检索结果-南通市图书馆

RSPSSL:A novel high-fidelity Raman spectral preprocessing scheme to enhance biomedical applications and chemical resolution visualization

引用

Light(Science & Applications) 2024年第2期13卷 366-386页

作者： Jiaqi Hu Gina Jinna chen chenlong Xue Pei Liang Yanqun Xiang Chuanlun Zhang Xiaokeng Chi Guoying Liu Yanfang Ye Dongyu Cui De Zhang Xiaojun yu Hong Dang Wen Zhang junfan chen Quan Tang Penglai Guo Ho-Pui Ho Yuchao Li Longqing Cong Perry Ping Shum State Key Laboratory of Optical Fiber and Cable Manufacture Technology Guangdong Key Laboratory of Integrated Optoelectronics IntellisenseDepartment of EEESouthern University of Science and TechnologyShenzhen 518055China College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060China Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Nephrology Chaozhou People’s HospitalChaozhou 521011China Clinical Research Design Division Sun Yatsen Memorial HospitalGuangzhouGuangdong 510120China School of Automation Northwestern Polytechnical UniversityXi’anShaanxi 710072China Department of Biomedical Engineering The Chinese University of Hong KongHong KongChina Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Institute of NanophotonicsJinan UniversityGuangzhou 511443China

Raman spectroscopy has tremendous potential for material analysis with its molecular fingerprinting capability in many branches of science and *** is also an emerging omics technique for metabolic profiling to shape precision ***,precisely attributing vibration peaks coupled with specific environmental,instrumental,and specimen noise is *** Raman spectral preprocessing to remove statistical bias noise and sample-related errors should provide a powerful tool for valuable information ***,we propose a novel Raman spectral preprocessing scheme based on self-supervised learning(RSPSSL)with high capacity and spectral *** can preprocess arbitrary Raman spectra without further training at a speed of~1900 spectra per second without human *** experimental data preprocessing trial demonstrated its excellent capacity and signal fidelity with an 88%reduction in root mean square error and a 60%reduction in infinite norm(L__(∞))compared to established *** this advantage,it remarkably enhanced various biomedical applications with a 400%accuracy elevation(ΔAUC)in cancer diagnosis,an average 38%(few-shot)and 242%accuracy improvement in paraquat concentration prediction,and unsealed the chemical resolution of biomedical hyperspectral images,especially in the spectral fingerprint *** precisely preprocessed various Raman spectra from different spectroscopy devices,laboratories,and diverse *** scheme will enable biomedical mechanism screening with the label-free volumetric molecular imaging tool on organism and disease metabolomics profiling with a scenario of high throughput,cross-device,various analyte complexity,and diverse applications.

关键词： spectral scheme resolution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于多参数MRI影像组学评估前列腺癌侵袭性

引用

陆军军医大学学报 2024年第2期46卷 170-180页

作者：杨静黄豆豆陈峻帆罗银灯刘玥希重庆医科大学附属第二医院放射科重庆400010

目的探讨多参数MRI上不同感兴趣区的影像组学模型和结合影像组学、PI-RADS 2.1评分、临床变量的综合模型在评估前列腺癌侵袭性方面的价值。方法收集本院2018年5月至2022年9月2个医疗中心经病理确诊为前列腺癌患者245例:渝中院区176例... 详细信息

目的探讨多参数MRI上不同感兴趣区的影像组学模型和结合影像组学、PI-RADS 2.1评分、临床变量的综合模型在评估前列腺癌侵袭性方面的价值。方法收集本院2018年5月至2022年9月2个医疗中心经病理确诊为前列腺癌患者245例:渝中院区176例,其中低侵袭性组[Gleason评分≤7(3+4)]77例,高侵袭性组[Gleason评分≥7(4+3)]99例;江南院区69例(低侵袭性组33例,高侵袭性组36例)。所有患者行多参数MRI检查后,在多参数MRI图像上分割2种ROI:肿瘤病变区域(tumor region, TR)和前列腺区域(prostate gland, PG)。评估与前列腺癌侵袭性相关的临床变量,并记录每位患者的PI-RADS 2.1评分。使用逻辑回归算法作为机器学习算法,建立多个前列腺癌侵袭性分层模型:影像组学模型(ModelTR、ModelPG、ModelPG+TR)、影像组学-临床联合模型、影像组学-PIRADS联合模型、临床-PIRADS联合模型和影像组学-临床-PIRADS综合模型。分别采用受试者工作特性(ROC)曲线、曲线下面积(AUC)和决策曲线分析(DCA)比较各模型的诊断价值和临床收益。结合影像组学评分、独立临床变量和PI-RADS2.1评分构建影像组学列线图。通过校准度、区分度和临床应用评价列线图性能。结果在3种影像组学模型中,ModelPG+TR的AUC值为0.919,高于ModelTR(AUC=0.874)和ModelPG(AUC=0.887)。在联合模型中,影像组学-PIRADS-临床综合模型的AUC为0.954,优于影像组学模型(AUC=0.919)、影像组学-临床联合模型(AUC=0.919)、影像组学-PIRADS联合模型(AUC=0.921)和临床-PIRADS联合模型(AUC=0.769)。列线图在评估前列腺癌侵袭性方面显示出良好的风险分层性能(AUC=0.919)和校准效能。决策曲线分析显示,影像组学模型ModelPG+TR和影像组学-临床-PIRADS综合模型获得了较高的临床净收益。结论结合前列腺和肿瘤区域特征的影像组学模型可准确评估前列腺癌的侵袭性;结合影像组学、PI-RADS 2.1评分和临床变量的综合模型能进一步提高对前列腺癌侵袭性的评估性能。

关键词：影像组学多参数磁共振成像前列腺肿瘤侵袭性前列腺体积肿瘤体积

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

特高压输电线路全过程机械化施工方案及费用分析

引用

山东电力技术 2024年第6期51卷 68-76页

作者：王成李钟龚涛陈俊帆李磊中国电力工程顾问集团西南电力设计院有限公司四川成都610021

现有特高压输电线路常采用全过程机械化施工方式,针对其设计方案和费用分析的研究仍较少。文中依托白鹤滩—浙江特高压直流输电线路工程,从物料及设备运输、基础选型及施工、组塔施工方案、环境和水资源保护管理方案等四个方面进行了专... 详细信息

现有特高压输电线路常采用全过程机械化施工方式,针对其设计方案和费用分析的研究仍较少。文中依托白鹤滩—浙江特高压直流输电线路工程,从物料及设备运输、基础选型及施工、组塔施工方案、环境和水资源保护管理方案等四个方面进行了专题研究,总结了适用于不同环境条件下特高压全过程机械化施工的推荐方案和改进建议;基于定额规定测算了人工费用和临时道路长度对机械化施工工程费用的影响规律。测算结果表明,山区机械化施工可使挖孔基础费用减少约7.4万元/基,对于广泛使用挖孔基础的工程,经济效果显著;对于丘陵和山地地区,临时新建施工道路修筑长度分别为320 m和500 m时,机械方案和人工方案费用大体持平,设计时可根据修路长度综合比较选择施工方式。

关键词：特高压输电线路机械化施工设计方案费用分析优化建议

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Uniqueness of Meromorphic Solutions for a Class of Complex Linear Differential-Difference Equations

引用

Journal of Mathematical Research with Applications 2022年第4期42卷 331-348页

作者： Hongjin LIN junfan chen Shuqing LIN School of Mathematics and Statistics Fujian Normal University

In this paper,we mainly study the uniqueness of transcendental meromorphic solutions for a class of complex linear differential-difference ***,suppose that f（z）is a finite order transcendental meromorphic solution of complex linear differential-difference equation:W1（z）f'（z+1）+W2（z）f（z）=W3（z）,where W1（z）,W2（z）,W3（z） are nonzero meromorphic functions,with their orders of growth being less than one,such that W1（z）+W2（z）■*** f（z） and a meromorphic function g（z） share 0,1,∞ CM,then either f（z）≡g（z） or f（z）+g（z）≡f（z）g（z） or f2（z）(g（z）-1)2+g2（z）(f（z）-1)2≡f（z）g（z）(f（z）g（z）-1) or there exists a polynomial φ（z）=az+b0such that ■ where a（≠0）,a0,b0are constants with ea0≠eb0.

关键词： meromorphic solution complex differential-difference equation shared value uniqueness finite order

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Microglia activation,classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage

引用

Neural Regeneration Research 2022年第7期17卷 1404-1411页

作者： junfan chen Zhiyuan Vera Zheng Gang Lu Wai Yee Chan Yisen Zhang George Kwok Chu Wong Division of Neurosurgery Department of SurgeryThe Chinese University of Hong KongHong Kong Special Administrative RegionChina Department of Neurosurgery Hainan Branch of Chinese People’s Liberation Army General HospitalSanyaHainan ProvinceChina CUHK-SDU Joint Laboratory on Reproductive Genetics School of Biomedical Sciencesthe Chinese University of Hong KongHong Kong Special Administrative RegionChina Bioinformatics Unit SDIVF R&D CentreHong Kong Science and Technology ParksHong Kong Special Administrative RegionChina Department of Interventional Neuroradiology Beijing Neurosurgical InstituteBeijing Tiantan HospitalCapital Medical UniversityBeijingChina

Subarachnoid hemorrhage is a devastating disease with significant mortality and morbidity,despite advances in treating cerebral *** has been recent progress in the intensive care management and monitoring of patients with subarachnoid hemorrhage,but the results remain ***,the resident immune cells of the brain,are increasingly recognized as playing a significant role in neurological diseases,including subarachnoid *** early brain injury following subarachnoid hemorrhage,microglial activation and neuroinflammation have been implicated in the development of disease complications and *** understand the disease processes following subarachnoid hemorrhage,it is important to focus on the modulators of microglial activation and the pro-inflammatory/anti-inflammatory cytokines and *** this review,we summarize research on the modulators of microglia-mediated inflammation in subarachnoid hemorrhage,including transcriptome changes and the neuroinflammatory signaling *** also describe the latest developments in single-cell transcriptomics for microglia and summarize advances that have been made in the transcriptome-based classification of microglia and the implications for microglial activation and neuroinflammation.

关键词： activation inflammation microglia modulator neuroinflammation sequencing signal pathway single-cell analysis stroke subarachnoid hemorrhage treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage

引用

Stroke & Vascular Neurology 2022年第1期7卷 62-70页

作者： Zhiyuan Vera Zheng junfan chen Hao Lyu Sin Yu Erica Lam Gang Lu Wai Yee Chan George K C Wong Department of Surgery The Chinese University of Hong KongShatinHong Kong Department of Surgery Hainan General HospitalHaikouHainanChina School of Biomedical Science The Chinese University of Hong KongShatinHong Kong

Background and purpose Signal transducer and activator of transcription 3(STAT3)may contribute to the proinflammation in the central nervous system diseases by modulating the microglial ***,this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage(SAH).Methods The SAH model was established by endovascular perforation in the ***-time PCR(RtPCR)and western blot were used to examine the dynamic STAT3 signalling pathway responses after *** clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH,the microglia-specific STAT3 knockout(KO)mice were generated by the Cre-LoxP *** neurological functions were assessed by Catwalk and Morris water maze *** loss after SAH was determined by immunohistochemistry *** polarisation status after STAT3 KO was then examined by RtPCR and *** The STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after *** factors and related mediators altered dynamically and *** STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after *** investigate the underlying mechanism,we examined the microglial reaction after STAT3 ***3 deletion reversed the increase of microglia after *** of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 ***,microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early *** STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent *** STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inf

关键词： STAT3 inflammation reversed

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

UNIQUENESS THEOREMS OF L-FUNCTIONS IN THE EXTENDED SELBERG CLASS

引用

Acta Mathematica Scientia 2020年第4期40卷 970-980页

作者： junfan chen Chunhui QIU College of Mathematics and Informatics/Fujian Key Laboratory of Mathematical Analysis and Applications Fujian Normal UniversityFuzhou 350117China School of Mathematical Sciences Xiamen UniversityXiamen 361005China

We establish uniqueness theorems of L-functions in the extended Selberg class,which show how an L-function and a meromorphic function are uniquely determined by their shared values in two finite *** can be seen as a n... 详细信息

关键词： L-function shared set meromorphic function uniqueness

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microglia accumulation and activation after subarachnoid hemorrhage

引用

Neural Regeneration Research 2021年第8期16卷 1531-1532页

作者： junfan chen George Kwok Chu Wong Division of Neurosurgery Department of SurgeryThe Chinese University of Hong KongHong Kong Special Administrative RegionChina

Subarachnoid hemorrhage(SAH) is a severe cerebrovascular disease accounting for a significant portion of young patients with stroke with high morbidity and mortality(van Gijn et al., 2007). Secondary brain injury resulting from neuroinflammation is considered to be a key pathological process(Zheng and Wong, 2017). Microglia, the resident immune cells of the brain, are implicated in numerous neurological diseases, such as Alzheimer's disease。

关键词： hemorrhage al. mortality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Machine learning molecular dynamics simulations of liquid methanol

引用

中国科学技术大学学报 2024年第6期54卷 12-21,I0009,I0010页

作者： Jie Qian junfan Xia Bin Jiang Hefei National Research Center for Physical Sciences at the Microscale Department of Chemical PhysicsUniversity of Science and Techno-logy of ChinaHefei 230026China

As the simplest hydrogen-bonded alcohol,liquid methanol has attracted intensive experimental and theoretical ***,theoretical investigations on this system have primarily relied on empirical intermolecular force fields or ab initio molecular dynamics with semilocal density *** by recent studies on bulk water using increasingly accurate machine learning force fields,we report a new machine learning force field for liquid methanol with a hybrid functional revPBE0 plus dispersion *** dynamics simulations on this machine learning force field are orders of magnitude faster than ab initio molecular dynamics simulations,yielding the radial distribution functions,selfdiffusion coefficients,and hydrogen bond network properties with very small statistical *** resulting structural and dynamical properties are compared well with the experimental data,demonstrating the superior accuracy of this machine learning force *** work represents a successful step toward a first-principles description of this benchmark system and showcases the general applicability of the machine learning force field in studying liquid systems.

关键词： liquid methanol molecular dynamics machine learning hydrogen bond force field

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Covert LEO Satellite Communication Aided by Generative Adversarial Network Based Cooperative UAV Jamming

引用

China Communications 2024年第9期 27-39页

作者： Shi Jia Li Xiaomeng Liao Xiaomin Tie Zhuangzhuang Hu junfan School of Communication Engineering Xidian University School of Information and Communications National University of Defense Technology

In this paper,we study the covert performance of the downlink low earth orbit(LEO) satellite communication,where the unmanned aerial vehicle(UAV) is employed as a cooperative *** maximize the covert rate of the LEO satellite transmission,a multi-objective problem is formulated to jointly optimize the UAV's jamming power and *** practical consideration,we assume that the UAV can only have partial environmental information,and can't know the detection threshold and exact location of the eavesdropper on the *** solve the multiobjective problem,we propose the data-driven generative adversarial network(DD-GAN) based method to optimize the power and trajectory of the UAV,in which the sample data is collected by using genetic algorithm(GA).Simulation results show that the jamming solution of UAV generated by DD-GAN can achieve an effective trade-off between covert rate and probability of detection errors when only limited prior information is obtained.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：