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A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

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Chinese Journal of Cancer Research 2024年第4期36卷 368-378页

作者： Ji Yeong An Sung Eun Oh Soomin Ahn Hyoung-II Kim Yoo Min Kim Minah Cho Keun Won Ryu Hong Man Yoon Young Kyu Park In Gyu Kwon Sung Hoon Noh Kyung hee lee In Cho Myoung Won Son Jong Won Kim Young-Woo Kim Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Department of Pathology and Translational Genomics Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Yonsei University College of Medicine Gastric Cancer Center Yonsei Cancer CenterYonsei University Health System Center for Gastric Cancer National Cancer Center Department of Surgery Chonnam National University Hwasun Hospital Chonnam National University College of Medicine Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine Department of Hematology-Oncology Yeungnam University Medical Center Department of Surgery Soonchunhyang University College of Medicine Department of Surgery Soonchunhyang University Cheonan Hospital Soonchunhyang University College of Medicine Department of Surgery Chung-Ang University Hospital Chung-Ang University College of Medicine

Objective: Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy decisions. In this study, we evaluated the clinical feasibility of the single patient classifier(SPC) test, a new clinical-grade prognostic assay, in stage Ⅱ-Ⅲ gastric cancer ***: A prospective multicenter study was conducted, involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine hospitals. The SPC test was employed to stratify patients into risk groups, and its feasibility and performance were evaluated. The primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative treatment. Furthermore, 3-year disease-free survivals of risk groups were ***: The SPC test met the primary endpoint criteria. The 99.5% of SPC tests were timely delivered to hospitals before the postoperative treatment started. In a clinical setting, the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 d. Furthermore, 3-year disease-free survivals were significantly different between risk groups classified with SPC ***: This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment strategies. It also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关键词： Prognostic test adjuvant chemotherapy advanced gastric cancer feasibility gastrectomy

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2D material inorganic liquid crystals for tunable deep UV light modulation

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National Science Review 2022年第12期9卷 62-63页

作者： Young hee lee Department of Energy Science and Department of Physics Sungkyunkwan University IBS Center for Integrated Nanostructure Physics Institute for Basic Science Sungkyunkwan University

Modulation of light refers to the modulation of electromagnetic radiation in the optical region including visible light as well as ultraviolet and infrared radiation,in which the amplitude (and therefore the intensity),phase,frequency or polarization of the radiated oscillations can be changed [1].Optical modulator devices are widely used in industry,as represented by liquid crystal optical modulators having an annual global market worth of over US$100 ***,

关键词： EXFOLIATION

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Spectral domain optical coherence tomography crosssectional image of optic nerve head during intraocular pressure elevation

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 1022-1029页

作者： Ji Young lee You Kyung lee jung Il Moon Myoung hee Park Department of Ophthalmology Yeouido St. Mary's HospitalCollege of Medicinethe Catholic University of Korea62Yeuido-dongYoungdeungpo-guSeoul 150-713Korea

AIM: To analyze changes of the optic nerve head(ONH) and peripapillary region during intraocular pressure(IOP) elevation in patients using spectral domain optical coherence tomography(SD-OCT).METHODS: Both an optic disc 200×200 cube scan and a high-definition 5-line raster scan were obtained from open angle glaucoma patients presented with monocular elevation of IOP(≥30 mm Hg) using SD-OCT. Additional baseline characteristics included age, gender, diagnosis,best-corrected visual acuity, refractive error, findings of slit lamp biomicroscopy, findings of dilated stereoscopic examination of the ONH and fundus, IOP, pachymetry findings, and the results of visual ***: The 24 patients were selected and divided into two groups: group 1 patients had no history of IOP elevation or glaucoma(n =14), and group 2 patients did have history of IOP elevation or glaucoma(n =10). In each patient, the study eye with elevated IOP was classified into group H(high), and the fellow eye was classified into group L(low). The mean deviation(MD)differed significantly between groups H and L when all eyes were considered(P =0.047) and in group 2(P =0.042), not in group 1(P =0.893). Retinal nerve fiber layer(RNFL) average thickness(P =0.050), rim area(P =0.015),vertical cup/disc ratio(P =0.011), cup volume(P =0.028),inferior quadrant RNFL thickness(P =0.017), and clockhour(1, 5, and 6) RNFL thicknesses(P =0.050, 0.012, and0.018, respectively), cup depth(P =0.008), central prelaminar layer thickness(P =0.023), mid-inferior prelaminar layer thickness(P =0.023), and nasal retinal slope(P =0.034)were significantly different between the eyes with groups H and ***:RNFLaveragethickness,rim area,vertical cup/disc ratio, cup volume, inferior quadrant RNFL thickness, and clock-hour(1, 5, and 6) RNFL thicknesses significantly changed during acute IOP elevation.

关键词： spectral domain optical coherence tomography optic nerve head elevated intraocular pressure open angle glaucoma retinal nerve fiver layer

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Anoxic gas recirculation system for fouling control in anoxic membrane reactor

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Journal of Environmental Sciences 2014年第6期26卷 1289-1293页

作者： Hansaem lee Daeju lee Seongwan Hong Geum hee Yun Sungpyo Kim jung Ki Hwang Woojae lee Zuwhan Yun Research Institute for Environmental Technology and Sustainable Development Korea UniversitySeoul 136-713 Korea Department of Environmental Engineering Korea UniversitySejong 339-700 Korea Dongbu Corporation Seoul 135-523 Korea

Anoxic gas recirculation system was applied to control the membrane fouling in pilot-scale 4- stage anoxic membrane bioreactor （MBR）. In the anaerobic-anoxic-anoxic-aerobic flow scheme, hydrophilic polytetrafluoroethylene （PTFE） membrane （0.2 μm, 7.2 m2/module） was submerged in the second anoxic zone. During 8 months operation, the average flux of the membrane was 21.3 L/（***）. Chemical cleaning of the membrane was conducted only once with sodium hydroxide and sodium hypochlorite. Dissolved oxygen （DO） concentration in the second anoxic zone was maintained with an average of 0.19 ± 0.05 mg/L. Gas chromatography analysis showed that the headspace gas in the second anoxic reactor was mainly consisted of N2 （93.0% ± 2.5%）, O2 （3.8% ± 0.6%）, and CO2 （3.0% ± 0.5%）, where the saturation DO concentration in liquid phase was 1.57 mg/L. Atmospheric 02 content （20.5% ± 0.8%） was significantly reduced in the anoxic gas. The average pH in the reactor was 7.2 ± 0.4. As a result, the recirculation of the anoxic gas was successfully applied to control the membrane fouling in the anoxic MBR.

关键词： anoxic gas recirculation system anoxic membrane bioreactor fouling

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The CONSTANS-like 4 transcription factor,AtCOL_4,positively regulates abiotic stress tolerance through an abscisic acid-dependent manner in Arabidopsis

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Journal of Integrative Plant Biology 2015年第3期57卷 313-324页

作者： Ji-hee Min jung-Sung Chung Kyeong-Hwan lee Cheol Soo Kim Department of Plant Biotechnology Chonnam National University Department of Agronomy Gyeongsang National University Department of Rural and Biosystems Engineering Chonnam National University

The precise roles of the B-box zinc finger family of transcription factors in plant stress are poorly *** analysis was performed on AtCOL4,an Arabidopsis thaliana ***-like 4 protein that is a putative novel transcription factor,and which contains a predicted transcriptional activation *** of an AtCOL4 promoter-b-glucuronidase（GUS） construct revealed substantial GUS activity in whole *** expression of AtCOL4 was strongly induced by abscisic acid（ABA）,salt,and osmotic *** in atcol4 resulted in increased sensitivity to ABA and salt stress during seed germination and the cotyledon greening *** contrast,AtCOL4-overexpressing plants were less sensitive to ABA and salt stress compared to the wild ***,in the presence of ABA or salt stress,the transcript levels of other ABA biosynthesis and stress-related genes were enhanced induction in AtCOL4-overexpressing and WT plants,rather than in the atcol4 ***,AtCOL4 is involved in ABA and salt stress response through the ABA-dependent signaling *** together,these findings provide compelling evidence that AtCOL4 is an important regulator for plant tolerance to abiotic stress.e

关键词： Abscisic acid B-box zinc finger family transcription factor salt stress

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Pancreatic pseudocyst filled with semisolid lipids mimicking solid mass on endoscopic ultrasound

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World Journal of Gastroenterology 2010年第8期16卷 1034-1038页

作者： Sang-Woo Cha Sae hee Kim Hyang Ie lee Yun jung lee Hyeon Woong Yang Sung hee jung Anna Kim Min Koo lee Hyun Young Han Dong Wook Kang Division of Gastroenterology Department of Internal Medicine Eulji University College of Medicine Eulji University Hospital Division of Gastroenterology Department of Surgery Eulji University College of Medicine Eulji University Hospital Division of Gastroenterology Department of Radiology Eulji University College of Medicine Eulji University Hospital Division of Gastroenterology Department of Pathology Eulji University College of Medicine Eulji University Hospital

Pancreatic pseudocysts,which account for 70%-90% of pancreatic cystic lesions,characteristically are non-epithelially lined cystic cavities that are contiguous with the pancreas. Pancreatic pseudocysts can be caused by acute,chronic or traumatic pancreatitis and should be differentiated from other pancreatic diseases with cystic appearances,especially cystic neoplasms. We report a unique case of a pancreatic pseudocyst filled with semisolid lipids,which appeared by endoscopic ultrasound as a solid mass,and was therefore resected.

关键词： Pancreatic pseudocyst Lipids Endosonog-raphy

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Study on the current structure of the thermohaline front in the southeastern entrance of the Yellow Sea during winter

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Acta Oceanologica Sinica 2015年第12期34卷 29-36页

作者： OH Kyung-hee lee Seok LIE Heung-Jae jung Kyung Tae QIAO Fangli Korea Institute of Ocean Science and Technology First Institute of Oceanography State Oceanic Administration

A thermohaline front is located at the southeastern entrance of the Yellow Sea in winter, and it is generated by the intrusion of warm saline water into the Yellow Sea caused by a strong northerly wind. Recently, a westward transversal current traveling away from the west coast of Korea toward the open sea area along the front was reported. The westward transversal current is dominant in the surface layer during the temperature inversion period. The formation and structure of this current are examined using a numerical vertical ocean-slice *** two different water masses meet, a front is formed and adjusted geostrophically. In this frontal zone, a horizontal pressure gradient flow by the vertically inclined isopycnal occurs under the thermal wind process in a baroclinic effect, and the cold fresh coastal water moves westward along the front in the upper layer. The barotropic effect across the front and the bottom friction effect strengthen the westward component of the velocity. The velocity of the bottom layer decreases remarkably in the increase of the bottom drag coefficient. This means that the bottom friction with the strong background tidal current causes a reduction in the current in the bottom layer.

关键词： Geostrophic adjustment Southeastern Yellow Sea Thermohaline front Thermal wind Westward transversal current

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Friction and wear of textured surfaces produced by 3D printing

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Science China(Technological Sciences) 2017年第9期60卷 1400-1406页

作者： HONG Yi ZHANG Peng lee Kwang-hee lee Chul-hee Department of Mechanical Engineering Inha University Incheon 402-751 Korea

Surface texture patterns have great potential for improving tribological performance in terms of reducing friction and wear. The most common methods for surface texatring are laser and injection molding. The 3D printing method is also used to build parts, patterns, and molds that feature fine details for a wide range of applications because texture manufacturing by 3D printing is faster, more flexible, and less expensive than traditional techniques. To date, there has been no research on textured surfaces produced by 3D printing. Therefore, a new fabrication method using 3D printing to improve friction and wear properties is a topic worth exploring. In this study, a reciprocating friction tester was used to evaluate the friction and wear properties of different surface textures produced by 3D printing. The surface of specimens was examined by electron microscope and scanning electron microscope before and after the test. The results show that surface texturing can be applied to 3D printed parts to improve their friction and wear performance.

关键词： three-dimensional (3D) printing texture friction wear

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Texture development and grain boundary phase formation in Ce-and Ce-La-substituted Nd-Fe-B magnets during hot-deformation process

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Journal of Materials Science & Technology 2022年第31期126卷 71-79页

作者： Ga-Yeong Kim Tae-Hoon Kim hee-Ryoung Cha Sang-hyub lee Dong-Hwan Kim Yang-Do Kim jung-Goo lee Department of Magnetic Materials Korea Institute of Materials ScienceChangwon 51508Republic of Korea Department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea R&D Center Star Group Ind.Co.Ltd.Daegu 42714Republic of Korea

In this study,the influence of Ce-and Ce-La-substitution for Nd in Nd-Fe-B magnets on their magnetic and microstructural changes in the course of the hot-deformation process was investigated to gain insight into further reducing the Nd content in fine-grained Nd-Fe-B hot-deformed *** found that the[001]texture and microstructure of the RE-rich grain boundary phases,which are the factors that de-termine the remanence and coercivity of hot-deformed magnets,were deteriorated by the Ce-and *** is because the volume fraction of the RE-rich liquid formed in the grain boundaries during the hot-press and hot-deformation decreased due to the Ce-and Ce-La-substitution,thereby in-creasing the friction between the 2:14:1 grains while the c-axes of grains were aligned by grain rotation and decreasing the RE concentration of grain boundary *** particular,the Ce-La-co-substitution further prevented the liquid formation within the grain boundaries of the magnets during hot-press and hot-deformation because the wettability of the RE-rich liquid on the 2:14:1 grains became poor when La was substituted for Nd in the 2:14:1 *** results indicate that there is room for further im-provement in both the remanence and coercivity of the Ce-and Ce-La-substituted magnets by intro-ducing additional liquid into the grain boundaries prior to hot-press and *** applying the Nd-Cu infiltration process to the melt-spun ribbons(intermediate infiltration,I-infiltration),both the remanence and coercivity of the Nd-saving(Nd 0.7 Ce 0.3)-Fe-B and(Nd 0.7 Ce 0.225 La 0.075)-Fe-B hot-deformed magnets were successfully improved.

关键词： Nd-Fe-B magnets Hot-deformation Nd-saving Ce-substitution La-substitution Infiltration

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Symptom Experience and Quality of Life in Colorectal Cancer Patients Undergoing Chemotherapy-A Secondary Publication

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Proceedings of Anticancer Research 2024年第1期8卷 117-128页

作者： Ayoung lee Jin-hee Park College of Nursing Ajou UniversitySuwonSouth Korea College of Nursing Research Institute of Nursing ScienceAjou UniversitySuwonSouth Korea

Objective:To evaluate symptom experience and quality of life(QoL)and to identify the predictors of QoL among colorectal cancer patients undergoing ***:A cross-sectional study was conducted on 107 colorectal cancer patients at a university-affiliated hospital between June 1 and July 30,*** Assessment of Cancer Therapy-Colorectal(FACT-C)and Memorial Symptom Assessment Scale-Short Form(MSAS-SF)were used to assess symptom experience and QoL of these *** were analyzed using Pearson’s correlation,t-test,ANOVA,and hierarchical multiple ***:The mean QoL score for colorectal cancer patients was 88.78±*** most frequently experienced physical and psychological symptoms were numbness/tingling and *** and psychological symptoms have a significant negative association with *** economic status was significantly associated with QoL in patients’general *** regression analyses showed that high psychological symptoms(β=-0.63,P<0.001),middle perceived economic status(β=-0.22,P=0.009),and low perceived economic status(β=-0.36,P<0.001)were statistically significant in predicting patients’low ***:Symptom experience and QoL are essential variables that should be acknowledged when delivering health care to colorectal cancer *** attention to the reduction and comprehensive symptom management of psychological distress could improve QoL among colorectal cancer patients.

关键词： Chemotherapy Colorectal neoplasms Quality of life Symptoms

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