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Survival improvement and prognostic factors in recent management of extrahepatic cholangiocarcinoma:A single-center study

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 153-156页

作者： jung Wan Choe Hyo jung kim Jae Seon kim Division of Gastroenterology Department of Internal MedicineKorea University Ansan HospitalKorea University College of Medicine516 Gojan-dongDanwon-guAnsan-siGyeonggi-do15355Korea Division of Gastroenterology Department of Internal MedicineKorea University Guro HospitalKorea University College of Medicine148 Gurodong-roGuro-guSeoul 08308Korea

Background:Cholangiocarcinoma was considered as a dismal disease with very poor prognosis until *** is increasingly found due to increased life *** surgical and medical management were advanced recently,data on the prognosis,especially extrahepatic cholangio-carcinoma(ECC),were *** study aimed to identify clinicopathologic features and prognosis of patients with ***:Patients followed up and diagnosed with ECC between January 2014 and December 2016 at a tertiary hospital were included,whereas those with intrahepatic cholangiocarcinoma,gallbladder cancer,and ampullary cancer were ***:A total of 83 patients were followed after the treatment(49 men and 34 women;median age 73.3 years).Cancer location was classified as distal common bile duct(25 patients),proximal com-mon bile duct(24 patients),common hepatic duct(20 patients),and hilar(14 patients).About 14.5%of patients had history of another malignant neoplasm,and 24.1%patients had chronic ***-cal resection was performed in 54 patients(65%)and dysplasia was combined in 63%(34/54).Adjuvant chemotherapy was performed in 54%(29/54),but only 7 underwent palliative chemotherapy in 29 non-surgical *** median overall survival in all patients was 30.9 *** analyzing the treatment modality,median survival of adjuvant chemotherapy,surgery only,palliative chemotherapy,and support-ive care groups were 42.9,30.9,12.0,and 8.9 months,respectively(P<0.05).In the Cox regression analy-sis of survival,age,surgical resection,chemotherapy,and comorbidity were significant prognostic factors,and the comorbidity was the only significant prognostic factor in the multivariable analysis(hazard ratio[HR]=2.80;95%CI:1.32–5.95;P=0.007).In a subgroup analysis of surgical patients,the presence of dysplasia was a favorable prognostic factor in the multivariable analysis(HR=0.29;95%CI:0.09–0.91;P=0.033).Conclusions:The overall survival of patients with ECC wa

关键词： Cholangiocarcinoma Survival Prognosis

Yolk-shell-structured （***.s）9S8 solid-solution powders：Synthesis and application as anode materials for Na-ionbatteries

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Nano Research 2017年第9期10卷 3178-3188页

作者： jung Hyun kim Yun Chan Kang Department of Materials Science and Engineering Korea University Anam-Dong Seongbuk-Gu Seou1136-713 Republic of Korea

Multicomponent metal sulfide materials with a yolk–shell structure and a single phase were studied for the first time as anode materials for sodium-ion batteries. Yolk–shell-structured Fe–Ni–O powders with a molar ratio of iron and nickel components of 1/1 were prepared via one-pot spray pyrolysis. The prepared Fe–Ni–O powders were transformed into yolk–shell-structured (Fe0.5Ni0.5)9S8 solid-solution powders via a sulfidation process. The initial discharge and charge capacities of the (Fe0.5Ni0.5)9S8 powders at a current density of 1 A·g−1 were 601 and 504 mA·h·g−1, respectively. The discharge capacities of the (Fe0.5Ni0.5)9S8 powders for the 2nd and 100th cycle were 530 and 527 mA·h·g−1, respectively, and their corresponding capacity retention measured from the 2nd cycle was 99%. The (Fe0.5Ni0.5)9S8 powders had high initial discharge and charge capacities at a low current density of 0.1 A·g−1, and the reversible discharge capacity decreased slightly from 568 to 465 mA·h·g−1 as the current density increased from 0.1 to 5.0 A·g−1. The synergetic effect of the novel yolk–shell structure and the multicomponent sulfide composition of the (Fe0.5Ni0.5)9S8 powders resulted in excellent sodium-ion storage performance.

关键词： metal sulfide multicomponent sulfide yolk–shell sodium-ion batteries spray pyrolysis

High performance of TiO_(2)/Cu_(x)O photoelectrodes for regenerative solar energy storage in a vanadium photoelectrochemical cell

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Green Energy & Environment 2022年第4期7卷 704-711页

作者： Harin Yoo Doohwan Lee jung Hyeun kim Department of Chemical Engineering University of Seoul163 SiripdaeroDongdaemun-guSeoul02504South Korea

Photocatalysts for harvesting solar energy to either electricity or chemical fuels have attracted much attention recently, but they have big obstacles such as wide bandgaps and rapid charge recombinations to overcome for final applications. In this study, we investigates a useful method to utilize vanadium redox pairs, which are commonly applied for vanadium redox flow batteries, to diminish charge recombinations and thus to enhance photocurrent response in regenerative solar energy storage. The results reveal significant improvements in photocurrent density by forming cuprous and cupric oxides in TiO_(2)/Cu_(x)O electrodes under solar AM 1.5 illuminations using the vanadium photoelectrochemical storage cell at 0.025 mol L^(-1) of vanadium redox species in the acid electrolytes. In addition, the stabilized photocurrent density of the copper content optimized TiO_(2)/Cu_(x)O electrodes is almost tripled from the TiO_(2) only electrode because the charge recombinations can be mitigated with the content optimized TiO_(2)/Cu_(x)O electrodes. Therefore, the optimized TiO_(2)/Cu_(x)O electrode results in the highest charge storing performance in the catholyte chamber, and the roles of vanadium redox species are also clearly demonstrated.

关键词： Photocatalyst Photoelectrochemical Copper oxide Charge recombination Redox pairs

Direct synthesis of highly conductive poly（3,4- ethylenedioxythiophene）：poly（4-styrenesulfonate）（PEDOT：PSS）/graphene composites and their applications in energy harvesting systems

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Nano Research 2014年第5期7卷 717-730页

作者： Dohyuk Yoo Jeonghun kim jung Hyun kim Department of Chemical and Biomolecular Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seou1120-749 Republic of Korea Electronic Materials Division R&D Center Dongjin Semichem Co. Ltd. 625-3 Yodang-Ri Yanggam-Myeon Hwaseong-Gun Gyeonggi-Do Republic of Korea

We report for the first time highly conductive poly（3,4-ethylenedioxythiophene）： poly（4-styrenesulfonate）（PEDOT：PSS）/graphene composites fabricated by in situ polymerization and their applications in a thermoelectric device and a platinum （Pt）-free dye-sensitized solar cell （DSSC） as energy harvesting systems. Graphene was dispersed in a solution of poly（4-styrenesulfonate）（PSS） and polymerization was directly carried out by addition of 3,4-ethylenedioxythiophene （EDOT） monomer to the dispersion. The content of the graphene was varied and optimized to give the highest electrical conductivity. The composite solution was ready to use without any reduction process because reduced graphene oxide was used. The fabricated film had a conductivity of 637 ***-1, corresponding to an enhancement of 41%, after the introduction of 3 wt.% graphene without any further complicated reduction processes of graphene being required. The highly conductive composite films were employed in an organic thermoelectric device, and the device showed a power factor of 45.7 μW·m^-1K^-2 which is 93% higher than a device based on pristine PEDOT：PSS. In addition, the highly conductive composite films were used in Pt-free DSSCs, showing an energy conversion efficiency of 5.4%, which is 21% higher than that of a DSSC based on PEDOT：PSS.

关键词： direct synthesis conductive polymer graphene composite thermoelectric material dye-sensitized solar cell

Significance of dysplasia in bile duct resection margin in patients with extrahepatic cholangiocarcinoma:A retrospective analysis

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World Journal of Clinical Cases 2022年第10期10卷 3078-3087页

作者： jung Wan Choe Hyo jung kim Jae Seon kim Department of Internal Medicine Korea University Ansan HospitalKorea University College of MedicineAnsan 15355South Korea Department ofInternal Medicine Korea University Guro HospitalKorea University College of MedicineSeoul 08308South Korea Department ofInternal Medicine Korea University Guro Hospital2

BACKGROUND Radical resection is the only indicator associated with survival in extrahepatic cholangiocarcinoma(EHCC).However,limited data are available regarding the implications of dysplasia at the resection margin following *** To evaluate the prognostic significance of dysplasia-positive margins in patients diagnosed with *** We reviewed the records of patients who had undergone surgery for EHCC with curative intent between January 2013 and July *** retrospectively analyzed the clinicopathological data of 116 patients followed for longer than 3 *** status of resection margin was used to classify patients into negative low-grade dysplasia(LGD)and high-grade dysplasia(HGD)/carcinoma in situ(CIS)*** Based on postoperative status,72 patients underwent resection with negative margins,19 had LGD-positive margins,and 25 showed HGD/CIS-positive *** mean survival rates of the patients with negative margins,LGD margins,and HGD/CIS margins were 49.1±4.5,47.3±6.0,and 20.8±4.4 mo,respectively(P70 years and HGD/CIS-positive margins were significant independent factors for survival(hazard ratio=1.90 and 2.47,respectively).CONCLUSION HGD/CIS margin in resected EHCC is associated with a poor ***,the LGDpositive resection margin is not a significant indicator of survival in patients with EHCC.

关键词： Dysplasia Cholangiocarcinoma Survival Extrahepatic cholangiocarcinoma Low-grade dysplasia High-grade dysplasia

Fabrication of Piezoelectric Cellulose Paper and Audio Application

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Journal of Bionic Engineering 2009年第1期6卷 18-21页

作者： jung-Hwan kim Sungryul Yun Joo-Hyung kim Jaehwan kim Creative Research Center for EAPap Actuator Department of Mechanical EngineeringINHA University253 Young-Hyun DongNam GuIncheon402-751Republic of Korea

We report the fabrication process of piezoelectric cellulose paper and the enhancement method of its piezoelectric property. Stretching method with different wet-drawing ratios was introduced to increase the piezoelectric property of cellulose paper during regeneration *** is observed that the Young's modulus and the piezoelectric charge constants are very dependent on the drawing ratio and the direction of nanofibrils of piezoelectric *** the enhanced piezoelectric property,we prove that the flexible regenerated piezoelectric cellulose can be applied to the potential acoustic applications such as thin piezoelectric paper speaker.

关键词： piezoelectric speaker piezoelectricity cellulose wet-drawing process

Slip-enhanced Reverse Electrodialytic Power Generation in Ion-selective Nanochannels

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Journal of Thermal Science 2013年第1期22卷 36-41页

作者： Byeongdong Kang Jaisuk Yoo Hyun jung kim Dong-Kwon kim Department of Mechanical Engineering Ajou University

Power generation by reverse electrodialysis in ion-selective nanochannels is numerically investigated. Especially,in the present study, the influence of hydrodynamic slip at the surface of nanochannels is investigated. The current-potential characteristics of the nanochannels are calculated by solving several governing equations:Nernst-Planck equation for the ionic concentrations, the Poisson equation for the electric potential, and the Navier-Stokes equation for the diffusioosmotic flow. Hydrodynamic slip is applied as the boundary condition at the surface of nanochannels. As the slip length increases, the diffusioosmotic flow velocity and electrical conductance of ions increase because the friction at the surface of nanochannels decreases. It is shown that the power generation is enhanced by 44% with a moderate 100nm slip length by using a nanochannel with 10nm height.

关键词： Reverse electrodialysis Ion-selective nanochannel Power generation Slip length

Multi-View Multi-Modal Head-Gaze Estimation for Advanced Indoor User Interaction

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Computers, Materials & Continua 2022年第3期70卷 5107-5132页

作者： jung-Hwa kim Jin-Woo Jeong Department of Computer Engineering Kumoh National Institute of TechnologyGumi39177Korea Department of Data Science Seoul National University of Science and TechnologySeoul01811Kore

Gaze estimation is one of the most promising technologies for supporting indoor monitoring and interaction ***,previous gaze estimation techniques generally work only in a controlled laboratory environment because they require a number of high-resolution eye *** makes them unsuitable for welfare and healthcare facilities with the following challenging characteristics:1)users’continuous movements,2)various lighting conditions,and 3)a limited amount of available *** address these issues,we introduce a multi-view multi-modal head-gaze estimation system that translates the user’s head orientation into the gaze *** proposed system captures the user using multiple cameras with depth and infrared modalities to train more robust gaze estimators under the aforementioned *** this end,we implemented a deep learning pipeline that can handle different types and combinations of *** proposed system was evaluated using the data collected from 10 volunteer participants to analyze how the use of single/multiple cameras and modalities affect the performance of head-gaze *** various experiments,we found that 1)an infrared-modality provides more useful features than a depth-modality,2)multi-view multi-modal approaches provide better accuracy than singleview single-modal approaches,and 3)the proposed estimators achieve a high inference efficiency that can be used in real-time applications.

关键词： Human-computer interaction deep learning head-gaze estimation indoor monitoring

Patient safety culture and handoff evaluation of nurses in small and medium-sized hospitals

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International Journal of Nursing Sciences 2021年第1期8卷 58-64,I0004页

作者： jung Hee kim jung Lim Lee Eun Man kim Department of Nursing Science Shinsung UniversityChungnamSouth Korea Department of Nursing Daejeon UniversityDaejeonSouth Korea Department of Nursing Science Sun Moon UniversityChungnamSouth Korea

Objectives:This study was conducted to investigate the current status of handoffs,perception of patient safety culture,and degrees of handoff evaluation in small and medium-sized hospitals and identified factors that make a difference in handoff ***:This is a descriptive study.425 nurses who work at small and medium-sized hospitals in South Korea were included in our *** completed a set of self-reporting questionnaires that evaluated demographic data,handoff-related characteristics,perception of patient safety culture,and handoff ***:Results showed that the overall score of awareness of a patient safety culture was 3.65±0.45,the level was *** score of handoff evaluation was 5.24±*** nurses experienced errors in handoff and most nurses had no guidelines and checklist in the *** evaluation differed significantly according to the level of education,work patterns,duration of hospital employment,handoff method,degree of satisfaction with the current handoff method,errors occurring at the time of handoff,handoff guidelines,and appropriateness of handoff education time(P<0.05).Conclusion:For handoff improvement,guidelines and standards should be *** is necessary to develop a structured handoff education *** formal handoff education should be implemented to spread knowledge uniformly.

关键词： Evaluation studies Handoff Hospital nursing staff Patient safety