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Orchestration of energy metabolism and osteogenesis by Mg^(2+)facilitates low-dose BMP-2-driven regeneration

Bioactive Materials 2022年第12期7卷 116-127页

作者： Sihan Lin shi Yin junfeng shi Guangzheng Yang Xutao Wen Wenjie Zhang Mingliang Zhou Xinquan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai JiaoTong University School of MedicineNo.639 Zhizaoju RoadShanghai200011People’s Republic of China College of Stomatology Shanghai JiaoTong UniversityNo.639 Zhizaoju RoadShanghai200011People’s Republic of China National Center for Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China National Clinical Research Center for Oral Diseases No.639 Zhizaoju RoadShanghai200011People’s Republic of China Shanghai Key Laboratory of Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China Shanghai Engineering Research Center of Advanced Dental Technology and Materials No.639 Zhizaoju RoadShanghai200011People’s Republic of China Department of Oral and Maxillofacial Surgery College and Hospital of StomatologyGuangxi Medical UniversityNo.10 Shuangyong RoadQingxiu DistrictNanningGuangxi530021People’s Republic of China

The clinical application of bone morphogenetic protein-2(BMP-2)is limited by several factors,including ineffectiveness at low doses and severe adverse effects at high *** address these efficacy and safety limitations,we explored whether orchestration of energy metabolism and osteogenesis by magnesium ion(Mg^(2+))could reduce the dose and thereby improve the safety of *** results demonstrated that rapid metabolic activation triggered by BMP-2 was indispensable for subsequent ***,inadequate metabolic stimulation was shown to be responsible for the ineffectiveness of low-dose ***,we identified that Mg^(2+),as an"energy propellant",substantially increased cellular bioenergetic levels to support the osteogenesis via the Akt-glycolysis-Mrs2-mitochondrial axis,and consequently enhanced the osteoinductivity of *** on the mechanistic discovery,microgel composite hydrogels were fabricated as low-dose BMP-2/Mg^(2+)codelivery system through microfluidic and 3D printing *** in vivo study further confirmed that rapid and robust bone regeneration was induced by the codelivery ***,these results suggest that this bioenergetic-driven,cost-effective,low-dose BMP-2-based strategy has substantial potential for bone repair.

关键词： Biomaterials Bone morphogenetic protein-2 Magnesium Energy metabolism Bone regeneration

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中草药饲料添加剂在肉牛养殖中的应用

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饲料工业 2024年第15期45卷 16-22页

作者：陈书礼胡张涛高嘉竞康永刚曹健师军锋陈琳胡建宏西北农林科技大学动物科技学院陕西杨凌712100 徐州生物工程职业技术学院江苏徐州221003 洛南县畜牧兽医工作站陕西商洛726100 永寿县动物疫病预防控制中心陕西咸阳713400 大荔县畜牧发展中心陕西渭南715100

随着畜牧业规模化和产业化的发展、全面禁抗时代的到来,肉牛行业对天然安全饲料添加剂的需求与日俱增,研究开发绿色、安全、无公害的替抗产品是肉牛养殖业发展的必然趋势。我国天然中草药资源丰富,且富含多种营养物质,被广泛应用于肉牛... 详细信息

随着畜牧业规模化和产业化的发展、全面禁抗时代的到来,肉牛行业对天然安全饲料添加剂的需求与日俱增,研究开发绿色、安全、无公害的替抗产品是肉牛养殖业发展的必然趋势。我国天然中草药资源丰富,且富含多种营养物质,被广泛应用于肉牛养殖行业中。中草药饲料添加剂具有多重功能,药用机理复杂。它能治病消炎杀菌、调节肠道菌群平衡、促进营养吸收和新陈代谢,提高动物生产性能和免疫机能、饲料消化率和畜产品品质。文章对中草药添加剂活性物质、生物功能以及在肉牛养殖方面的应用进行了综述,旨在为中草药添加剂的广泛应用及肉牛健康养殖提供参考。

关键词：中草药饲料添加剂活性物质肉牛健康养殖

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Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration

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Bone Research 2022年第4期10卷 816-825页

作者： Qianju Wu Longwei Hu Ran Yan junfeng shi Hao Gu Yuwei Deng Ruixue Jiang Jin Wen Xinquan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghaiChina Stomatological Hospital of Xiamen Medical College XiamenFujian 361008China Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghaiChina

The restoration of bone defects caused by osteoporosis remains a challenge for *** ranelate has been applied in preventative treatment approaches due to the biological functions of the trace element strontium(Sr).In this study,we aimed to fabricate bioactive scaffolds through Sr incorporation based on our previously developed modified amino-functional mesoporous bioactive glass(MBG)and to systematically investigate the bioactivity of the resulting scaffold in vitro and in vivo in an osteoporotic rat *** results suggested that Sr-incorporated amino-functional MBG scaffolds possessed favorable ***,with the incorporation of Sr,osteogenic and angiogenic capacities were upregulated in *** in vivo results showed that the Sr-incorporated amino-functional MBG scaffolds achieved better bone regeneration and vessel ***,bioinformatics analysis indicated that the Sr-incorporated amino-functional MBG scaffolds could reduce reactive oxygen species levels in bone marrow mesenchymal stem cells in the osteoporotic model by activating the cAMP/PKA signaling pathway,thus playing an anti-osteoporosis role while promoting *** study demonstrated the feasibility of incorporating trace elements into scaffolds and provided new insights into biomaterial design for facilitating bone regeneration in the treatment of osteoporosis.

关键词： osteoporosis treatment regeneration

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Shale oil and gas exploitation in China:Technical comparison with US and development suggestions

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石油勘探与开发:英文版 2023年第4期50卷 944-954页

作者： LEI Qun WENG Dingwei GUAN Baoshan shi junfeng CAI Bo HE Chunming SUN Qiang HUANG Rui PetroChina Research Institute of Petroleum Exploration&Development Beijing 100083China CNPC Key Laboratory of Oil&Gas Reservoir Stimulation Langfang 065007China

The shale oil and gas exploitation in China is technically benchmarked with the United States in terms of development philosophy,reservoir stimulation treatment,fracturing parameters,fracturing equipment and materials,oil/gas production technology,and data/achievements *** is recognized that the shale oil and gas exploitation in China is weak in seven aspects:understanding of flow regimes,producing of oil/gas reserves,monitoring of complex fractures,repeated stimulation technology,oil/gas production technology,casing deformation prevention technology,and wellbore maintenance *** with the geological and engineering factors of shale oil and gas in China,the development suggestions of four projects are proposed from the macro-and micro-perspective,namely,basic innovation project,exploitation technology project,oil/gas production stabilization project,and supporting efficiency-improvement project,so as to promote the rapid,efficient,stable,green and extensive development of shale oil and gas industry chain and innovation chain and ultimately achieve the goal of“oil volume stabilizing and gas volume increasing”.

关键词： shale oil and gas reservoir stimulation oil/gas production technology oil/gas development philosophy reservoir stimulation treatment flow regime

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1株鹿源布鲁氏菌分离鉴定及遗传进化分析

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经济动物学报 2024年第1期28卷 8-17页

作者：李连民石俊峰李婷刘菲李健明杜锐吉林农业大学动物科学技术学院吉林农业大学中药材学院动物生产及产品质量安全教育部重点实验室吉林省梅花鹿高效养殖和产品开发技术工程研究中心

梅花鹿是我国重要的名贵药用动物，具有较高的药用价值，用途广泛，在大健康产业中具有重要地位。然而，布鲁氏菌病制约了梅花鹿产业的发展。试验从梅花鹿流产胎中分离到1株布鲁氏菌（Brucella），采用常规及分子分型方法进行鉴定。结... 详细信息

梅花鹿是我国重要的名贵药用动物，具有较高的药用价值，用途广泛，在大健康产业中具有重要地位。然而，布鲁氏菌病制约了梅花鹿产业的发展。试验从梅花鹿流产胎中分离到1株布鲁氏菌（Brucella），采用常规及分子分型方法进行鉴定。结果表明：该分离菌株为羊种1型；用MLVA-16方法对分离菌株进行分类及遗传进化分析，结果显示其与地中海型亲缘关系更近，但有4～5个位点不同于其他菌株，表明此鹿源布鲁氏菌分离株可能存在基因变异。试验为鹿布鲁氏菌病的主要流行菌株提供了参考，同时为揭示布鲁氏菌的跨种传播机制提供了新线索。

关键词：梅花鹿鹿源布鲁氏菌分离鉴定遗传进化分析

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Secondary prevention medication persistence and prognosis of acute ischaemic stroke or transient ischaemic attack

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Stroke & Vascular Neurology 2021年第3期6卷 376-383,I0009-I0017页

作者： Lei Zhang junfeng shi Yuesong Pan Zixiao Li Hongyi Yan Chelsea Liu Wei Lv Xia Meng Yongjun Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Changping District Hospital BeijingChina Yixing People’s Hospital Jiangsu ProvinceChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Epidemiology Johns Hopkins Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMarylandUSA

Introduction The risk of disability and mortality is high among recurrent stroke,which highlights the importance of secondary prevention *** aim to evaluate medication persistence for secondary prevention and the prognosis of acute ischaemic stroke or transient ischaemic attack(TIA)in *** Patients with acute ischaemic stroke or TIA from the China National Stroke Registry II were divided into 3 groups based on the percentage of persistence in secondary prevention medication classes from discharge to 3 months after onset(level I:persistence=0%,level II:0%

关键词： prevention medication acute

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基于作业成本法的煤炭企业定额体系建设实践与路径研究

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中国煤炭 2024年第6期50卷 35-43页

作者：袁团辉梁星尚文凯史俊锋袁镇昔龚汉珠张燕波王昆中煤华利能源控股有限公司北京市东城区100011 山西保利裕丰煤业有限公司山西省临汾市042100 中国中煤华利能源控股有限公司山西分公司山西省晋中市031300 山西保利平山煤业股份有限公司山西省晋城市048205

结合煤炭企业实施标准成本管理的需要,基于煤炭企业定额体系建设方法与依据,从划分作业中心、确定定额制定主体、确定定额测算方法以及确定定额计算公式与表现形式4个方面给出了基于作业成本法的定额体系建设流程与方法,并进一步通过算... 详细信息

结合煤炭企业实施标准成本管理的需要,基于煤炭企业定额体系建设方法与依据,从划分作业中心、确定定额制定主体、确定定额测算方法以及确定定额计算公式与表现形式4个方面给出了基于作业成本法的定额体系建设流程与方法,并进一步通过算例分析,对流程和方法进行了验证。最后,从6个方面提出了煤炭企业基于定额标准的成本管理体系建设路径,一是明确定额系统边界,二是划分作业中心并识别资源消耗动因,三是明确基础数据采集粒度,四是确定定额计算公式与表现形式,五是建立动态调整与校准的长效机制,六是建立基于数据融合共享的成本管控数智化平台。

关键词：作业成本法定额体系建设路径煤炭企业

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钙结合双酵母对苹果采后青霉病诱导抗性机制

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食品研究与开发 2024年第10期45卷 84-92页

作者：蔺楠胡俊月丛龙美杜静婷施俊凤张立新山西农业大学食品科学与工程学院山西太原030031

水果含有丰富的营养物质,但其在采后贮藏或运输期易发生侵染性病害而导致果肉腐烂和品质下降,造成严重的经济损失。为筛选抑制效果最佳的CaCl_(2)浓度并探究其与双酵母最佳结合浓度下对苹果果实的抗性诱导机制,该文通过体外接种实验确... 详细信息

水果含有丰富的营养物质,但其在采后贮藏或运输期易发生侵染性病害而导致果肉腐烂和品质下降,造成严重的经济损失。为筛选抑制效果最佳的CaCl_(2)浓度并探究其与双酵母最佳结合浓度下对苹果果实的抗性诱导机制,该文通过体外接种实验确定添加CaCl_(2)后的最佳培养时间为24 h;体内实验表明不同浓度CaCl_(2)诱导双酵母对苹果青霉病均有抑制效果,其中2.0%CaCl_(2)抑制效果最佳;通过在苹果伤口及表面处的生长动态发现2.0%CaCl_(2)可促进双酵母迅速定殖;2.0%CaCl_(2)诱导后可以显著提高苹果中苯丙烷代谢相关酶、活性氧代谢相关酶活性和物质含量。相较对照和使用双酵母复配,CaCl_(2)处理能够增强拮抗酵母的生防效力,一方面可以促进拮抗酵母的生长和定殖,另一方面可以降低果实的发病率并增强果实的抗病性。

关键词：苹果青霉病拮抗酵母生物防治抗性相关酶

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Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu

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Bioactive Materials 2023年第7期25卷 239-255页

作者： Zeqian Xu Xuanyu Qi Minyue Bao Tian Zhou junfeng shi Zhiyan Xu Mingliang Zhou Aldo R.Boccaccini Kai Zheng Xinquan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineNo.639 Zhizaoju RoadShanghai200011People’s Republic of China College of Stomatology Shanghai Jiao Tong UniversityNo.639 Zhizaoju RoadShanghai200011People’s Republic of China National Center for Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China National Clinical Research Center for Oral Diseases No.639 Zhizaoju RoadShanghai200011People’s Republic of China Shanghai Key Laboratory of Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China Shanghai Engineering Research Center of Advanced Dental Technology and Materials No.639 Zhizaoju RoadShanghai200011People’s Republic of China Department of Oral Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai200023People’s Republic of China Institute of Biomaterials University of Erlangen-NurembergCauerstrasse 691058ErlangenGermany Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing Medical UniversityNanjing210029People’s Republic of China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing210029People’s Republic of China

TypeⅡdiabetes mellitus(TIIDM)remains a challenging clinical issue for both dentists and *** virtue of persistent hyperglycemia and altered host metabolism,the pathologic diabetic micromilieu with chronic inflammation,advanced glycation end products accumulation,and attenuated biomineralization severely impairs bone regeneration *** to“remodel”the pathologic diabetic micromilieu,we 3D-printed bioscaffolds composed of Sr-containing mesoporous bioactive glass nanoparticles(Sr-MBGNs)and gelatin methacrylate(GelMA).Sr-MBGNs act as a biomineralization precursor embedded in the GelMA-simulated extracellular matrix and release Sr,Ca,and Si ions enhancing osteogenic,angiogenic,and immunomodulatory *** addition to angiogenic and anti-inflammatory outcomes,this innovative design reveals that the nanocomposites can modulate extracellular matrix reconstruction and simulate biomineralization by activating lysyl oxidase to form healthy enzymatic crosslinked collagen,promoting cell focal adhesion,modulating osteoblast differentiation,and boosting the release of OCN,the noncollagenous proteins(intrafibrillar mineralization dependent),and thus orchestrating osteogenesis through the Kindlin-2/PTH1R/OCN *** 3D-printed bioscaffold provides a multifunctional biomineralization-inspired system that remodels the“barren”diabetic microenvironment and sheds light on the new bone regeneration approaches for TIIDM.

关键词： Biomineralization TypeⅡDiabetes mellitus 3D printing Sr-containing mesoporous bioactive glass nanoparticles Enzymatic cross-links

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IBC promotes the expression of ER beta in gastric cancer cells to improve sensitivity of apatinib treatment

IBC promotes the expression of ER beta in gastric cancer cel...

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2018年中国肿瘤标志物学术大会暨第十二届肿瘤标志物青年科学家论坛

作者： junfeng shi Jinfei CHEN 南京市第一医院

Objective: Gastric cancer(GC) is the fourth most common malignant tumor in the world,most of which belong to adenocarcinoma, and the ratio of male and female incidence is 2:*** beta(estrogen receptor β, ERβ) is a steroid hormone receptor. Its expression level in gastric cancer is significantly higher than that of ER alpha, suggesting that ER beta plays an important role in the treatment of gastric cancer. Isobavachalcone(IBC), as a kind of phytoestrogen, can regulate the expression of ER beta. Apatinib, a novel molecular targeting agent used in the treatment of advanced gastric cancer. Hence, the present study sought to design a zebrafish model implanted the human gastric cancer cell line for studying personalized molecular-targeted cancer therapy, which was evaluated in vivo efficacy of IBC combined with apatinib in the treatment of gastric ***:MTT assay was used to detect the toxicity of IBC drugs to gastric cancercells. The expression level of key genes in gastric cancer cells was detectedby Western blot. Then, MTT and Realtime PCR were used to evaluate the effect ofapatinib on cells and the regulation of ER. The synergistic effect of IBC and apatinibwas verified by the zebrafish bearing tumor experiment. All data were analyzedby SPSS 21.0 ***: We found that IBC could enhance the expression of ER beta and promote the apoptosis of gastric cancer cells. In the zebrafish animal model, IBC combined with apatinib exhibited thebest antitumor growth effect with dose and time dependence, which may be themechanism underlying the profound antitumor clinical effect of ***:The data indicated that IBC combined with apatinib therapy should be effective anti-angiogenesis and can be recommended as a proper antitumor growth therapy for GC ***, zebrafish models could be designed as a potential practical tool to explorenew anti-gastric cancer drugs.

关键词： Gastric cancer Isobavachalcone(IBC) apatinib estrogen receptor β(ERβ) zebrafish model

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