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母体苯丙酮尿症:一项来自1978～1997年英国登记人群的报道

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世界核心医学期刊文摘（儿科学分册） 2005年第9期1卷 15-15页

作者： lee P.J. Ridout D. Walter J.H. Cockburn F. 宁亮 Charles Dent Metabolic Unit Natl. Hosp. Neurol. and Neurosurg. Queen Square London WC1N 3BG United Kingdom Dr.

Background: The effects of maternal phenylalanine on the fetus include facial dysmorphism, microcephaly, intrauterine growth retardation, developmental delay, and congenital heart disease. Aims: To evaluate the impact of phenylalanine restricted diet in pregnant women with phenylketonuria (PKU) on their offspring. Methods: Data on virtually all pregnancies of women with PKU in the United Kingdom between 1978 and 1997 were reported to the United Kingdom PKU Registry. The effect of the use and timing in relation to pregnancy of a phenylalanine restricted diet on birth weight, birth head circumference, the presence or absence of congenital heart disease (CHD), 4 year developmental quotient, and 8 year intelligence quotient were examined. Results: A total of 228 pregnancies resulted in live births (seven twin pregnancies were excluded). In 110 (50% ), diet started before conception. For this group mean (SD) birth weight was 3160 (612) g, birth head circumference 33.6 (1.9) cm, 4 year DQ 108.9 (13.2), 8 year IQ 103.4 (15.6), and incidence of CHD was 2.4% . In comparison, for those born where treatment was started during pregnancy (n=91), birth weight was 2818 (711) g, birth head circumference 32.7 (2.0) cm, 4 year DQ 96.8 (15.0), 8 year IQ 86.5 (13.0), and incidence of CHD was 17% . Month-by-month regression analyses suggested that metabolic control by 12-16 weeks gestation had most influence on outcome. Conclusions: Many features of the maternal PKU syndrome are preventable by starting a phenylalanine restricted diet. Women with PKU and their carers must be aware of the risks and should start the diet before conception, or as soon after as possible.

关键词：苯丙酮尿症面部畸形头围小头畸形先天性心脏病活产饮食限制生长发育生时

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应用全身18F-FDG PET/CT诊断腮腺意外瘤:与灰阶和能量多普勒超声成像、超声引导下细针抽吸活组织检查或芯针活组织检查结果比较

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国际医学放射学杂志 2009年第6期 598-598页

作者： S.K.lee B.H.Rho K.S.Won 刘壮盛 Department of Radiology Dongsan Medical CenterKeimyung University School of Medicine194 Dongsan-dongJung-guDaegu700-712South Korea

应用18F-FDG PET/CT对连续10例受试者(9例存在其他部位恶性肿瘤,1例为健康人)的12个腮腺意外瘤进行研究,计算每个FDG浓聚区的最大标准化摄取值(SUVmax),并分析相应的超声、病理结果。超声引导下细针抽吸活组织检查(FNAB)(n=9)和芯针活组织

关键词：腮腺 F-FDG PET/CT 唾液腺活组织检查实验室诊断细针抽吸 FDG 超声引导下 PET

用灵敏的血管紧张素Ⅰ放射免疫分析法测定血浆肾素酶活性

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Acta Biochimica et Biophysica Sinica 1979年第4期 353-363页

作者：李迪元张昀陆以信虞颂芬陈贤妙赵光胜上海市高血压研究所

报导一个简单的血浆肾素活性（PRA）测定法,利用灵敏的放射免疫分析法（RIA）测定血管紧张素Ⅰ（ATⅠ）产生速率。抗ATI血清是用多聚左旋赖氨酸-琥珀酰-ATⅠ免疫家兔而获得,它和七种肽类激素的免疫学交叉反应是可以忽略的,其中与ATⅡ为... 详细信息

报导一个简单的血浆肾素活性（PRA）测定法,利用灵敏的放射免疫分析法（RIA）测定血管紧张素Ⅰ（ATⅠ）产生速率。抗ATI血清是用多聚左旋赖氨酸-琥珀酰-ATⅠ免疫家兔而获得,它和七种肽类激素的免疫学交叉反应是可以忽略的,其中与ATⅡ为低于0.2%。它的有效亲和常数Keff高至4.4×1010升/克分子。使用这个优质抗血清及125Ⅰ标记ATⅠ,并结合双抗体分离技术,已建立了一个特异而灵敏的RIA。其检出极限是9.1±2.7微微克ATⅠ/管（均值±标准差）,精密度是1.5±0.8%;测定保温后血浆中ATⅠ（136微微克量及3批连续测定中）批内变异系数C.V是2.5%,批间C.V.是15%。当确定PRA方法学时,研究了一些影响因素,并证实了血浆保温条件显著地影响ATⅠ的产生速率。我们的方法具有某些优点,例如:1)一旦血液被采集,立即加入作为抗凝剂和ATⅠ保护剂的Na2·EDTA,8-羟基喹啉和二巯基丙醇;2)保温的血浆中加入1/10体积4MTris-HCl缓冲液（pH 7.4）,使它维持在生理条件而又尽可能减少稀释;3)证明当保温期间ATⅠ的生成量线性范围可维持3～6小时以上;4)加至血浆中未标记ATⅠ的回收率达98.5%,表明在37℃3小时（PRA）及4℃3天（RIA）的整个保温期间,满意地抑制了蛋白水解酶的作用。为了测试PRA法的精密度,对二份混合血浆,在连续5批检定中进行复管测定,得均值是0.88毫微克AT Ⅰ/毫升/小时和2.35毫微克AT Ⅰ/毫升/小时,其批内C.V.分别是4.3%和1.7%,批间C.V.分别是20%和10%。

关键词：血浆肾素保温时间 PRA ATI 放射免疫分析法酶活性酶活力

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急性心肌炎暴发阶段的预测因素

世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 40-40页

作者： lee C. -H. Tsai W. - C. Hsu C. - H. 尹涛(译) 杜媛(校) 不详 Department of Internal Medicine School of Medicine National Cheng Kung University Medical Center 138 Sheng-Li Road Tainan 704 Taiwan

Background: Patients who develop fulminant myocarditis often die of sudden car diac arrest, arrhythmia, or severe heart failure soon after onset if they do not receive percutaneous cardiopulmonary support in time. The purpose of this study was to identify the risk factors of clinical symptoms/signs or laboratory findi ngs that could predict the fulminant course of acute myocarditis. Methods and re sults: Thirty-five patients(mean age 28±8 years, 17 males) who had been admitt ed to intensive care unit with the diagnosis of acute myocarditis by clinical pr esentations were retrospectively recruited. They were divided into the fulminant group(n=11) and the non-fulminant group(n=24). Clinical features, laboratory d ata, and images on admission were analyzed. Overall in-hospital mortality was 1 7%(6/35). Mortality was higher in the fulminant group(45%vs. 4%, p=0.027). Mu ltivariate analysis revealed that prolongations of the QRS complex(118±27 vs. 8 8±10 ms, p=0.048) and depressed left ventricular ejection fraction(41±7%vs. 5 7±7%, p=0.027) were the only independent factors significantly associated with the fulminant course of acute myocarditis. Conclusion: The in-hospital mortali ty of acute fulminant myocarditis was high. Prolongations of the QRS complex and depressed left ventricular ejection fraction on admission were independent posi tive predictors for the development of acute fulminant myocarditis.

关键词：暴发性心肌炎急性心肌炎预测因素临床表现诊断实验室检查指标院内死亡率左室射血分数重症监护室

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睾丸及睾丸旁良性实性肿块的影像学特征

国际医学放射学杂志 2011年第6期 612-612页

作者： S.B. Park W.C. lee J.K. Kim S.H. Choi K.H. Moon 朱叶青 Department of Radiology Cheil General Hospital and Women’s Healthcare Center Kwandong University College of Medicine 1-19 Mookjeong-dong Jung-gu Seoul 100-380 Korea

目的睾丸内实性肿块通常高度疑为恶性。相反,大多数睾丸外实性肿块包括睾丸旁肿块为良性。睾丸恶性实性肿块的典型影像学特征已十分明确,但是各种不常见原因的睾丸良性实性肿块及其影像学特征尤其容易引起误诊。因此,睾丸及睾丸旁实性... 详细信息

目的睾丸内实性肿块通常高度疑为恶性。相反,大多数睾丸外实性肿块包括睾丸旁肿块为良性。睾丸恶性实性肿块的典型影像学特征已十分明确,但是各种不常见原因的睾丸良性实性肿块及其影像学特征尤其容易引起误诊。因此,睾丸及睾丸旁实性肿块应该仔细评价。本文旨在介绍一

关键词：睾丸新生物囊肿阴囊疾病超声 MRI

超声导引下经皮胆囊胆管成像对早期排除胆道闭锁和类型判定的有效性

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国际医学放射学杂志 2012年第1期 87-87页

作者： S.Y.lee G.C.Kim B.H.Choe H.K.Ryeom Y.J.Jang H.J.Kim 管宇 Department of Radiology Kyungpook National University School of Medicine101 Dongin dong 2 GaJung guDaegu 700-422Republic of Korea

目的评估超声引导下经皮胆囊胆管成像对胆汁淤积性肝病婴儿胆道闭锁的早期诊断及其特征的有效性。材料与方法本研究获得当地伦理委员会批准。受试者父母签

关键词：胆道闭锁早期诊断胆囊 PCC 胆道经皮超声引导下有效性

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise