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Clean-DM1, a Korean Polyherbal Formula, Improves High Fat Diet-Induced Diabetic Symptoms in Mice by Regulating IRS/PI3K/AKT and AMPK Expressi.nsi. Pancreas and Liver Tissues

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Chinese Journal of Integrative Medicine 2024年第2期30卷 125-134页

作者： Piao Wang Yi Liu Seok Yong Kang Chenzi Lyu Xiang Han Tianjun Ho Kyung Jae Lee Xianglong Meng Yong-ki.Park Hyo Won jung Department of Herbology College of Korean MedicineDongguk UniversityGyeongju 38066Korea College of Pharmacy&Graduate School of Pharmaceutical Sciences Ewha Womans UniversitySeoul 03760Korea Korean Medicine R&D Center Dongguk UniversityGyeongju 38066Korea Shanxi Key Laboratory of Traditional Herbal Medicines Processi.g Shanxi University of Chinese MedicineJinzhong(030619)ShanxiProvinceChina

Objective:To investigate the effects of Clean-DM1(C-DM1),a polyherbal formulation of Radix Scrophulariae,Radix Astragali,Rhizoma Atractylodis,and Radix Salviae Miltiorrhizae,on high-fat diet(HFD)-induced diabetes ***:The information about active components of C-DM1 extract and molecular mechanism was obtained from network pharmacology *** compounds of C-DM1 extract by high performance liquid chromatography-mass spectrometry(HPLC-MS)analysi. were conducted for quality *** in vivo study,mice were induced diabetes by HFD for 12 *** mice in the normal group(Nor)were maintained with a regular diet and treated with saline by *** HFD model mice were randomly divided into 3 groups,including a HFD diabetic model group,a C-DM1 extract-administered group(C-DM1,500 mg/kg),and metformin-administered groups(Met,500 mg/kg),8 mice in each *** intake,body weight(BW),and fasting blood glucose(FBG)levels were recorded weekly for 4 *** 4 weeks of treatment,alanine aminotransferase(ALT),aspartate aminotransferase(AST),blood glucose,low-densi.y lipoprotein cholesterol(LDL-C)were determined usi.g an automated clinical chemistry analyzer,and homeostatic model for assessi.g insulin resi.tance(HOMA-IR)levels and oral glucose tolerance test(OGTT)were *** histopathological changes of liver and pancreatic tissues were observed by hematoxylin-eosi. *** receptor substrate(IRS)/phosphatidylinosi.ol 3 ki.ase(PI3K)/protein ki.ase B(AKT)and adenosi.e 5'-monophosphate-activated protein ki.ase(AMPK)expressi.ns in liver and pancreas tissues were detected by Western blot ***:HPLC-MS identified dihydroisotanshinone,dihydroisotanshinone I,cryptotanshinone,harpagosi.e,and atractylosi.e A in C-DM1 *** administration of C-DM1 extract si.nificantly decreased body weight,calorie intake,and the levels of blood glucose and insulin in the diabetic mice(P<0.05 or P<0.01).The C-DM1 extract administration improved the im

关键词： high-fat diet type 2 diabetes mellitus herbal formulation insulin receptor substrate/phosphatidylinosi.ol 3 ki.ase/protein ki.ase B adenosi.e 5'-monophosphate-activated protein ki.ase network pharmacology high performance liquid chromatography-mass spectrometry analysi.

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MV-Honeypot:Security Threat Analysi. by Deploying Avatar as a Honeypot in COTS Metaverse Platforms

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 655-669页

作者： Arpita Dinesh Sarang Mohsen Ali Alawami ki.Woong Park SysCore Lab.(Convergence Engineering for Intelligent Drone) Sejong UniversitySeoul05006Republic of Korea Divisi.n of Computer Engineering Hankuk University of Foreign StudiesYongin-si17035Republic of Korea Department of Information Security Sejong UniversitySeoul05006Republic of Korea

Nowadays,theuse of Avatars that are unique digital depictions has increased by users to access Metaverse—a virtual reality environment—through multiple devices and for various ***,the Avatar and Metaverse are being developed with a new theory,application,and desi.n,necessi.ating the association of more personal data and devices of targeted users every *** Avatar and Metaverse technology explosi.n raises privacy and security concerns,leading to cyber ***-Honeypot,or Metaverse-Honeypot,as a commercial off-the-shelf solution that can counter these cyber attack-causi.g vulnerabilities,should be *** fill this gap,we study user’s engagements with Avatars in Metaverse,analyze possi.le security vulnerabilities,and create a model named si.plified Avatar Relationship Association with Non-linear Gradient(SARANG)that draws the full diagram of infrastructure components and data flow through accessi.g Metaverse in this *** also determine the most si.nificant threat for each component’s cyberattacks that will affect user data and *** a result,the commercial off-the-shelf(COTS)of the MV-Honeypot must be established.

关键词： Avatar metaverse cybersecurity cloud computing internet of things artificial intelligence security analysi.

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Novel fabrication techniques for ultra-thin si.icon based flexible electronics

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International Journal of Extreme Manufacturing 2024年第4期6卷 116-149页

作者： Ju Young Lee Jeong Eun Ju Chanwoo Lee Sang Min Won ki.Jun Yu School of Electrical and Electronic Engineering Yonsei University50 Yonsei-roSeodaemunguSeoul 03722Republic of Korea Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea YU-Korea Institute of Science and Technology(ki.T)Institute Yonsei University50Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Flexible electronics offer a multitude of advantages,such as flexibility,lightweight property,portability,and high *** unique properties allow for seamless applications to curved and soft surfaces,leading to extensi.e utilization across a wide range of fields in consumer *** applications,for example,span integrated circuits,solar cells,batteries,wearable devices,bio-implants,soft robotics,and biomimetic ***,flexible electronic devices have been developed usi.g a variety of materials such as organic,carbon-based,and inorganic semiconducting ***(si.owing to its mature fabrication process,excellent electrical,optical,thermal properties,and cost efficiency,remains a compelling material choice for flexible ***,the research on ultra-thin si.in the context of flexible electronics is studied rigorously *** thinning of si.is crucially important for flexible electronics as it reduces its bending stiffness and the resultant bending strain,thereby enhancing flexibility while preserving its exceptional *** review provides a comprehensi.e overview of the recent efforts in the fabrication techniques for forming ultra-thin si.usi.g top-down and bottom-up approaches and explores their utilization in flexible electronics and their applications.

关键词： flexible electronics si.icon fabrication technique top-down approach bottom-up approach

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Optimal sequential therapy usi.g tyrosi.e ki.ase inhibitors as the first-line treatment in patients with metastatic renal cell carcinoma: A nationwide multicenter study

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Asi.n Journal of Urology 2024年第3期11卷 450-459页

作者： jung ki.Jo Seong Il Seo MinYong Kang Jinsoo Chung Cheol Kwak Sung-Hoo Hong Cheryn Song Jae Young Park Chang Wook Jeong Seok Hwan Choi Sung Han ki. Eu Chang Hwang Chan Ho Lee Hakmin Lee Department of Urology Medical and Digital EngineeringCollege of MedicineHanyang UniversitySeoulRepublic of Korea Department of Urology Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Urology National Cancer CenterGoyangRepublic of Korea Department of Urology Seoul National University HospitalSeoulRepublic of Korea Department of Urology Kangnam St Mary’s HospitalSeoulRepublic of Korea Department of Urology Asan Medical CenterSeoulRepublic of Korea Department of Urology Korea University Ansan HospitalAnsanRepublic of Korea Department of Urology Kyungpook National University HospitalDaeguRepublic of Korea Department of Urology Chonnam National University Hwasun HospitalHwasunRepublic of Korea Department of Urology Inje University Busan Paik HospitalBusanRepublic of Korea Department of Urology Seoul National University Bundang HospitalSeongnamRepublic of Korea

Objective:The purpose of the study was to identify the best sequence of therapy beginning with a tyrosi.e ki.ase inhibitor(Tki.as the first-line therapy for patients with metastatic renal cell carcinoma(mRCC)in terms of overall survival(OS),progressi.n-free survival(PFS),and rates of discontinuation and adverse effects during the treatment ***:This is a retrospective,nationwide multicenter study of patients with mRCC after diagnosi. at 10 different tertiary medical centers in Korea from January 1992 to December *** focused on patients at either“favorable”or“intermediate”risk according to the International mRCC Database Consortium criteria,and they were followed up(median 335 days).Finally,a total of 1409 patients were selected as the study *** generated a Cox proportional hazard model adjusted for covariates,and the different therapy schemes were statistically tested in terms of OS as well as *** addition,frequencies of discontinuation and adverse events were compared among the therapy ***:Of the primary patterns of treatment sequences(24 sequences),“sunitinib epazopanib”and“sunitinibeeverolimuseimmunotherapy”showed the most beneficial results in both OS and PFS with si.nificantly lower hazards than“sunitinib”,which is the most commonly treated agent in *** that the“Tki.Tki.structure showed relatively higher discontinuation rates with higher adverse effects,the overall beneficial sequence would be“sunitinibeeverolimuseimmunotherapy”.Conclusi.n:Among several sequential therapy starting with Tki.,“sunitinibeeverolimuse immunotherapy”was found to be the best scheme for mRCC patients with“favorable”or“intermediate”risks.

关键词： Tyrosi.eki.ase inhibitor Metastaticrenalcell carcinoma Overall survival Progressi.n-free survival

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Multifunctional MXene/Carbon Nanotube Janus Film for Electromagnetic Shielding and Infrared Shielding/Detection in Harsh Environments

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Nano-Micro Letters 2024年第10期16卷 543-560页

作者： Tufail Hassan Aamir Iqbal Byungkwon Yoo Jun Young Jo Nilufer Cakmakci Shabbir Madad Naqvi Hyerim ki. Sungmin jung Noushad Hussain Ujala Zafar Soo Yeong Cho Seunghwan Jeong Jaewoo ki. jung Min Oh Sangwoon Park Youngjin Jeong Chong Min Koo School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea Department of Materials Science and Engineering Soongsil UniversitySeoul 06978Republic of Korea Institute of Advanced Composi.e Materials Korea Institute of Science and Technology92 Chudong-roBongdong-eupWanju-gunJeollabuk-do 55324Republic of Korea R&D Center INNOMXENE Co. Ltd.Daejeon 34365Republic of Korea School of Chemical Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea

Multifunctional,flexible,and robust thin films capable of operating in demanding harsh temperature environments are crucial for various cutting-edge *** study presents a multifunctional Janus film integrating highly-crystalline Ti_(3)C_(2)T_(x) MXene and mechanically-robust carbon nanotube(CNT)film through strong hydrogen *** hybrid film not only exhibits high electrical conductivity(4250 S cm^(-1)),but also demonstrates robust mechanical strength and durability in both extremely low and high temperature environments,showing exceptional resi.tance to thermal *** hybrid Janus film of 15μm thickness reveals remarkable multifunctionality,including efficient electromagnetic shielding effectiveness of 72 dB in X band frequency range,excellent infrared(IR)shielding capability with an average emissi.ity of 0.09(a minimal value of 0.02),superior thermal camouflage performance over a wide temperature range(−1 to 300℃)achieving a notable reduction in the radiated temperature by 243℃ against a background temperature of 300℃,and outstanding IR detection capability characterized by a 44%increase in resi.tance when exposed to 250 W IR *** multifunctional MXene/CNT Janus film offers a feasi.le solution for electromagnetic shielding and IR shielding/detection under challenging conditions.

关键词： MXene/carbon nanotube Janus film Electromagnetic interference shielding Infrared shielding Thermal camouflage Infrared detection

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Immediate Effect of Electro-acupuncture on Endometrial Blood Flow in Patients with Recurrent Implantation Failure:A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第4期30卷 291-298页

作者： LAI Yuan-yuan LIU Li-ying WU Yong-na HUANG Lei ZHENG Xiao-yan GAN Di YU si.yi ZHONG Ying LIANG Fan-rong ZHOU Ying YANG Jie Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu(610032)China si.huan Jinxin Xi'nan Women's and Children's Hospital Chengdu(610032)China Yuan TCM Wellness Pte.Ltd.(999002) Pulse TCM SingaporeSingapore

Objective To investigate the immediate effects of electro-acupuncture(EA)on endometrial blood flow among recurrent implantation failure(RIF)*** Eighty RIF patients,enrolled from March 2022 to December 2022,were randomly allocated into either the EA group(40 cases)or the waiting-list(WL)group(40 cases)by usi.g a random number *** EA group underwent acupuncture at points of Shenting(GV 24),Baihui(GV 4),Benshen(GB 13),bilateral Zigong(EX-CA 1),Huangshu(ki.16),Sanyinjiao(SP 6)and Xuehai(SP10),and electric acupuncture apparatus was connected to EX-CA 1,ki.16,SP 6,and SP 10 with disperse-dense waves at 4/20 Hz frequencies for 30 min after transvaginal ultrasound,while the WL group received no *** primary outcome measured was the endometrial volume blood *** secondary outcomes included the bilateral uterine artery index,endometrial volume,endometrial blood flow type,vascular distribution index(VI^(MV))for endometrial and ovary,clinical pregnancy rate,and embryo implantation *** In the EA group,there was a notable decrease in the bilateral pulsatility index and a si.nificant improvement in the endometrial blood flow type post-EA(Psi.nificant disparities were observed in vascular index,flow index,vascular blood flow index,uterine arterial blood flow indices,endometrial volume,clinical pregnancy rate and embryo implantation rate between the two groups after treatment(P>0.05).Besi.es,no adverse events related to EA were *** EA can promptly ameliorate VI^(MV) for the endometrial and right ovary,and endometrial blood flow *** randomized controlled trials are warranted to investigate the long-term effects of EA on blood flow of RIF patients and its implications for pregnancy outcomes.(Trial registration ***2200057377

关键词： electro-acupuncture recurrent implantation failure transvaginal ultrasound endometrial receptivityanalysi. randomized controlledtrial

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Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 si.naling

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World Journal of Diabetes 2024年第2期15卷 287-304页

作者： Huai-Jie Wang Li-Bin Zhang si.Peng Sun Qing-Tao Yan Zhi-Qin Gao Fang-Ming Fu Mei-Hua Qu Translational Medical Center Weifang Second People's HospitalWeifang 261041Shandong ProvinceChina Department of Endocrinology Weifang Second People's HospitalWeifang 261041Shandong ProvinceChina Department of Pediatric Surgery Weifang People’s HospitalWeifang 261041Shandong ProvinceChina School of Bioscience and Technology Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Endocrinology Jinan Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM)is often accompanied by impaired glucose utilization in the brain,leading to oxidative stress,neuronal cell injury and *** studies have shown that duodenal jejunal bypass(DJB)surgery si.nificantly improves brain glucose metabolism in T2DM rats,the role and the metabolism of DJB in improving brain oxidative stress and inflammation condition in T2DM rats remain *** To investigate the role and metabolism of DJB in improving hypothalamic oxidative stress and inflammation condition in T2DM *** A T2DM rat model was induced via a high-glucose and high-fat diet,combined with a low-dose streptozotocin injection.T2DM rats were divided into DJB operation and Sham operation *** surgical intervention was carried out on T2DM *** differential expressi.n of hypothalamic proteins was analyzed usi.g quantitative proteomics *** related to oxidative stress,inflammation,and neuronal injury in the hypothalamus of T2DM rats were analyzed by flow cytometry,quantitative real-time PCR,Western blotting,and *** Quantitative proteomics analysi. showed si.nificant differences in proteins related to oxidative stress,inflammation,and neuronal injury in the hypothalamus of rats with T2DM-DJB after DJB surgery,compared to the T2DM-Sham groups of *** stress-related proteins(glucagon-like peptide 1 receptor,Nrf2,and HO-1)were si.nificantly increased(Psi.nificantly reduced(Psi.g the expressi.n of interleuki.(IL)-1βand *** surgery si.nificantly reduced(Psi.n of factors related to neuronal injury(glial fibrillary acidic protein and Caspase-3)in the hypothalamus of T2DM rats and upregulated(Psi.n of neuroprotective factors(C-fos,ki.7,Bcl-2,and BDNF),thereby reducing hypot

关键词： Duodenal jejunal bypass surgery Type 2 diabetes mellitus Neuron apoptosi. Inflammatory Oxidative stress Hypothalamic injury

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Potential industrial applications of photo/electrocatalysi.: Recent progress and future challenges

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Green Energy & Environment 2024年第5期9卷 859-876页

作者： Jinhao Li Jing Ren Shaoquan Li Guangchao Li Molly Meng-jung Li Rengui Li Young Soo Kang Xiaoxin Zou Yong Luo Bin Liu Yufei Zhao State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China Quzhou Institute for Innovation in Resource Chemical Engineering Quzhou324000China State Key Laboratory of Organic-Inorganic Composi.es Beijing University of Chemical TechnologyBeijing100029China Department of Applied Physi.s The Hong Kong Polytechnic UniversityHong Kong999077China State Key Laboratory of Catalysi. Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian National Laboratory for Clean EnergyZhongshan Road 457Dalian116023China Environmental and Climate Technology Track of Korea Institute of Energy Korea Institute of Energy TechnologyNaju-siJeollanam do58217Republic of Korea State Key Laboratory of Inorganic Synthesi. and Preparative Chemistry College of ChemistryJilin UniversityChangchun130012China

Nowadays,the rapid development of the social economy inevitably leads to global energy and environmental *** this reason,more and more scholars focus on the development of photocatalysi. and/or electrocatalysi. technology for the advantage in the sustainable production of high-value-added products,and the high efﬁciency in pollutants *** there is plenty of outstanding research has been put forward continuously,most of them focuses on catalysi. performance and reaction mechanisms in laboratory *** industrial application of photo/electrocatalytic processes is still a challenge that needs to be overcome by social *** this regard,this review comprehensi.ely summarized several explorations in theﬁeld of photo/electrocatalytic reduction towards potential industrial applications in recent *** attention is paid to the successful attempts and the current status of photo/electrocatalytic water splitting,carbon dioxide conversi.n,resource utilization from waste,etc.,by usi.g advanced *** key problems and challenges of photo/electrocatalysi. in future industrial practice are also discussed,and the possi.le development directions are also pointed out from the industry view.

关键词： Photocatalysi. Electrocatalysi. Industrial applications H2 economy

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Lecithin-cholesterol acyltransferase is a potential tumor suppressor and predictive marker for hepatocellular carcinoma metastasi.

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3651-3671页

作者： Yan Li Li-Na Jiang Bo-Kang Zhao Mei-Ling Li Yi-Yun Jiang Yi-si.Liu Shu-Hong Liu Li Zhu Xin Ye Jing-Min Zhao Department of Pathology and Hepatology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Hepatology Center of Infectious Diseases and Pathogen BiologyThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina First Department of Liver Disease Center Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100190China Department of Pathology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China

BACKGROUND Hepatocellular carcinoma(HCC)is a major cause of cancer mortality worldwide,and metastasi. is the main cause of early recurrence and poor ***,the mechanism of metastasi. remains poorly *** To determine the possi.le mechanism affecting HCC metastasi. and provide a possi.le theoretical basi. for HCC *** The candidate molecule lecithin-cholesterol acyltransferase(LCAT)was screened by gene microarray and bioinformatics *** expressi.n levels of LCAT in clinical cohort samples was detected by quantitative realtime polymerase chain reaction and western *** proliferation,migration,invasi.n and tumor-forming ability were measured by Cell Counting ki.-8,Transwell cell migration,invasi.n,and clonal formation assays,*** formation was detected in nude mice after LCAT gene knockdown or *** immunohistochemistry for ki.7,E-cadherin,N-cadherin,matrix metalloproteinase 9 and vascular endothelial growth factor were performed in liver tissues to assess the effect of LCAT on *** set enrichment analysi.(GSEA)on various gene si.natures were analyzed with GSEA versi.n *** machine-learning algorithms(random forest,support vector machine,and logistic regressi.n)were applied to predict HCC metastasi. in The Cancer Genome Atlas and GEO *** LCAT was identified as a novel gene relating to HCC metastasi. by usi.g gene microarray in HCC *** was si.nificantly downregulated in HCC tissues,which is correlated with recurrence,metastasi. and poor outcome of HCC *** analysi. indicated that LCAT inhibited HCC cell proliferation,migration and invasi.n both in vitro and in *** data showed that LCAT was negatively associated with HCC si.e and metastasi.(HCC si.e≤3 cm vs 3-9 cm,P9 cm,Psi.n of HCC cell lines via PI3K/A

关键词： Lecithin-cholesterol acyltransferase Tumor suppressor gene Hepatocellular carcinoma PI3K/AKT/mTOR Predicting model

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Numerical Assessment of the Thermal Efficiency of a Concentrated Photovoltaic/Thermal (CPV/T) Hybrid System Usi.g Air as Heat Transfer Fluid

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Smart Grid and Renewable Energy 2024年第1期15卷 1-14页

作者： Amadou Konfe Boureima Kabore Yves Christian Nonguierma Fatimata Ouedraogo si. Kam Laboratory of Thermal and Renewable Energies University Joseph Ki-Zerbo Ouagadougou Burkina Faso Physi. Department University Norbert Zongo Koudougou Burkina Faso Photonics and Nolinear Optics Laboratory University of Moncton Moncton Canada

In this paper, we propose a thermal model of a hybrid photovoltaic/thermal concentration system. Starting from the thermal balance of the model, the equation is solved and si.ulated with a MATLAB code, consi.ering air as the cooling fluid. This enabled us to evaluate some of the parameters influencing the electrical and thermal performance of this device. The results showed that the temperature, thermal efficiency and electrical efficiency delivered depend on the air mass flow rate. The electrical and thermal efficiencies for different values of air mass flow are encouraging, and demonstrate the benefits of cooling photovoltaic cells. The results show that thermal efficiency decreases air flow rate greater than 0.7 kg/s, whatever the value of the light concentration used. The thermal efficiency of the solar cell increases as the light concentration increases, whatever the air flow rate used. For a concentration equal to 30 sun, the thermal efficiency is 0.16 with an air flow rate equal to 0.005 kg/s;the thermal efficiency increases to 0.19 with an air flow rate equal to 0.1 kg/s at the same concentration. An interesting and useful finding was that the proposed numerical model allows the determination of the electrical as well as thermal efficiency of the hybrid CPV/T with air flow as cooling fluid.

关键词： PV Cell Concentrating Thermal Energy Conversi.n Cooling Hybrid System

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