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Radiolabeling and evaluation of ^(188)Re-RGD as an agent for α_vβ_3 receptor expression

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Nuclear Science and Techniques 2012年第1期23卷 47-51页

作者： yufei MA junfeng yu Cheng WANG Hua SHEN Hua WU Department of Nuclear Medicine the First affiliataed HospitalXiamen University55 Zhenhai Rd.Xiamen 361003China Centre of Radiopharmaceutical Research Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghai 201800China

Integrin αvβ3,a cell adhesion molecule,plays a key role in angiogenesis and tumor cell metastasis and is therefore an important target for new therapeutic and diagnostic *** RGD bind to αvβ3 particularly,a lot of RGD containing peptides were radiolabeled and evaluated as imaging or therapeutic *** this study,a new 188Re-RGD peptide analog was synthesized and *** 30min,the 188Re-H-E[c(RGDyK)]2 was obtained in radiochemical purity of better than 95%.The His-E[c(RGDyK)]2 had a good integrin-binding affinity (50% inhibitiory concentracer (IC50=46.5×10-9 nm) and exhibited active accumulation (7.20±1.06) in S180 *** of relatively fast washout in blood and normal tissues,the target/non-target ratio was *** experiments to improve the tumor targeting efficacy and in vivo kinetic profiles are in progress towards developing it into a promising radio agent.

关键词：放射性标记 AV RGD序列评价代理受体细胞粘附分子肿瘤细胞

The mediatory role of water quality on the association between extreme precipitation events and infectious diarrhea in the Yangtze River Basin,China

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Fundamental Research 2024年第3期4卷 495-504页

作者： junfeng yu Liang Zhao Xin-Zhong Liang Hung Chak Ho Masahiro Hashizume Cunrui Huang School of Public Health Sun Yat-sen UniversityGuangzhou 510080China The State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Department of Atmospheric and Oceanic Science University of MarylandCollege ParkMD 20740USA Department of Public and International Affairs City University of Hong KongHong Kong 999077China Department of Global Health Policy Graduate School of MedicineThe University of TokyoTokyo 113-0033Japan Vanke School of Public Health Tsinghua UniversityBeijing 100084China Institute of Healthy China Tsinghua UniversityBeijing 100084China

Extreme precipitation is exacerbating the burden of infectious diarrhea in the context of climate change,it is necessary to identify the critical and easy-to-intervene intermediate factors for public health *** quality may be the most important mediator,while relevant empirical evidence is *** study aimed to examine the role of water quality in the process of infectious diarrhea caused by extreme *** infectious diarrhea cases,meteorological factors and water quality data in Yangtze River Basin in China between October 29,2007 to February 19,2017 were ***-stage statistical models were used to estimate city-specific extreme precipitation,water quality and infectious diarrhea relationships that were pooled to derive regional estimates.A causal mediation analysis was used to assess the mediation effect of water *** Yangtze River Basin,extreme precipitation events had a significant impact on infectious diarrhea(Incidence Rate Ratios[IRR]:1.027,95%Confidence Interval[CI]:1.013~1.041).After extreme precipitation events,the dissolved oxygen(DO)in surface water decreased(-0.123 mg/L,95%CI:-0.159 mg/L~-0.086 mg/L),while the un-ionized ammonia(NH(3)-N)increased(0.004 mg/L,95%CI:0.001 mg/L~0.006 mg/L).The combined overall effect of DO and NH(3)-N on infectious diarrhea showed that both low and high concentrations were associated with an increased risk of infectious *** causal mediation analysis showed that the mediation proportion of the two water quality indexes(DO and NH(3)-N)is 70.54%(P<0.001).To reduce the health effects of extreme precipitation,in contrast to current population-oriented health strategies,those that take into account more direct and easy-to-intervene water quality indicators should be encouraged by future policies.

关键词： Extreme precipitation Infectious diarrhea Water quality Dissolved oxygen Un-ionized ammonia Mediation analysis

Synthesis,crystal structures,electrochemical and spectroscopic properties of ruthenium(Ⅱ) complexes containing diamino-1,3,5-triazine derivatives

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Science China Chemistry 2010年第10期53卷 2099-2105页

作者： CHEN yu, XU WenChao, KOU junfeng, WEI XuHui, yu BoLe, CHAO Hui & JI LiangNian MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China MOE Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry and Chemical Engineering Sun Yat-Sen University Guangzhou China

Three Ru(Ⅱ) complexes [Ru(bpy)2(1-IQTNH)](ClO4)2 (1), [Ru(bpy)2(2-QTNH)](ClO4)2 (2) and [Ru(bpy)2(3-IQTNH)](ClO4)2 (3) (bpy = 2,2′-bipyridine, 1-IQTNH = 6-(isoquinolin-1-yl)-1,3,5-triazine-2,4-diamine, 2-QTNH = 6-(quinolin-2-yl)-1,3,5-triazine-2,4-diamine, 3-IQTNH = 6-(isoquinolin-3-yl)-1,3,5-triazine-2,4-diamine) have been synthesized and characterized by elemental analysis, 1H NMR spectroscopy, electrospray ionization mass spectrometry and X-ray crystallography. The electrochemical and spectroscopic properties of the complexes differ from those of [Ru(bpy)3]2+ owing to the structural differences between the ligands and their complexes.

关键词： ruthenium(Ⅱ) complex diamino-1 3 5-triazine crystal structures electrochemistry spectroscopy

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兰州恐龙园室内馆大跨度网壳结构设计

建筑结构 2021年第S1期51卷 519-523页

作者：于军峰华东建筑设计研究院有限公司都市总院上海200070

兰州恐龙园室内馆为跨度170m的轻质大跨屋面,采用双层网壳实现。总结了上部网壳的结构设计指标;地震工况下补充分析了大震弹塑性分析、屈曲稳定分析;对于抗风设计考虑了数值风洞分析;考虑大跨度施工的难度,对施工方案做了简要介绍。最... 详细信息

兰州恐龙园室内馆为跨度170m的轻质大跨屋面,采用双层网壳实现。总结了上部网壳的结构设计指标;地震工况下补充分析了大震弹塑性分析、屈曲稳定分析;对于抗风设计考虑了数值风洞分析;考虑大跨度施工的难度,对施工方案做了简要介绍。最后对用钢量做了总结。

关键词：轻质大跨屋面双层网壳大震弹塑性分析屈曲稳定分析

Effects of lobaplatin and oxaliplatin on biological behavior of colorectal carcinoma cell line

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The Chinese-German Journal of Clinical Oncology 2010年第1期9卷 36-39页

作者： Xue Bai Bo yu junfeng Du Shujun yuan Fuyi Zuo Liang Sun General Surgery Center of PLA General Hospital of Beijing Command Beijing 100700 China

Objective： The aim of the study was to observe the effects of Iobaplatin and oxaliplatin on biological behavior of colorectal carcinoma cell line. Methods： The human colorectal carcinoma cell line LoVo and HR-8348 were used in the present study, and different concentrations of Iobaplatin and oxaliplatin served as inhibitors. The invasion and metastasis potential were evaluated with Transwell chamber, and cell inhibition ratio was measured with MTT assay. Results： Lobaplatin and oxaliplatin could significantly decrease the abilities of invasion and metastasis of LoVo and HR-8348 as compared with the control group （P 〈 0.01）, but no difference between Iobaplatin and oxaliplatin groups was observed （P 〉 0.05）. No difference was found in the cell inhibition ratio between the Iobaplatin and oxaliplatin groups （P 〉 0.05）. Lobaplatin could inhibit colorectal carcinoma cells that oxaliplatin couldn＇t do. Conclusion： Lobaplatin is a new antitumor platinum drug and can inhibit colorectal carcinoma cells. Moreover, Iobaplatin could also inhibit colorectal carcinoma cells which are resistant to oxaliplatin.

关键词： colorectal cancer oxaliplatin Iobaplatin chemotherapy

Setup of Hematology Quality Control Procedures with Retained Patient Samples

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Setup of Hematology Quality Control Procedures with Retained...

中华医学会第九次全国检验医学学术会议暨中国医院协会临床检验管理专业委员会第六届全国临床检验实验室管理学术会议

作者： WANG HOUFANG,yu junfeng,MU yu,SU NFEI Department of Laboratory Medicine,Beijing United Family Hospital,China

INTRODUCTION Patient blood samples constitute ideal quality control material in many *** principal challenges involve the design of a system which combines excellent performance characteristics with a minimum of extra *** study is to setup a Hematology quality control procedure with retained patient samples. METHODS LH500 Hematology analyzer was

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琼东南盆地2号断裂东带发育特征及形成机理

大地构造与成矿学 2008年第3期32卷 293-299页

作者：于俊峰段如泰中海石油(中国)有限公司湛江分公司广东湛江524057

本文通过2号断裂陵水带、松南带基本结构及特征分析了它自新生代以来特别是古近纪的活动史和构造-沉积发育史。并发现,2号断裂松南带发育比陵水带更加复杂的结构样式,在此基础上,结合该断裂带的深部切片和地震资料,运用断层传播连接热... 详细信息

本文通过2号断裂陵水带、松南带基本结构及特征分析了它自新生代以来特别是古近纪的活动史和构造-沉积发育史。并发现,2号断裂松南带发育比陵水带更加复杂的结构样式,在此基础上,结合该断裂带的深部切片和地震资料,运用断层传播连接热点理论剖析了这种结构的成因,认为2号断裂松南带以L1023测线为界在成因上存在较大差异,这种差异是由早期断陷和所控充填方式都不同的两条断裂交叉连接而成,而且指出了这种成因断裂在油气勘探中应该注意的问题和意义。

关键词：琼东南盆地 2号断裂东带断层活动断层传播断层连接

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有限理性下侦查错误的成因分析及预防

江西警察学院学报 2024年第4期 51-56页

作者：余俊锋中南财经政法大学湖北武汉430073

基于人们对客观世界认识的有限理性和世界物质变化形态的多样性,导致侦查错误发生的原因是多元的,发生侦查错误不仅会使整个侦查活动无法顺利推进,还可能会侵犯犯罪嫌疑人的合法权益。鉴于侦查错误的发生是一种不可避免的客观现象,通过... 详细信息

基于人们对客观世界认识的有限理性和世界物质变化形态的多样性,导致侦查错误发生的原因是多元的,发生侦查错误不仅会使整个侦查活动无法顺利推进,还可能会侵犯犯罪嫌疑人的合法权益。鉴于侦查错误的发生是一种不可避免的客观现象,通过侦查人员对案件认识的有限理性、侦查思维、侦查决策偏差等可能导致侦查错误的原因进行剖析,并从转变侦查思维、纠正侦查决策偏差、提升侦查人员的内在素养等方面提出优化之策,以期为减少侦查错误提供有价值的理论参考。

关键词：有限理性侦查错误侦查决策偏差侦查思维

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中国餐厨垃圾处理的现状、问题和对策

生态学报 2012年第14期32卷 4575-4584页

作者：胡新军张敏余俊锋张古忍中山大学有害生物控制与资源利用国家重点实验室/昆虫学研究所广州510275

餐厨垃圾具有高水分、高盐分、高有机质含量、组分时空差异明显、危害性与资源性并存的特点。目前国内外常用的餐厨垃圾处理技术如焚烧、卫生填埋、生态饲料、厌氧消化、好氧堆肥和蚯蚓堆肥等,通常存在着资源化利用效率低、经济效益不... 详细信息

餐厨垃圾具有高水分、高盐分、高有机质含量、组分时空差异明显、危害性与资源性并存的特点。目前国内外常用的餐厨垃圾处理技术如焚烧、卫生填埋、生态饲料、厌氧消化、好氧堆肥和蚯蚓堆肥等,通常存在着资源化利用效率低、经济效益不够理想的缺陷。总结相关文献及报道,中国在餐厨垃圾资源化处理上存在"行政瓶颈"和"技术瓶颈"两大方面的问题:"行政瓶颈"的解决之道在于完善管理及处理体系,各级政府部门切实重视、加大投入,强力推进垃圾分类投放;而对于"技术瓶颈",除综合运用多种现有处理技术外,开发新技术提高餐厨垃圾的资源化循环利用程度,是关键所在。

关键词：餐厨垃圾资源化循环利用垃圾处理