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Do peripartum and postmenopausal women with primary liver cancer have a worse prognosis? A nationwide cohort in Taiwan

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World Journal of Hepatology 2021年第11期13卷 1766-1776页

作者： Guan-Woei Tseng Mei-Chen Lin Shih-Wei Lai Cheng-Yuan Peng Po-Heng Chuang Wen-Pang Su jung-takao Hsueh-Chou Lai Department of Medicine China Medical UniversityTaichung 40402Taiwan Management Office for Health Data China Medical University HospitalTaichung 404Taiwan Department of Family Medicine China Medical University HospitalTaichung 404Taiwan Center for Digestive Disease Department of Internal Medicine China Medical University HospitalTaichung 404Taiwan School of Chinese Medicine China Medical UniversityTaichung 404Taiwan

BACKGROUND While primary liver cancer(PLC)is one of the most common cancers around the world,few large-scale population-based studies have been reported that evaluated the clinical survival outcomes among peripartum and postmenopausal women with *** To investigate whether peripartum and postmenopausal women with PLC have lower overall survival rates compared with women who were not peripartum and *** The Taiwan National Health Insurance claims data from 2000 to 2012 was used for this propensity-score-matched study.A cohort of 40 peripartum women with PLC and a reference cohort of 160 women without peripartum were *** the women with PLC with/without menopause study,a study cohort of 10752 menopausal females with PLC and a comparison cohort of 2688 women without menopause were *** Patients with peripartum PLC had a non-significant risk of death compared with the non-peripartum cohort[adjusted hazard ratios(aHR)=1.40,95%confidence intervals(CI):0.89-2.20,P=0.149].The survival rate at different follow-up durations between peripartum PLC patients and those in the non-peripartum cohort showed a non-significant *** who were diagnosed with PLC younger than 50 years old(without menopause)had a significant lower risk of death compared with patients diagnosed with PLC at or older than 50 years(postmenopausal)(aHR=0.64,95%CI:0.61-0.68,P<0.001).The survival rate of women<50 years with PLC was significantly higher than older women with PLC when followed for 0.5(72.44%vs 64.16%),1(60.57%vs 51.66%),3(42.92%vs 31.28%),and 5 year(s)(37.02%vs 21.83%),respectively(P<0.001).CONCLUSION Peripartum females with PLC have no difference in survival rates compared with those patients without *** females with PLC have worse survival rates compared with those patients without menopause.

关键词： Primary liver cancer Peripartum and postmenopausal women Prognosis Nationwide cohort Peripartum women Postmenopausal women

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Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

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Oncology Research 2025年第1期33卷 57-65页

作者： RYUL KIM JOO KYUNG PARK MINSUK KWON MINAE AN jung YONG HONG JOON OH PARK SUNG HEE LIM SEUNG TAE KIM Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(NK)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for NK cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

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Saccharomyces cerevisiae in neuroscience:how unicellular organism helps to better understand prion protein?

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Neural Regeneration Research 2021年第3期16卷 489-495页

作者： takao Ishikawa Department of Molecular Biology Institute of BiochemistryFaculty of BiologyUniversity of WarsawWarsawPoland

The baker's yeast Saccharomyces(S.)cerevisiae is a single-celled eukaryotic model organism widely used in research on life *** a unicellular organism,*** has some evident limitations in application to ***,yeast prions are extensively studied and they are known to share some hallmarks with mammalian prion protein or other amyloidogenic proteins found in the pathogenesis of Alzheimer's,Parkinson's,or Huntington's ***,the yeast *** has been widely used for basic research on aggregation properties of proteins in cellulo and on their ***,a yeast-based study revealed that some regions of mammalian prion protein and amyloidβ1–42 are capable of induction and propagation of yeast *** is one of the examples showing that evolutionarily distant organisms share common mechanisms underlying the structural conversion of prion proteins making yeast cells a useful system for studying mammalian prion *** has also been used to design novel screening systems for anti-prion compounds from chemical *** assays are cheap in maintenance and safe for the researcher,making them a very good choice to perform preliminary screening before further characterization in systems engaging mammalian cells infected with *** this review,not only classical red/white colony assay but also yeast-based screening assays developed during last year are *** analysis and research carried out using yeast prions force us to expect that prions are widely present in ***,the last few years brought us several examples indicating that the mammalian prion protein is no more peculiar protein–it seems that a better understanding of prion proteins nature-wide may aid us with the treatment of prion diseases and other amyloid-related medical conditions.

关键词： amyloid artificial prion baker's yeast budding yeast drug screening fusion protein neurodegenerative diseases prion protein yeast-based assay

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Magnetic properties of soft layer/FePt-MgO exchange coupled composite perpendicular recording media

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Chinese Physics B 2008年第10期17卷 3907-3909页

作者：阴津华 takao Suzuki 潘礼庆 Department of Physics University of Science and Technology Beijing Information Storage Materials Laboratory Toyota Technological Institute

The magnetic properties of exchange coupled composite （ECC） media that are composed of perpendicular magnetic recording media FePt MgO and two kinds of soft layers have been studied by using an x-ray diffractometer, a polar Kerr magneto-optical system （PMOKE） and a vibrating sample magnetometer （VSM）. The results show that ECC media can reduce the coercivities of perpendicular magnetic recording media FePt-MgO. The ECC media with granular-type soft layers have weaker exchange couplings between magnetic grains and the magnetization process, for ECC media of this kind mainly follow the Stoner Wohlfarth model.

关键词： exchange coupled composite media perpendicular magnetic recording media magnetic properties

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The H∞ Robust Stability and Performance Conditions for Uncertain Robot Manipulators

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 270-272页

作者： Geun Il Song Hae Yeon Park jung Hoon Kim the Department of Electrical Engineering Pohang University of Science and Technology (POSTECH) the Department of Electrical Engineering Pohang University of Science and Technology (POSTECH) the Institute for Convergence Research and Education in Advanced Technology Yonsei University

Dear Editor,H∞This letter develops a new framework for the robust stability and performance conditions as well as the relevant controller synthesis with respect to uncertain robot *** often exist model uncertainties between the nominal model and the real robot manipulator and disturbances. Hence, dealing with their effects plays a crucial role in leading to high tracking performances, as discussed in [1]–[5].

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A Straight-bladed Vertical Axis Wind Turbine with a Directed Guide Vane Row-Effect of Guide Vane Geometry on the Performance-

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Journal of Thermal Science 2009年第1期18卷 54-57页

作者： Manabu takao Hideki KUMA takao MAEDA Yasunari KAMADA Michiaki OKI Atsushi MINODA Department of Mechanical Engineering Matsue National College of Technology Department of Mechanical Engineering Mie University

The objective of this study is to show the effect of guide vane geometry on the performance. In order to overcome the disadvantages of vertical axis wind turbine, a straight-bladed vertical axis wind turbine （S-VAWT） with a directed guide vane row has been proposed and tested by the authors. According to previous studies, it was clarified that the performance of the turbine can be improved by means of the directed guide vane row. However, the guide vane geometry of S-VAWT has not been optimized so far. In order to clarify the effect of guide vanegeometry, the effects of setting angle and gap between rotor blade and guide vane on power coefticlent and start- ing characteristic were investigated in the experiments. The experimental study of the proposed wind turbine was carried out by a wind tunnel. The wind tunnel with a diameter of 1.8m is open jet type. The wind velocity is 8 m/s in the experiments. The rotor has three straight blades with a profile of NACA0018 and a chord length of 100 mm, a diameter of 0.6 m and a blade height of 0.7 m. The guide vane row consists of 3 arc plates.

关键词： fluid machinery wind energy vertical axis wind turbine guide vane

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Periodical shedding of cloud cavitation from a single hydrofoil in high-speed cryogenic channel flow

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Journal of Thermal Science 2009年第1期18卷 58-64页

作者： Yutaka ITO Koichi SETO takao NAGASAKI Tokyo Institute of Technology

In order to explain criteria for periodical shedding of the cloud cavitation, flow patterns of cavitation around a piano-convex hydrofoil were observed using a cryogenic cavitation tunnel of a blowdown type. Two hydrofoils of similarity of 20 and 60 mm in chord length with two test sections of 20 and 60 mm in width were prepared. Working fluids were water at ambient temperature, hot water and liquid nitrogen. The parameter range was varied between 0.3 and 1.4 for cavitation number, 9 and 17 m/sec for inlet flow velocity, and -8° and 8° for the flow incidence angle, respectively. At incidence angle 8°, that is, the convex surface being suction surface, periodical shedding of the whole cloud cavitation was observed on the convex surface under the specific condition with cavitation number and inlet flow velocity, respectively, 0.5, 9 m/sec for liquid nitrogen at 192℃ and 1.4, 11 m/sec for water at 88℃, whereas under the supercavitation condition, it was not observable. Periodical shedding of cloud cavitation occurs only in the case that there are both the adverse pressure gradient and the slow flow region on the hydrofoil.

关键词： cloud cavitation cryogen visualization hydrofoil

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Influence of image classification accuracy on saliency map estimation

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CAAI Transactions on Intelligence Technology 2018年第3期3卷 140-152页

作者： Taiki Oyama takao Yamanaka Department of Information and Communication Sciences Sophia University 7-1 Kioi-cho Chiyoda-ku Tokyo 102-0094 Japan

Saliency map estimation in computer vision aims to estimate the locations where people gaze in images. Since people tend to look at objects in images, the parameters of the model pre-trained on ImageNet for image classification are useful for the saliency map estimation. However, there is no research on the relationship between the image classification accuracy and the performance of the saliency map estimation. In this study, it is shown that there is a strong correlation between image classification accuracy and saliency map estimation accuracy. The authors also investigated the effective architecture based on multi-scale images and the up-sampling layers to refine the saliencymap resolution. The model achieved the state-of-the-art accuracy on the PASCAL-S, OSIE, and MIT1003 datasets. In the MIT saliency benchmark, the model achieved the best performance in some metrics and competitive results in the other metrics.

关键词：计算机视觉图像处理发展现状计算机技术

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Effect of End Plates on the Performence of a Wells Turbine for Wave Energy Conversion

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Journal of Thermal Science 2006年第4期15卷 319-323页

作者： Manabu takao Toshiaki Setoguchi YoichiKinoue KenjiKaneko Department of Mechanical Engineering Matsue National College of Technology 14-4 Nishiikuma-choMatsue-shiShimane 690-8518Japan Institute of Ocean Energy Saga University1 Honjo-machiSaga-shiSaga 840-8502Japan Department of Mechanical Engineering Saga University1 Honjo-machiSaga-shiSaga 840-8502Japan

In order to improve the performance of the Wells turbine for wave energy conversion, the effect of end plates on the turbine characteristics has been investigated experimentally by model testing under steady flow conditions. The end plate attached to the tip of the original rotor blade is slightly larger than the original blade profile. The characteristics of the Wells turbine with end plates have been compared with those of the original Wells turbine, i.e., the turbine without end plate. As a result, it has been concluded that the characteristics of the Wells turbine with end plates are superior to those of the original Wells turbine and the characteristics are dependent on the size and position of end plate. Furthermore, the effect of annular plate on the turbine performance, which encircles the turbine and is attached to the tip, was investigated as an additional experiment. However, its device was not effective in improving the turbine characteristics.

关键词： fluid machinery natural energy Wells turbine end plate wave energy conversion ocean energy.

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Using orbital sensitivity analysis to pinpoint the role of orbital interactions in thermoelectric power factor

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npj Computational Materials 2023年第1期9卷 937-945页

作者： Wenhao Zhang Jean-François Halet takao Mori WPI Center for Materials Nanoarchitectonics(MANA) National Institute for Materials ScienceTsukubaJapan Graduate School of Pure and Applied Sciences University of TsukubaTsukubaJapan CNRS-Saint-Gobain-NIMS Laboratory for Innovative Key Materials and Structures(LINK)National Institute for Materials ScienceTsukubaJapan

The modification of the electronic band structure is of critical importance for thermoelectric materials whose heat to electricity power generation is related to carrier effective mass and alignment of semiconductor band *** approach to optimize the electronic band structure is by modification of orbital interactions through doping or *** the current ab-initio quantum chemical calculations can help us to investigate orbital components of electronic bands,they reveal little information on the relative tunability of electronic states and transport properties with respect to orbital *** this work,we present a method,based on a symmetry-adapted tight-binding model and sensitivity analysis,that can pinpoint the role of orbital interactions in determining electronic band structure and transport *** an application,a systematic theoretical analysis is used to show how the power factor of PbTe can/cannot be improved by playing with interatomic orbital *** orbital interaction sensitivity analysis introduced in this work can easily be applied to other compounds or properties.

关键词： properties orbital symmetry

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