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Nano Research 2019年第10期12卷 2554-2558页

作者： Taeksu lee Soongeun Kwon San ghee jung Hyungjun Lim Jae-Jong lee Department of Nano Manufacturing Technology Korea Institute of Machinery and Materials(KIMM)156 Gajeongbuk-RoYuseong-GuDaejeon 34103Republic of Korea

Syn thesis of metal nano structures arrays with large amounts of small nano-gaps on a homoge nous macroscale is of significant in terest and importa nee in chemistry,biotech no logy,physics,and nan otech no logy because of their enhan ced ***,the fabricatio n of uncovered nano-gaps with high-density and uniformity is rather difficult due to the complex and multiple synthetic *** this research,a facile and low-cost approach is demonstraind for the synthesis of high-density small nano-gaps(about 3.4 nm)between silver nanostructure array patter ns(SNAPs)over a large *** nan o?hole patter ns were periodically gen erated over an entire substrate using nano-impri nt *** reacti on at the high over-potential produced multiple silver nano crystals inside the nano-hole patter ns,gen erati ng a high-de nsity of small and un covered ***,we fully dem on strate their applicati on in the rapid detectio n of rhodamine 6G(R6G)molecules by surface-enhaneed Raman scattering(SERS)spectroscopy with a very low detection limit(1 fM)as well as excellent signal uniformity(RSD<8.0%±2.5%),i ndicati ng an extra ordinary capability for single-molecule detecti on.

关键词： nanoImprint lithography surface-enhanced Raman scattering(SERS)spectroscopy electrodeposition nano patterning gold silver

Factors influencing stereoacuity levels after surgery to correct unilateral developmental cataracts in children

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International Journal of Ophthalmology(English edition) 2013年第3期6卷 331-336页

作者： Soo jung lee Wan-Soo Kim Department of Ophthalmology Haeundae Paik Hospital

·AIM: To evaluate factors influencing stereoacuity after surgery to correct unilateral developmental pediatric cataracts. ·METHODS: We retrospectively surveyed 110 patients who had undergone removal of unilateral acquired developmental cataracts and primary posterior chamber intraocular lens implantation between February 1992 and December 2009. In all patients, stereoacuity was assessed using the Titmus test at the last follow -up period of minimum 2 years after surgery. Patients were divided into two groups according to the extent of stereoacuity : group 1 ( = 42 ) had stereoacuity values ≤ 100sec/arc and group 2 ( =68) values >100sec/arc. The values of ten parameters associated with stereoacuity were measured in each group: Cataract types, preoperative best corrected visual acuity (BCVA) of the affected eyes, preoperative inter -ocular difference of BCVA, age at cataract surgery, operative method, secondary cataract, postoperative strabismus, postoperative BCVA of the affected eyes, postoperative inter-ocular difference of BCVA, and anisometropia. ·RESULTS: The extent of stereoacuity was significantly associated with both operative method and secondary cataract ( =0.000 and =0.016, respectively). All patients in whom the posterior capsule was preserved, had poor stereoacuity >100sec/arc. Significant correlations with the extent of stereoacuity were found with postoperative strabismus ( =0.048),postoperative BCVA of the affected eyes ( =0.002), anisometropia ( =0.034). ·CONCLUSION: Postoperative stereoacuity was better in patients who underwent either optic capture or anterior vitrectomy after posterior continuous curvilinear capsulorhexis, and who didn’t develop secondary cataracts or strabismus postoperatively. Furthermore, postoperative BCVA of the affected eyes, and anisometropia influenced the stereoacuity of the patients surgically treated for unilateral developmental pediatric cataracts. ·

关键词： anisometropia developmental cataract secondary cataract stereoacuity stereopsis strabismus unilateral pediatric cataract visual acuity

Comparison of contrast sensitivity based on the surgical results for intermittent exotropia

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International Journal of Ophthalmology(English edition) 2019年第11期12卷 1725-1730页

作者： Hae Rang Kim Soo jung lee Department of Ophthalmology Haeundae Paik Hospital Inje University College of Medicine

AIM: To compare contrast sensitivity(CS) based on the surgical results for intermittent exotropia(IXT) and to examine the relationship between CS and ***: Medical records of the patients who underwent bilateral lateral rectus muscle recession for IXT between 4 and 12 years old were reviewed retrospectively. They were categorized based on the surgical results;successful correction group(n=36) and overcorrection group(esotropia ≥10 PD at 3 mo postoperatively, n=18). Using CGT-2000 test for CS was performed binocularly, and subjective reports of photophobia was investigated preoperatively and at 3 mo postoperatively. Objective photophobia was defined as a significant decrease in CS in the presence of ***: Preoperatively, there was no difference in CS between the groups. Postoperatively, under mesopic conditions, significant improvement of CS was observed at 6.3°, 4°, and 2.5° in the successful correction group and at 6.3° and 4° in the overcorrection group, regardless of glare. Under photopic conditions, at all visual angles except 0.64°, improvement in CS was noted in both groups while CS worsened significantly at 0.64° in the overcorrection group postoperatively. At all visual angles under photopic conditions postoperatively, regardless of glare, CS in the overcorrected group was significantly worse than that in the successful correction group, and CS was significantly decreased by addition of glare in both groups. All patients except one(96.4%) in the successful correction group and 8 patients(61.5%) in overcorrection group showed improvement of photophobia postoperatively, which correlated with CS under photopic conditions(P=0.001, 0.03).CONCLUSION: After surgery for IXT, CS under photopic conditions improve at all visual angles except 0.64°, while CS is significantly worse in the overcorrection group postoperatively at 0.64°. Subjective photophobia havesignificant correlation with CS under photopic conditions, and may be used as an object

关键词： contrast sensitivity intermittent exotropia overcorrection photophobia success

Inter-observer Reliability of Indicators and Decision of Pattern Identification Using Diagnostic Flowchart with Traditional Korean Medicine

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Chinese Journal of Integrative Medicine 2017年第5期23卷 338-344页

作者： Ju Ah lee Jeeyoun jung Mi Mi Ko Myeong Soo lee Korean Medicine Fundamental Research Division Korea Institute of Oriental Medicine Daejeon 305-811 Republic of Korea Clinical Research Division Korea Institute of Oriental Medicine Daejeon 305-811 Republic of Korea

Objective： To evaluate the consistency of patterns and pattern identification（PI）, and the improvement in the diagnosis of blood stasis after the standard operating procedures（SOPs） were enhanced by using a diagnostic flowchart. Methods： A total of 358 subjects who were admitted by the Jaseng Hospital of Korean Medicine between June 2013 and December 2014 were included in the study. Each patient was independently diagnosed by two experts from the same department. In 2014, the SOPs included the use of a diagnostic flowchart for each indicator. Inter-observer consistency was assessed by simple percent agreement and by the kappa and AC1 statistics. Results： The improvements in inter-observer agreement for the indicators（for al patients） and PI were greater in 2014 than in 2013. In 2013, the j-value measure of agreement between the two experts ranged from ＂poor＂（κ=–0.051） to ＂good＂（κ=0.968）. The AC1 measure of agreement between the experts was generally high for the indicators and ranged from –0.010 to 0.978. In most cases, agreement was considerably lower when it was assessed by the j-values compared with the AC1 values. In 2014, the j-value measure of agreement on the indicators（for the subjects） general y ranged from poor to good, with the values ranging from –0.007 to 0.994. Moreover, the AC1 measure of agreement between the experts was general y high for al of the indicators and ranged from ＂moderate＂（AC1=0.408） to ＂excel ent＂（AC1=0.996）. Conclusions： In four examinations, there was moderate agreement between the clinicians on the PI indicators of blood stasis. To improve clinician consistency（e.g., in the diagnostic criteria used）, it is necessary to analyse the reasons for inconsistency and to improve clinician training.（Trial registration No. KCT0000916）

关键词： blood stasis inter-observer reliability pattern identification traditional Chinese medicine traditional Korean medicine

An Effective Threat Detection Framework for Advanced Persistent Cyberattacks

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Computers, Materials & Continua 2023年第5期75卷 4231-4253页

作者： So-Eun Jeon Sun-Jin lee Eun-Young lee Yeon-Ji lee jung-Hwa Ryu jung-Hyun Moon Sun-Min Yi Il-Gu lee Department of Future Convergence Technology Engineering Sungshin Women’s UniversitySeoul02844Korea Department of Convergence Security Engineering Sungshin Women’s UniversitySeoul02844Korea

Recently,with the normalization of non-face-to-face online environments in response to the COVID-19 pandemic,the possibility of cyberattacks through endpoints has *** endpoint devices are managed meticulously to prevent cyberattacks and ensure timely responses to potential security *** particular,because telecommuting,telemedicine,and teleeducation are implemented in uncontrolled environments,attackers typically target vulnerable endpoints to acquire administrator rights or steal authentication information,and reports of endpoint attacks have been increasing *** persistent threats(APTs)using various novel variant malicious codes are a form of a sophisticated ***,conventional commercial antivirus and anti-malware systems that use signature-based attack detectionmethods cannot satisfactorily respond to such *** this paper,we propose a method that expands the detection coverage inAPT attack *** this model,an open-source threat detector and log collector are used synergistically to improve threat detection *** the scope of attack log collection through interworking between highly accessible open-source tools can efficiently increase the detection coverage of tactics and techniques used to deal with APT attacks,as defined by MITRE Adversarial Tactics,Techniques,and Common Knowledge(ATT&CK).We implemented an attack environment using an APT attack scenario emulator called Carbanak and analyzed the detection coverage of Google Rapid Response(GRR),an open-source threat detection tool,and Graylog,an open-source log *** proposed method expanded the detection coverage against MITRE ATT&CK by approximately 11%compared with that conventional methods.

关键词： Advanced persistent threat cybersecurity endpoint security MITRE ATT&CK open-source threat detector threat log collector

Factors associated with strabismus after cataract extraction and primary intraocular lens implantation in congenital cataracts

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 522-527页

作者： Soo jung lee Wan-Soo Kim Department of Ophthalmology Haeundae Paik Hospital

AIM:To evaluate factors associated with the development of strabismus after cataract extraction and primary intraocular lens ***:The medical records of 122 patients,aged1.5mo to 9y,who had undergone cataract extraction with primary intraocular lens implantation between January1993 and August 2011 were *** patients(17 eyes)with strabismus before cataract surgery were *** were divided into those with congenital bilateral cataracts(64 patients,128 eyes)and those with unilateral cataracts(44 patients,44 eyes).The associations between the development of strabismus and age at cataract surgery,pre-and post-cataract extraction corrected distance visual acuity(CDVA),interocular CDVA difference,nystagmus,surgical method,and secondary cataract were ***:Factors significantly associated with the development of strabismus included age at cataract surgery(≤1y),preoperative mean CDVA≤20/100,presence of nystagmus in the bilateral cataract group and postoperative interocular CDVA difference>20/70 in the unilateral *** CDVA≤20/100 and preservation of posterior capsule,and presence of secondary cataract were significant factors in both ***:Children with congenital cataracts should be monitored carefully after cataract surgery for the development of strabismus,especially when they underwent surgery at age≤1y,and they have nystagmus,large postoperative interocular CDVA difference,poor preoperative and postoperative CDVA,preservation of the posterior capsule,or secondary cataract.

关键词： strabismus congenital cataract nystagmus

Recognition of Association Between Blood Stasis Syndrome and Traumatic Injury among Doctors of Korean Medicine:A Cross-Sectional Observation Study

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Chinese Journal of Integrative Medicine 2018年第4期24卷 254-259页

作者： Jeeyoun jung Mi Mi Ko Ju Ah lee Myeong Soo lee Korean Medicine Fundamental Research Division Korea Institute of Oriental Medicine Clinical Research Division Korea Institute of Oriental Medicine

Objective： To investigate the diagnostic indicators and herbal treatments for blood stasis syndrome（BSS） patients with traumatic injuries and to identify the association between BSS and traumatic injury in Korea. Methods： Two-hundred and four patients with traumatic injury were recruited from the Gangnam and Daejeon branches of Jaseng Hospital of Oriental Medicine between June 2014 and December 2014. Two independent doctors of Korean medicine（DKMs） determined the diagnosis of BSS or non-BSS based on the subjects＇ signs and symptoms. The scores assigned to BSS symptoms and DKMs＇ reasons for diagnosing BSS in patients with traumatic injury were investigated. Both medication and herbal prescription records from a 3-month period were collected for all patients diagnosed with BSS by both DKMs. Results： A total of 169 of 204（82.8%） patients received consistent diagnosis related to BSS by two DKMs. Among them, 54.4%（92 cases） were diagnosed with BSS, and 45.6%（77 cases） were not diagnosed with BSS. DKMs most frequently cited symptoms of recent traumatic injury as justifications for BSS diagnoses, and also selected pain-related indicators such as abdominal pain, sharp pain and nocturnal pain as important reasons in diagnosing BSS. In addition, an inconsistency in the pattern identification theory with respect to traumatic injury was observed. Although only 92 cases（54.4%） of patients were diagnosed with BSS, 77.6% of them were prescribed decoctions for BSS. Conclusions： DKMs considered traumatic injury could cause BSS, and utilized decoction for BSS in patients with traumatic injury without confirming a diagnosis of BSS because they assumed the main symptoms or pathologies of traumatic injury to be closely related to BSS.

关键词： blood stasis syndrome Korean medicine traumatic injury herbal medicine diagnosis pattern identification

Thioredoxin Reductase Type C （NTRC） Orchestrates Enhanced Thermotolerance to Arabidopsis by Its Redox-Dependent Holdase Chaperone Function

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Molecular Plant 2013年第2期6卷 323-336页

作者： Ho Byoung Chae Jeong chan Moon Mi Rim Shin Yong Hun Chi Young Jun jung Sun Yong lee Ganesh M. Nawkar Hyun Suk jung Jae Kyung Hyun Woe Yeon Kim chang Ho Kang Dae-Jin Yun Kyun Oh lee Sang Yeol lee Division of Applied Life Science (BK21 Program) and PMBBRC Gyeongsang National University 501 Jinju-daero Jinju 660-701 Korea Division of Electron Microscopic Research Korea Basic Science Institute 113 Gwahangno Yuse0ng-guDaejeon 303-333 Korea

Genevestigator analysis has indicated heat shock induction of transcripts for NADPH-thioredoxin reduc-tase, type C （NTRC） in the light. Here we show overexpression of NTRC in Arabidopsis （NTRC°E） resulting in enhanced tolerance to heat shock, whereas NTRC knockout mutant plants （ntrcl） exhibit a temperature sensitive phenotype. To investigate the underlying mechanism of this phenotype, we analyzed the protein＇s biochemical properties and protein structure. NTRC assembles into homopolymeric structures of varying complexity with functions as a disulfide reductase, a foldase chaperone, and as a holdase chaperone. The multiple functions of NTRC are closely correlated with protein structure.. Complexes of higher molecular weight （HMW） showed stronger activity as a holdase chaperone, while low molecular weight （LMW） species exhibited weaker holdase chaperone activity but stronger disulfide reductase and fol-dase chaperone activities. Heat shock converted LMW proteins into HMW complexes. Mutations of the two active site Cys residues of NTRC into Ser （C217/454S-NTRC） led to a complete inactivation of its disulfide reductase and foldase chaperone functions, but conferred only a slight decrease in its holdase chaperone function. The overexpression of the mutated C217/454S-NTRC provided Arabidopsis with a similar degree of thermotolerance compared with that of NTRC°E plants. However, after prolonged incubation under heat shock, NTRC°E plants tolerated the stress to a higher degree than C217/454S-NTRC°E plants. The results suggest that the heat shock-mediated holdase chaperone function of NTRC is responsible for the increased thermotolerance of Arabidopsis and the activity is significantly supported by NADPH.

关键词： NADPH-thioredoxin reductase type C (NTRC) oligomeric complexes disulfide reductase foldase and holdasechaperone functions redox thermotolerance.

DynamicalMotion Driven by Periodic Forcing on an Open Elastic Tube in Fluid

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Communications in Computational Physics 2012年第7期12卷 494-514页

作者： Wanho lee Sookkyung Lim Eunok jung Konkuk University Department of Mathematics1 Hwayang-dongGwangjin-guSeoul143-701Republic of Korea University of Cincinnati Department of Mathematical Sciences839 Old ChemCincinnatiOH 45221USA

We present a three dimensional model of an open elastic tube immersed in fluid to understand valveless pumping mechanism.A fluid-tube interaction problem is simulated by the volume conserved immersed boundarymethodwhich prevents the generation of spurious velocity field near the tube and local cluster of the tube *** order to explain pumping phenomena without valves,average net flow ismeasured by changing parameter values such as pumping frequency,compression duration,and pumping *** frequencies that make the system reach maximal or minimal net flow are selected to study case by *** also study the effectiveness of fluid mixing using the Shannon entropy increase rate.

关键词： Valveless pumping volume conserved immersed boundary method fluid mixing average net flow

Fabrication of Microlens Array and Its Application:A Review

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Chinese Journal of Mechanical Engineering 2018年第1期31卷 10-18页

作者： Wei Yuan Li-Hua Li Wing-Bun lee chang-Yuen chan State Key Laboratory of Ultra-precision Machining Technology Partner Laboratory in the Hong Kong Polytechnic University Shenzhen Branch of State Key Laboratory of Ultra-precision Machining Technology PolyU Shenzhen Research Institute

Microlens arrays are the key component in the next generation of 3D imaging system, for it exhibits some good optical properties such as extremely large field of view angles, low aberration and distortion, high temporal resolution and infinite depth of field. Although many fabrication methods or processes are proposed for manufacturing such precision component, however, those methods still need to be improved. In this review, those fabrication methods are categorized into direct and indirect method and compared in detail. Two main challenges in manufacturing microlens array are identified: how to obtain a microlens array with good uniformity in a large area and how to produce the microlens array on a curved surface? In order to effectively achieve control of the geometry of a microlens,indirect methods involving the use of 3D molds and replication technologies are suggested. Further development of ultraprecision machining technology is needed to reduce the surface fluctuation by considering the dynamics of machine tool in tool path planning. Finally, the challenges and opportunities of manufacturing microlens array in industry and academic research are discussed and several principle conclusions are drawn.

关键词： Microlens array Ultraprecision machining 3D image system MEMS