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Sex-dependent difference in the effect of metformin on colorectal cancer-specific mortality of diabetic colorectal cancer patients

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World Journal of Gastroenterology 2017年第28期23卷 5196-5205页

作者： jung won park Jin Ha Lee Ye Hyun park Soo jung park Jae Hee Cheon won Ho Kim Tae Il Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Cancer Prevention Center Yonsei University College of Medicine

To assess factors associated with the higher effect of metformin on mortality in diabetic colorectal cancer (CRC) patients, since the factors related to the effectiveness of metformin have not been identified *** January 2000 and December 2010, 413 patients diagnosed with both stage 3/4 CRC and diabetes mellitus were identified. Patients’ demographics and clinical characteristics were analyzed. The effect of metformin on CRC-specific mortality and the interactions between metformin and each adjusted factor were *** follow-up duration was median 50 mo (range: 1-218 mo). There were 85 deaths (45.9%) and 72 CRC-specific deaths (38.9%) among 185 patients who used metformin, compared to 130 total deaths (57.0%) and 107 CRC-specific deaths (46.9%) among 228 patients who did not use metformin. In multivariate analysis, survival benefit associated with metformin administration was identified (HR = 0.985, 95%CI: 0.974-0.997, P = 0.012). Interaction test between metformin and sex after adjustment for relevant factors revealed that female CRC patients taking metformin exhibited a significantly lower CRC-specific mortality rate than male CRC patients taking metformin (HR = 0.369, 95%CI: 0.155-0.881, P = 0.025). Furthermore, subgroup analysis revealed significant differences in CRC-specific mortality between the metformin and non-metformin groups in female patients (HR = 0.501, 95%CI: 0.286-0.879, P = 0.013) but not male patients (HR = 0.848, 95%CI: 0.594-1.211, P = 0.365). There were no significant interactions between metformin and other adjusted factors on CRC-specific *** showed a strong sex-dependent difference in the effect of metformin on CRC-specific mortality in advanced stage CRC patients with diabetes.

关键词： Colorectal cancer Metformin Survival Sex

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CORE:Common Region Extension Based Multiple Protein Structure Alignment for Producing Multiple Solution

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Journal of Computer Science & Technology 2013年第4期28卷 647-656页

作者： Woo-Cheol Kim Sanghyun park jung-Im won College of Information Sciences and Technology The Pennsylvania State University University Park Department of Computer Science Yonsei University Research Center of Information and Electronic Engineering Hallym University Chuncheon

Over the past several decades, biologists have conducted numerous studies examining both general and specific functions of proteins. Generally, if similarities in either the structure or sequence of amino acids exist for two proteins, then a common biological function is expected. Protein function is determined primarily based on the structure rather than the sequence of amino acids. The algorithm for protein structure alignment is an essential tool for the research. The quality of the algorithm depends on the quality of the similarity measure that is used, and the similarity measure is an objective function used to determine the best alignment because of their individual strength and weakness However, none of existing similarity measures became golden standard They require excessive filtering to find a single alignment. In this paper, we introduce a new strategy that finds not a single alignment, but multiple alignments with different lengths. This method has obvious benefits of high quality alignment. However, this novel method leads to a new problem that the running time for this method is considerably longer than that for methods that find only a single alignment. To address this problem~ we propose algorithms that can locate a common region （CORE） of multiple alignment candidates, and can then extend the CORE into multiple alignments. Because the CORE can be defined from a final alignment, we introduce CORE＊ that is similar to CORE and propose an algorithm to identify the CORE＊. By adopting CORE＊ and dynamic programming, our proposed method produces multiple alignments of various lengths with higher accuracy than previous methods. In the experiments, the alignments identified by our algorithm are longer than those obtained by TM-align by 17% and 15.48%, on average, when the comparison is conducted at the level of super-family and fold, respectively.

关键词： structure alignment similarity search protein structure

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Nonlinear Electrical Impedance Tomography Method Using a Complete Electrode Model for the Characterization of Heterogeneous Domains

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Computer Modeling in Engineering & Sciences 2023年第3期134卷 1707-1735页

作者： Jeongwoo park Bong-Gu jung Jun won Kang Department of Civil and Environmental Engineering Hongik UniversitySeoul04066Korea

This paper presents an electrical impedance tomography(EIT)method using a partial-differential-equationconstrained optimization *** forward problem in the inversion framework is described by a complete electrodemodel(CEM),which seeks the electric potential within the domain and at surface electrodes considering the contact impedance between *** finite element solution of the electric potential has been validated using a commercial *** inverse medium problem for reconstructing the unknown electrical conductivity profile is formulated as an optimization problem constrained by the *** method seeks the optimal solution of the domain’s electrical conductivity to minimize a Lagrangian functional consisting of a least-squares objective functional and a regularization *** the stationarity of the Lagrangian leads to state,adjoint,and control problems,which constitute the Karush-Kuhn-Tucker(KKT)first-order optimality ***,the electrical conductivity profile of the domain is iteratively updated by solving the KKT conditions in the reduced space of the control *** results show that the relative error of the measured and calculated electric potentials after the inversion is less than 1%,demonstrating the successful reconstruction of heterogeneous electrical conductivity profiles using the proposed EIT *** method thus represents an application framework for nondestructive evaluation of structures and geotechnical site characterization.

关键词： Electrical impedance tomography complete electrode model inverse medium problem Karush-Kuhn-Tucker(KKT)optimality conditions nondestructive evaluation of structures

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The H∞ Robust Stability and Performance Conditions for Uncertain Robot Manipulators

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 270-272页

作者： Geun Il Song Hae Yeon park jung Hoon Kim the Department of Electrical Engineering Pohang University of Science and Technology (POSTECH) the Department of Electrical Engineering Pohang University of Science and Technology (POSTECH) the Institute for Convergence Research and Education in Advanced Technology Yonsei University

Dear Editor,H∞This letter develops a new framework for the robust stability and performance conditions as well as the relevant controller synthesis with respect to uncertain robot *** often exist model uncertainties between the nominal model and the real robot manipulator and disturbances. Hence, dealing with their effects plays a crucial role in leading to high tracking performances, as discussed in [1]–[5].

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Inhibitory Effect of the Extract of Phellodendron amurense Ruprecht Root on Collagen-Induced Arthritis in Mice

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Chinese Journal of Integrative Medicine 2017年第10期23卷 755-762页

作者： Hyo won jung Kyung-Ho Kim Yong-Ki park Department of Herbology College of Korean Medicine Dongguk University Gyeongju (740-814) Republic of Korea Korean Medicine Research and Development Center Dongguk University Gyeongju (740-814) Republic of Korea Department of Acupuncture College of Korean Medicine Dongguk University Gyeongju (740-814) Republic of Korea

Objective： To investigate whether the dried root of Phellodendron amurense Ruprecht（Phellodendri cortex; PC） extract improves arthritic symptoms through anti-inflammatory and immune-modulatory effects in collagen-induced arthritis in mice. Methods： Rheumatoid arthritis（RA） was induced in male DBA/1 mice by immunization with type Ⅱ collagen（ColⅡ）. CIA mice were divided into 5 groups（n=10 per a group） with normal, CIA control, PC extract（50 mg/kg and 100 mg/kg）-treated, and meloxicam（50 mg/kg）-treated as the reference drug. The PC extract or meloxicam were administered orally in CIA mice once a day for 14 days after arthritis induction. Arthritic score, levels of anti-ColⅡ IgG2a antibody, prostaglandin E2（PGE2）, tumor necrosis factor（TNF）-α, and interleukin（IL）-17 in the sera of CIA mice were measured. Histopathological changes in the ankle joints of CIA mice were also analyzed by staining with hematoxylin and eosin（H and E）, safranin-O and immunohistochemistry using anti-TNF-α and anti-IL-17 antibodies. Results： The arthritic score was increased in CIA mice in a time-dependent manner, as were the serum levels of anti-ColⅡ IgG2a antibody, PGE2, TNF-α, and IL-17. However, the oral administration of PC extract at 50 and 100 mg/kg in CIA mice significantly decreased the arthritic scores, and the serum levels of anti-ColⅡ IgG2a, PGE2, TNF-α, and IL-17 compared with those in the CIA group（P〈0.05 or P〈0.01）. Furthermore, histopathological improvement of the joint architecture in CIA mice was observed after administration of PC extract. PC extract also significantly inhibited the expression of TNF-α and IL-17 in the joints of CIA mice by suppressing the expression of their m RNA and proteins. Conclusion： PC extract may improve the pathological progression of RA through the inhibition of joint destruction by synovial inflammation and immune-stimulation, therefore, it would be a potential anti-arthritic agent in RA.

关键词： Phellodendron amurense Phellodendri cortex collagen-induced arthritis anti-arthritic effect

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Interfacial modulation of bifunctional electrolyte additive engineering for dendrite-free and robust lithium metal anode

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Journal of Energy Chemistry 2024年第10期97卷 120-127,I0003页

作者： Mahammad Rafi Shaik Yongmin park Young-Kwang jung won Bin Im Division of Materials Science and Engineering Hanyang University222Wangsimni-roSeongdongguSeoul 0473Republic of Kor Department of Chemical Engineering and Biotechnology University of CambridgeCambridge CB3 OASUK

Anode materials for rechargeable electric car batteries are obtained from Li-metal owing to their extremely high specific capacity and low redox ***,safety concerns related to dendrite formation on the anode surface caused by the uneven distribution of Li-ions during the discharge process interfere with the use of Li-metal in industrial *** this study,methyl vinyl sulfone(MVS),a sulfone-based functional electrolyte additive,is used in an additive engineering strategy to control Lielectrolyte interactions and address the aforementioned *** dendrite growth may be restricted,and transition metal degradation on the surface of the cathode can be reduced by the MVS-derived functional electrolyte additive interfacial *** electrochemical performance of an ethylene carbonate/dimethyl carbonate(EC/DMC)+1 wt% MVS Li-metal anode of a Li||Li symmetric cell exhibits remarkable cycle stability,maintaining a low overvoltage for over 750 h at 1 mA cm^(-2),and capacity of 1 mA h cm^(-2).Additionally,LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811) full cells with the MVS additive exhibit enhanced electrochemical stability for 250 cycles at a current density of 100 mA g^(-1).This study provides an innovative approach for stabilizing the metal-electrolyte interfacial layer that may be used for practical applications in metal-based rechargeable batteries.

关键词： Lithium rechargeable battery Dendrite-free Electrolyte additive Bifunctional electrolyte Interfacial layer

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The Effect of Fabrication Conditions for GDC Buffer Layer on Electrochemical Performance of Solid Oxide Fuel Cells

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Nano-Micro Letters 2013年第3期5卷 151-158页

作者： jung-Hoon Song Myung Geun jung Hye won park Hyung-Tae Lim Fuel Cell Project Research Institute of Industrial Science and Technology (RIST) School of Nano & Advanced Materials Engineering Changwon National University

A Gd-doped ceria（GDC） buffer layer is required between a conventional yttria-stabilized zirconia（YSZ） electrolyte and a La-Sr-Co-Fe-O3（LSCF） cathode to prevent their chemical reaction. In this study,the effect of varying the conditions for fabricating the GDC buffer layer, such as sintering temperature and amount of sintering aid, on the solid oxide fuel cell（SOFC） performance was investigated. A finer GDC powder（i.e., ultra-high surface area）, a higher sintering temperature（1290℃）, and a larger amount of sintering aid（12%） resulted in improved densification of the buffer layer; however, the electrochemical performance of an anode-supported cell containing this GDC buffer layer was poor. These conflicting results are attributed to the formation of（Zr, Ce）O2 and/or excess cobalt grain boundaries（GBs） at higher sintering temperatures with a large amount of sintering aid（i.e., cobalt oxide）. A cell comprising of a cobalt-free GDC buffer layer, which was fabricated using a low-temperature process, had lower cell resistance and higher stability. The results indicate that electrochemical performance and stability of SOFCs strongly depend on fabrication conditions for the GDC buffer layer.

关键词： Solid oxide fuel cell(SOFC) Gd-doped ceria Sintering aid Sol-gel spin coating

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Single-step Preparation of Nano-homogeneous NiO/YSZ Composite Anode for Solid Oxide Fuel Cells

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Nano-Micro Letters 2013年第2期5卷 111-116页

作者： jung-Hoon Song Mi Young park Hye won park Hyung-Tae Lim Research Institute of Industrial Science and Technology (RIST) Fuel Cell Project Changwon National University School of Nano & Advanced Materials Engineering

Homogeneous co-precipitation and hydrothermal treatment were used to prepare nano- and highly dispersed Ni O/YSZ(yttria-stabilized zirconia) composite powders. Composite powders of size less than 100 nm were successfully prepared. This process did not require separate sintering of the YSZ and Ni O to be used as the raw materials for solid oxide fuel cells. The performance of a cell fabricated using the new powders(*** density ~0.87 W/cm^2) was higher than that of a cell fabricated using conventional powders(max. power density ~0.73 W/cm^2). Co-precipitation and hydrothermal treatment proved to be very effective processes for reducing cell production costs as well as improving cell performance.

关键词： Fuel cells Powder processing Electrochemistry Hydrothermal process NiO/YSZ composite anode

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Complete remission of advanced hepatocellular carcinoma by radiofrequency ablation after sorafenib therapy

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World Journal of Gastroenterology 2015年第8期21卷 2568-2572页

作者： jung Gil park Soo Young park Hye won Lee Division of Gastroenterology and Hepatology Department of Internal Medicine CHA University Gumi CHA Medical Center Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine Kyungpook National University Department of Pathology School of Medicine Kyungpook National University

Sorafenib,a potent multikinase inhibitor,lead to a significant improvement in progression free survival and overall survival in patients with advanced hepatocellular carcinoma(HCC).Though sorafenib has proven its efficacy in advanced stage HCC,there are limitedreports on the role of sorafenib allowing for curative treatment by *** herein report a case of advanced HCC with vascular invasion,which showed treatment response by sorafenib therapy as to allow for radiofrequency ablation as curative *** patient was followed-up for 6 mo without recurrence with continued sorafenib therapy.

关键词： Hepatocellular carcinoma Radiofrequency ablation S

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Effects of homogenization temperature on microstructure and mechanical properties of high-speed-extruded Mg–5Bi–3Al alloy

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Journal of Magnesium and Alloys 2022年第10期10卷 2833-2846页

作者： Jae won Cha Sang-Cheol Jin Jae-Gil jung Sung Hyuk park School of Materials Science and Engineering Kyungpook National University80 DaehakroDaegu 41566Republic of Korea Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

This study investigates the effects of billet homogenization temperature on the dynamic recrystallization behavior during high-speed extrusion and resultant microstructure and tensile properties of the Mg–5Bi–3Al(BA53,wt%)*** billets homogenized at 350 and450℃(350H and 450H billets)are extruded at a high speed of 69 m/*** 350H billet has a relatively smaller grain size and a higher abundance of fine Mg3Bi2particles compared to the 450H *** extrusion of the 350H billet,enhanced dynamic recrystallization occurs as a result of its finer grains and abundance of particles,while the growth of recrystallized grains is suppressed by the grain-boundary pinning effect of ***,the extruded 350H material is characterized by smaller grains,relatively greater number of Mg3Bi2particles,and a higher internal strain energy than the extruded 450H *** tensile strength of the extruded 350H material is higher than that of the extruded 450H material owing to stronger grain-boundary hardening,particle hardening,and strain hardening *** extruded 350H material also exhibits a higher tensile elongation as its smaller grains inhibit the formation of crack-inducing undesirable twins during *** results from this study demonstrate that a decrease in the homogenization temperature from 450 to 350℃leads to improved strength and ductility in the high-speed-extruded BA53 material.

关键词： Mg–Bi–Al alloy High-speed extrusion Homogenization Dynamic recrystallization Tensile properties

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