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Periportal thickening on magnetic resonance imaging for hepatic fibrosis in infantile cholestasis

World Journal of Gastroenterology 2020年第21期26卷 2821-2830页

作者： Myung Hwan lee hyun Joo Shin Haesung Yoon Seok Joo Han Hong Koh Mi-jung lee Department of Radiology Severance HospitalSeverance Pediatric Liver Disease Research GroupResearch Institute of Radiological ScienceYonsei University College of MedicineSeoul 03722South Korea Department of Surgery Severance HospitalSeverance Pediatric Liver Disease Research GroupYonsei University College of MedicineSeoul 03722South Korea Division of Gastroenterology Hepatology and NutritionDepartment of PediatricsSeverance Children’s HospitalSeverance Pediatric Liver Disease Research GroupYonsei University College of MedicineSeoul 03722South Korea

BACKGROUND Untreated neonatal cholestasis can progress to liver cirrhosis and end stage liver disease in infancy due to prolonged hepatocyte and biliary tree injury and may require liver ***,non-invasive evaluation of hepatic fibrosis is important in infants with *** To investigate the usefulness of periportal thickening(PT)measured on liver magnetic resonance imaging(MRI)for the assessment of hepatic fibrosis in infants with cholestasis including biliary atresia(BA).METHODS This retrospective study included infants less than 6 mo who underwent liver MRI and biopsy for the evaluation of infantile *** and spleen size were measured on *** assessment was based on aspartate transaminase to platelet ratio index(APRI).The grade of histopathologic fibrosis was assessed by the METAVIR grading *** and diagnostic performance of PT,normalized spleen size ratio(SR,using the upper normal size limit),and APRI for diagnosing hepatic fibrosis were obtained by receiveroperating characteristic(ROC)curve *** A total of 155 patients were included,110 of which were diagnosed with *** age at the time of MRI was 57.6±34.4 *** were positive correlations between fibrosis grade and PT and SR,even after adjusting age(all,P<0.001).For the diagnosis of significant fibrosis(METAVIR grade F2-F4),the area under the ROC curve was 0.899(95%CI:0.840–0.941)for PT(cutoff,4.2 mm),which was higher than 0.741(95%CI:0.664–0.808)for SR and 0.712(95%CI:0.634–0.782)for APRI(both,P<0.001).For the diagnosis of cirrhosis(F4),the area under the ROC curve was the highest with SR as 0.790(95%CI:0.718–0.852).CONCLUSION Liver MRI findings of PT and SR are useful to assess clinically significant hepatic fibrosis(F2 and higher)in infants with cholestasis including BA.

关键词： Infants Cholestasis Biliary atresia Liver Fibrosis Magnetic resonance imaging

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A case with acute-on-chronic liver failure receiving liver transplantation during daclatasvir and asunaprevir therapy in chronic hepatitis C patient

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Gastroenterology Report 2019年第5期7卷 371-373,I0003页

作者： Wonhyeong Park Jihwan jung Soo hyun Yang Danbi lee Hyo Jeong Kang Department of Internal Medicine Veterans Health Service Medical CenterSeoulKorea Department of Internal Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

We report a case with hepatitis C virus genotype 1 b liver cirrhosis who received liver transplantation because of acute-onchronic liver failure during daclatasvir(DSV)and asunaprevir(ASV)combination *** our knowledge,this is the first case received liver transplantation during DSVtASV ***,clinicians should pay particular attention to the possibility of acute liver failure during DSV and ASV combination therapy.

关键词： Chronic hepatitis C liver failure:daclatasvir asunaprevir

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Sorption enhanced catalytic CF4 hydrolysis with a three-stage catalyst-adsorbent reactor

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Frontiers of Chemical Science and Engineering 2017年第4期11卷 537-544页

作者： Han, Jae-Yun Kim, Chang-hyun lee, Boreum Nam, Sung-Chan jung, Ho-Young Lim, Hankwon lee, Kwan-Young Ryi, Shin-Kun Advanced Materials and Devices Laboratory Korea Institute of Energy Research (KIER) Daejeon Korea Department of Chemical and Biological Engineering Korea University Seoul Korea Department of Advanced Materials and Chemical Engineering Catholic University of Daegu Gyeongbuk Korea Department of Environment and Energy Engineering Chonnam National University Gwangju Korea

In this study, we developed a three-stage catalyst-adsorbent reactor for the catalytic hydrolysis of CF4. Each stage is composed of a catalyst bed followed by an adsorbent bed using Ca（OH）2 to remove HF. The three stages are connected in series to enhance the hydrolysis of CF4 and eliminate a scrubber to dissolve HF in water at the same time. With a 10 wt-% Ce/AlaO3 catalyst prepared by the incipient wetness method using boehmite and a granular calcium hydroxide as an adsorbent, the CF4 conversion in our proposed reactor was 7%-23% higher than that in a conventional single-bed catalytic reactor in the temperature range of 923-1023 K. In addition, experimental and numerical simulation （Aspen HYSYS） results showed a reasonable trend of increased CF4 conversion with the adsorbent added and these results can be used as a useful design guideline for our newly proposed multistage reactor system.

关键词： PFCs catalytic hydrolysis calcium hydro-xide sorption enhanced process simulation

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Adaptive Consistent Management to Prevent System Collapse on Shared Object Manipulation in Mixed Reality

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Computers, Materials & Continua 2023年第4期75卷 2025-2042页

作者： Jun lee hyun Kwon Department of Game Software Hoseo UniversityAsan-siKorea Department of Artificial Intelligence and Data Science Korea Military AcademySeoulKorea

A concurrency control mechanism for collaborative work is akey element in a mixed reality environment. However, conventional lockingmechanisms restrict potential tasks or the support of non-owners, thusincreasing the working time because of waiting to avoid conflicts. Herein, wepropose an adaptive concurrency control approach that can reduce conflictsand work time. We classify shared object manipulation in mixed reality intodetailed goals and tasks. Then, we model the relationships among goal,task, and ownership. As the collaborative work progresses, the proposedsystem adapts the different concurrency control mechanisms of shared objectmanipulation according to the modeling of goal–task–ownership. With theproposed concurrency control scheme, users can hold shared objects andmove and rotate together in a mixed reality environment similar to realindustrial sites. Additionally, this system provides MS Hololens and Myosensors to recognize inputs from a user and provides results in a mixed realityenvironment. The proposed method is applied to install an air conditioneras a case study. Experimental results and user studies show that, comparedwith the conventional approach, the proposed method reduced the number ofconflicts, waiting time, and total working time.

关键词： Mixed reality upper body motion recognition shared object manipulation adaptive task concurrency control

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Contrast-enhanced ultrasound in the diagnosis of nodules in liver cirrhosis

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World Journal of Gastroenterology 2014年第13期20卷 3590-3596页

作者： Tae Kyoung Kim hyun-jung Department of Medical Imaging Toronto General HospitalUniversity of TorontoToronto ON M5G 2N2Canada

Contrast-enhanced ultrasound(CEUS)using microbubble contrast agents are useful for the diagnosis of the nodules in liver *** can be used as a problem-solving method for indeterminate nodules on computed tomography(CT)or magnetic resonance imaging(MRI)or as an initial diagnostic test for small newly detected liver *** has unique advantages over CT and MRI including no renal excretion of contrast,real-time imaging capability,and purely intravascular *** carcinoma(HCC)is characterized by arterial-phase hypervascularity and later washout(negative enhancement).Benign nodules such as regenerative nodules or dysplastic nodules are usually isoechoic or slightly hypoechoic in the arterial phase and isoechoic in the late ***,there are occasional HCC lesions with atypical enhancement including hypovascular HCC and hypervascular HCC without *** are infrequently detected during HCC surveillance and mostly show rimlike or diffuse hypervascularity followed by rapid *** are often found at HCC surveillance and are easily diagnosed by *** can be effectively used in the diagnostic work-up of small nodules detected at HCC *** is also useful to differentiate malignant and benign venous thrombosis and to guide and monitor the local ablation therapy for HCC.

关键词： Hepatocellular carcinoma Liver cirrhosis Dysplastic nodule Contrast ultrasound Imaging

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Stick-and-play system based on interfacial adhesion control enhanced by micro/nanostructures

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Nano Research 2021年第9期14卷 3143-3158页

作者： jung II Yoo Seung hyun Kim Heung Cho Ko School of Materials Science and Engineering Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea

The evolution of membrane-type electronics has facilitated the development of stick-and-play systems,which confer diverse electrical functions to various planar or arbitrary curvilinear *** stick-and-play concept is based on the development of thin electronic devices in a printable format and their subsequent transfer to target *** development of this technology requires control of the interfacial adhesion of the electronic prints for retrieval from a carrier and transfer to the target ***,we discuss the transfer printing for membrane-type electronics,starting from an overview of materials available for flexible substrates,transfer printing of electronic prints for retrieval,and assembly for further ***,we explain the stick-and-play concept based on fabricated membrane-type electronics;"stick" and “play"refer to the transfer of electronic devices and the performance of their electronic functions,*** particular,we broadly survey various methods based on micro/nanostructures,including gecko-inspired,interlocking,cephalopod-sucker-inspired,and cilia structures,which can be employed to stick-and-play systems for enhancing interfacial adhesion with complex target surfaces under dynamic and wet ***,we highlight the stick-and-play system application of micro/nanostructures for skin-attachable biomedical electronics,e-textiles,and environmental monitoring electronics.

关键词： transfer printing interfacial adhesion flexible electronics stick-and-play system bioinspired adhesive

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Small but big leaps towards neuroglycomics:exploring N-glycome in the brain to advance the understanding of brain development and function

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Neural Regeneration Research 2024年第3期19卷 489-490页

作者： Boyoung lee hyun Joo An Center for Cognition and Sociality Institute for Basic Science(IBS)DaejeonSouth Korea Asia-Pacific Glycomics Reference Site DaejeonSouth Korea Graduate School of Analytical Science&Technology Chungnam National UniversityDaejeonSouth Korea

Glycosylation is a process that involves the addition of sugar moieties or glycans to different types of molecules,including proteins,lipids,and nucleic *** these,protein glycosylation is one of the most prevalent forms of post-translational modification,playing a crucial role in biological *** more than ten monosaccharides identified within mammalian brain cells and more than 1×1012 possible combinations,the heterogeneity of glycosylation is extensive(Conroy et al.,2021).The diversity of glycans and the complexity of their structures allow for a wide range of protein functions.N-glycans are one of the most abundant forms of glycans and are involved in various cellular functions.N-glycans can be added to proteins at specific sequons,Asn-X-Ser/Thr,and are classified into three main types in mature glycoproteins:high mannose,complex,and *** mannose N-glycans consist of 5-9 mannose residues linked to a chitobiose core and undergo processing into complex or hybrid forms in the Golgi apparatus(Varki et al.,2017).Complex N-glycans are more diverse and contain various branched structures such as antennae with fucose,galactose,and sialic acid *** N-glycans contain one or more complex branches in conjunction with an oligomannose branch(Fisher and Ungar,2016).Understanding the specific functions of these different types of N-glycans in protein regulation,folding,and function is an active area of research in the life sciences,including glycobiology.

关键词： functions function apparatus

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Anti-MMP-2 and MMP-9 activity of Salsola komarovii Iljin extract and its solvent fractions

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Asian Pacific Journal of Tropical Biomedicine 2020年第10期10卷 460-469页

作者： jung-Ha Kil Fatih Karadeniz Ga hyun Yu Hojun Kim Junse Kim jung Hwan Oh jung Im lee Chang-SukKong Youngwan Seo Marine Biotechnology Center for Pharmaceuticals and Foods Silla UniversityBaegyang-daero 700 beon-gil 140Sasang-guBusan 46958Korea Department of Food and Nutrition College of Medical and Life SciencesSilla UniversityBaegyang-daero 700 beon-gil 140Sasang-guBusan 46958Korea Division of Marine Bioscience Korea Maritime and Ocean UniversityBusan 49112Korea

Objective: To investigate matrix metalloproteinases(MMP)-2 and MMP-9 inhibitory effect of Salsola komarovii Iljin, an edible halophyte with health beneficial ***: Salsola komarovii crude extracts(SKI), and solvent(n-hexane, 85% aq. MeOH, n-BuOH, and H2O) fractionated extracts of SKI were prepared. Gelatin zymography was carried out to observe MMP enzymatic activity. The release of the MMP enzymes was measured by enzyme-linked immunosorbent assay. Expression of MMPs in m RNA and protein level were investigated by polymerase chain reaction analysis and immunoblotting, ***: SKI and SKI fractions inhibited active MMP-2 and MMP-9 amount in the treated cell culture medium. Also, SKI suppressed the release of MMP-2 and MMP-9 from stimulated HT1080 human fibrosarcoma cells. Furthermore, SKI suppressed the m RNA and protein expression of MMP-2 and MMP-9. SKI fractions showed parallel effects except for H2O fraction which did not yield any significant MMP inhibitory effect. Among fractions, 85% aq. Me OH was the most active fraction to inhibit both the enzymatic effect and expression of MMP-2 and ***: SKI may contain potential MMP release inhibitory compounds. Salsola komarovii is a promising source of compounds against MMP and could be utilized in the development of antitumor agents.

关键词： release utilized effect

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Unraveling the role of METTL14 in metabolic dysfunction-associated fatty liver disease:insights and therapeutic implications

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1781-1783页

作者： So jung Kim Jeongeun hyun Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonanRepublic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonanRepublic of Korea Mechanobiology Dental Medicine Research Center College of DentistryDankook UniversityCheonanRepublic of Korea

The recent article published in Signal Transduction and Targeted Therapy sheds light on the significance of N6-methyladenosine(m6A)methyltransferase-like protein METTL14 in mitigating the progression of metabolic dysfunction-associated fatty liver disease(MAFLD).1 In this study,Wang et *** the downregulation of METTL14 in hepatocytes from both MAFLD patients and high-fat diet(HFD)-induced MAFLD mouse models,underscoring its pivotal role in maintaining hepatic lipid and redox homeostasis in normal livers.

关键词： liver homeostasis al.

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Mobile lens- induced angle closure glaucoma and rubeosis iridis in Sturge Weber syndrome

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 1080-1082页

作者： Dong hyun lee Jonghoon Shin Jae hyun Seo Ik Soo Byon Jae Ho jung Ji Eun lee Department of Ophthalmology Pusan National University Yangsan Hospital Department of Ophthalmology Pusan National University Hospital Research Institute for Convergence of Biomedical Science and Technology Yangsan Pusan National University Hospital Medical Institute School of MedicinePusan National University

Dear Sir,I am Dong hyun lee from the Department of Ophthalmology at the Pusan National University Yangsan Hospital,Yangsan,***,I present the development of a lens-induced angle closed glaucoma and iris neovascularization in the patient with Sturge Weber syndrome(SWS)with open angle *** consent was obtained from a patient before each procedure The study was conducted in accordance with the tenets of the Declaration of Helsinki.

关键词： induced angle closure glaucoma and rubeosis iridis in Sturge Weber syndrome SWS open IOP Mobile lens Figure

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