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Optimal sequential therapy using tyrosine kinase inhibitors as the first-line treatment in patients with metastatic renal cell carcinoma: A nationwide multicenter study

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Asian journal of Urology 2024年第3期11卷 450-459页

作者： jung ki jo Seong Il Seo MinYong Kang Jinsoo Chung Cheol Kwak Sung-Hoo Hong Cheryn Song Jae Young Park Chang Wook Jeong Seok Hwan Choi Sung Han kim Eu Chang Hwang Chan Ho Lee Hakmin Lee Department of Urology Medical and Digital EngineeringCollege of MedicineHanyang UniversitySeoulRepublic of Korea Department of Urology Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Urology National Cancer CenterGoyangRepublic of Korea Department of Urology Seoul National University HospitalSeoulRepublic of Korea Department of Urology Kangnam St Mary’s HospitalSeoulRepublic of Korea Department of Urology Asan Medical CenterSeoulRepublic of Korea Department of Urology Korea University Ansan HospitalAnsanRepublic of Korea Department of Urology Kyungpook National University HospitalDaeguRepublic of Korea Department of Urology Chonnam National University Hwasun HospitalHwasunRepublic of Korea Department of Urology Inje University Busan Paik HospitalBusanRepublic of Korea Department of Urology Seoul National University Bundang HospitalSeongnamRepublic of Korea

Objective:The purpose of the study was to identify the best sequence of therapy beginning with a tyrosine kinase inhibitor(Tki)as the first-line therapy for patients with metastatic renal cell carcinoma(mRCC)in terms of overall survival(OS),progression-free survival(PFS),and rates of discontinuation and adverse effects during the treatment ***:This is a retrospective,nationwide multicenter study of patients with mRCC after diagnosis at 10 different tertiary medical centers in Korea from January 1992 to December *** focused on patients at either“favorable”or“intermediate”risk according to the International mRCC Database Consortium criteria,and they were followed up(median 335 days).Finally,a total of 1409 patients were selected as the study *** generated a Cox proportional hazard model adjusted for covariates,and the different therapy schemes were statistically tested in terms of OS as well as *** addition,frequencies of discontinuation and adverse events were compared among the therapy ***:Of the primary patterns of treatment sequences(24 sequences),“sunitinib epazopanib”and“sunitinibeeverolimuseimmunotherapy”showed the most beneficial results in both OS and PFS with significantly lower hazards than“sunitinib”,which is the most commonly treated agent in *** that the“TkieTki”structure showed relatively higher discontinuation rates with higher adverse effects,the overall beneficial sequence would be“sunitinibeeverolimuseimmunotherapy”.Conclusion:Among several sequential therapy starting with Tkis,“sunitinibeeverolimuse immunotherapy”was found to be the best scheme for mRCC patients with“favorable”or“intermediate”risks.

关键词： Tyrosine kinase inhibitor Metastatic renal cell carcinoma Overall survival Progression-free survival

Novel ternary metals-based telluride electrocatalyst with synergistic effects of high valence non-3d metal and oxophilic Te for pH-universal hydrogen evolution reaction

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journal of Energy Chemistry 2023年第5期80卷 736-743,I0015页

作者： Seunghwan jo Wenxiang Liu Yanan Yue ki Hoon Shin Keon Beom Lee Hyeonggeun Choi Bo Hou jung Inn Sohn Division of Physics and Semiconductor Science Dongguk UniversitySeoul 04620Republic of Korea School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072HubeiChina School of Physics and Astronomy Cardiff UniversityCardiff CF243AAWalesUK

Electrocatalyst designs based on oxophilic foreign atoms are considered a promising approach for developing efficient pH-universal hydrogen evolution reaction(HER)electrocatalysts by overcoming the sluggish alkaline HER ***,we design ternary transition metals-based nickel telluride(Mo WNi Te)catalysts consisting of high valence non-3d Mo and W metals and oxophilic Te as a first demonstration of non-precious heterogeneous electrocatalysts following the bifunctional *** Mo WNi Te showed excellent HER catalytic performance with overpotentials of 72,125,and 182 mV to reach the current densities of 10,100,and 1000 mA cm^(-2),respectively,and the corresponding Tafel slope of 47,52,and 58 mV dec-1in alkaline media,which is much superior to commercial Pt/***,the HER performance of Mo WNi Te is well maintained up to 3000 h at the current density of 100 mA cm^(-2).It is further demonstrated that the Mo WNi Te exhibits remarkable HER activities with an overpotential of 45 mV(31 mV)and Tafel slope of 60 mV dec-1(34 mV dec-1)at 10 mA cm^(-2)in neutral(acid)*** superior HER performance of Mo WNi Te is attributed to the electronic structure modulation,inducing highly active low valence states by the incorporation of high valence non-3d transition *** is also attributed to the oxophilic effect of Te,accelerating water dissociation kinetics through a bifunctional catalytic mechanism in alkaline *** functional theory calculations further reveal that such synergistic effects lead to reduced free energy for an efficient water dissociation process,resulting in remarkable HER catalytic performances within universal pH environments.

关键词： Telluride catalyst Oxophilic effect High valence non-3d metal Bifunctional mechanism pH-universal hydrogen evolution reaction

Early experience of the compression anastomosis ring (CAR^(TM) 27) in left-sided colon resection

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World journal of Gastroenterology 2011年第43期17卷 4787-4792页

作者： jung-Yeon Lee Jin-Hee Woo Hong-jo Choi ki-Jae Park Young-Hoon Roh ki-Han kim Hak-Yoon Lee Department of Surgery Dong-A University Medical Center

AIM:To evaluate clinical validity of the compression anastomosis ring(CARTM27) anastomosis in left-sided colonic resection. METHODS:A non-randomized prospective data collection was performed for patients undergoing an elective left-sided colon resection,followed by an anastomosis using the CARTM27 between November 2009 and January *** criteria of the use of the CARTM27 were anastomoses between the colon and at or above the intraperitoneal *** primary short-term clinical endpoint,rate of anastomotic leakage,and other clinical outcomes,including intraand postoperative complications,length of operation time and hospital stay,and the ring elimination time were evaluated. RESULTS:A total of 79 patients(male,43;median age,64 years) underwent an elective left-sided colon resection,followed by an anastomosis using *** was performed laparoscopically in 70 patients,in whom two patients converted to open procedure(2.9%) .There was no surgical *** an intraoperative complication,total disruption of the anastomosis occurred by premature enforced tension on the proximal segment of the anastomosis in one *** ring was removed and another new CARTM27 anastomosis was *** patient with sigmoid colon cancer showed postoperative anastomotic leakage after 6 d postoperatively and temporary diverting ileostomy was *** date of expulsion of the ring could not be recorded because most patients were not aware that the ring had been *** patients manifested clinical symptoms of anastomotic stricture. CONCLUSION:Short-term evaluation of the CARTM27 anastomosis in elective left colectomy suggested it to be a safe and efficacious alternative to the standard hand-sewn or stapling technique.

关键词： Compression anastomosis Colon Anastomotic leakage CARTM27

A new damage quantification approach for shear-wall buildings using ambient vibration data

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Frontiers of Structural and Civil Engineering 2015年第1期9卷 17-25页

作者： Seung-Hun SUNG Hyung-jo jung Department of Civil and Environmental Engineering Korea Advanced Institute of Science and Technology Daejeon 305- 701 Korea

This paper presents a new approach to estimate damage seventy tor slaear-wall DUlltllngs using alagona~ terms of a modal flexibility matrix estimated from dynamic properties. This study aims to provide a fundamental concept for quantifying the damage of realistic buildings by investigating an idealized shear-wall building. Numerical studies were performed on a 5-story shear-wall building model to validate the applicability of the presented approach, using two damage patterns. With the numerical simulations, the proposed approach accurately determined the damage ratio of the specimens. Experiments were also conducted on a 5-story shear-wall building model for which the system parameters were almost the same as those in numerical simulations. The estimated damage-quantification results from the experimental validations demonstrated that the performance of the presented method for shear-wall buildings was both suitable and accurate.

关键词： damage identification modal flexibility damage quantification shear-wall buildings

Fabrication of periodically aligned vertical singlecrystalline anatase TiO2 nanotubes with perfect hexagonal open-ends using chemical capping materials

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Nano Research 2014年第1期7卷 104-109页

作者： Hui Song Kyubong jo Bock Young jung Gun Young jung School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST) Gwangju Republic of Korea Department of Chemistry and Interdisciplinary Program of Integrated Biotechnology Sogang University Seoul Republic of Korea Department of General Dentistry College of Dentistry Yonsei University Seoul Republic of Korea

A vertically aligned anatase TiO2 （A-TiO2） nanotube array has been fabricated by coating a ZnO nanorod （NR） template with a TiO2 precursor solution. After coating, the ZnO NR cores were selectively etched in an acidic environment to form TiO2 nanotubes （NTs）. More specifically, after growing the ZnO NRs via a hydrothermal method, one drop of the TiO2 precursor solution was cast to coat the ZnO NRs, the tops of which were previously covered with chemical capping materials by electrostatic interaction, and then the sample was sintered. Finally, the sample was immersed in an acidic solution resulting in selective etching of the ZnO NR cores. Thus, only TiO2 NTs remained on the substrate. The capping material is effectively used to create a perfect, hexagonal open-ended TiO2 NT array, which interestingly extends onset absorption towards the visible region.

关键词： TiO2 nanotubes chemical capping material ZnO nanorod template laser interferencelithography

Adoption of wide-bandgap microcrystalline silicon oxide and dual buffers for semitransparent solar cells in building-integrated photovoltaic window system

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journal of Materials Science & Technology 2019年第8期35卷 1563-1569页

作者： johwa Yang Hyunjin jo Soo-Won Choi Dong-Won Kang jung-Dae Kwon Surface Technology Division Korea Institute of Materials ScienceChangwon 641-831 Republic of Korea School of Energy Systems Engineering Chung-Ang UniversitySeoul 06974 Republic of Korea

We focused on developing penetration-type semitransparent thin-film solar cells(STSCs) using hydrogenated amorphous Si(a-Si:H) for a building-integrated photovoltaic(BIPV) window system. Instead of conventional p-type a-Si:H, p-type hydrogenated microcrystalline Si oxide(p-μc-SiOx:H) was introduced for a wide-bandgap and conductive window layer. For these purposes, we tuned the CO2/SiH4 flow ratio(R) during p-μc-SiOx:H deposition. The film crystallinity decreased from 50% to 13% as R increased from 0.2 to 1.2. At the optimized R of 0.6, the quantum efficiency was improved under short wavelengths by the suppression of p-type layer parasitic absorption. The series resistance was well controlled to avoid fill factor loss at R = 0.6. Furthermore, we introduced dual buffers comprising p-a-SiOx:H/i-a-Si:H at the p/i interface to alleviate interfacial energy-band mismatch. The a-Si:H STSCs with the suggested window and dual buffers showed improvements in transmittance and efficiency from 22.9% to 29.3% and from 4.62% to 6.41%, respectively, compared to the STSC using a pristine p-a-Si:H window.

关键词： Microcrystalline silicon oxide Building-integrated photovoltaics Semitransparent Thin film Solar cells

Selexipag as Add-on Therapy for Patients with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease:A Single-Center Retrospective Study

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Congenital Heart Disease 2021年第3期16卷 233-244页

作者： Se Yong jung Doyoung jung Ah Young kim Jae Hee Seol jung Min Park jo Won jung Jae Young Choi Division of Pediatric Cardiology Congenital Heart Disease CenterSeverance Cardiovascular HospitalDepartment of PediatricsYonsei University College of MedicineSeoulKorea

Purpose:This study examined the efficacy and safety of selexipag in treating pulmonary arterial hypertension(PAH)associated with congenital heart disease(CHD).Materials and Methods:We conducted a retrospective study of patients with CHD-associated PAH,treated with selexipag since December *** adult patients(mean age,45.4 years;women,77%)were treated with selexipag as add-on *** characteristics,World Health Organization functional class,6-minute walking distance(6MWD)test results,N-terminal pro-B-type natriuretic peptide levels,echocardiographic data,and incidence of side effects were ***:The majority of patients(12/13,92.3%)experienced more than one treatment-associated complication;one patient dropped out of the study due to intolerable *** results of 6MWD test(from 299.2±56.2 m to 363.8±86.5 m,p=0.039)and tricuspid regurgitation(TR)pressure gradient(from 84.7±20.5 mmHg to 61.6±24.0 mmHg,p=0.018)improved and remained improved after selexipag treatment in 12 *** on the results of a non-invasive risk assessment,8(66.7%)patients showed improvement,3(25.0%)showed no interval change,and the status of one patient(8.3%)***,compared to patients treated with a low dosage,patients treated with a medium-to-high dosage showed a greater increase in 6MWD results(88.3±26.4 m vs.55.3±27.6 m,p=0.043)and a greater reduction in the TR pressure gradient(-33.7±10.9 mmHg vs.-12.5±12.0 mmHg,p=0.015).Conclusion:Selexipag is an efficient pulmonary vasodilator as add-on therapy in treating CHD-associated PAH.

关键词： Selexipag congenital heart disease pulmonary arterial hypertension

Coral-Like Yolk–Shell-Structured Nickel Oxide/Carbon Composite Microspheres for High-Performance Li-Ion Storage Anodes

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Nano-Micro Letters 2019年第1期11卷 46-63页

作者： Min Su jo Subrata Ghosh Sang Mun Jeong Yun Chan Kang jung Sang Cho Department of Engineering Chemistry Chungbuk National University Department of Chemical Engineering Chungbuk National University Department of Materials Science and Engineering Korea University

In this study, coral?like yolk–shell?structured NiO/C composite microspheres(denoted as CYS?NiO/C) were prepared using spray pyrolysis. The unique yolk–shell structure was characterized, and the formation mechanism of the structure was proposed. Both the phase separation of the polyvinylpyrrolidone and polystyrene(PS) colloidal solution and the decompo?sition of the size?controlled PS nanobeads in the droplet played crucial roles in the formation of the unique coral?like yolk–shell structure. The CYS?NiO/C microspheres delivered a reversible discharge capacity of 991 mAh g^(-1) after 500 cycles at the current density of 1.0 A g^(-1). The dis?charge capacity of the CYS?NiO/C microspheres after the 1000 th cycle at the current density of 2.0 A g^(-1) was 635 mAh g^(-1), and the capacity retention measured from the second cycle was 91%. The final discharge capacities of the CYS?NiO/C microspheres at the current densities of 0.5, 1.5, 3.0, 5.0, 7.0, and 10.0 A g^(-1) were 753, 648, 560, 490, 440, and 389 mAh g^(-1), respectively. The synergetic e ect of the coral?like yolk–shell structure with well?defined interconnected mesopores and highly conductive carbon resulted in the excellent Li+?ion storage properties of the CYS?NiO/C microspheres.

关键词： Yolk-shell Nickel oxide Carbon composite Anode materials Spray pyrolysis Lithium-ion batteries

Development of temperature-robust damage factor based on sensor fusion for a wind turbine structure

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Frontiers of Structural and Civil Engineering 2015年第1期9卷 42-47页

作者： jong-Woong PARK Sung-Han SIM Jin-Hak YI Hyung-jo jung Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Urbana IL 61801 USA School of Urban and Environmental Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan 689- 798Republic of Korea Coastal Development & Ocean Engineering Research Division Korea Institute of Ocean Science and Technology Ansan 426-744Republic of Korea Department of Civil and Environmental Engineering KAIST Daejeon 305-701 Republic of Korea

Wind power systems have gained much attention due to the relatively high reliability, maturity in technology and cost competitiveness compared to other renewable alternatives. Advances have been made to increase the power efficiency of the wind turbines while less attention has been focused on structural integrity assessment of the structural systems. Vibration-based damage detection has widely been researched to identify damages on a structure based on change in d^mmic characteristics. Widely spread methods are natural frequency-based, mode shape-based, and curvature mode shape-based methods. The natural frequency-based methods are convenient but vulnerable to environmental temperature variation which degrades damage detection capability; mode shapes are less influenced by temperature variation and able to locate damage but requires extensive sensor instrumentation which is costly and vulnerable to signal noises. This study proposes novelty of damage factor based on sensor fusion to exclude effect of temperature variation. The combined use of an accelerometer and an inclinometer was considered and damage factor was defined as a change in relationship between those two measurements. The advantages of the proposed method are： 1） requirement of small number of sensor, 2） robusmess to change in temperature and signal noise and 3） ability to roughly locate damage. Validation of the proposed method is carried out through numerical simulation on a simplified 5 MW wind turbine model.

关键词： sensor fusion damage detection structural health monitoring