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铁死亡与椎间盘退变关系的研究进展

中国脊柱脊髓杂志 2024年第5期34卷 548-554页

作者：赵继荣马俊飞薛旭史凡凡杨正汉陈倩文甘肃中医药大学兰州市730000 甘肃省中医院脊柱微创骨科兰州市730050

细胞死亡贯穿人体生长发育、动态平衡和疾病发生发展的各个阶段,它同自然界生命体的生长凋亡一样,是正常的生命现象。最初,生物学家把细胞的死亡按生理和病理的不同分为两种死亡方式即主动有序的程序性死亡(如细胞凋亡)和受到强烈理化... 详细信息

细胞死亡贯穿人体生长发育、动态平衡和疾病发生发展的各个阶段,它同自然界生命体的生长凋亡一样,是正常的生命现象。最初,生物学家把细胞的死亡按生理和病理的不同分为两种死亡方式即主动有序的程序性死亡(如细胞凋亡)和受到强烈理化或生物因素作用引起的细胞无序性死亡(如细胞坏死)[1]。随着科学技术的不断进步,近年来又发现了3种新的可受调控的程序性细胞死亡方式:细胞自噬、细胞焦亡与铁死亡[2]。

关键词：人体生长发育细胞自噬细胞焦亡程序性细胞死亡细胞坏死椎间盘退变细胞凋亡程序性死亡

GSDMD与骨质疏松症中成骨细胞的相关性研究进展

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中国骨质疏松杂志 2024年第7期30卷 1028-1032,1055页

作者：麻永胜王立强蒋宜伟周玉英马晨光宋重东刘沛马俊飞史达甘肃中医药大学甘肃兰州730000 敦煌医学与转化教育部重点实验室甘肃兰州730000 甘肃中医药大学附属医院甘肃兰州730000 西安市红会医院陕西西安710054

细胞焦亡(Pyroptosis)是伴炎症反应的程序性死亡方式,Gasdermin D(GSDMD)是介导细胞焦亡的关键蛋白,也是主要执行者。当病原微生物等刺激炎性小体后,激活焦亡信号半胱天冬氨酸蛋白酶(caspase),使其切割GSDMD,然后GSDMD的氨基末端(N端)... 详细信息

细胞焦亡(Pyroptosis)是伴炎症反应的程序性死亡方式,Gasdermin D(GSDMD)是介导细胞焦亡的关键蛋白,也是主要执行者。当病原微生物等刺激炎性小体后,激活焦亡信号半胱天冬氨酸蛋白酶(caspase),使其切割GSDMD,然后GSDMD的氨基末端(N端)转移至细胞膜上形成允许水分子等物质进入的细胞内孔隙,从而引起细胞肿胀及裂解,导致细胞死亡,即细胞焦亡。近年来科学研究进展发现,GSDMD可能通过介导成骨细胞焦亡参与了骨代谢疾病特别是骨质疏松症的发病机制,抑制成骨细胞焦亡可调控骨质疏松症的发展。成骨细胞焦亡或许作为一种促炎性调控骨细胞死亡的方式干预骨代谢,而且对其研究是当下新颖的科研热点。笔者从细胞焦亡分析并探讨GSDMD介导成骨细胞焦亡的分子机制,对其与细胞焦亡领域之间的关系进行综述,分析成骨细胞焦亡与骨质疏松疾病之间的联系,为骨质疏松症的研究和诊疗提供关键的靶点蛋白因子机制。

关键词：细胞焦亡 GSDMD 成骨细胞分子机制骨质疏松症

基于氧化应激的中医药干预椎间盘退变的研究进展

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中国现代应用药学 2024年第1期41卷 138-144页

作者：杨正汉赵继荣马俊飞陈倩文陈文赵宁甘肃中医药大学兰州730000 甘肃省中医院兰州730050

椎间盘退变(intervertebral disc degeneration,IDD)是脊柱疾病发生的病变基础,随着人们工作生活方式的发展变化,IDD近年来逐渐呈现出年轻化的趋势。对IDD的有效防治日益成为临床研究中的热点。近年来相关研究表明氧化应激在IDD中具有... 详细信息

椎间盘退变(intervertebral disc degeneration,IDD)是脊柱疾病发生的病变基础,随着人们工作生活方式的发展变化,IDD近年来逐渐呈现出年轻化的趋势。对IDD的有效防治日益成为临床研究中的热点。近年来相关研究表明氧化应激在IDD中具有重要作用。由于细胞或机体中的活性氧平衡被打破而导致细胞外基质以及椎间盘细胞表型变化,诱发椎间盘氧化应激从而导致IDD的发生。同时氧化应激能够通过对椎间盘细胞凋亡、自噬、衰老及细胞外基质等方式来影响IDD的发展。目前关于IDD的治疗,临床多使用阿片类以及活血止痛类的药物,其在一定程度上能够缓解部分症状,但易诱发胃肠道不良反应,同时由于治疗周期漫长在一定程度上导致患者依从性较差,给治疗带来较大困难。中医药以其物优价廉、不良反应少等优势在治疗IDD中占据重要的地位。随着分子生物学以及网络药理学等现代科技的研究深入,发现中医药能够通过干预氧化应激相关功能表达,即减缓细胞凋亡、自噬及减缓细胞外基质降解等方式,发挥治疗IDD的作用。本文阐述氧化应激在IDD中的作用,以及中医药干预氧化应激的研究成果,以期为中医药防治IDD提供参考和依据。

关键词：氧化应激椎间盘退变活性氧中医药

A tug-of-war to control plant emission of an airborne alarm signal

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Stress Biology 2023年第1期3卷 526-529页

作者： Jie Hao junfei ma Hua Shi Ying Wang Plant Pathology Department University of FloridaGainesville 32611USA State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan Agricultural UniversityKunming 650201China

Aphids represent a major threat to *** of different viruses are *** aphid attack,plants release volatile organic compounds(VOCs)as airborne alarm signals to turn on the airborne defense(AD)of neighboring plants,thereby repelling aphids as well as reducing aphid fitness and virus *** phenomenon provides a critical community-wide plant protection to fend off aphids,but the underlying molecular basis remains undetermined for a long *** a recent article,Gong et *** the NAC2-SAMT1 module as the core component regulating the emission of methyl-salicylate(MeSA),a major component of VOCs in aphid-attacked ***,they showed that SABP2 protein is critical for the perception of volatile MeSA signal by converting MeSA to Salicylic Acid(SA),which is the cue to elicit AD against aphids at the community ***,they showed that multiple viruses use a conserved glycine residue in the ATP-dependent helicase domain in viral proteins to shuttle NAC2 from the nucleus to the cytoplasm for degradation,leading to the attenuation of MeSA emission and *** findings illuminate the functional roles of key regulators in the complex MeSA-mediated airborne defense process and a counter-defense mechanism used by viruses,which has profound significance in advancing the knowledge of plant-pathogen interactions as well as providing potential targets for gene editing-based crop breeding.

关键词： Salicylic acid Methyl-salicylate NAC2 SAMT1 SABP2 Airborne defense

Highly fluorescence Ta_(4)C_(3) MXene quantum dots as fluorescent nanoprobe for heavy ion detection and stress monitoring of fluorescent hydrogels

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Chinese Chemical Letters 2022年第4期33卷 1850-1854页

作者： Shouzhen Li junfei ma Xuelin Zhao Peide Zhu Meng Xu Yingchun Niu Dixian Luo Quan Xu State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development National Energy Shale Oil Research and Development CenterChina University of Petroleum(Beijing)Beijing 102249China Department of Musculoskeletal Tumor Senior Department of Orthopedicsthe Fourth Medical Center of PLA General HospitalBeijing 100142China Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen 518000China

Compared with other transition metal Mxene derived quantum dots(MQD_(S)),Ta-based Mxene quantum dots have good functionality,but Ta-based Mxene quantum dots and their applications have not been studied so *** this paper,we report for the first time the synthesis of high fluorescence quantum yield(QY) N-doped Ta_(4)C_(3) quantum dots(N-MQDs) using Ta_(4)C_(3) quantum dots in acid reflux damaged Ta_(4)C_(3) nanosheets as precursors and ethylenediamine as nitrogen *** prepared N-MQDs have excellent blue photoluminescence(PL) properties,particle size is only 2.60 nm,QY is up to 23.4%,and good *** addition,it has been reported that N-MQDs can be used as fluorescent probe for detection of Fe;and remote force sensing analysis In liquid ion sensing,N-MQDS shows a unique selective quenching of Fe;with a detection limit as low as 2 μmol/L,and has great potential as a fast and super-sensitive fluorescent probe for the detection of heavy *** importantly,in solid mechanics sensing,the introduction of N-MQDs into self-healing hydrogels can be developed into a fluorescent hydrogel that can be used for accurate remote force measurement and applied in the field of mechanical sensing ***,Ta-based N-MQDs show excellent potential in the field of fluorescence sensing,which provides a door for multi-dimensional sensing of new materials in the future.

关键词： MXene quantum dots Fluorescent probe Fluorescent hydrogel Hydrothermal method Quantum yield

中药通过干预miRNA表达治疗椎间盘退行性变

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中医学报 2024年第6期39卷 1151-1156页

作者：马俊飞赵继荣史凡凡蒋鹏薛旭杨正汉陈倩文甘肃中医药大学甘肃兰州730000 甘肃省中医院甘肃兰州730050

椎间盘退行性变的发病机制十分复杂,包括炎症、基因、遗传、免疫及生物力学因素等多个方面。炎症反应在疾病发生过程中扮演着关键角色,炎症因子的异常表达可加速疾病的发展进程。非编码微小RNA(microRNA,miRNA)作为基因表达的重要调控分... 详细信息

椎间盘退行性变的发病机制十分复杂,包括炎症、基因、遗传、免疫及生物力学因素等多个方面。炎症反应在疾病发生过程中扮演着关键角色,炎症因子的异常表达可加速疾病的发展进程。非编码微小RNA(microRNA,miRNA)作为基因表达的重要调控分子,在疾病的发生发展中发挥关键作用,通过调节miRNA的表达,可以抑制炎症反应的发生,进而修复椎间盘组织。中药通过干预miRNA表达调节椎间盘炎症反应成为新的热点。中药复方如芍药甘草汤、独活寄生汤等,以及中药单体如淫羊藿苷、川续断总皂苷等,可以通过调节miRNA的表达干预炎症反应,有望减缓疾病发展,成为治疗椎间盘退行性变的潜在药物。因此,中药通过干预miRNA表达抑制椎间盘炎症反应从而延缓疾病发展是一种潜在的治疗途径。

关键词：椎间盘退行性变 miRNA 炎症反应中药复方中药单体

Highly green fluorescent Nb2C MXene quantum dots for Cu2+ion sensing and cell imaging

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Chinese Chemical Letters 2020年第12期31卷 3173-3177页

作者： Xiang Yan junfei ma Kaixuan Yu Jiapeng Li Lei Yang Jjiaqi Liu Juncheng Wang Lulu Cai School of materials Science and Engineering.Baise University.Baise 533000 China State Key Laboratory of Heavy Oilt Processing China University of Petroleum-BeijingBeijing 102249China Personalized Drug Therapy Key Laboratory of Sichuan Province Department of PharmacySichuan Provincial Peoples Hospital School MedicineUniversity of Electronic Science and Technology of China.Chengdu 610072China Stomatology Department of the General Haspital of Chinese PLA Beijing 100853China

Niobium carbide MXene quantum dots(Nb2 C MQDs)derived from 2 D Nb2 CTx(MXene)are the rising-star material ***,a sulfur and nitrogen co-doped Nb2 C MQDs(S,N-MQDs)were synthesized through a hydrothermal *** obtained Nb2 C MQDs have excellent green fluorescence with a quantum yield(QY)of 17.25%.In addition,they exhibited excitatio n-dependent photoluminescence,antiphotobleaching and dispersion *** emit light at 520 nm when excited at 390 *** Nb2 C MQDs could be successfully applied to copper ion detection with detection limit of 2μmol/L and Caco-2 cells imaging.

关键词： 2D-QDs Nb2C-Mxene Cell imaging Ion sensing Sulfur-nitrogen co-doping

mass production of highly fluorescent full color carbon dots from the petroleum coke

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Chinese Chemical Letters 2021年第4期32卷 1532-1536页

作者： junfei ma Linzhou Zhang Xiu Chen Rigu Su Quan Shi Suoqi Zhao Quan Xu Chunming Xu State Key Laboratory of Heavy Oil Processing China University of Petroleum-BeijingBeijing 102249China Engineering Technology Research Institute o/PetroChina Xinjiang Oilfield Company Karamay 834000China

Heavy oil is treated as an undesirable raw material in traditional refining markets because of its low ***,its rich natural aromatic structure and heteroatomic compounds make it possible to be a precursor to large-scale production of carbon *** heavy oil and three SDA products as precursors,we synthesized highly fluorescent multi-color carbon dots(CDs)by hydrothermal method,which can precisely control the photoluminescence wavelength in the range of 350-650 *** synthesized carbon dots have the advantages of good long-term stability and stability under extreme pH conditions and low ***,the carbon dots synthesized with asphalt as the precursor have the highest fluorescence quantum yield.X-ray photoelectron spectroscopy(XPS)is used to elucidate the effects of different precursor on emission color change and photoluminescence quantum yield(PLQY),thus providing a controlled tuning of the system for the functionalization of *** we further used the CDs in macrophage *** pathway gives a reliable and repeatable industry possibility and may boost the applications of CDs into reality.

关键词： Full color Carbon dots Petroleum coke macrophage labeling SDA

The SLCP-driven land use changes and farmers' responses in the loess hilly and gully region:a case study for Ansai County

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Ecological Economy 2009年第4期5卷 375-381页

作者： Wang Qian Lu Changhe Yu Bohua ma junfei Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 P. R. China Graduate University Chinese Academy of Sciences Beijing 100049 P. R. China

Taking Ansai County located in loess hilly and gully area as a case,this study analyzes the land use changes driven by the SLCP(Slope Land Conversion Program)and the farmers'responses by household survey and participatory rapid appraisal(PRA).It is found that the SLCP aroused various changes in land use,agricultural production,rural incomes,*** the period of 1999-2005,the farmland and grasslands were reduced by 26,809 ha and 17,571 ha respectively,while forestland increased by 38,203 ha;greenhouse vegetable and orchard got a quick development,with the area enlarged by about 7 times and nearly doubled *** SLCP reduced the area of crops particularly those that normally grown on slope lands,*** sowing area of winter wheat dropped from 19.39% of the total cropping area in 1999 to 0.98%in *** animals,pigs and sheep have a decline in the number because the remained land and the ban on grazing on natural grasslands can not provide sufficient feed *** to the financial subsidy,farmers increased land inputs and thus *** achieve long-term sustain-able development and improve rural income,the government should continuously support farmers to improve the land management,to adopt alternative land use systems,and to increase inputs on soil *** and fruit production are two promise land use systems,and should be further developed.

关键词：生态经济区域经济 SLCP 土地问题