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Molecular mechanisms of apoptosis induced by Scorpio water extract in human hepatoma HepG2 cells

World Journal of Gastroenterology 2005年第7期11卷 943-947页

作者： Kang-Beom Kwon Eun-Kyung Kim jung-gook lim Eun-Sil Jeong Byung-Cheul Shin Young-Se Jeon Kang-San Kim Eun-A Seo Do-Gon Ryu Department of Physiology Department of Rehabilitation Medicine Department of Internal Medicine Department of Food and Nutrition

AIM: To clarify the mechanism underlying the anti-mutagenic and anti-cancer activities of Scorpio water extract (SWE).METHODS: Human hepatoma HepG2 cells were incubated with various concentrations of SWE. After 24-h incubation,cytotoxicity and apoptosis evaluations were determined by MTT and DNA fragmentation assay, respectively. After treatment with SWE, mitochondrial membrane potential(MMP) was determined by measuring the retention of the dye 3,3'-dihexyloxacarbocyanine (DiOC6(3)) and the protein expression including cytochrome C and poly-(ADPribose) polymerase (PARP)were measured by Western blotting. Caspase-3 and -9 enzyme activities were measured using specific fluorescence dyes such as Ac-DEVD-AFC and ***: We found that treatment with SWE induced apoptosis as confirmed by discontinuous DNA fragmentation in cultured human hepatoma HepG2 cells. Our investigation also showed that SWE-induced apoptosis of HepG2 cells were associated with intracellular events including disruption of MMP, increased translocation of cytochrome C from mitochondria to cytosol, activation of caspase-3,and PARP. Pre-treatment of N-acetyl-Asp-Glu-Val-Asp-CHO(Ac-DEVD-CHO), a caspase-3 specific inhibitor, or cydosporin A (CsA), an inhibitor of MMP disruption, completely abolished SWE-induced DNA ***: These results suggest that SWE possibly causes mitochondrial damage, leading to cytochrome C release into cytosol and activation of caspases resulting in PARP cleavage and execution of apoptotic cell death in HepG2 cells. These results further suggest that Scorpio may be a valuable agent of therapeutic intervention of human hepatomas.

关键词：分子机制 HepG2 肝细胞瘤肿瘤细胞线粒体蝎子

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Some Results on Noetherian Warfield Domains

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Algebra Colloquium 2022年第1期29卷 67-78页

作者： Kui Hu jung Wook lim Dechuan Zhou College of Science Southwest University of Science and Technology MianyangSichuan 621010China Kyungpook National University Daegu 41566Korea Department of Mathematics College of Natural Sciences Kyungpook National UniversityDaegu 41566Korea

Let R be a *** this paper,we show that if R is one dimensional,then R is a Noetherian Warfield domain if and only if every maximal ideal of R is 2-generated and for every maximal ideal M of R,M is divisorial in the ring(M:M).We also prove that a Noetherian domain R is a Noetherian Warfield domain if and only if for every maximal ideal M of R,M^(2) can be generated by two ***,we give a sufficient condition under which all ideals of R are strongly Gorenstein projective.

关键词： strongly Gorenstein projective module Noetherian Warfield domain strongly Gorenstein Dedekind domain

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An Improved Time Feedforward Connections Recurrent Neural Networks

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Intelligent Automation & Soft Computing 2023年第6期36卷 2743-2755页

作者： Jin Wang Yongsong Zou Se-jung lim School of Hydraulic&Environmental Engineering Changsha University of Science&TechnologyChangsha410014China School of Computer&Communication Engineering Changsha University of Science&TechnologyChangsha410014China AI Liberal Arts Studies Division of ConvergenceHonam UniversityGwangju-si62399Korea

Recurrent Neural Networks(RNNs)have been widely applied to deal with temporal problems,such as flood forecasting and financial data *** the one hand,traditional RNNs models amplify the gradient issue due to the strict time serial dependency,making it difficult to realize a long-term memory *** the other hand,RNNs cells are highly complex,which will signifi-cantly increase computational complexity and cause waste of computational resources during model *** this paper,an improved Time Feedforward Connections Recurrent Neural Networks(TFC-RNNs)model was first proposed to address the gradient issue.A parallel branch was introduced for the hidden state at time t−2 to be directly transferred to time t without the nonlinear transforma-tion at time t−*** is effective in improving the long-term dependence of ***,a novel cell structure named Single Gate Recurrent Unit(SGRU)was *** cell structure can reduce the number of parameters for RNNs cell,consequently reducing the computational ***,applying SGRU to TFC-RNNs as a new TFC-SGRU model solves the above two ***,the performance of our proposed TFC-SGRU was verified through sev-eral experiments in terms of long-term memory and anti-interference *** results demonstrated that our proposed TFC-SGRU model can cap-ture helpful information with time step 1500 and effectively filter out the *** TFC-SGRU model accuracy is better than the LSTM and GRU models regarding language processing ability.

关键词： Time feedforward connections long-short term memory gated recurrent unit SGRU RNNs

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Efficacy of acupuncture on cardiovascular complications in patients with diabetes mellitus in Korea:A nationwide retrospective cohort

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Journal of Integrative Medicine 2023年第2期21卷 176-183页

作者： Hyejin jung Tiana Won Ga-Yeon Kim Jowon Jang Sujung Yeo Sabina lim Department of Meridian&Acupoint College of Korean MedicineKyung Hee UniversitySeoul02447Republic of Korea WHO Collaborating Center for Traditional Medicine East-West Medical Research InstituteKyung Hee UniversitySeoul02447Republic of Korea Department of Meridian and Acupoint College of Korean MedicineSang Ji UniversityWonju26339Republic of Korea

Objective The main aim of this study is to investigate whether acupuncture could be an effective complementary treatment for reducing the risk of macrovascular complications in diabetic patients currently taking antidiabetic medications using a nationwide population-based *** We conducted a retrospective cohort study to assess the efficacy of acupuncture on cardiovascular complications in diabetic patients using data from patients between 40 and 79 years of age,newly diagnosed with diabetes between 2003 and 2006,found in the National Health Insurance Service-National Sample Cohort(NHIS-NSC)in *** the data,we identified 21,232 diabetic patients who were taking antidiabetic medication between 2003 and *** selected patients were divided into two groups-those who received acupuncture at least three times and those who received no acupuncture(non-acupuncture)in the year following their diagnosis of *** 1:1 propensity score matching(PSM),each group had 3350 patients,and the observation ceased at the occurrence of a major adverse cardiovascular event(MACE),which was defined as either myocardial infarction,stroke,or death due to cardiovascular *** After PSM,the acupuncture group had a lower incidence of MACE(hazard ratio[HR]:0.87;95%confidence interval[CI]:0.81-0.94;P=0.0003)and all-cause mortality(HR:0.77;95%CI:0.70-0.84;P<0.0001)than the non-acupuncture group;the HRs for stroke-related mortality(HR:0.75;95%CI:0.56-1.00;P=0.0485),ischemic heart disease mortality(HR:0.53;95%CI:0.34-0.84;P=0.006)and circulatory system disease mortality(HR:0.67;95%CI:0.55-0.82;P<0.0001)were lower in the acupuncture group than in the non-acupuncture group in the secondary *** Our results indicate that diabetic patients receiving acupuncture treatment might have a lower risk of MACE,all-cause mortality and cardiovascular *** population-based retrospective study suggests beneficial effects of acupuncture in preventing macro

关键词： Acupuncture Diabetes Major adverse cardiovascular event Myocardial infarction Stroke Macrovascular complication

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Reconstruction of the lower back wound with delayed infection after spinal surgery:A case report

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世界临床病例杂志 2023年第27期11卷 6646-6652页

作者： DoWon Kim SooA lim SuRak Eo jung Soo Yoon Department of Plastic and Reconstructive Surgery DongGuk University Ilsan HospitalGoyang 10326South Korea

BACKGROUND Orthopedic surgeries after device implantation are susceptible to infections and may require device removal in the worst *** this reason,many efforts are being made to control infections after spinal surgery;however,the number of infec-tion cases is increasing owing to the increasing number of elderly *** SUMMARY A 75-year-old male with a chronic spinal defect due to previous spine surgery underwent reconstruction using a perforator-based island *** bursectomy and confirmation that there was no connection with the deep tissue,reconstruction was ***,wound disruption occurred with abscess formation on postoperative day 29,which led to an imaging workup revealing delayed deep tissue *** Infection is one of the most common causes of surgical wound dehiscence and is associated with devastating results if not controlled promptly and *** should always suspect delayed infections when reconstructing chronic soft tissue defects.

关键词： Surgical wound dehiscence Surgical wound infection Lumbar spine Complications Abscess Case report

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Transparent neural implantable devices:a comprehensive review of challenges and progress

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npj Flexible Electronics 2022年第1期6卷 439-456页

作者： Young Uk Cho Se Lin lim jung-Hoon Hong Ki Jun Yu Department of Electrical and Electronic Engineering Yonsei UniversitySeoulKorea Department of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology InstituteYonsei UniversitySeoulKorea

The key to designing an implantable device lies in condensing the synergistic effects of diagnostic and therapeutic methods in a single *** conjunction with the integration of electrophysiology and optical modalities,a transparent neural interface alleviates challenges of conventional metal-based *** this review,the multimodal sensing and stimulation functionalities of recent research are ***,issues that arise when combining functionalities of conventional metal-based,opaque electrode arrays together with optical modalities—(1)photoelectric artifacts,(2)optical image blocking,and(3)light transmission efficiency—are ***,an introduction of advancing material candidates for transparent neural interfaces follows with the latest research.

关键词： neural transparent modal

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Recurred forehead osteoma disseminated after previous osteoma excision:A case report

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World Journal of Clinical Cases 2023年第31期11卷 7684-7689页

作者： Dong Yun Lee SooA lim jung Soo Yoon SuRak Eo Plastic and Reconstructive Surgery DongGuk University Medical CenterGoYang 10326South Korea

BACKGROUND Forehead osteoma is a commonly encountered benign facial bone *** excision of benign forehead masses is widely ***,we report a rare case of recurrent forehead osteoma that disseminated after a previous osteoma *** SUMMARY A 54-year-old female patient had previously undergone endoscopic removal of a single forehead osteoma at 30 years of ***,she had a recurrent osteoma around the same site and underwent another endoscopic resection at 40 years of *** her first visit to our outpatient clinic,she presented with a cobblestone-like irregular surface on the forehead and a 3D facial bone computed tomography scan revealed a widely ragged surface of the inoculated osteoma on the outer table of the frontal *** general anesthesia,we performed a radical complete excision of the disseminated osteoma through a bicoronal incision using an osteotome,chisel,mallet,and *** hypothesized that the recurrence may have been caused by the inoculation of residual osteoma remnants from the previous *** surgeons should be cautious when removing osteoma particles,particularly when using an endoscopic *** To prevent recurrence,it is essential to conduct additional meticulous burring and a thorough inspection of the surface after copious irrigation.

关键词： Recurred osteoma Inoculation Dissemination Bicoronal approach Craniofacial Case report

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Occurrence of human leukocyte antigen B51-related ankylosing spondylitis in a family:Two case reports

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World Journal of Clinical Cases 2022年第3期10卷 992-999页

作者： Mie Jin lim Eul Noh Ro-Woon Lee Kyong-Hee jung Won Park Rheumatology/Internal Medicine Inha UniversityIncheon 22332South Korea Radiology Inha UniversityIncheon 22332South Korea

BACKGROUND Ankylosing spondylitis(AS)is strongly associated with the human leukocyte antigen(HLA)B27 *** regions where conventional polymerase chain reaction for HLA typing is available for antigens such as HLA B27 or HLA B51,it is common to perform the HLA B27 test for evaluation of *** HLA B27-associated clustered occurrences of AS have been reported in families,we report the first case series of HLA B51-related occurrences of AS in a *** SUMMARY A father and his daughters were diagnosed with AS and did not have the HLA B27 *** they were positive for HLA B51,they exhibited no signs of Behçet’s disease(BD).Of the five daughters,one had AS,and three,including the daughter with AS,were positive for HLA *** two daughters with the HLA B51 haplotype(excluding the daughter with AS)exhibited bilateral grade 1 sacroiliitis,whereas the daughters without the HLA B51 haplotype did not have ***,this Korean family exhibited a strong association with the HLA B51 haplotype and clinical sacroiliitis,irrespective of the symptoms of *** It is advisable to check for HLA B51 positivity in patients with AS/spondyloarthropathy who test negative for HLA B27.

关键词： Ankylosing spondylitis Spondyloarthropathy Human leukocyte antigen B51 Human leukocyte antigen B27 Sacroiliitis Case report

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CO_(2)-adsorbent spongy electrode for non-aqueous Li–O_(2) batteries

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Journal of Energy Chemistry 2022年第2期31卷 646-653页

作者： Yiseul Yoo Giseung Lee Min-Gi Jeong Hun-Gi jung Sunghee Shin Dongjin Byun Taeeun Yim Hee-Dae lim Center for Energy Storage Research Korea Institute of Science and Technology(KIST)Hwarang-ro 14-gil 5Seongbuk-guSeoul 02792Republic of Korea Department of Materials Science and Engineering Korea University145 Anam-roSeongbuk-guSeoul 02841Republic of Korea Department of Chemistry Incheon National University119 Academy-roYeonsu-guIncheon 22012Republic of Korea Department of Chemical and Biological Engineering Korea UniversitySeoul 02841Republic of Korea

Regulation of the Li_(2)CO_(3) byproduct is the most critical challenge in the field of non-aqueous Li–O_(2) *** considerable efforts have been devoted to preventing Li_(2)CO_(3) formation,no approaches have suggested the ultimate solution of utilizing the clean Li_(2)O_(2) reaction instead of that of Li_(2)CO_(3).Even if extremely pure O_(2) is used in a Li–O_(2) cell,its complete elimination is impossible,eventually generating CO_(2) gas during *** this paper,we present the new concept of a CO_(2)-adsorbent spongy electrode(CASE),which is designed to trap the evolved CO_(2) using adsorption *** candidates composed of amine functional groups(–NH2)for capturing CO_(2) were screened,with quadrapurebenzylamine(QPBZA)exhibiting superior CO_(2)-adsorbing ability among the proposed ***,we fabricated the CASE by sandwiching QPBZA between porous carbon layers,which facilitated the transport of gaseous *** new electrode was demonstrated to effectively capture the evolved CO_(2) during charge,therefore altering the reaction pathways to the ideal *** is highly advantageous to mitigate the undesirable CO_(2) incorporation in the next discharge,resulting in improved *** novel concept of a CO_(2)-sponging electrode provides an alternative route to the realization of practically meaningful Li–O_(2) batteries.

关键词： Li-O_(2)battery Benzylamine CO_(2)adsorption Li_(2)CO_(3) Li_(2)O_(2) CO_(2)-sponging electrode

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Successful reconstruction of an ankle defect with free tissue transfer in a hemophilia A patient with repetitive hemoarthrosis:A case report

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World Journal of Clinical Cases 2023年第17期11卷 4079-4083页

作者： Dong Yun Lee SooA lim SuRak Eo jung Soo Yoon Department of Plastic and Reconstructive Surgery DongGuk University Medical CenterGoYang 10326South Korea

BACKGROUND Hemophilia, an uncommon yet consequential hereditary bleeding disorder, manifests as two clinically indistinguishable forms that hinder the normal functioning of the coagulation cascade. This impairment renders individuals more susceptible to excessive bleeding during significant surgical interventions. Moreover, individuals with severe hemophilia frequently encounter recurring hemarthrosis, resulting in progressive joint destruction and, subsequently, the need for hip and knee replacement *** SUMMARY The patient was a 53-year-old man with hemophilia A as the underlying disease and had self-injected factor Ⅷ twice weekly for several decades. He had undergone ankle fusion surgery for recurrent hemarthrosis at the Department of Orthopedic Surgery 1 mo prior and was referred to our department because of skin necrosis after a hematoma at the surgical site. An anterolateral thigh perforator free flap was created after three cycles of factor Ⅷ administration in addition to the concomitant administration of tranexamic acid(TXA)(Transamin 250 mg cap, 1 cap tid, q8h). After the operation, from postoperative days(PODs) 1-5, the factor Ⅷ dose and interval were maintained, and q12h administration was tapered to q24h administration after POD 6. Because the patient’s flap was stable 12 d after the operation, factor Ⅷ administration was tapered to twice a week. At 6 mo follow-up, the patient recovered well without any *** To the best of our knowledge, there are very few reports of successful free flaps in patients with hemophilia, and none have been reported in patients with hemophilia A. Moreover, there are several reports on the efficacy of TXA in free flaps in general patients;however, there are no case reports of combining factor Ⅷ and TXA in patients with hemophilia. Therefore, we report this case to contribute to future academic research.

关键词： Free tissue transfer Anterolateral thigh free flap Hemophilia A Hemoarthrosis Factor VIII Tranexamic acid Case report

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