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Repair of a large patellar cartilage defect using human umbilical cord blood-derived mesenchymal stem cells:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12665-12670页

作者： Jun-Seob song Ki-Taek Hong Ki Jeon song Seok jung Kim Department of Orthopedic Surgery Gangnam JS HospitalSeoul 06053South Korea Department of Orthopedic Surgery Uijeongbu Street Mary’s HospitalCollege of MedicineThe Catholic University of KoreaUijeongbu 11765GyeonggidoSouth Korea

BACKGROUND Patellar dislocation may cause cartilage defects of various *** defects commonly require surgical treatment;however,conventional treatments are *** SUMMARY A 15-year-old male with a large patellar cartilage defect due to patellar dislocation was treated via human umbilical cord blood-derived mesenchymal stem cell(hUCB-MSC)*** our knowledge,this is the first report of this treatment for this *** patient recovered well as indicated by good visual analog scale,International Knee Documentation Committee and McMaster Universities Osteoarthritis Index *** resonance imaging showed cartilage regeneration 18 mo *** Umbilical cord blood-derived hUCB-MSCs may be a useful treatment option for the repair of large patellar cartilage defects.

关键词： Cartilage defect Umbilical cord Mesenchymal stem cells Patellar dislocation Magnetic resonance imaging Case report

Piezoelectric strain sensor with high sensitivity and high stretchability based on kirigami design cutting

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npj Flexible Electronics 2022年第1期6卷 529-536页

作者： Young-Gyun Kim Ji-Hyeon song Seongheon Hong Sung-hoon Ahn Department of Mechanical Engineering Seoul National UniversityGwanak-ro 1Gwanak-guSeoul 08826Republic of Korea MX Division Samsung ElectronicsSamsungro 129Suwon-siGyeonggi-do 16677Republic of Korea Department of Mechanical Engineering Dankook UniversityJukjeon-ro 152Suji-guYongin 16890Republic of Korea Institute of Advanced Machines and Design Seoul National UniversityGwanak-ro 1Gwanak-guSeoul 08826Republic of Korea

Wearable technology requires high-performance sensors with properties such as small size,flexibility,and wireless ***,sensitivity,and tunability are crucial sensor properties;stretchability and sensitivity ensure user comfort and accurate sensing performance,while tunability is essential for implementing sensors in diverse applications with different ranges of *** this study,we developed a high performance kirigami piezoelectric strain *** finite element analysis,the sensing performance was evaluated,and the kirigami patterns were *** electromechanical properties of sensors with four different kirigami patterns were analyzed.A sensor voltage measurement circuit was also designed,amplifying the output voltage 86.5 times by improving measurement accuracy.A piezoelectric kirigami sensor was constructed with a sensitivity of 9.86 V/cm^(2) and a stretchability of 320.8%,higher than those of previously reported kirigami piezoelectric strain ***,the fabricated sensor was successfully applied in a haptic glove for playing musical instruments.

关键词： stretch strain piezoelectric

Transparent neural implantable devices:a comprehensive review of challenges and progress

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npj Flexible Electronics 2022年第1期6卷 439-456页

作者： Young Uk Cho Se Lin Lim jung-hoon Hong Ki Jun Yu Department of Electrical and Electronic Engineering Yonsei UniversitySeoulKorea Department of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology InstituteYonsei UniversitySeoulKorea

The key to designing an implantable device lies in condensing the synergistic effects of diagnostic and therapeutic methods in a single *** conjunction with the integration of electrophysiology and optical modalities,a transparent neural interface alleviates challenges of conventional metal-based *** this review,the multimodal sensing and stimulation functionalities of recent research are ***,issues that arise when combining functionalities of conventional metal-based,opaque electrode arrays together with optical modalities—(1)photoelectric artifacts,(2)optical image blocking,and(3)light transmission efficiency—are ***,an introduction of advancing material candidates for transparent neural interfaces follows with the latest research.

关键词： neural transparent modal

Next High Performance and Low Power Flash Memory Package Structure

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Journal of Computer Science & Technology 2007年第4期22卷 515-520页

作者： jung-hoon Lee ERI Control Instrumentation EngineeringGyeongSang National UniversityJinju660-701Korea

In general, NAND flash memory has advantages in low power consumption, storage capacity, and fast erase/write performance in contrast to NOR flash. But, main drawback of the NAND flash memory is the slow access time for random read operations. Therefore, we proposed the new NAND flash memory package for overcoming this major drawback. We present a high performance and low power NAND flash memory system with a dual cache memory. The proposed NAND flash package consists of two parts, i.e., an NAND flash memory module, and a dual cache module. The new NAND flash memory system can achieve dramatically higher performance and lower power consumption compared with any conventionM NAND-type flash memory module. Our results show that the proposed system can reduce about 78% of write operations into the flash memory cell and about 70% of read operations from the flash memory cell by using only additional 3KB cache space. This value represents high potential to achieve low power consumption and high performance gain.

关键词： flash memory NAND-type NOR-type memory localities buffer or cache memory

Novel ternary metals-based telluride electrocatalyst with synergistic effects of high valence non-3d metal and oxophilic Te for pH-universal hydrogen evolution reaction

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Journal of Energy Chemistry 2023年第5期80卷 736-743,I0015页

作者： Seunghwan Jo Wenxiang Liu Yanan Yue Ki hoon Shin Keon Beom Lee Hyeonggeun Choi Bo Hou jung Inn Sohn Division of Physics and Semiconductor Science Dongguk UniversitySeoul 04620Republic of Korea School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072HubeiChina School of Physics and Astronomy Cardiff UniversityCardiff CF243AAWalesUK

Electrocatalyst designs based on oxophilic foreign atoms are considered a promising approach for developing efficient pH-universal hydrogen evolution reaction(HER)electrocatalysts by overcoming the sluggish alkaline HER ***,we design ternary transition metals-based nickel telluride(Mo WNi Te)catalysts consisting of high valence non-3d Mo and W metals and oxophilic Te as a first demonstration of non-precious heterogeneous electrocatalysts following the bifunctional *** Mo WNi Te showed excellent HER catalytic performance with overpotentials of 72,125,and 182 mV to reach the current densities of 10,100,and 1000 mA cm^(-2),respectively,and the corresponding Tafel slope of 47,52,and 58 mV dec-1in alkaline media,which is much superior to commercial Pt/***,the HER performance of Mo WNi Te is well maintained up to 3000 h at the current density of 100 mA cm^(-2).It is further demonstrated that the Mo WNi Te exhibits remarkable HER activities with an overpotential of 45 mV(31 mV)and Tafel slope of 60 mV dec-1(34 mV dec-1)at 10 mA cm^(-2)in neutral(acid)*** superior HER performance of Mo WNi Te is attributed to the electronic structure modulation,inducing highly active low valence states by the incorporation of high valence non-3d transition *** is also attributed to the oxophilic effect of Te,accelerating water dissociation kinetics through a bifunctional catalytic mechanism in alkaline *** functional theory calculations further reveal that such synergistic effects lead to reduced free energy for an efficient water dissociation process,resulting in remarkable HER catalytic performances within universal pH environments.

关键词： Telluride catalyst Oxophilic effect High valence non-3d metal Bifunctional mechanism pH-universal hydrogen evolution reaction

Simple method of measuring ocular rotation in supine position during small incision lenticule extraction

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1331-1337页

作者： Jiho song Hwanho Lee Moon Sun jung Jae-hyung Kim Seoul Daabom Eye Center CheongjuChungbuk 28396Republic of Korea Department of Ophthalmology Chungbuk National University HospitalCollege of MedicineChungbuk National UniversityCheongjuChungbuk 28644Republic of Korea

AIM:To introduce a novel measurement method of static cyclotorsion in small incision lenticule extraction(SMILE)and to investigate the effect of preoperative parameters on cyclotorsion and the effect of cyclotorsion on postoperative ***:The medical records of 242 patients and 484 eyes who under went SMILE surger y were retrospectively *** intraocular pressure,refractive error,and corneal thickness were *** values and visual acuity were measured at 1d,1,3,and *** cyclotorsion in the supine position was measured by calculating the location and angle of the incision site of the cornea in the anterior slit photograph taken after ***:Of the total 484 eyes in 242 patients,preopera tive means phericale quivalent(SE)was-4.10±1.64 D,and the mean astigmatism was-0.82±0.74 *** distance visual acuity(UCVA)and SE improved significantly after the ***,219(45.2%)eyes had excyclotorsion,235(48.6%)eyes had incyclotorsion,and 30(6.2%)eyes had no *** right eyes tended to be excyclotorted,and the left eyes tended to be incyclotorted(P<0.01).The mean cyclotorsion was 1.18°±3.69°,and the mean absolute value of cyclotorsion was 3.14°±2.26°.The range of cyclotorsion was 0.5°–11.4°.It was found that the smaller the preoperative sphere,the higher the amount of cyclotorsion(r=0.11,P=0.016).There was no significant association between the amount of cyclotorsion and preoperative *** was no correlation between sex,preoperative corneal thickness,preoperative intraocular pressure,amount of cyclotorsion,and direction of *** ratio of right eye excyclotorsion and left eye incyclotorsion on 1d was higher than that at 1,3,and 6mo(all P<0.01).There was no difference between the 1,3,and 6mo results in the right and left eyes(P=0.15,P=0.16,respectively).CONCLUSION:The newly devised ocular cyclotorsion measurement method can be used to evaluate ocular cyclotorsion after ***

关键词： anterior slit photograph astigmatism cyclotorsion myopia small incision lenticule extraction

Robotic versus laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: A propensity score-matched analysis

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 154-159页

作者： Dakyum Shin Jaewoo Kwon Jae hoon Lee Seo Young Park Yejong Park Woohyung Lee Ki Byung song Dae Wook Hwang song Cheol Kim Division of Hepato-Biliary and Pancreatic Surgery Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine88 Olympic-ro 43-gilSongpa-guSeoul 05505Korea Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of Medicine29 Saemunan-roJongno-guSeoul 03181Korea Department of Statistics and Data Science Korea National Open University86 Daehak-roJongno-guSeoul 03087Korea

Background: Minimally invasive surgery is becoming increasingly popular in the field of pancreatic surgery. However, there are few studies of robotic distal pancreatectomy(RDP) for pancreatic ductal adenocarcinoma(PDAC). This study aimed to investigate the efficacy and feasibility of RDP for PDAC. Methods: Patients who underwent RDP or laparoscopic distal pancreatectomy(LDP) for PDAC between January 2015 and September 2020 were reviewed. Propensity score matching analyses were performed. Results: Of the 335 patients included in the study, 24 underwent RDP and 311 underwent LDP. A total of 21 RDP patients were matched 1:1 with LDP patients. RDP was associated with longer operative time(209.7 vs. 163.2 min;P = 0.003), lower open conversion rate(0% vs. 4.8%;P < 0.001), higher cost(15 722 vs. 12 699 dollars;P = 0.003), and a higher rate of achievement of an R0 resection margin(90.5% vs. 61.9%;P = 0.042). However, postoperative pancreatic fistula grade B or C showed no significant intergroup difference(9.5% vs. 9.5%). The median disease-free survival(34.5 vs. 17.3 months;P = 0.588) and overall survival(37.7 vs. 21.9 months;P = 0.171) were comparable between the groups. Conclusions: RDP is associated with longer operative time, a higher cost of surgery, and a higher likelihood of achieving R0 margins than LDP.

关键词： Minimally invasive surgery Robotic distal pancreatectomy Laparoscopic distal pancreatectomy Pancreatic ductal adenocarcinoma Propensity score matching

Acute liver injury induces expression of FGF23 in hepatocytes via orphan nuclear receptor ERRγ signaling

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Genes & Diseases 2023年第3期10卷 679-682页

作者： Yoon Seok jung Yong-hoon Kim Kamalakannan Radhakrishnan jung-Ran Noh jung Hyeon Choi Hyo-Jin Kim Jae-Ho Jeong Steven Dooley Chul-Ho Lee Hueng-Sik Choi School of Biological Sciences and Technology Chonnam National UniversityGwangju 61186Republic of Korea Laboratory Animal Resource Center Korea Research Institute of Bioscience and Biotechnology125 Gwahak-roYuseong-guDaejeon 34141Republic of Korea Department of Functional Genomics KRIBB School of BioscienceKorea University of Science and Technology(UST)Daejeon 34113Republic of Korea Combinatorial Tumor Immunotherapy MRC Chonnam National University Medical SchoolHwasun-gunJeonnam 58128Republic of Korea Department of Microbiology Chonnam National University Medical SchoolGwangju 61186Republic of Korea Molecular Hepatology Section Medical Faculty MannheimHeidelberg University69117 HeidelbergGermany

Fibroblast growth factor 23(FGF23)is an osteocyte-and osteoblast-derived hormone that primarily regulates phosphate and vitamin D *** FGF23 levels are abnormally increased in pathological conditions like acute or chronic kidney injury,resulting in disease progression as well as increased rates of morbidity and mortality.^(1) However,FGF23 production in acute liver injury is not fully *** this study.

关键词： FGF23 acute vitamin

Reevaluation of the expanded indications in undifferentiated early gastric cancer for endoscopic submucosal dissection

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World Journal of Gastroenterology 2022年第15期28卷 1548-1562页

作者： Jiyoung Yoon Seung-Yeon Yoo Young Soo Park Kee Don Choi Beom Su Kim Moon-Won Yoo In Seob Lee Jeong Hwan Yook Ga Hee Kim Hee Kyong Na Ji Yong Ahn Jeong hoon Lee Kee Wook jung Do hoon Kim Ho June song Gin Hyug Lee Hwoon-Yong jung Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Although the criteria for the indication of endoscopic submucosal dissection(ESD)for undifferentiated early gastric cancer(UD-EGC)have been recently proposed,accumulating reports on the non-negligible rate of lymph node metastasis(LNM)after indicated ESD raise questions on the reliability of the current *** To investigate the prevalence and risk factors of LNM in UD-EGC cases meeting the expanded indication for *** We retrospectively reviewed 4780 UD-EGC cases that underwent surgical resection between January 2008 and February 2019 at Asan Medical Center,a tertiary university hospital in *** identify the risk factors of LNM of UDEGC meeting the expanded criteria for ESD,we performed a case-control study by matching the cases with LNM to those without at a ratio of 1:*** reviewed the clinical,endoscopic,and histologic features of the cases to identify features with a significant difference according to the presence of *** and multivariate logistic regression analyses were performed to estimate the odds ratios(ORs).RESULTS Of the 4780 UD-EGC cases,1240(25.9%)were identified to meet the expanded indication for *** the 1240 cases,14(1.1%)cases had *** the various clinical,endoscopic,and histopathological features that were evaluated,mixed histology(tumors consisting of 10%-90%of signet ring cells)had a marginally significant association(P=0.059)with the risk of ***,diffuse blurring of the muscularis mucosae(MM)underneath the tumorous epithelium,a previously unrecognized histologic feature,had a significant association with the absence of LNM(P=0.028).Multivariate logistic regression analysis showed that the blurring of MM was the only explanatory variable significantly associated with a reduced risk of LNM(OR:0.12,95%CI:0.02-0.95;P=0.045).CONCLUSION The risk of LNM is higher than expected when using the current expanded indication for *** evaluation could provide useful clues for reducing the

关键词： Gastric cancer Undifferentiated carcinoma Endoscopic submucosal dissection Lymph node metastasis