to be more sensitive to the dilution temperature rather than other particle size ranges. Comparison with particle composition between vehicle speed cycles and regulatory cycle showed that sulfate was slightly increased at regulatory cycle, while other components were relatively similar. During cold start test, semivolatile nucleation particles were increased due to effect of cold environment. Research on particle formation dependent on dilution conditions of diesel passenger cars under the NEDC is important to verify impact on vehicular traffic and secondary aerosol formation in Seoul.

关键词： Diesel passenger cars Particle number emissions Correlation analysis Particle number concentration Ultrafine particle number concentration

Design the IoT Botnet Defense Process for Cybersecurity in Smart City

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Intelligent Automation & Soft Computing 2023年第9期37卷 2979-2997页

作者： Donghyun Kim Seungho Jeon Jiho Shin jung taek Seo Department of Information Security Gachon UniversitySeongnam13120Korea Department of Smart Security Gachon UniversitySeongnam13120Korea Police Science Institute Korean National Police UniversityAsan31539Korea Department of Computer Engineering Gachon UniversitySeongnam13120Korea

The smart city comprises various infrastructures,including health-care,transportation,manufacturing,and energy.A smart city’s Internet of Things(IoT)environment constitutes a massive IoT environment encom-passing numerous *** many devices are installed,managing security for the entire IoT device ecosystem becomes challenging,and attack vectors accessible to attackers ***,these devices often have low power and specifications,lacking the same security features as general Information Technology(IT)systems,making them susceptible to *** vulnerability is particularly concerning in smart cities,where IoT devices are connected to essential support systems such as healthcare and *** can lead to significant human and property *** rep-resentative attack that exploits IoT device vulnerabilities is the Distributed Denial of Service(DDoS)attack by forming an IoT *** a smart city environment,the formation of IoT botnets can lead to extensive denial-of-service attacks,compromising the availability of services rendered by the ***,the same IoT devices are typically employed across various infrastructures within a smart city,making them potentially vulnerable to similar *** paper addresses this problem by designing a defense process to effectively respond to IoT botnet attacks in smart city *** proposed defense process leverages the defense techniques of the MITRE D3FEND framework to mitigate the propagation of IoT botnets and support rapid and integrated decision-making by security personnel,enabling an immediate response.

关键词： Smart city IoT botnet cybersecurity