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Exploration of the mechanism of cavitation vortex rope and vortex development in the draft tube of tubular turbine units

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International Journal of Agricultural and Biological Engineering 2024年第1期17卷 163-171,F0002页

作者： Chuang Cheng Zhenggui Li Changrong Shen Shenglong Gu Chuchu Zeng Chuanzheng Bai Meng Liu Junfeng Hu Qinghai University of Science and Technology Xining 810000China Key Laboratory of Fluid and Power Machinery Ministry of Education(Xihua University)Chengdu 610039China South-to-North Water Diversion East Jiangsu Water Source Co. Ltd.Nanjing 210029China School of civil engineering and water resources Qinghai UniversityXining 810016China Dongyuan Branch of Shenzhen Water Planning and Design Institute Co. Ltd.Changsha 410000China

Draft tube vortex rope is considered a special cavitation flow phenomenon in tubular turbine units.Cavitation vortex rope is one of the most detrimental factors affecting the safety of hydraulic turbines.In this study,ANSYS CFX software was utilized to numerically simulate the internal cavitation flow of a hydraulic turbine draft tube.The evolution of the cavitation vortex core was characterized by vortex line distribution and vorticity transport equation.The shape and number of blades influenced the revolving direction and distribution characteristics of the vortex close to the runner cone,which formed a counterclockwise-clockwise-counterclockwise distribution pattern.Simultaneously,there were many secondary flows in the draft tube.Mutual cancellation and dissipation between the flows was one of the reasons for reduction in vorticity.When the cross-sectional shape of the draft tube was changed,the vorticity was distributed from the center of the vortex rope to all parts of the cross-sectional draft tube,with extreme values at the center and at the walls.The vortex stretching and dilatation terms played a major role in the change in vorticity,with the baroclinic torque having an effect at the center of the vortex rope,this study is helpful to understand the flow of water in the draft tube and guide the design and optimization of the draft tube in engineering application.

关键词： cavitation vortex rope vorticity transport equation vortex line draft tube

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A novel FGFR1 inhibitor CYY292 suppresses tumor progression,invasion,and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis

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Genes & Diseases 2024年第1期11卷 479-494页

作者： Yanran Bi Ruiling Zheng Jiahao hu Ruiqing Shi junfeng Shi Yutao Wang Peng Wang Wenyi Jiang Gyudong Kim Zhiguo Liu Xiaokun Li Li Lin School of Pharmaceutical Science Wenzhou Medical UniversityWenzhouZhejiang 325035China College of Pharmacy and Research Institute of Drug Development Chonnam National UniversityGwangju 61186Republic of Korea Department of Dermatology Wenzhou Hospital of Integrated Traditional Chinese and Western MedicineWenzhouZhejiang 325000China Zhejiang Lab for Regenerative Medicine Oujiang LaboratoryWenzhouZhejiang 325035China

Glioblastoma(GBM)is a malignant brain tumor that grows quickly,spreads widely,and is resistant to treatment.Fibroblast growth factor receptor(FGFR)1 is a receptor tyrosine kinase that regulates cellular processes,including proliferation,survival,migration,and dif-ferentiation.FGFR1 was predominantly expressed in GBM tissues,and FGFR1 expression was negatively correlated with overall survival.We rationally designed a novel small molecule CYY292,which exhibited a strong affinity for the FGFR1 protein in GBM cell lines in vitro.CYY292 also exerted an effect on the conserved Ser777 residue of FGFR1.CYY292 dose-depen-dently inhibited cell proliferation,epithelial-mesenchymal transition,stemness,invasion,and migration in vitro by specifically targeting the FGFR1/AKT/Snail pathways in GBM cells,and this effect was prevented by pharmacological inhibitors and critical gene knockdown.In vivo experiments revealed that CYY292 inhibited U87MG tumor growth more effectively than AZD4547.CYY292 also efficiently reduced GBM cell proliferation and increased survival in orthotopic GBM models.This study further elucidates the function of FGFR1 in the GBM and reveals the effect of CYY292,which targets FGFR1,on downstream signaling pathways directly reducing GBM cell growth,invasion,and metastasis and thus impairing the recruitment,activation,and function of immune cells.

关键词： Blood-brain barrier EMT FGFR1 FGFR1 inhibitor Glioblastoma

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Rapid characterization of non-volatile phenolic compounds reveals the reliable chemical markers for authentication of traditional Chinese medicine Xiang-ru among confusing Elsholtzia species

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Chinese Journal of Natural Medicines 2024年第4期22卷 375-384页

作者： ZENG Zhen ZHANG Chen hu Jiadong WANG Feiyan WU Ziding WANG Jing ZHANG Jun YANG Shuda CHEN junfeng LI Mingming TONG Qi QIU Shi CHEN Wansheng The SATCM Key Laboratory for New Resources&Quality Evaluation of Chinese Medicine Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Pharmacy Second Affiliated Hospital of Navy Medical UniversityShanghai 200003China Kunming Plant Classification Biotechnology Co. Ltd.Kunming 650500China School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical UniversityKunming 650500China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Beijing100700China

The aerial parts of Mosla chinensis Maxim.and Mosla chinensis cv.'Jiangxiangru'(MCJ)are widely utilized in traditional Chinese medicine(TCM),known collectively as Xiang-ru.However,due to clinical effectiveness concerns and frequent misidentification,the original plants have increasingly been substituted by various species within the genera Elsholtzia and Mosla.The challenge in distinguishing between these genera arises from their similar morphological and metabolic profiles.To address this issue,our study introduced a rapid method for metabolic characterization,employing high-resolution mass spectrometry-based metabolomics.Through detailed biosynthetic and chemometric analyses,we pinpointed five phenolic compounds—salviaflaside,cynaroside,scutellarein-7-O-D-glucoside,rutin,and vicenin-2—among 203 identified compounds,as reliable chemical markers for distinguishing Xiang-ru from closely related Elsholtzia species.This methodology holds promise for broad application in the analysis of plant aerial parts,especially in verifying the authenticity of aromatic traditional medicinal plants.Our findings underscore the importance of non-volatile compounds as dependable chemical markers in the authentication process of aromatic traditional medicinal plants.

关键词： Genus Elsholtzia Genus Mosla Traditional Chinese medicine Xiang-ru Non-volatile phenolic compounds Liquid chromatography-mass spectrometry

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Corrigendum to"A novel FGFR1 inhibitor CYY292 suppresses tumor progression,invasion,and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis"[Genes&Diseases 11(2024)479-494]

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Genes & Diseases 2024年第3期11卷 485-490页

作者： Yanran Bi Ruiling Zheng Jiahao hu Ruiqing Shi junfeng Shi Yutao Wang Peng Wang Wenyi Jiang Gyudong Kim Zhiguo Liu Xiaokun Li Li Lin School of Pharmaceutical Science Wenzhou Medical UniversityWenzhou 325035China College of Pharmacy and Research Institute of Drug Development Chonnam National UniversityGwangju 61186Republic of Korea Department of Dermatology Wenzhou Hospital of Integrated Traditional Chinese and Western MedicineWenzhou 325000China Zhejiang Lab for Regenerative Medicine Oujiang LaboratoryWenzhou 325035China

The authors regret that in Figure 3C,the Western Blot(WB)image representing GAPDH levels was mistakenly chosen as the same image for ERK(indicated by the red dotted-line rectangle).We have attached the original WB strip for GAPDH to demonstrate that this was an unintentional error in image selection.Additionally,we noticed that the Transwell images in the two upper panels of the right column in Figure 4J are misleading due to errors in image selection.We have attached the original data to show that this was also an unintentional error.We assure you that these two corrections do not alter the scientificconclusionof thearticle.

关键词： GSK3β invasion metastasis

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Microenvironment-responsive chemotherapeutic nanogels for enhancing tumor therapy via DNA damage and glutathione consumption

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Chinese Chemical Letters 2022年第9期33卷 4197-4202页

作者： Mengjie Ye Yuan Gao Mengyun Liang Wei Qiu Xian bin Ma Jiming Xu Junfeng Hu Peng Xue Yuejun Kang Zhigang Xu Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationSchool of Materials and Energy and Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and DevicesSouthwest UniversityChongqing 400715China Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikou 571158China

Although targeted therapy and immunotherapy are now shining in the treatment of some cancers,chemotherapy is still the cornerstone of drug treatment for many cancer patients.The emergence of chemotherapy prodrugs can improve the drug activity and reduce the side effects of chemotherapy.When used,the tumor microenvironment has characteristics different from normal tissues,and the existence of the microenvironment provided a more convenient way to design responsive nanodrugs.Herein,we designed a glutathione(GSH)-responsive prodrug nanogels for enhancing tumor chemotherapy.In the nanogels of HHNP,10-hydroxycamptothecin(HCPT)played an essential role in killing cancer cells.HCPT was jointed with a cross-linker agent with disulfide bond and was further coated with polyethylene glycol,which not only prolonged the half-life of the drug,but also made HCPT accurate transport to the tumor fractions and achieved precise and controllable release.The proposal of HHNP effectively retained the biological activity of the drug,and introduced functions such as targeting,selective release and biodegradation,which greatly improved the medical efficiency of the drug and effectively reduced the toxic and side effects.This chemotherapeutic prodrug nanogel offers a new window for constructing efficient drug delivery platform.

关键词： Nanogel Prodrug GSH-responsive DNA damage Chemotherapy

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基于视觉的软体机器人位姿测量与控制

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现代制造工程 2024年第5期 39-47页

作者：张俊胡俊峰江西理工大学机电工程学院赣州341000

气动软体机器人具有良好的灵活性和安全性,适合在非结构化的复杂环境中执行任务。因为很难在软体机器人上安装传感器来直接测量形状和位姿,故难以实现精确的位置控制,其运动精度一般远低于传统刚性机器人。针对上述问题,提出了一种基于... 详细信息

气动软体机器人具有良好的灵活性和安全性,适合在非结构化的复杂环境中执行任务。因为很难在软体机器人上安装传感器来直接测量形状和位姿,故难以实现精确的位置控制,其运动精度一般远低于传统刚性机器人。针对上述问题,提出了一种基于视觉的软体机器人形状重建、位姿测量以及逆运动学控制的方法。实验结果表明,采用该方法的软体机器人末端执行器位置的均方根误差小于6 mm,测量关键点位置误差小于2.80 mm,整体形状的位置偏差为1.67 mm,弯曲角度、偏转角度平均误差分别为3.6°和3.4°,控制到达期望位置和角度的最大误差分别为3.47 mm和0.24°。实验结果表明所提出的位姿测量和控制方法对提高软体机器人的运动精度和工作能力有很大的作用。

关键词：气动软体机器人形状重建位姿测量逆运动学控制

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研发强度目标导向对绿色发展的影响研究--基于合成控制法的实证研究

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湖南科技大学学报（社会科学版） 2024年第1期27卷 149-158页

作者：胡俊峰季爱佳南通大学商学院(管理学院) 江苏南通226001 江苏长江经济带研究院江苏南通226001

政府工作报告中的研发强度指标所形成的目标导向效应,对推动区域绿色发展意义重大。以首次设立“研发强度目标”为准自然实验,采用反事实视角下的合成控制法研究研发强度目标导向对区域绿色发展水平的影响。研究发现:研发强度目标导向... 详细信息

政府工作报告中的研发强度指标所形成的目标导向效应,对推动区域绿色发展意义重大。以首次设立“研发强度目标”为准自然实验,采用反事实视角下的合成控制法研究研发强度目标导向对区域绿色发展水平的影响。研究发现:研发强度目标导向整体上实现了碳排放强度降低以及工业废气排放量与能源消耗量下降,并显著提高了区域绿色发展水平。异质性分析发现研发强度目标导向对东部、中部及西部地区产生的政策效应存在差异。

关键词：研发强度目标导向绿色发展合成控制法

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Recent advances in chemical protein synthesis:method developments and biological applications

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Science China Chemistry 2024年第4期67卷 1060-1096页

作者： Suwei Dong Ji-Shen Zheng Yiming Li huan Wang Gong Chen Yongxiang Chen Gemin Fang Jun Guo Chunmao He Honggang hu Xuechen Li Yanmei Li Zigang Li Man Pan Shan Tang Changlin Tian Ping Wang Bian Wu Chuanliu Wu junfeng Zhao Lei Liu State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230027China School of Food and Biological Engineering Engineering Research Center of Bio-processMinistry of EducationHefei University of TechnologyHefei 230009China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China Department of Chemistry Tsinghua UniversityBeijing 100084China Institute of Health Sciences Anhui UniversityHefei 230601China College of Chemistry Central China Normal UniversityWuhan 430079China School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510640China School of Medicine or Institute of Translational Medicine Shanghai UniversityShanghai 200444China Department of Chemistry The University of Hong KongHong Kong 999077China Shenzhen Graduate School Peking UniversityShenzhen 518055China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Life Sciences University of Science and Technology of ChinaHefei 230026China Department of Chemical Biology Shanghai Jiao Tong UniversityShanghai 200240China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China Department of Chemistry Xiamen UniversityXiamen 361005China School of Pharmaceutical Science Guangzhou Medical UniversityGuangzhou 511436China

The central dogma of modern biology underscores the pivotal roles proteins play in diverse biological processes,the study of which necessitates advanced methods to produce proteins with precision and versatility.Chemical protein synthesis,a powerful approach utilizing chemical reactions for the de novo construction of structurally accurate proteins,has emerged as a transformative tool for studying proteins and generating protein derivatives/mimics inaccessible by natural biological machinery,including post-translationally modified proteins,proteins comprised of unnatural amino acids,as well as mirror-image proteins.This review summarizes recent strides in synthetic method developments for chemical protein synthesis,including innovative techniques in solid-phase peptide synthesis,the challenges presented by difficult sequences in either synthesis or folding and the exploration of novel ligation reactions using both chemical and enzymatic methods.Furthermore,the review also delves into newly developed protocols for site-selective protein modifications and the generation of stapled or macrocyclized peptides/miniproteins,highlighting the power of chemical methods to make structurally diverse proteins.Recent applications of synthetic proteins in investigating post-translational modifications(phosphorylation,lipidation,glycosylation,ubiquitination,etc.),mirror-image biological processes and drug development are further discussed.Together,these topics provide a comprehensive overview of the current landscape of chemical protein synthesis.

关键词： chemical protein synthesis solid-phase peptide synthesis ligation reactions post-translational modifications mirror-image proteins peptide drugs

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Structural transition, electric transport, and electronic structures in the compressed trilayer nickelate LaNiO

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Jingyuan Li Cuiqun Chen Chaoxin huang Yifeng Han Mengwu huo Xing huang Peiyue Ma Zhengyang Qiu junfeng Chen Xunwu hu Lan Chen Tao Xie Bing Shen hualei Sun Daoxin Yao Meng Wang Center for Materials of the Universe School of Molecular Sciences Arizona State University Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices School of Physics Sun Yat-sen University School of Sciences Sun Yat-sen University

Atomic structure and electronic band structure are fundamental properties for understanding the mechanism of superconductivity. Motivated by the discovery of pressure-induced high-temperature superconductivity at 80 K in the bilayer Ruddlesden-Popper nickelate La3Ni2O7, the atomic structure and electronic band structure of the trilayer nickelate La4Ni3O10under pressure up to 44.3 GPa are investigated. A structural transition from the monoclinic P21/a space group to the tetragonal I4/mmm around 12.6-13.4 GPa is identified, accompanied by a drop of resistance below 7 K. Density functional theory calculations suggest that the bonding state of Ni 3dz2orbital rises and crosses the Fermi level at high pressures, which may give rise to possible superconductivity observed in resistance under pressure in La4Ni3O10. The trilayer nickelate La4Ni3O10shows some similarities with the bilayer La3Ni2O7and has unique properties, providing a new platform to investigate the underlying mechanism of superconductivity in nickelates.

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基于滚动接触的仿脊椎多向连续体机械臂的设计与实验

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机械传动 2024年第5期48卷 114-121页

作者：董栋周亮胡俊峰江西理工大学机电工程学院江西赣州341000

针对刚性连续体以及柔性连续体在面对复杂、狭小的空间内的作业需求,基于滚动基础的原理设计了一种仿脊椎的连续体机械臂,在保证连续体单元滚动接触的前提下,可实现连续体多向的运动并减少了连续体各节段模块之间在运动时的相互干涉。... 详细信息

针对刚性连续体以及柔性连续体在面对复杂、狭小的空间内的作业需求,基于滚动基础的原理设计了一种仿脊椎的连续体机械臂,在保证连续体单元滚动接触的前提下,可实现连续体多向的运动并减少了连续体各节段模块之间在运动时的相互干涉。设计的连续体单元结构简单,使用弹性绳成为单元之间的连接元件,具有多轴顺应性;对连续体建立运动学模型并进行了实验验证。结果表明,该连续体具备在非结构化环境下良好的适应能力和运动能力。

关键词：狭小复杂工作空间连续体机械臂滚动接触降低干涉

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