检索结果-南通市图书馆

Optimal sequential therapy using tyrosine kinase inhibitors as the first-line treatment in patients with metastatic renal cell carcinoma: A nationwide multicenter study

引用

Asian Journal of Urology 2024年第3期11卷 450-459页

作者： jung Ki Jo Seong Il Seo MinYong Kang Jinsoo Chung Cheol Kwak Sung-Hoo Hong Cheryn Song Jae Young Park Chang Wook Jeong Seok Hwan Choi Sung Han kim Eu Chang Hwang Chan Ho Lee Hakmin Lee Department of Urology Medical and Digital EngineeringCollege of MedicineHanyang UniversitySeoulRepublic of Korea Department of Urology Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Urology National Cancer CenterGoyangRepublic of Korea Department of Urology Seoul National University HospitalSeoulRepublic of Korea Department of Urology Kangnam St Mary’s HospitalSeoulRepublic of Korea Department of Urology Asan Medical CenterSeoulRepublic of Korea Department of Urology Korea University Ansan HospitalAnsanRepublic of Korea Department of Urology Kyungpook National University HospitalDaeguRepublic of Korea Department of Urology Chonnam National University Hwasun HospitalHwasunRepublic of Korea Department of Urology Inje University Busan Paik HospitalBusanRepublic of Korea Department of Urology Seoul National University Bundang HospitalSeongnamRepublic of Korea

Objective:The purpose of the study was to identify the best sequence of therapy beginning with a tyrosine kinase inhibitor(TKI)as the first-line therapy for patients with metastatic renal cell carcinoma(mRCC)in terms of overall survival(OS),progression-free survival(PFS),and rates of discontinuation and adverse effects during the treatment ***:This is a retrospective,nationwide multicenter study of patients with mRCC after diagnosis at 10 different tertiary medical centers in Korea from January 1992 to December *** focused on patients at either“favorable”or“intermediate”risk according to the International mRCC Database Consortium criteria,and they were followed up(median 335 days).Finally,a total of 1409 patients were selected as the study *** generated a Cox proportional hazard model adjusted for covariates,and the different therapy schemes were statistically tested in terms of OS as well as *** addition,frequencies of discontinuation and adverse events were compared among the therapy ***:Of the primary patterns of treatment sequences(24 sequences),“sunitinib epazopanib”and“sunitinibeeverolimuseimmunotherapy”showed the most beneficial results in both OS and PFS with significantly lower hazards than“sunitinib”,which is the most commonly treated agent in *** that the“TKIeTKI”structure showed relatively higher discontinuation rates with higher adverse effects,the overall beneficial sequence would be“sunitinibeeverolimuseimmunotherapy”.Conclusion:Among several sequential therapy starting with TKIs,“sunitinibeeverolimuse immunotherapy”was found to be the best scheme for mRCC patients with“favorable”or“intermediate”risks.

关键词： Tyrosinekinase inhibitor Metastaticrenalcell carcinoma Overall survival Progression-free survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acupuncture ameliorates atopic dermatitis by modulating gut barrier function in a gut microbiota-dependent manner in mice

引用

Journal of Integrative Medicine 2024年第05期 600-613页

作者： Mijung Yeom Sora Ahn Dae-Hyun Hahm Sun-Young Jang Se Hoon Jang Su-Yang Park Jae-Hwan Jang Jihan Park Ju-Young Oh In-Seon Lee Kyuseok kim Soon-Kyeong kwon Hi-Joon Park Acupuncture and Meridian Science Research Center College of Korean MedicineKyung Hee University Department of Physiology School of MedicineKyung Hee University BioNanocomposite Research Center Kyung Hee University Department of Science in Korean Medicine College of Korean MedicineGraduate SchoolKyung Hee University College of Korean Medicine Kyung Hee University Department of Ophthalmology Otorhinolaryngology and Dermatology of Korean MedicineCollege of Korean MedicineKyung Hee University Division of Applied Life Science (BK21) Gyeongsang National University Department of Anatomy & Information Sciences College of Korean MedicineKyung Hee University

Objective: Atopic dermatitis(AD) is a chronic inflammatory skin disease that may be linked to changes in the gut microbiome. Acupuncture has been proven to be effective in reducing AD symptoms without serious adverse events, but its underlying mechanism is not completely understood. The purpose of this study was to investigate whether the potential effect of acupuncture on AD is gut ***: AD-like skin lesions were induced by applying MC903 topically to the cheek of the *** was done at the Gok-Ji(LI11) acupoints. AD-like symptoms were assessed by lesion scores,scratching behavior, and histopathological changes; intestinal barrier function was measured by fecal output, serum lipopolysaccharide levels, histopathological changes, and mRNA expression of markers involved in intestinal permeability and inflammation. Gut microbiota was profiled using 16S rRNA gene sequencing from fecal ***: Acupuncture effectively improved chronic itch as well as the AD-like skin lesions with epidermal thickening, and also significantly altered gut microbiota structure as revealed by β-diversity indices and analysis of similarities. These beneficial effects were eliminated by antibiotic depletion of gut microbiota,but were reproduced in gut microbiota-depleted mice that received a fecal microbiota transplant from acupuncture-treated mice. Interestingly, AD mice had intestinal barrier dysfunction as indicated by increased intestinal permeability, atrophy of the mucosal structure(reduced villus height and crypt depth), decreased expression of tight junctions and mucus synthesis genes, and increased expression of inflammatory mediators in the ileum. Acupuncture attenuated these abnormalities, which was gut ***: Acupuncture ameliorates AD-like phenotypes in a gut microbiota-dependent manner and some of these positive benefits are explained by modulation of the intestinal barrier, providing new perspective for non-phar

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Characterization of particulate matter from diesel passenger cars tested on chassis dynamometers

引用

Journal of Environmental Sciences 2017年第4期29卷 21-32页

作者： Sungwoon jung Jaehyun Lim Sangil kwon Sangwoo Jeon Jeongsoo kim Jongtae Lee Sunmoon kim Transportation Pollution Research Center National Institute of Environmental Research Incheon Republic of Korea Division of Global Environment Research National Institute of Environmental Research Incheon Republic of Korea Compliance & Defects Investigation Office Korea Automobile Testing & Research Institute Hwasung Republic of Korea

Emission characterization of particle number as well as particle mass from three diesel passenger cars equipped with diesel particulate filter（DPF）, diesel oxidation catalyst（DOC）and exhaust gas recirculation（EGR） under the vehicle driving cycles and regulatory *** particle number emissions（PNEs） decreased gradually during speed-up of vehicle from 17.3 to 97.3 km/hr. As the average vehicle speed increases, the size-segregated peak of particle number concentration shifts to smaller size ranges of particles. The correlation analysis with various particulate components such as particle number concentration（PNC）,ultrafine particle number concentration（UFPNC） and particulate matter（PM） mass was conducted to compare gaseous compounds（CO, CO2, HC and NOx）. The UFPNC and PM were not only emitted highly in Seoul during severe traffic jam conditions, but also have good correlation with hydrocarbons and NOxinfluencing high potential on secondary aerosol generation. The effect of the dilution temperature on total PNC under the New European Driving Cycle（NEDC）, was slightly higher than the dilution ratio. In addition, the nuclei mode（DP： ≤ 13 nm） was confirmed to be more sensitive to the dilution temperature rather than other particle size ranges. Comparison with particle composition between vehicle speed cycles and regulatory cycle showed that sulfate was slightly increased at regulatory cycle, while other components were relatively similar. During cold start test, semivolatile nucleation particles were increased due to effect of cold environment. Research on particle formation dependent on dilution conditions of diesel passenger cars under the NEDC is important to verify impact on vehicular traffic and secondary aerosol formation in Seoul.

关键词： Diesel passenger cars Particle number emissions Correlation analysis Particle number concentration Ultrafine particle number concentration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regeneration-associated macrophages： a novel approach to boost intrinsic regenerative capacity for axon regeneration

引用

Neural Regeneration Research 2016年第9期11卷 1368-1371页

作者： Min jung kwon Hyuk Jun Yoon Byung Gon kim Department of Brain Science Ajou University School of Medicine Suwon Republic of Korea Department of Neurology Ajou University School of Medicine Suwon Republic of Korea Neuroscience Graduate Program Department of Biomedical Sciences Ajou University Graduate School of Medicine Suwon Republic of Korea

Axons in central nervous system （CNS） do not regenerate spontaneously after injuries such as stroke and traumatic spinal cord iniury. Both intrinsic and extrinsic factors are responsible for the regeneration fail- ure, Although intensive research efforts have been invested on extrinsic regeneration inhibitors, the extent to which glial inhibitors contribute to the regeneration failure in viva still remains elusive. Recent exper- imental evidence has rekindled interests in intrinsic factors for the regulation of regeneration capacity in adult mammals. In this review, we propose that activating macrophages with pro-regenerative molecular signatures could be a novel approach for boosting intrinsic regenerative capacity of CNS neurons. Using a conditioning injury model in which regeneration of central branches of dorsal root ganglia sensory neu- rons is enhanced by a preceding injury to the peripheral branches, we have demonstrated that perineuronal macrophages surrounding dorsal root ganglia neurons are critically involved in the maintenance of en- hanced regeneration capacity. Neuron-derived chemokine （C-C motif） ligand 2 （CCL2） seems to mediate neuron-macrophage interactions conveying injury signals to perineuronal macrophages taking on a soley pro-regenerative phenotype, which we designate as regeneration-associated macrophages （RAMs）. Ma- nipulation of the CCL2 signaling could boost regeneration potential mimicking the conditioning injury, suggesting that the chemokine-mediated RAM activation could be utilized as a regenerative therapeutic strategy for CNS injuries.

关键词： axon regeneration conditioning injury neuron-macrophage interaction regeneration-associatedmacrophage cAMP CCL2 M2 polarization spinal cord injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Real-Time Tunable Gas Sensing Platform Based on SnO2 Nanoparticles Activated by Blue Micro-Light-Emitting Diodes

引用

Nano-Micro Letters 2024年第12期 111-127页

作者： Gi Baek Nam jung-El Ryu Tae Hoon Eom Seung Ju kim Jun Min Suh Seungmin Lee Sungkyun Choi Cheon Woo Moon Seon Ju Park Soo Min Lee Byungsoo kim Sung Hyuk Park Jin Wook Yang Sangjin Min Sohyeon Park Sung Hwan Cho Hyuk Jin kim Sang Eon Jun Tae Hyung Lee Yeong Jae kim Jae Young kim Young Joon Hong Jong-In Shim Hyung-Gi Byun Yongjo Park Inkyu Park Sang-Wan Ryu Ho Won Jang Department of Materials Science and Engineering Seoul National University Research Laboratory of Electronics Department of Mechanical Engineering Massachusetts Institute of Technology Ming Hsieh Department of Electrical and Computer Engineering University of Southern California Department of Display Materials Engineering Soonchunhyang University Department of Photonics and Nanoelectronics BK21 FOUR ERICA-ACE Center Hanyang University ERICA Department of Nanotechnology and Advanced Materials Engineering Sejong University Department of Electronics Information and Communication Engineering Kangwon National University Advance Institute of Convergence Technology Seoul National University Department of Mechanical Engineering Korea Advanced Institute of Science and Technology Department of Physics Chonnam National University

Micro-light-emitting diodes（μLEDs） have gained significant interest as an activation source for gas sensors owing to their advantages, including room temperature operation and low power consumption. However, despite these benefits, challenges still exist such as a limited range of detectable gases and slow response. In this study, we present a blue μLED-integrated light-activated gas sensor array based on SnO2nanoparticles（NPs） that exhibit excellent sensitivity, tunable selectivity, and rapid detection with micro-watt level power consumption. The optimal power for μLED is observed at the highest gas response, supported by finite-difference time-domain simulation. Additionally, we first report the visible light-activated selective detection of reducing gases using noble metal-decorated SnO2NPs. The noble metals induce catalytic interaction with reducing gases, clearly distinguishing NH3, H2, and C2H5OH. Real-time gas monitoring based on a fully hardwareimplemented light-activated sensing array was demonstrated, opening up new avenues for advancements in light-activated electronic nose technologies.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Evaluation of particle growth systems for sampling and analysis of atmospheric fine particles

引用

Particuology 2011年第6期9卷 606-610页

作者： Dae Seong kim Sang Bum Hong jung-Taek kwon Kihong Park Department of Environmental Science and Engineering Gwangju Institute of Science and Technology Korea Polar Research Institute Laboratory of Toxicology College of Veterinary Medicine Seoul National University

Three types of water-based condensational growth systems, which can enable particles to grow in size to facilitate sampling and subsequent chemical analysis, were evaluated. The first one is a mixing type growth system where aerosols are mixed with saturated water vapor, the second one is a thermal diffusive growth system where warm flow enters cold-walled tube, and the third one is a laminar flow type where cold flow enters a warm wet-wall tube. Hygroscopic sodium chloride （NaCl）, ammonium sulfate （（NH4）2SO4） and ammonium nitrate （NH4N03）, and non-hygroscopic polystyrene latex （PSL） particles, in the size range of 50-400 nm, were used to determine their growth factors through the growth systems. Our data showed that the third-type growth system could enable particles to grow most efficiently regardless of their hygroscopic property. Collection efficiency of particles in the size range of 0.05-2.5 μm, in a continuous aerosol sampler after they passed through the third-type growth system was about 100%, suggesting that the third-type growth system would he the most useful among the tested growth systems for sampling and subsequent chemical analysis of fine and ultrafine particles.

关键词： Particle growth chamber Condensational growth Particle sampler Hygroscopic particles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Correction:Impact of Transition Metal Layer Vacancy on the Structure and Performance of P2 Type Layered Sodium Cathode Material

引用

Nano-Micro Letters 2024年第12期16卷 532-532页

作者： Orynbay Zhanadilov Sourav Baiju Natalia Voronina Jun Ho Yu A-Yeon kim Hun-Gi jung Kyuwook Ihm Olivier Guillon Payam Kaghazchi Seung-Taek Myung Department of Nanotechnology and Advanced Materials Engineering and Sejong Battery Institute Hybrid Materials Research CenterSejong University98 Gunja-DongGwangjin-GuSeoul 05006South Korea Institute of Energy and Climate Research-Materials Synthesis and Processing(IEK-1) Forschungszentrum Jülich GmbH52425 JülichGermany Center for Energy Storage Research Korea Institute of Science and TechnologySeoul 02792South Korea KIST-SKKU Carbon-Neutral Research Center Sungkyunkwan UniversitySuwon 16419South Korea Department of Energy Science Sungkyunkwan UniversitySuwon 16419South Korea Pohang Accelerator Laboratory 80 Jigokro-127-BeongilNam-GuPohangGyeongbuk 37673South Korea MESA+Institute for Nanotechnology University of Twente7500 AE EnschedeThe Netherlands

Following publication of the original article[1],the authors reported that the author Hun-Gi jung should be affiliated as 3,4 and 5 instead of 4 and *** author’s name“A.-Yeon kim”needed to be updated to“A-Yeon kim”,removing the *** correct author’s name and affiliation have been provided in this *** original article[1]has been corrected.

关键词： removing Transition Impact

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diel vertical migration of the copepod Calanus sinicus before and during formation of the Yellow Sea Cold Bottom Water in the Yellow Sea

引用

Acta Oceanologica Sinica 2013年第9期32卷 99-106页

作者： KANG jung-Hoon SEO MinHo kwon Oh Youn kim Woong-Seo South Sea Environment Research Division Korea Institute of Ocean Science&Technology (KIOST) Deep-sea and Seabed Resources Research Division

To understand the effects of the Yellow Sea Cold Bottom Water （YSCBW） on the diel vertical migration （D- VM） of the copepod Calanus sinicus, we surveyed vertical distribution of C. sinicus at a fixed station in the Yellow Sea before （spring） and during （summer） formation of the YSCBW. Cold water （〈10℃） was observed in the bottom layer when the water column was thermally stratified in summer, but the water column was thermally well-mixed in spring 2010. Samples were collected from five different layers at 3-h intervals using an opening-closing net. Adult females （1-155 ind./m3） showed a clear normal DVM pattern throughout the entire water column in spring, whereas adult males did not migrate. DVM of copepodite V （CV） individuals was not clear, but the maximum abundance of CI-CIV occurred consistently in the upper 10-20 m layer, where there was a high concentration of chlorophyll-a （Chl-a）（0.49-1.19μg/L）. In summer, weak DVM was limited to cold waters beneath the thermocline for adult females （〈30 ind./m3）, but not for adult males. The maximum abundance of CI-CIV also occurred consistently in the subsurface layer （20-40 m） together with high concentrations of Chl-a （0.81-2.36 μg/L）. CV individuals （1-272 ind./m3） moved slightly upward noc- turnally to the near-surface layer （10-20 m）, where the average temperature was 25.74℃, but they were not found in the surface layer （0-10 m; 28.31℃）. These results indicate that the existence of the YSBCW affected food availability at depth and the vertical temperature distribution, leading to variation in the amplitude and shape of stage-specific vertical distributions （CI to adults） in C. sinicus before and during the formation of cold waters in the Yellow Sea during the study period.

关键词： Yellow Sea Cold Bottom Water (YSCBW) copepod Calanus sinicus developmental stages,diel vertical migration (DVM)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Is transcranial direct current stimulation a potential method for improving response inhibition?

引用

Neural Regeneration Research 2013年第11期8卷 1048-1054页

作者： Yong Hyun kwon jung Won kwon Department of Physical Therapy Yeungnam College of Science & Technology Department of Physical Therapy College of Rehabilitation Science Daegu University

Inhibitory control of movement in motor learning requires the ability to suppress an inappropriate action, a skill needed to stop a planned or ongoing motor response in response to changes in a variety of environments. This study used a stop-signal task to determine whether transcranial direct-current stimulation over the pre-supplementary motor area alters the reaction time in motor inhibition. Forty healthy subjects were recruited for this study and were randomly assigned to either the transcranial direct-current stimulation condition or a sham-transcranial direct-current stimulation condition. All subjects consecutively performed the stop-signal task before, during, and after the delivery of anodal transcranial direct-current stimulation over the pre-supplementary motor area （pre-transcranial direct-current stimulation phase, transcranial direct-current stimulation phase, and post-transcranial direct-current stimulation phase）. Compared to the sham condition, there were significant reductions in the stop-signal processing times during and after transcranial direct-current stimulation, and change times were significantly greater in the transcranial direct-current stimulation condition. There was no significant change in go processing-times during or after transcranial direct-current stimulation in either condition. Anodal transcranial direct-current stimulation was feasibly coupled to an interactive improvement in inhibitory control. This coupling led to a decrease in the stop-signal process time required for the appropriate responses between motor execution and inhibition. However, there was no transcranial direct-current stimulation effect on the no-signal reaction time during the stop-signal task. Transcranial direct-current stimulation can adjust certain behaviors, and it could be a useful clinical intervention for patients who have difficulties with response inhibition.

关键词： neural regeneration neurorehabilitation transcranial direct current stimulation pre-supplementarymotor area stop-signal task response inhibition inhibitory control motor learning behavioralmodification grants-supported paper neuroregeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of vehicle weight on natural frequencies of bridges measured from traffic-induced vibration

引用

Earthquake Engineering and Engineering Vibration 2003年第1期2卷 109-116页

作者： Chul-Young kim Dae-Sung jung Nam-Sik kim Soon-Duck kwon Maria Q.Feng Dept.of Civil & Envir.Eng. Myongji UniversityKorea Professor Dept.of Civil & Envir.Eng. Myongji UniversityKorea Research Associate Hyundai Institute of Construction Technology Hyundai E&C Co.Ltd.Korea Chief Researcher Dept.of Civil Engineering Chonbuk National UniversityKorea Professor Dept.of Civil & Envir.Eng. University of CaliforniaIrvineCaliforniaUSA Professor

Recently,ambient vibration test(AVT)is widely used tu estimate dynamic characteristics of large civil struc- *** characteristics ean be affected by various envirnnmental factors such as humidity,intensity of wind,and *** these environmental conditions,tire mass of vehicles may change the measured valnes when traffic-in- duced vibration is used as a source of AVT tor *** effect of vehicle mass on dynamic characteristics is investigated through traffic-induced vibration tests on three bridges;(1)three-span suspension bridge(128m+404m+128m),(2) five-span continuous steel box girder bridge(59m+3@ 95m+59m),(3)simply supported plate girder bridge(46m). Acceleration histories of each measurement location under normal traffic are recorded for 30 minutes at *** recor- ded histories are divided into individual vibrations and are combined into two groups aceording to the level of vibration;one by heavy vehicles such as trucks and buses and the other by light vehicles such as passenger *** processing of the two groups of signals shows that,for the middle and long-span bridges,the difference can be hardly detected,but,for the short span bridges whose mass is relatively small,the measured natural frequencies can change up to 5.4%.

关键词： ambient vibration test traffic induced vibration vehicle mass suspension bridge short-span bridge dynamic characteristics natural frequency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：