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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Facile synthesis of fully ordered L10-FePt nanoparticles with controlled Pt-shell thicknesses for electrocatalysis

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Nano Research 2017年第8期10卷 2866-2880页

作者： Yonghoon Hong Hee Jin Kim Daehee Yang Gaehang Lee Ki Min Nam Myung-hwa jung Young-Min Kim Sang-II choi Won Seok Seo Department of Chemistry Sogang University Seou104107 Republic of Korea Department of Chemistry and Green-Nano Materials Research Center Kyungpook National University Daegu 41566 Repubfic of Korea Korea Basic Science Institute and University of Science and Technology Daejeon 34133 Republic of Korea Department of Chemistry Mokpo National University Jeonnam 58554 Republic of Korea Department of Physics Sogang University Seoul 04107 Republic of Korea Center for Integrated Nanostructure Physics Institute for Basic Science (IBS) Suwon 16419 Repubfic of Korea Department of Energy Science Sungkyunkwan University (SKKU) Suwon 16419 Republic of Korea

We report a simple one-step approach for the synthesis of -4 nm uniform and fully L10-ordered face-centered tetragonal （fct） FePt nanoparticles （NPs） embedded in -60 nm MCM-41 （fct-FePt NPs@MCM-41）. We controlled the Pt-shell thickness of the fct-FePt NPs by treating the fct-FePt NPs@MCM-41 with acetic acid （HOAc） or hydrochloric acid （HC1） under sonicafion, thereby etching the surface Fe atoms of the NPs. The fct-FePt NPs deposited onto the carbon support （fct-FePt NP/C） were prepared by mixing the fct-FePt NPs@MCM-41 with carbon and subsequently removing the MCM-41 using NaOH. We also developed a facile method to synthesize acid-treated fct-FePt NP/C by using a HF solution for simultaneous surface-Fe etching and MCM-41 removal. We studied the effects of both surface-Fe etching and Pt-shell thickness on the electrocatalytic properties of fct-FePt NPs for the methanol oxidation reaction （MOR）. Compared with the non-treated fct-FePt NP/C catalyst, the HOAc-treated and HCl-treated catalysts exhibit up to 34% larger electrochemically active surface areas （ECASAs）; in addition, the HCl-treated fct-FePt NP （with -1.0 nm Pt shell）/C catalyst exhibits the highest specific activity. The HF-treated fct-FePt NP/C exhibits an ECASA almost 2 times larger than those of the other acid-treated fct-FePt NP/C catalysts and shows the highest mass activity （1,435 mA·mgPt^-1, 2.3 times higher than that of the commercial Pt/C catalyst） and stability among the catalysts tested. Our findings demonstrate that the surface-Fe etching for the generation of the Pt shell on fct-FePt NPs and the Pt-shell thickness can be factors for optimizing the electrocatalysis of the MOR.

关键词： FePt face centered tetragonal bimetallic methanol oxidation reaction electrocatalysts

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Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging

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Bioactive Materials 2022年第8期7卷 182-205页

作者： hwa Seung Han Song Yi Koo Ki Young choi Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung25451Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul02792Republic of Korea

Over thousands of years,natural bioactive compounds derived from plants(bioactive phytocompounds,BPCs)have been used worldwide to address human health ***,they are a significant resource for drug discovery in the development of modern *** many BPCs have promising biological activities,most of them cannot be effectively utilized in drugs for therapeutic applications because of their inherent limitations of low solubility,structural instability,short half-life,poor bioavailability,and non-specific distribution to *** have utilized emerging nanoformulation(NF)technologies to overcome these limitations as they have demonstrated great potential to improve the solubility,stability,and pharmacokinetic and pharmacodynamic characteristics of *** review exemplifies NF strategies for resolving the issues associated with BPCs and summarizes recent advances in their preclinical and clinical applications for imaging and *** review also highlights how innovative NF technologies play a leading role in next-generation BPC-based drug development for extended therapeutic ***,this review discusses the opportunities to take BPCs with meaningful clinical impact from bench to bedside and extend the patent life of BPC-based medicines with new formulations or application to new adjacent diseases beyond the primary drug indications.

关键词： Natural products Phytocompound Nanoformulation Drug delivery Phototherapy

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Consistency of intensity ratio between spectral lines with similar self-absorption characteristics during ungated laser induced breakdown spectroscopy measurements

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Plasma Science and Technology 2019年第3期21卷 77-83页

作者： jung-hwan IN Youngmin MOON Jang-Hee choi Sungho JEONG Optical Lens Research Center Korea Photonics Technology Institute School of Mechanical Engineering Gwangju Institute of Science and Technology

This work reports that the intensity ratio of spectral lines having similar self-absorption characteristics during laser induced breakdown spectroscopy(LIBS) analysis can become nearly constant over a wide range of irradiation conditions if the intensities are integrated over a sufficiently long time. It is shown that the plasma temperature and intensity ratio of these spectral lines have temporal similarity. The spectral lines with similar self-absorption properties may be selected to improve the accuracy and consistency of LIBS analysis results under an environment with fluctuating measurement conditions.

关键词： laser induced breakdown spectroscopy intensity ratio self-absorption characteristics CIGS solar cell

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Omnidirectional color wavelength tuning of stretchable chiral liquid crystal elastomers

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Light(Science & Applications) 2024年第6期13卷 1062-1074页

作者： Seungmin Nam Wontae jung Jun Hyuk Shin Su Seok choi Department of Electrical Engineering Pohang University of Science and Technology(POSTECH)PohangKorea

Wavelength-tunable structural colors using stimuli-responsive materials,such as chiral liquid crystals(CLCs),have attracted increasing attention owing to their high functionality in various tunable photonic ***,on-demand omnidirectional wavelength control is highly desirable from the perspective of wavelength-tuning ***,despite numerous previous research efforts on tunable CLC structural colors,only mono-directional wavelength tuning toward shorter wavelengths has been employed in most studies to *** this study,we report the ideally desired omnidirectional wavelength control toward longer and shorter wavelengths with significantly improved tunability over a broadband wavelength *** using areal expanding and contractive strain control of dielectric elastomer actuators(DEAs)with chiral liquid crystal elastomers(CLCEs),simultaneous and omnidirectional structural color-tuning control was *** breakthrough in omnidirectional wavelength control enhances the achievable tuning freedom and versatility,making it applicable to a broad range of high-functional photonic applications.

关键词： tuning tunable directional

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Intermittent, low-dose, antiandrogen monotherapy as an alternative therapeutic option for patients with positive surgical margins after radical prostatectomy

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Asian Journal of Andrology 2018年第3期20卷 270-275页

作者： Kyung hwa choi Seung Ryeol Lee Young Kwon Hong Dong Soo Park Department Urology CHA Bundang Medical Center CHA University Seongnam Korea.

The aim of the present study was to determine whether oncologic outcomes and adverse events associated with active on/off intermittent antiandrogen monotherapy （daily bicalutamide, 50 mg per day） are comparable with those of standard external beam radiation therapy （EBRT） or combined androgen blockade （CAB） therapy in prostate cancers with positive surgical margins after radical prostatectomy. Two hundred twenty-three patients with positive surgical margins post-radical prostatectomy who underwent active surveillance （AS, n = 32）, EBRT without hormone therapy （n = 55）, intermittent antiandrogen monotherapy without EBRT （IAAM, n= 50）, or CAB without EBRT （n = 86）, between 2007 and 2014, were reviewed retrospectively. Pathologic outcomes, biochemical recurrence rates, radiological disease progression, and adverse events were collected from medical records. Biochemical recurrence rates, biochemical recurrence-free survival rates, and radiological recurrence were not different between the groups （P = 0.225, 0.896, and 0.284, respectively）. Adverse event rates and severities were lower for IAAM compared with EBRT or CAB （both P 〈 0.05）, but were comparable to those for AS （P = 0.591 and 0.990, respectively）. Grade ：〉3 adverse events were not reported in the IAAM or AS groups. Erectile dysfunction and loss of libido rates were lower in the IAAM group compared with the EBRT and CAB groups （P = 0.032）. Gastrointestinal complications were more frequently reported in the EBRT group （P = 0.008）. Active on/off IAAM treatment might be an appropriate treatment option for patients with positive surgical margins after radical prostatectomy. Furthermore, regarding oncologic outcomes, IAAM was comparable to standard EBRT but had a milder adverse event profile.

关键词： androgen receptor antagonists disease progression margins of excision prostatectomy prostatic neoplasms

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Effects of Polymeric Stabilizers on the Synthesis of Gold Nanoparticles

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Journal of Materials Science & Technology 2014年第2期30卷 107-111页

作者： Eun jung Kim Jeong Hyun Yeum Jin Hyun choi Department of Advanced Organic Materials Science and Engineering Kyungpook National University Department of Bio-fibers and materials Science Kyungpook National University

Gold nanoparticles （AuNPs） stabilized with sodium alginate （SA）, glycol chitosan （GC）, polyvinyl alcohol （PVA）, and polyethyleneimine （PEI） were synthesized in aqueous solutions at room temperature. Different sizes and size distributions of AuNPs were obtained according to the polymeric stabilizers. The mean particle diameters of AuNPs synthesized with GC and PVA as stabilizers were about 5.1 and 5.3 nm, respectively, while those of AuNPs stabilized with SA and PEI were 8.4 and 10.8 nm, respectively. When SA was used, relatively large particles aggregated to form large clusters. In the case of GC, a number of small particles built up large clusters. When PVA was used, the size and the number of nanoperticles were estimated small with a low weight content of Au. For this reason, the PVA-stabilized AuNPs formed clusters with a small hydrodynamic size. The AuNPs synthesized in the aqueous solution of PEI without a reducing agent, sodium borohydride, were uniform in size and formed the smallest nanoclusters （67.4 nm）. In this case, the highest Au content was obtained. Sufficiently grown nanoparticles with a high Au content and a limited hydrodynamic size are considered to be suitable for a variety of applications.

关键词： Gold nanoparticles Sodium alginate Glycol chitosan Polyvinyl alcohol Polyethyleneimine

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Tree-Based Index Overlay in Hybrid Peer-to-Peer Systems

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Journal of Computer Science & Technology 2010年第2期25卷 313-329页

作者： InSung Kang SungJin choi Member, IEEE SoonYoung jung SangKeun Lee Computer Science and Engineering Department Korea University Seoul 136-713 Korea Corporate Center KT (Korea Telecom) Seoul 137-792 Korea Computer Science Education Department Korea University Seoul 136-701 Korea

Hybrid Peer-to-Peer （P2P） systems that construct overlay networks structured among superpeers have great potential in that they can give the benefits such as scalability, search speed and network traffic, taking advantages of superpeer-based and the structured P2P systems. In this article, we enhance keyword search in hybrid P2P systems by constructing a tree-based index overlay among directory nodes that maintain indices, according to the load and popularity of a keyword. The mathematical analysis shows that the keyword search based on semi-structured P2P overlay can improve the search performance, reducing the message traffic and maintenance costs.

关键词： tree-based index overlay keyword search fault-tolerance performance

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Clinicopathologic factors influencing the accuracy of EUS for superficial esophageal carcinoma

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World Journal of Gastroenterology 2014年第20期20卷 6322-6328页

作者： jung Im jung Gwang Ha Kim Hoseok I Do Youn Park Tae Kyun Kim Young hwa Cho Yong Wan Sung Mun Ki choi Bong Eun Lee Geun Am Song Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research Institute Pusan National University Hospital Busan 602-739 South Korea Department of Chest Surgery Pusan National University School of Medicine Busan 602-739 South Korea Department of Pathology Pusan National University School of Medicine Busan 602-739 South Korea

AIM: To identify clinicopathologic factors influencing the accuracy of a high-frequency catheter probe endoscopic ultrasonography (EUS) for superficial esophageal carcinomas (SECs).

关键词： Esophageal cancer Endoscopic ultrasonography Accuracy

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An Experimental Study on the Behavior of Square Concrete-Filled High Strength Steel Tube Columns

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Journal of Iron and Steel Research International 2011年第S1期18卷 878-882页

作者： Hyung-suk jung Chang-sik choi Department of sustainable architectural engineering Hanyang UniversitySeoulKorea Department of architectural engineering Hanyang UniversitySeoulKorea

The paper presents an experimental study on the behavior of square concrete-filled high strength steel tube columns until *** specimens were tested to investigate the effect of high strength steel and plain strength concrete on the load carrying capacity of the square concrete-filled steel tube *** effect of the concrete which filled in the steel tube was also ***,the effect of high strength steel and the presence of concrete were also *** main parameters in the tests were:(1) the ultimate strength of steel (800 Mpa),(2) the presence of concrete in steel tube (hollow steel tube and concrete-filled steel tube),and (3) slender *** main objectives of these tests were three-step:(1) to describe a series of tests on composite columns,(2) to analyze the influence of several parameters,and (3) to compare the accuracy of the predictions by using the specifications in the code (AISC-LRFD,EC4 and AIJ etc.) for the design of high-strength composite *** results indicate that the ultimate strength of steel and presence of concrete had significant influence on both the axial compressive load capacity and the ductile of the square steel tube.

关键词： square concrete-filled steel tubes high strength steel axial compression

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