检索结果-南通市图书馆

Global Health Journal 2021年第4期5卷 194-197页

作者： xuyuehe Ren Junfang Xu Feng Cheng Department of Epidemiology Bloomberg School of Public HealthJohns Hopkins Universiy615N Wolfe StreetBaltimore 21205U.S.A. Research Institute of Health Policy School of Public HealthZhejiang University866 Yuhangtang RoadHangzhou 310058China Vanke School of Pubic Health Tsinghua University30 Shuangqing RoadBeijing 100084China Institute for Healthy China Tsinghua Universiy30 Shuangqing RoadBeijing 100084China

The Global Fund has long been the largest international assistance in human immunodeficiency virus(HIV)responses for three Southeast Asian countries,including Myanmar,Laos,and Vietnam.However,it recently decided to reduce or withdraw its funding from countries not yet going through donor phase out,aiming to make these countries respond with their own resources.In examining whether these three countries are well-prepared to donor transition,we uncover potential challenges that will appear in their healthcare systems and especially in the prevention and control for vulnerable populations.By reviewing China's succesful experience in donor transition,we propose recommendations for these pre transition countries,in terms of program operation,budget allocation,and social stigmatization.

关键词： HIV AIDS The Global Fund Donor transition Funding withdrawal

Long noncoding RNAs in the metabolic control of inflammation and immune disorders

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2019年第1期16卷 1-5页

作者： Junfang Xu xuetao Cao Institute of Immunology Zhejiang University School of MedicineHangzhou 310058China Department of Immunology&Center for Immunotherapy Institute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100005China

The metabolic control of immune cell development and function has been shown to be critical for the maintenance of immune homeostasis and is also involved in the pathogenesis of immune disorders.Pathogenic infections or cancers may induce metabolic reprogramming through different pathways to meet the energy and metabolite demands for pathogen propagation or cancer progression.In addition,some deregulated metabolites could trigger or regulate immune responses,thus causing chronic inflammation or immune disorders,such as viral infection,cancer and obesity.Therefore,the methods through which metabolism is regulated and the role of metabolic regulation in inflammation and immunity attract much attention.Epigenetic regulation of inflammation and immunity is an emerging field.Long noncoding RNAs(lncRNAs)have been well documented to play crucial roles in many biological processes through diverse mechanisms,including immune regulation and metabolic alternation.Here,we review the functions and mechanisms of lncRNAs in the metabolic regulation of inflammatory immune disorders,aiming to deepen our understanding of the epigenetic regulation of inflammation and immunity.

关键词： inflammation immunity disorders

Antiretroviral regimen change among people infected with HIV:evidence from a crosssectional study in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global Health Journal 2018年第3期2卷 21-30页

作者： Junfang Xu Peicheng Wang Liangmin Gao Xinyu Peng Feng Cheng Research Center for Public Health School of MedicineTsinghua UniversityBeijing 100084China Institute for International and Area Studies Tsinghua UniversityBeijing 100084China National Center for AIDS/STD Control and Prevention China Center for Disease Control and PreventionBeijing 102206China

Background:The rate of death among people living with HIV/AIDS has decreased significantly as a result of treatment with highly active antiretroviral therapy(HAART).However,the issues of drug induced toxicities and complexity of current HAART regimens has remained of great concern.The aim of this study was to determine factors in uencing antiretroviral regimen changes among people living with HIV/AIDS in China.Methods:This retrospective study collected data through face-to-face interviews with people living with HIV/AIDS who were receiving HAART,and gathered relevant information from infectious disease hospitals.The following information were collected:social-demographic characteristics,antiretroviral therapies,CD4 cell counts,virus loads,reasons for changing medication and other related data.Mean and percentages were used to describe the frequency of regimen change among patients,and binary logistic regression was employed to test the factors in uencing regimen change.Results:1,123 people who had experienced regimen change were included in the analysis.On average,patients remained on HAART for 10.2 months before changing regimen,and the average CD4 cell count and viral load(VL)were 383.1 cells/ l and 28,132.4 copies/mL respectively when changing regimen.The reasons for modi cation were determined as treatment failure(52.5%),adverse reactions(32.3%),and other reasons including pregnancy(15.2%).There are significant differences in regimen change among people with different genders(P<0.001),modes of transmission(P<0.001),duration of HAART(P<0.001)and initial CD4 cell counts(P=0.0024).Males,drug users,people taking long-term medication,and those with lower initial CD4 counts when starting HAART tend to change regimen.Conclusion:Treatment failure was the main reason for the change of HAART regimen.Males,drug users,people on longterm medication and those with lower initial CD4 cell counts when starting HAART were most likely to change regimen.

关键词： antiretroviral therapy regimen change HIV China

Myocardial injury and related mortality in hospitalized patients with COVID-19 during the Omicron pandemic:new perspectives and insights

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virologica Sinica 2023年第6期38卷 940-950页

作者： Wu He Ke xu Li Ni junfang Wu Yuxuan Zhang Kun Miao Luyun Wang Dao Wen Wang Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan430030China

Myocardial injury is one of the most common comorbidity in SARS-CoV-2 infected patients,and has poor prognosis.However,the incidence of myocardial injury in patients with SARS-CoV-2 infection has not been sufficiently investigated during the Omicron wave.We conducted a retrospective study of 2690 patients with confirmed SARS-CoV-2 Omicron infection from Tongji Hospital.The results indicated that the myocardial injury accounted for 30.8%of the total patients with SARS-CoV-2 infection and was associated with higher in-hospital mortality than those without injury before and after propensity score matching(PSM)[adjusted hazard ratio(HR),10.61;95%confidence interval(CI),7.76–14.51;P<0.001;adjusted HR,2.70;95%CI,1.86–3.93;P<0.001;respectively].Further,the levels of cytokines(IL-1β,IL-6,IL-10,and TNF-α)in patients with myocardial injury were higher than those without injury,and the higher levels of cytokines in the myocardial injury group were associated with increased mortality.Administration of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers(ACEI/ARB)could significantly reduce the mortality in patients with myocardial injury(adjusted HR,0.52;95%CI,0.38–0.71;P<0.001).Additionally,the level of angiotensin II increased in patients with SARS-CoV-2 infection was even higher in myocardial injury group compared to those without injury.Collectively,the study summarized the clinical characteristic and outcome of SARS-CoV-2 infected patients with myocardial injury during the Omicron wave in China,and validated the protective role of ACEI/ARB in improving the survival of those with myocardial injury.

关键词： COVID-19 Omicron Myocardial injury In-hospital mortality Cytokine storm

Growth,Nitrogen Uptake and Flow in Maize Plants Affected by Root Growth Restriction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2009年第7期51卷 689-697页

作者： Liangzheng xu junfang Niu Chunjian Li Fusuo Zhang The Key Laboratory of Plant Nutrition Ministry of Agriculture Department of Plant Nutrition China Agricultural University Beijing 100193 China School of Life Sciences Jiaying University Meizhou 514015 China Centre of Agricultural Resources Institute of Genetics and Developmental Biology the Chinese Academy of Sciences Shijiazhuang 050021 China

The objective of the present study was to investigate the influence of a reduced maize root-system size on root growth and nitrogen （N） uptake and flow within plants. Restriction of shoot-borne root growth caused a strong decrease in the absorption of root ： shoot dry weight ratio and a reduction in shoot growth. On the other hand, compensatory growth and an increased N uptake rate in the remaining roots were observed. Despite the limited long-distance transport pathway in the mesocotyl with restriction of shoot-borne root growth, N cycling within these plants was higher than those in control plants, implying that xylem and phloem flow velocities via the mesocotyl were considerably higher than in plants with an intact root system. The removal of the seminal roots in addition to restricting shoot-borne root development did not affect whole plant growth and N uptake, except for the stronger compensatory growth of the primary roots. Our results suggest that an adequate N supply to maize plant is maintained by compensatory growth of the remaining roots, increased N uptake rate and flow velocities within the xylem and phloem via the mesocotyl, and reduction in the shoot growth rate.

关键词： nitrogen flow nitrogen uptake root system components Zea mays

曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文长链非编码RNA lnc—DC通过STAT3调控人DC的分化和功能

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国肿瘤生物治疗杂志 2016年第5期23卷 I0001-I0002页

作者： Pin Wang Yiquan xue Yanmei Han Li Lin Cong Wu Sheng xu Zhengping Jiang Junfang Xu Qiuyan Liu xuetao Cao Institute of Immunology Zhejiang University School of Medicine Hangzhou 310058 China.

树突状细胞（DC）是免疫系统中重要的抗原提呈细胞，其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物丛因组能够转录产生大量的长链非编码RNA（10ngnoncodingRNA，IncRNA），其在免疫系统中的功能还知之甚少。

关键词：非编码RNA 学术论文 STAT3 科研团队长链曹雪涛 DC 国际

Changes in clinical indicators among human immunodeficiency virus patients who failed in antiretroviral therapy during 2004–2016 in Yunnan, China: an observational cohort study

维普期刊数据库

维普期刊数据库更多评论

在线全文

学校读者我要写书评

暂无评论

Global Health Journal 2020年第2期4卷 57-63页

作者： Peicheng Wang Junfang Xu Bingbing Guo Jason K Wang Liangmin Gao Qianyun Wang Jun Jing Feng Cheng Research Center for Public Health School of MedicineTsinghua University30 Shuangqing RoadBeijing 100084China Research Institute of Health Policy School of Public HealthZhejiang University866 Yuhangtang RoadHangzhou 310058China College of Life Science and Bioengineering Beijing University of Technology100 Ping Le YuanBeijing 100124China Schwarzman College Tsinghua University30 Shuangqing RoadBeijing 100084China Department of Sociology Tsinghua University30 Shuangqing RoadBeijing 100084China

Background:This study aimed to investigate the changes in the clinical indicators and influencing factors of treatment duration among human immunodeficiency virus(HIV)patients in whom antiretroviral therapy(ART)was unsuccessful.Methods:In this retrospective study,a total of 9,418 HIV patients who failed in ART during 2004–2016 were included and divided into two treatment groups—Group 1(treatment time≤3 years,n1=5,218)and Group 2(treatment time>3 years,n2=4,200).Patient follow-up data,including age,cluster of differentiation 4(CD4)count,and viral load,glucose,creatinine,and triglyceride levels,were extracted from electronic health record databases.Covariance analysis for repeated measures was used to analyze the biochemical indicators,and multiple logistic regression modeling was used to compare relevant data extracted from the Group 1 and Group 2 HIV patient cohorts with different treatment time.Results:The median initial CD4 count was 175.0 cells/μl(interquartile range,77.0–282.0),while the initial CD4 counts for Group 1 were lower than those for Group 2(P<0.05).A significant interaction between group and time effects was observed(P<0.05)in total cholesterol(TC).Changes in hemoglobin level among HIV patients were also significantly associated with treatment time(P=0.001).The initial CD4 count(odds ratio[OR]=0.756),female sex(OR=0.713),Zerit(d4T)(OR=1.443),TC(OR=1.285),and aspartate aminotransferase level(OR=1.002)were significantly associated with the survival time of dead patients with HIV(P<0.05).Additionally,the initial CD4 count(OR=1.456),age(OR=1.022),time interval(OR=0.903),patient’s living status(OR=0.597),d4T(OR=2.256),and triglyceride(OR=0.930)and hemoglobin levels(OR=0.997)were significantly associated with the treatment time of HIV patients with drug withdrawal(P<0.05).Conclusion:The initial biochemical parameters can affect the survival and treatment time of HIV patients.With a comprehensive understanding of the physiological and biochemical indicators of patients,we can reduce the probability of dru

关键词： Treatment time Biochemical indicators HIV/AIDS Failure of antiretroviral therapy

IFN-dependent and-independent lncRNAs regulate viral infection and innate antiviral responses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IFN-dependent and-independent lncRNAs regulate viral infecti...

Geometric regulation of collective cell tangential ordering migration

第十三届全国免疫学学术大会

作者： Pin Wang Junfang Xu Yujia Wang xuetao Cao second military medical university Department of Immunology & Center for Immunotherapy Institute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical Sciences Institute of Immunology Zhejiang University School of Medicine

Viral infection is one of the major threats to human health worldwide nowadays. Molecule mechanism studies in viral-host interaction would benefit us dealing with this threat. During viral infection, changes occurred in host cells at multiple levels, of which the most significant would be changes at transcriptional level, where many long noncoding RNAs(lncRNAs) genes’ expression are markedly changed. Interferon(IFN) are vital cytokines that control viral infection through activation of interferon-stimulated genes. Through comparing the transcriptome of wild type macrophages and Ifnabr KO macrophages, we identified two groups of lncRNAs in viral infection, IFN-dependent and-independent lncRNAs, and confirmed in expreriments with many other viral stimulations or recombinant IFN treatment. Among these lncRNAs, we performed siRNA-mediated functional screening and focused on a few of them to continue with molecular mechanism investigation, including lncRNA-ACOD1, lncRNA-304, lncRNA-105, and lncLRRC55. We found that IFN-independent lncRNA-ACOD1 facilitates viral replication in both mouse and human cells through directly binding metabolic enzyme GOT2 and promoting its catalysis. And IFN-dependent lncRNA-304, lncRNA-105, and lncLRRC55 could regulate TBK1/IRF3 signaling. Our work reveals a feedback way of virus-induced lncRNA-mediated regulation of viral replication and antiviral signaling, which are potential targets for developing broad-acting antiviral therapeutics.

关键词： viral innate immunity lncRNA IFN-I

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2024年第2期17卷 94-103页

作者： Hao Dong Yuming Zhou xuehe Ma junfang Liu Fulin Xing Jianyu Yang Qiushuo Sun Qingsong Hu Fen Hu Leiting Pan Jingjun xu The Key Laboratory of Weak-Light Nonlinear Photonics of Education Ministry School of Physics and TEDA Institute of Applied Physics Nankai University Tianjin 300071 P.R.China State Key Laboratory of Medicinal Chemical Biology Frontiers Science Center for Cell Responses College of Life Sciences Nankai University Tianjin 300071 P.R.China Shenzhen Research Institute of Nankai Uniwersity Shenzhen Guangdong 518083P.R.China Collaborative Innovation Center of Extreme Optics Shanxi University.Taiyuan Shanxi 030006P.R.China

Collective cell migration is a coordinated movement of multi-cell systems essential for various processes throughout life.The collective motions often occur under spatial restrictions,hallmarked by the collective rotation of epithelial cells confined in circular substrates.Here,we aim to explore how geometric shapes of confinement regulate this collective cell movement.We develop quantitative methods for cell velocity orientation analysis,and find that boundary cells exhibit stronger tangential ordering migration than inner cells in circular pattern.Furthermore,decreased tangential ordering movement capability of collective cells in triangular and square patterns are observed,due to the disturbance of cell motion at unsmooth corners of these patterns.On the other hand,the collective cell rotation is slightly affected by a convex defect of the circular pattern,while almost hindered with a concave defect,also resulting from different smoothness features of their boundaries.Numerical simulations employing cell Potts model well reproduce and extend experimental observations.Together,our results highlight the importance of boundary smoothness in the regulation of collective cell tangential ordering migration.

关键词： Collective cell migration spatial restrictions tangential ordering geometric regula-tion cell Potts model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

北京地区农宅不同节能减碳方案经济性浅析

建筑节能（中英文） 2023年第2期51卷 132-136,144页

作者：徐俊芳北京市建筑节能与建筑材料管理事务中心北京101160 北京市住房和城乡建设科学技术研究所北京101160

在国家碳达峰碳中和的战略目标下,农宅节能减碳成为民用建筑领域节能减碳重点工作之一,应给予更多的关注和重视。以50年为农宅生命期,对2层250 m^(2)、单层120 m^(2)和单层75 m^(2)轻钢结构农宅执行不同节能标准、采用不同清洁采暖方案... 详细信息

在国家碳达峰碳中和的战略目标下,农宅节能减碳成为民用建筑领域节能减碳重点工作之一,应给予更多的关注和重视。以50年为农宅生命期,对2层250 m^(2)、单层120 m^(2)和单层75 m^(2)轻钢结构农宅执行不同节能标准、采用不同清洁采暖方案的经济性和碳排放进行测算分析,以寻求适合农宅的节能减碳技术路线。结果表明,农宅节能减碳应选择主动和被动节能技术相结合的技术路线,即在执行一定节能标准(节能75%或节能80%)的基础上,增设太阳能光伏应用,可达到与超低能耗或近零能耗农宅同样的节能减排效果,且具有较好的经济性,如节能75%农宅采用光伏+电暖器方案的收益投资比最佳,节能80%农宅的光伏+电暖器方案采暖的能耗和碳排放为负值。

关键词：农宅节能减碳采暖方案经济性对比分析