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Light(Science & Applications) 2023年第12期12卷 2610-2623页

作者： Baekcheon Seong Woovin Kim Younghun Kim Kyung-A Hyun Hyo-Il jung Jong-Seok Lee Jeonghoon yoo Chulmin Joo Department of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea The DABOM Inc Seoul 03722Republic of Korea School of Integrated Technology Yonsei UniversityIncheon 21983Republic of Korea

Several image-based biomedical diagnoses require high-resolution imaging capabilities at large spatial ***,conventional microscopes exhibit an inherent trade-off between depth-of-field(DoF)and spatial resolution,and thus require objects to be refocused at each lateral location,which is time ***,we present a computational imaging platform,termed E2E-BPF microscope,which enables large-area,high-resolution imaging of large-scale objects without serial *** method involves a physics-incorporated,deep-learned design of binary phase filter(BPF)and jointly optimized deconvolution neural network,which altogether produces high-resolution,high-contrast images over extended depth *** demonstrate the method through numerical simulations and experiments with fluorescently labeled beads,cells and tissue section,and present high-resolution imaging capability over a 15.5-fold larger DoF than the conventional *** method provides highly effective and scalable strategy for DoF-extended optical imaging system,and is expected to find numerous applications in rapid image-based diagnosis,optical vision,and metrology.

关键词： image diagnosis binary

Complete restoration of congenital conductive hearing loss by staged surgery: A case report

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World Journal of Clinical Cases 2021年第33期9卷 10286-10292页

作者： Ji Seob yoo Chan Mi Lee Yun Na Yang Eun jung Lee Department of Otorhinolaryngology-Head and Neck Surgery Jeonbuk National University College of MedicineJeonju 54907South Korea Biomedical Research Institute Clinical Medicine of Jeonbuk National UniversityJeonbuk National University HospitalJeonju 54907South Korea

BACKGROUND Stapedial tendon ossification is a rare disease,with only a few *** stapedial tendon originates from the apex of the pyramidal eminence and is attached to the neck of the *** stapedial tendon ossification,the stapes is fixed,causing conductive hearing *** most cases,complete hearing restoration is achieved by dividing the stapedial tendon after exploratory *** SUMMARY A 28-year-old woman presented to our hospital with the major complaint of bilateral hearing loss that started during *** tympanotomy was performed due to suspicion of otosclerosis or middle ear *** found bilateral conductive hearing loss due to stapedial tendon ossification with a middle ear anomaly during *** have been several reports of complete recovery of hearing after resection of the stapedial ***,in this case,recovery of hearing was insufficient,even with the division of the stapedial *** the second surgery,the stapes anomaly and footplate fixation were confirmed,and hearing was completely recovered after ***,we report this case with a review of the relevant *** This is the first case of stapedial tendon ossification and fixation of the footplate surgically diagnosed on both *** surgical treatment,successful results are expected.

关键词： Stapedial tendon ossification Middle ear anomaly Footplate fixation Congenital hearing loss Stapedotomy Case report

Ischemic colitis during interferon-ribavirin therapy for chronic hepatitis C:A case report

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世界胃肠病学杂志：英文版 2012年第31期18卷 4233-4236页

作者： Su jung Baik Tae Hun Kim Kwon yoo Il Hwan Moon Min-Sun Cho Department of Gastroenterology Health Promotion CenterYonsei University Gangnam Severance HospitalSeoul 158-050South Korea Department of Internal Medicine Ewha Medical Research InstituteEwha University Mokdong HospitalEwha Womans University School of MedicineSeoul 158-710South Korea Department of Pathology Ewha University Mokdong HospitalEwha Womans University School of MedicineSeoul 158-710South Korea

Ischemic colitis is a rare complication of interferon *** 9 cases in 6 reports have been described *** report describes a case of ischemic colitis during pegylated interferon and ribavirin treatment for chronic hepatitis C,and includes a review of the relevant literature.A 48-year-old woman was treated with pegylated interferon-2a and ribavirin for chronic hepatitis C,genotype *** 19 wk of treatment,the patient complained of severe afebrile abdominal pain with *** signs were stable and serum white blood cell count was within the normal *** computed tomography showed diffuse colonic wall thickening from the splenic flexure to the proximal sigmoid colon,which is the most vulnerable area for the development of ischemic *** revealed an acute mucosal hyperemic change,with edema and ulcerations extending from the proximal descending colon to the sigmoid *** mucosal biopsy revealed acute exudative *** chain reaction and culture for Mycobacterium tuberculosis were negative and the cultures for cytomegalovirus,Salmonella and Shigella species were *** discontinuation of interferon and ribavirin therapy,abdominal pain and hematochezia subsided and,following colonoscopy showed improvement of the mucosal *** colitis cases during interferon therapy in patients with chronic hepatitis C reported so far have all involved the descending *** colitis is a rarely encountered complication of interferon administration in patients with chronic hepatitis C and should be considered when a patient complains of abdominal pain and hematochezia.

关键词：干扰素α 丙型肝炎利巴韦林结肠炎治疗缺血慢性病例报告

Time- and cell-type specific changes in iron, ferritin, and transferrin in the gerbil hippocampal CA1 region after transient forebrain ischemia

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Neural Regeneration Research 2016年第6期11卷 924-930页

作者： Dae Young yoo Ki-Yeon yoo Joon Ha Park Hyun jung Kwon Hyo Young jung Jong Whi Kim Goang-Min Choi Seung Myung Moon Dae Won Kim Yeo Sung yoon Moo-Ho Won In Koo Hwang Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Department of Oral Anatomy Research Institute of Oral Sciences College of Dentistry Gangneung-Wonju National University Department of Neurobiology School of Medicine Kangwon National University Department of Biochemistry and Molecular Biology Research Institute of Oral Sciences College of Dentistry Gangneung-Wonju National University Department of Thoracic and Cardiovascular Surgery Chuncheon Sacred Heart Hospital College of Medicine Hallym University Department of Neurosurgery Dongtan Sacred Heart Hospital College of Medicine Hallym University

In the present study, we used immunohistochemistry and western blot analysis to examine changes in the levels and cellular localization of iron, heavy chain ferritin（ferritin-H）, and transferrin in the gerbil hippocampal CA1 region from 30 minutes to 7 days following transient forebrain ischemia. Relative to sham controls, iron reactivity increased significantly in the stratum pyramidale and stratum oriens at 12 hours following ischemic insult, transiently decreased at 1–2 days and then increased once again within the CA1 region at 4–7 days after ischemia. One day after ischemia, ferritin-H immunoreactivity increased significantly in the stratum pyramidale and decreased at 2 days. At 4–7 days after ischemia, ferritin-H immunoreactivity in the glial components in the CA1 region was significantly increased. Transferrin immunoreactivity was increased significantly in the stratum pyramidale at 12 hours, peaked at 1 day, and then decreased significantly at 2 days after ischemia. Seven days after ischemia, Transferrin immunoreactivity in the glial cells of the stratum oriens and radiatum was significantly increased. Western blot analyses supported these results, demonstrating that compared to sham controls, ferritin H and transferrin protein levels in hippocampal homogenates significantly increased at 1 day after ischemia, peaked at 4 days and then decreased. These results suggest that iron overload-induced oxidative stress is most prominent at 12 hours after ischemia in the stratum pyramidale, suggesting that this time window may be the optimal period for therapeutic intervention to protect neurons from ischemia-induced death.

关键词： ferritin transferrin hippocampal stratum minutes glial Ferritin hippocampus rabbit reactivity

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Clusterin mRNA expression in apoptotic and activated rat thymocytes

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Cell Research 2003年第1期13卷 49-58页

作者： jung-HYUNPARK,JEE-SUNPARK,SUNG-KYUJU,KWAN-BOKLEE,KWAN-HEEYOU,MYUNG-HEEKANG,yoo-KYOUNGPARK,SHIN-YOUNGNA Experimental Department Department Department Department Department Department Institute Immunology Branch National Cancer Institute NIH Bethesda MD 20892 USA of Biology College of Natural Science Chungnam National University 220 Gung-dong Yuseong-gu Daejeon 305-764 Korea of Biology College of Natural Science Chungnam National University 220 Gung-dong Yuseong-gu Daejeon 305-764 Korea of Biology College of Natural Science Chungnam National University 220 Gung-dong Yuseong-gu Daejeon 305-764 Korea of Biology College of Natural Science Chungnam National University 220 Gung-dong Yuseong-gu Daejeon 305-764 Korea of Food and Nutrition Hannam University Daejeon 306-791 Korea of Food and Nutrition Hannam University Daejeon 306-791 Korea for Virology and Immunobiology University of Wuerzburg Versbacher Str. 7 97078 Wuerzburg Germany

Clusterin is a 75-80 kDa heterodimeric glycoprotein, that is produced in most tissues but which exact biological role is still not clear. Particularly, its role in protection or promotion of apoptosis is heavily disputed, since data supporting both views have been reported in several independent studies. To clarify this issue, and also to determine whether clusterin expression itself might be affected by apoptosis, in the present study, rat thymocytes were treated with dexamethasone, -a synthetic glucocorticoid that elicits apoptosis in thymocytes-, and clusterin mRNA expression was analyzed by semi-quantitative RT-PCR before and after induction of apoptosis. Interestingly, neither the treatment with dexamethasone in vitro nor triggering of apoptosis in vivo up- regulated clusterin expression, opposing the view that clusterin is involved in apoptotic processes. On the other hand, a new clusterin mRNA isoform was detected and isolated, whose expression was restricted to freshly isolated thymocytes. This

关键词： clusterin sgp-2 thymocytes apoptosis mRNA isoforms.

Association between the early high level of serum tacrolimus and recurrence of hepatocellular carcinoma in ABO-incompatible liver transplantation

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2727-2738页

作者： Ji Won Han Jong Young Choi Eun Sun jung Ji Hoon Kim Hee Sun Cho Jae-Sung yoo Pil Soo Sung Jeong Won Jang Seung Kew yoon Ho Joong Choi Young Kyoung You Department of Internal Medicine The Catholic University of KoreaSeoul 06591South Korea The Catholic University Liver Research Center College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Hospital Pathology The Catholic University of KoreaSeoul 06591South Korea Department of Surgery The Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Clinical factors predicting graft survival(GS)after ABO-incompatible(ABOi)liver transplantation(LT),and differences between recipients with and without hepatocellular carcinoma(HCC)are *** To analyze the impact of serial serum tacrolimus trough concentration in recipients with or without(HCC)in ABOi living-donor liver transplantation(LDLT).METHODS We analyzed a historical cohort of 89 recipients who underwent ABOi LDLT,including 47 patients with *** The 1-,3-,5-,and 10-year GS rates were 85.9%,73.3%,71.4%,and 71.4%,respectively,and there were no significant differences between HCC and non-HCC *** multivariate Coxregression analyses,tacrolimus trough concentrations below 5.4 ng/mL at 24 wk post-LT,in addition to the antibody-mediated rejection(AMR)were associated with poor-graft *** HCC patients,AMR[hazard ratio(HR)=63.20,P7.3 ng/mL were significant predictive factors for HCC *** propensity score matching,patients with high tacrolimus concentrations at 4 wk had significantly poor recurrence-free *** Elevated tacrolimus levels at 4 wk after ABOi LDLT have been found to correlate with HCC ***,careful monitoring and control of tacrolimus levels are imperative in ABOi LT recipients with HCC.

关键词： ABO-incompatible Liver transplantation Tacrolimus Hepatocellular carcinoma

Analysis of Wireless Backhaul Networks Based on Aerial Platform Technology for 6G Systems

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Computers, Materials & Continua 2020年第2期62卷 473-494页

作者： Sooeun Song Minsu Choi Yunyeong Goh Jusik Yun Wonsuk yoo Wonsik Yang Jaewook jung Jong-Moon Chung School of Electrical and Electronic Engineering Yonsei UniversitySeoul03722Korea

As next generation communication technologies emerge,new high data rate applications and high-definition large-screen video streaming have become very *** a result,network traffic has been increasing so much that existing backhaul networks soon will not be able to support all traffic *** support these needs in future 6G mobile systems,the establishment of an additional backhaul wireless network is considered *** one of the solutions,a wireless backhaul network based on an aerial platform has been *** order to explore the potential of aerial platforms as wireless backhaul networks,in this paper,the categories for wireless backhaul networks based on aerial platforms are *** paper includes a survey of the definitions and characteristics of low altitude platforms(LAPs)and high altitude platforms(HAPs),as well as channel models according to the *** wireless backhaul network designs based on aerial platforms,altitude and platform selection options,deployment options,energy issues,and security based on target location and performance were considered in the analysis and investigation.

关键词： Wireless backhaul network aerial platform high altitude platform low altitude platform

Hypothyroid effects on astrocytes and microglia in the adult rat hippocampus

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Neural Regeneration Research 2009年第12期4卷 1078-1082页

作者： Choong Hyun Lee jung Hoon Choi In Koo Hwang Ki-Yeon yoo Hyung-Cheul Shin Moo-Ho Won Department of Anatomy and Neurobiology and Institute of Neurodegeneration and NeuroregenerationCollege of MedicineHallym University South Korea Institute of Naturat Medicine Hallym University Department ofAnatomy and Cell Biology College of Veterinary Medicine and BK21 Program for Veterinary ScienceSeoul National Unlversity South Korea Institute of Natural Medicine Hallym University Department of Physiology College of MedicineHallym University

BACKGROUND： Thyroid hormones modulate proliferation of astrocytes and microglia depending on maturation stage and localization. Studies have demonstrated that triiodothyronine treatment or thyroidectomy during developmental stages results in morphological alterations and changes in the number of astrocytes and microglia. Little is known about the effects of hypothyroidism on astrocytes and microglia in adults. OBJECTIVE： To investigate the effects of hypothyroidism on morphology and number of astrocytes and microglia in the adult rat hippocampus. DESIGN, TIME AND SETTING： A randomized, controlled, neuroendocrinological, animal study was performed at the College of Medicine, Hallym University, South Korea between May 2008 and April 2009. MATERIALS： Methimazole, rabbit anti-glial fibrillary acidic protein （GFAP） antiserum, and rabbit anti-lba-1 antiserum were purchased from Sigma, USA. Rabbit anti-GFAP polyclonal antibody was provided by Chemicon, USA. Rabbit anti-lba-1 polyclonal antibody was purchased from Wako, Japan. Terminal deoxynucleotidyl transferase dUTP-biotin nick-end-labeling （TUNEL） kit was provided by Roche Molecular Biochemicals, Mannheim, Germany. METHODS： Hypothyroidism was induced in Wistar rats via methimazole administration （0.025%） in drinking water for 5 weeks, starting at 6 months of age. MAIN OUTCOME MEASURES： Following methimazole treatment, hippocampai neuronal death was determined using TUNEL staining. The morphology and number of GFAP and lba-1 immunoreactive cells were detected by immunohistochemistry. Hippocampal GFAP and lba-1 protein levels were detected by Western blot analysis. Serum-free triiodothyronine and thyroxine levels were quantified. RESULTS： TUNEL-positive neurons were not observed in the hippocampus of euthyroid and hypothyroid rats. Compared with the euthyroid rats, the number of GFAP immunoreactive astrocytes was decreased, and serum triiodothyronine and thyroxine levels were significantly decreased. In contrast, the numb

关键词： astrocytes hippocampus hypothyroidism microglia Wistar rats

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Effects of Cordyceps militaris extract on angiogenesis and tumor growth

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Acta Pharmacologica Sinica 2004年第5期25卷 115-123页

作者： Hwa-seung yoo,Jang-woo SHIN,jung-hyo CHO,Chang-gue SON,Yeon-weol LEE,Sang-yong PARK,Chong-kwan CHO Daejeon University Daejeon 301-724 Department of East-West Cancer Center College of Oriental Medicine Daejeon University Daejeon 301-724 Department of East-West Cancer Center College of Oriental Medicine Daejeon University Daejeon 301-724 Department of East-West Cancer Center R&D Lab of Bulrolife Co Ltd Daejeon Korea College of Oriental Medicine Daejeon University Daejeon 301-724 Institute ofTraditional Medicine and Bioscience Daejeon University Daejeon 301-724 Department of East-West Cancer Center College of Oriental Medicine

AIM: To evaluate the effects of Cordyceps militaris extract (CME) on angiogenesis and tumor growth. METHODS:Human umbilical vein endothelial cells (HUVEC), HT1080, and B16-F10 cells were used. DNA fragment, angio-genic related gene expressions (MMPs, bFGF, VEGF, etc), capillary tube formation, wound healing in vitro, tumorgrowth in vivo were measured. RESULTS: CME inhibited growth of HUVECs and HT1080 (P<0.01). CME 100and 200 mg/L reduced MMP-2 gene expression in HT1080 cells by 6.0 % and 22.9 % after 3-h and 14.9 % and32.8 % after 6-h treatment. CME did not affect MMP-9 gene expression in B16-F10 melanoma cells. CME 100 and200 mg/L also reduced bFGF gene expression in HUVECs by 22.2 % and 41.3 %. CME inhibited tube formation ofendothelial cells in vitro and in vivo. CME repressed the growth of B16-F10 melanoma cells in mice compared withcontrol group (P<0.05). CONCLUSION: CME has antiangiogenetic properties.

关键词： Cordyceps militaris angiogenesis human umbilical vein endothelial cells HT1080 cells B16-F10cells matrix metalloproteinases basic fibroblast growth factor

Glucose metabolism and neurogenesis in the gerbil hippocampus after transient forebrain ischemia

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Neural Regeneration Research 2016年第8期11卷 1254-1259页

作者： Dae Young yoo Kwon Young Lee Joon Ha Park Hyo Young jung Jong Whi Kim Yeo Sung yoon Moo-Ho Won jung Hoon Choi In Koo Hwang Department of Anatomy and Cell Biology College of Veterinary Medicineand Research Institute for Veterinary ScienceSeoul National University Department of Anatomy College of Veterinary Medicine and Institute of Veterinary ScienceKangwon National University Department of Neurobiology School of MedicineKangwon National University

Recent evidence exists that glucose transporter 3（GLUT3） plays an important role in the energy metabolism in the *** previous studies have been conducted using focal or hypoxic ischemia models and have focused on changes in GLUT3 expression based on protein and m RNA levels rather than tissue *** the present study,we observed change in GLUT3 immunoreactivity in the adult gerbil hippocampus at various time points after 5 minutes of transient forebrain *** the sham-operated group,GLUT3 immunoreactivity in the hippocampal CA1 region was weak,in the pyramidal cells of the CA1 region increased in a time-dependent fashion 24 hours after ischemia,and in the hippocampal CA1 region decreased significantly between 2 and 5 days after ischemia,with high level of GLUT3 immunoreactivity observed in the CA1 region 10 days after *** a double immunofluorescence study using GLUT3 and glial-fibrillary acidic protein（GFAP）,we observed strong GLUT3 immunoreactivity in the ***3 immunoreactivity increased after ischemia and peaked 7 days in the dentate gyrus after ischemia/*** a double immunofluorescence study using GLUT3 and doublecortin（DCX）,we observed low level of GLUT3 immunoreactivity in the differentiated neuroblasts of the subgranular zone of the dentate gyrus after ***3 immunoreactivity in the sham-operated group was mainly detected in the subgranular zone of the dentate *** results suggest that the increase in GLUT3 immunoreactivity may be a compensatory mechanism to modulate glucose level in the hippocampal CA1 region and to promote adult neurogenesis in the dentate gyrus.

关键词： nerve regeneration transient forebrain ischemia glucose transporter 3 pyramidal cells astrocytes neuroblasts neural regeneration

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