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Seroprevalence of anti-HAV among patients with chronic viral liver disease

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World Journal of Gastroenterology 2011年第2期17卷 236-241页

作者： Hyun Chin Cho Seung Woon Paik Yu Jin Kim Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Byung Chul yoo Hee jung Son Seon Woo Kim Division of Gastroenterology Samsung Medical CenterSungkyunkwan University School of Medicine Division of Gastroenterology Center for Health PromotionSamsung Medical CenterSungkyunkwan University School of Medicine Biostatics Team Samsung Medical CenterSungkyunkwan University School of Medicine

AIM:To investigate the current seroprevalence of hepatitis A virus(HAV) antibodies in patients with chronic viral liver disease in *** also tried to identify the factors affecting the prevalence of HAV antibodies. METHODS:We performed an analysis of the clinical records of 986 patients(mean age:49±9 years,714 males/272 females) with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection who had undergone HAV antibody testing between January 2008 and December ***:The overall prevalence of IgG anti-HAV was 86.61%(854/986) in patients with chronic liver disease and was 88.13%(869/986) in age-and gendermatched patients from the Center for Health *** anti-HAV prevalence was 80.04%(405/506) in patients with chronic hepatitis B,86.96%(20/23) in patients with chronic hepatitis C,93.78%(422/450) in patients with HBV related liver cirrhosis,and 100%(7/7) in patients with HCV related liver *** anti-HAV prevalence according to the decade of age was as follows:20s(6.67%) ,30s(50.86%) ,40s(92.29%) ,50s(97.77%) ,and 60s(100%) .The antiHAV prevalence was significantly higher in patients older than 40 years compared with that in patients younger than 40 years of *** analysis showed that age≥40 years,female gender and metropolitan cities as the place of residence were independent risk factors for IgG anti-HAV seropositivity. CONCLUSION:Most Korean patients with chronic liver disease and who are above 40 years of age have already been exposed to hepatitis A virus.

关键词： Chronic hepatitis B Chronic hepatitis C Hepatitis A virus Korea Seroprevalence

One-year clinical outcomes in invasive treatment strategies for acute ST-elevation myocardial infarction complicated by cardiogenic shock in eld-erly patients

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Journal of Geriatric Cardiology 2013年第3期10卷 235-241页

作者： Yeon Pyo yoo Ki-Woon Kang Hyeon Soo yoon Jin Cheol Myung Yu Jeong Choi Won Ho Kim Sang Hyun Park Kyung Tae jung Myung Ho Jeong Division of Cardiology Hyosung General Hospital 162-90 Sandang dong Chungju 360-802 South Korea Division of Cardiology Eulji University Hospital Eulji University School of Medicine 1306 Dunsan dong Seogu Daejeon 302-120 South Korea Division of Cardiology Worker`s Compensation&Welfare Service Hospital 833 Gaejok-ro Daejeon 306-060 South Korea Division of Cardiology Chunman National University Hospital 42 Jaebong-ro Kwangju 501-757 South Korea

Objective To investigate the clinical outcomes of an invasive strategy for elderly (aged≥75 years) patients with acute ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS). Methods Data on 366 of 409 elderly CS patients from a total of 6,132 acute STEMI cases enrolled in the Korea Acute Myocardial Infarction Registry between January 2008 and June 2011, were collected and analyzed. In-hospital deaths and the 1-month and 1-year survival rates free from major adverse cardiac events (MACE;defined as all cause death, myocardial infarction, and target vessel revascularization) were reported for the patients who had undergone invasive (n=310) and conservative (n=56) treatment strategies. Results The baseline clinical characteristics were not significantly different between the two groups. There were fewer in-hospital deaths in the invasive treatment strategy group (23.5%vs. 46.4%, P<0.001). In addition, the 1-year MACE-free survival rate after invasive treatment was significantly lower compared with the conservative treatment (51%vs. 66%, P=0.001). Conclusions In elderly patients with acute STEMI complicated by CS, the outcomes of invasive strategy are similar to those in younger patients at the 1-year follow-up.

关键词： Acute myocardial infarction Elderly patients Cardiogenic shock

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Outcome of laparoscopic cholecystectomy is not influenced by chronological age in the elderly

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World Journal of Gastroenterology 2009年第6期15卷 722-726页

作者： Hyung Ook Kim jung Won Yun Jun Ho Shin Sang Il Hwang Yong Kyun Cho Byung Ho Son Chang Hak yoo Yong Lai Park Hungdai Kim Departments of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of MedicineSeoul 110-746 South Korea Departments of Internal Medicine Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 110-746South Korea

AIM:To evaluate the outcome of laparoscopic cholecystectomy(LC)in patients aged 80 years and older. METHODS:A total of 353 patients aged 65 to 79 years(group 1)and 35 patients aged 80 years and older(group 2)underwent *** were further classified into two other groups:those with uncomplicated gallbladder disease(group A)or those with complicated gallbladder disease(group B). RESULTS:There were no significant differences between the age groups(groups 1 and 2)with respect to clinical characteristics such as age,gender,comorbid disease,or disease *** operative time,conversion rate,and the incidence of major postoperative complications were similar in groups 1 and ***,the percentage of high-risk patients was significantly higher in group 2 than in group 1 (20.0%vs 5.7%,P<0.01).Group A comprised 322 patients with a mean age of 71.0±5.3 years,and group B comprised 51 patients with a mean age of 69.9±4.8 *** group B,mean operative time (78.4±49.3 min vs 58.3±35.8 min,P<0.01),mean postoperative hospital stay(7.9±6.5 d vs 5.0±3.7 d, P<0.01),and the incidence of major postoperative complications(9.8%vs 3.1%,P<0.05)were significantly greater than in group *** conversion rate tended to be higher in group B,but this difference was not significant. CONCLUSION:Perioperative outcomes in elderly patients who underwent LC seem to be influenced by the severity of gallbladder disease,and not by chronologic *** octogenarians,LC should be performed at an earlier,uncomplicated stage of the disease whenever possible to improve perioperative outcomes.

关键词： Elderly Laparoscopic cholecystectomy Octogenarians Gallbladder Cholecystitis

Anti-Proliferative Effects of Ginsenosides Extracted from Mountain Ginseng on Lung Cancer

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Chinese Journal of Integrative Medicine 2016年第5期22卷 344-352页

作者： Dong Gyu Lee Sung-ll Jang Young-Rang Kim Kyeong Eun Yang So jung yoon Zee-Won Lee Hyun Joo An Ik-Soon Jang Jong-Soon Choi Hwa-Seung yoo Division of Life Science Korea Basic Science InstituteDaejeon 305-333Korea East-West Cancer Center Dunsan Oriental Hospital of Daejeon UniversityDaejeon 302-122Korea Graduate School of Analytical Science and Technology Chungnam National UniversityDaejeon 305-764Korea

Objective： To investigate the effect of three major ginsenosides from mountain ginseng as anti- cancer substance and explore the underlying mechanism involved in lung cancer. Methods： The inhibitory proliferation of lung cancer by major five ginsenosides （Rbl, Rb2, Rgl, Rc, and Re） was examined using 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl tetrazolium bromide assay. Calculated 50% inhibition （IC50） values of five ginsenosides were determined and compared each other. Apoptosis by the treatment of single ginsenoside was performed by fluorescence-assisted cytometric spectroscopy. The alterations of apoptosis-related proteins were evaluated by Western blot analysis. Results： The abundance of ginsenosides in butanol extract of mountain ginseng （BX-MG） was revealed in the order of Rbl, Rgl, Re, Rc and Rb2. Among them, Rbl was the most effective to lung cancer cell, followed by Rb2 and Rgl on the basis of relative IC50 values of IMR90 versus A549 cell. The alterations of apoptotic proteins were confirmed in lung cancer A549 cells according to the administration of Rbl, Rb2 and Rgl. The expression levels of caspase-3 and caspase-8 were increased upon the treatment of three ginsenosides, however, the levels of caspase-9 and anti-apoptotic protein Bax were not changed. Conclusion： Major ginsenosides such as Rbl, Rb2 and Rgl comprising BX-MG induced apoptosis in lung cancer cells via extrinsic apoptotic pathway rather than intrinsic mitochondrial pathway.

关键词： Butanol extract of mountain ginseng ginsenoside lung cancer apoptosis

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Soybean isoflavones alter parvalbumin in hippocampus of mid-aged normal female,ovariectomized female,and normal male rats

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Acta Pharmacologica Sinica 2006年第1期27卷 59-65页

作者： In Koo HWANG yoon-bok LEE Ki-yeon yoo Tae-cheon KANG Soon Sung LIM Sang Moo KIM Heon-soo SOHN Woo-jung KIM Hyun Kyung SHIN Moo Ho WON Department of Anatomy College of MedicineHallym UniversityChunchon 200-702Korea Department of Laboratory Animal Research.Central Research Institute Dr Chung's Food Co Ltd.Cheongju 361-782Korea Division of Life Science and Silver Biotechnology Research Center Korea Faculty of Marine Bioseience and Technology.Kangneung National University Kangneung 210-702Korea Faculty of Food Science and Technology College of Life SciencesSejong UniversitySejong 143-747Korea

Aim:To investigate the long-term effect of soybean isoflavones on changes inparvalbumin (PV) immunoreactivity in the hippocampus in normal female,ovariec-tomized (OVX) female and normal male ***:Ten-month-old rats wereassigned to one of 9 groups (n=7 in each group) based on body weight using arandomized complete-block *** groups were:control diet-treated females,OVX females,and males;0.3g/kg isoflavone-treated females,OVX females,andmales;and 1.2g/kg isoflavone-treated females,OVX females,and *** PVimmunostaining was conducted by using the standard avidin-biotin ***:PV immunoreactivity and the number of PV-immunoreactiveneurons in all the groups after isoflavone treatment were significantly changed inthe hippocampal CA1 region and in the dentate gyrus,but not in the hippocampalCA2/3 *** immunoreactivity and the number of PV-immunoreactive neu-rons in the control diet OVX females were similar to those in the control diet,andwere greater than those in the control diet normal *** immunoreactivityand the number of PV-immunoreactive neurons in all the isoflavone-treated groupsdecreased dose-dependently after isoflavone ***:Long-termadministration of isoflavones may induce a reduction of PV in interneurons in thehippocampal CA1 region and in the dentate *** reduction of PV in theseregions suggests that the long-term administration of isoflavones may cause achange in calcium homeostasis in the hippocampal CA1 region and in the dentategyrus.

关键词： isoflavones ovariectomy hippocampus immunohistochemistry

Aberrant expression of krUppel-like factor 6 protein in colorectal cancers

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World Journal of Gastroenterology 2006年第14期12卷 2250-2253页

作者： Yong-Gu Cho Byung-Jun Choi Jae-Whie Song Su-Young Kim Suk-Woo Nam Sug-Hyung Lee Nam-Jin yoo jung-Young Lee Won-Sang Park Department of Pathology College of Medicine The Catholic University of Korea505 Banpo-dongSeocho-guSeoul 137-701Korea Department of Pathology College of Medicine The Catholic University of Korea505 Banpo-dongSeocho-guSeoul 137-701Korea Department of PediatricsCollege of MedicineThe Catholic University of Korea505 Banpo-dongSeocho-guSeoul 137-701Korea

AIM： TO investigate whether krüppel-like factor 6 （KLF6） plays an important role in the development and/or progression of colorectal cancer. METHODS： A total of 123 formalin-fixed and paraffinembedded colorectal cancer specimens were analyzed by immunohistochemistry using tissue microarray for the expression of KLF6 protein. The specimens were collected over a 3-year period in the laboratories at our large teaching hospital in Seoul, Republic of Korea. The correlation of KLF6 expression with clinicopathologic parameters was analyzed by χ^2 test and Bartholomew test. RESULTS： Normal colonic epithelium showed weak to moderate expression of KLF6, whereas reduced KLF 6 expression or loss of KLF6 expression was seen in 45 （36.6%） of the 123 colorectal carcinoma specimens. Interestingly, aberrant expression of KLF6 was detected in 25 （43.1%） of 58 cases with metastasis to regional lymph node and in 31 （47.0%） of 66 tumors more than 5 cm in size. Statistically, loss of KLF6 expression was significantly associated with tumor size （P〈0.05）. However, there was no significant correlation between KLF6 expression and Dukes＇ stage （Bartholomew test, P〉 0.05）, tumor location and lymph node metastasis （χ^2 test, P〉0.05）.CONCLUSION： Loss of KLF6 expression may be a common and early event in colorectal carcinogenesis.

关键词： KLF6 Mutation Immunohistochemistry Aggressiveness Tumor stage Colorectal cancer

The expression of DNA damage checkpoint proteins and prognostic implication in metastatic brain tumors

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The expression of DNA damage checkpoint proteins and prognos...

Soluble components of Hericium erinaceum induce NK cell activation via production of interleukin-12 in mice splenocytes

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Do-Hyun Nam Ho Jun Seol Hae Yong yoo Juyoun Jin Kyeung Min Joo jung-II Lee Department of Neurosurgery Samsung Biomedical Research Instituteand Cancer Stem Cell Research CenterSamsung Medical CenterSungkyunkwan University School of Medicine

Resistance to radiation is a possible cause of recurrence or treatment failure in brain *** expression of the DNA damage checkpoint pathway components was investigated in cell lines and metastatic brain tumor（MBT） *** association between the expression levels and survival outcome were evaluated to find out possible therapeutic targets in brain *** of human non-small cell lung cancer cell lines was determined by checking their viability after treatment with varying doses of ionizing radiation（IR）.The expression of DNA checkpoint proteins were analyzed by Western blots and *** the basis of the clinical data for the MBT patients,the association between the expression of the components and patients’ survival was *** expression levels of TopBP1 and Chk1 protein were higher in radioresistant lung cancer cell line compared to radiosensitive cell *** activity of Chk1 in response to IR was also higher in radioresistant cell lines than in radiosensitive cell *** assessed radiation survival of lung cancer cell lines after treating them with Chk1 inhibitor,***7762 significantly sensitized both radioresistant and radiosensitive cells to *** also observed a strong inverse relationship between progression-free survival（PFS） and expression level of phosphorylated Chk1（P-Chk1） and *** association between the PFS and the expression of TopBP1 and P-Chk1 was observed for the first *** further investigation for understanding the role of these proteins are necessary,these two DNA damage checkpoints proteins can be promising targets for enhancing therapeutic potentials in the MBTs.

关键词： DNA damage checkpoint metastatic brain tumor P-Chk1 radioresistance TopBP1

来源： cnki会议评论

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Acta Pharmacologica Sinica 2007年第6期28卷 901-907页

作者： Myung-hyun YIM Jang-woo SHIN Jin-young SON Se-mi OH Seung-hyun HAN jung-hyo CHO Chong-kwan CHO Hwa-seung yoo Yeon-weol LEE Chang-gue SON East-West Cancer Center Dunsan Oriental Hospital of Daejeon UniversityDaejeon 302-122Korea

Aim:To investigate the immunoregulatory functions of water extracts of Hericiumerinaceum （WEHE） focusing on natural killer （NK） cell-based anticancer ***:Mouse splenocytes or purely isolated NK ceils were stimulated with1-100 mg/L WEHE for 24 h followed by co-culture with51Cr-labled Yac-1 cells for4 h,then NK cell-derived cytolytic activity was measured using a *** antibodies against mouse interleukin-12 （IL-12） were addedinto the WEHE-stimulated splenocytes,thereafter,cytotoxicity was measured toexamine the involvement of ***-PCR and ELISA analyses were performed toconfirm the induction of transcription and the translation of IL-12 and interferon-gamma （IFN-gamma） in the WEHE-treated ***:WEHE enhancedthe cytolytic activity of total splenocytes towards Yac-1 ceils in a ***,this activation was not observed when the NK cells isolatedfrom the splenocytes were treated with ***,the treatment withantibodies against IL-12 abolished the effect of WEHE on splenocyte-derivedcytolytic ***-PCR and ELISA analyses showed the induction of IL-12 andIFN-gamma in the WEHE-treated ***:WEHE indirectlyactivates the cytolytic ability of NK cells via the induction of IL-12 in totalsplenocytes,and possibly via other immuno-mediators or cellular components.

关键词： Hericium erinaceum NK cells interleukin-12

Macrophage PD-L1 strikes back: PD-1/PD-L1 interaction drives macrophages toward regulatory subsets

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Advances in Bioscience and Biotechnology 2013年第8期4卷 19-29页

作者： Yun-jung Lee Young-Hye Moon Kyeong Eun Hyung Jong-Sun yoo Mi Ji Lee Ik Hee Lee Byung Sung Go Kwang Woo Hwang Laboratory of Host Defense Modulation College of Pharmacy Chung-Ang University Seoul Korea

Activated macrophages have been simply de?ned as cells that secrete in?ammatory mediators and kill intracellular pathogens until few years ago. Recent studies have proposed a new classification system to separate activated macrophages based on their functional phenotypes: host defense, wound healing, and immune regulation. Regulatory macrophages can arise following innate or adaptive immune responses and hinder macrophage-mediated host defense and inflammatory functions by inhibiting the production of pro-inflammatory mediators. In this study, we investigated whether PD-1 and PD-L1 interaction between macrophages and T cells alters macrophage activities. Our data provide evidence for PD-1/PD-L1 engagement inducing a regulatory profile in macrophages. Regulatory macrophages derived from PD-L1 signaling lost their host defense activity, which consists of the production of pro-inflammatory cytokine IL-6 and the exhibition of increased IL-10, SPHK1 and LIGHT gene levels in early phases of LPS stimulation. This differentiation seems to occur through excessive activation of TLR4 downstream MAPK signaling pathways. Regulatory macrophages induced from PD-1/PD-L1 interaction decrease inflammatory mediators and produce anti-inflammatory cytokines, so this macrophage subset has been under considerable attention as a possible immune regulation mechanism. Understanding and modulating regulatory macrophages may lead to new approches to treat or prevent auto-immune diseases such as type I diabetes, rheumatic syndrome and hypersensitivity-related diseases, which are concerned with the overproduction of inflammatory cytokines in macroages.

关键词： Regulatory Macrophage PD-1 PD-L1