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Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats

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World Journal of Gastroenterology 2015年第25期21卷 7754-7763页

作者： Eugene Chang Lisa Kim Se Eun park Eun-Jung Rhee Won-young Lee Ki-Won Oh Sung-Woo park Cheol-young park Department of Nutritional Science and Food Management Ewha Womans University Diabetes Research Institute Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Division of Endocrinology and Metabolism Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine

AIM: To investigate whether ezetimibe ameliorates hepatic steatosis and induces autophagy in a rat model of obesity and type 2 diabetes. METhODS: Male age-matched lean control LETO and obese and diabetic OLETF rats were administered either PBS or ezetimibe(10 mg/kg per day) via stomach gavage for 20 wk. Changes in weight gain and energy intake were regularly monitored. Blood and liver tissue were harvested after overnight fasting at the end of study. histological assessment was performed in liver tissue. The concentrations of glucose, insulin, triglycerides(TG), free fatty acids(FFA), and total cholesterol(TC) in blood and TG, FFA, and TG in livertissue were measured. m RNA and protein abundance involved in autophagy was analyzed in the liver. To investigate the effect of ezetimibe on autophagy and reduction in hepatic fat accumulation, human huh7 hepatocytes were incubated with ezetimibe(10 μmol/L) together with or without palmitic acid(PA, 0.5 mmol/L, 24 h). Transmission electron microscopy(TEM) was employed to demonstrate effect of ezetimibe on autophagy formation. Autophagic flux was measured with bafilomycin A1, an inhibitor of autophagy and following immunoblotting for autophagy-related protein ***: In the OLETF rats that received ezetimibe(10 mg/kg per day), liver weight were significantly decreased by 20% compared to OLETF control rats without changes in food intake and body weight(P he serum glucose, insulin, hOMA-IR, and lipid profiles were also improved by ezetimibe(P hagy-related m RNA expression including ATG5, ATG6, and ATG7 and the protein level of microtubule-associated protein light chain 3(LC3) were significantly increased in the liver in rats that received ezetimibe(P hepatocytes cultured in vitro,

关键词： Autophagy Ezetimibe hepatic steatosis Nonalcoholic fatty liver disease

4-1BB-4-1BBL cis-interaction contributes to the survival of selfreactive CD8^(+)T cell

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Cellular & Molecular Immunology 2023年第9期20卷 1077-1080页

作者： Eunjung Cho Rohit Singh Chungyong han Seon-hee Kim Kwang h.Kim Bo-Mi park Dong hoon Shin Seongeun han young h.Kim Byoung S.Kwon Ki Taek Nam Beom K.Choi Immuno-oncology Branch Division of Rare and Refractory CancerNational Cancer CenterGoyang 10408Republic of Korea Severance Biomedical Science Institute Brain Korea 21 Project for Medical ScienceYonsei University College of MedicineSeoulRepublic of Korea Department of Cancer Biomedical Science Graduate School of Cancer Science and PolicyNational Cancer CenterGoyang 10408Republic of Korea Department of Biomedical Laboratory Science Catholic Kwandong UniversityGangneung 25601Republic of Korea Biomedicine Production Branch Research InstituteNational Cancer CenterGoyang 10408Republic of Korea Anticancer Resistance Branch Division of Rare and Refractory CancerResearch InstituteNational Cancer CenterGoyang 10408Republic of Korea Eutilex Co. Ltd.Geumcheon-guSeoul 08594Republic of Korea Department of Medicine Tulane University Health Sciences CenterNew OrleansLA 70112USA Innobationbio Co. Ltd.Mapo-guSeoul 03929Republic of Korea

4-1BB is an inducible receptor expressed on activated T cells,while its ligand,4-1BBL,is mainly expressed in antigen-presenting cells and macrophages[1,2].To the best of our knowledge,ligandmediated transactivation of... 详细信息

关键词： interaction activation knowledge

Scolopendra subspinipes mutilans protected the ceruleininduced acute pancreatitis by inhibiting high-mobility group box protein-1

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World Journal of Gastroenterology 2013年第10期19卷 1551-1562页

作者： Il-Joo Jo Gi-Sang Bae Kyoung-Chel park Sun Bok Choi Won-Seok Jung Su-young Jung Jung-hee Cho Mee-Ok Choi ho-Joon Song Sung-Joo park Department of herbology School of Oriental MedicineWonkwang UniversityIksanJeonbuk 540-749South Korea Department of Beauty Science Kwangju women's UniversityKwangju 506-713South Korea hanbang Body-fluid Research Center Wonkwang UniversityIksanJeonbuk 540-749South Korea Jeollanamdo Development Institute for Korean Traditional Medicine JangheungJeollanamdo 529-851South Korea

AIM:To evaluate the inhibitory effects of Scolopendra subspinipes mutilans(SSM) on cerulein-induced acute pancreatitis(AP) in a mouse ***:SSM water extract(0.1,0.5,or 1 g/kg) was administrated intraperitoneally 1 h prior to the first injection of *** AP developed,the stable cholecystokinin analogue,cerulein was injected hourly,over a 6 h *** samples were taken 6 h later to determine serum amylase,lipase,and cytokine *** pancreas and lungs were rapidly removed for morphological examination,myeloperoxidase assay,and real-time reverse transcription polymerase chain *** specify the role of SSM in pancreatitis,the pancreatic acinar cells were isolated using collagenase *** the cells were pre-treated with SSM,then stimulated with *** cell viability,cytokine productions and high-mobility group box protein-1(hMGB-1) were ***,the regulating mechanisms of SSM action were ***:The administration of SSM significantly attenuated the severity of pancreatitis and pancreatitis associated lung injury,as was shown by the reduction in pancreatic edema,neutrophil infiltration,vacuolization and *** treatment also reduced pancreatic weight/body weight ratio,serum amylase,lipase and cytokine levels,and mRNA expression of multiple inflammatory mediators such as tumor necrosis factor-α and interleukin-1β.In addition,treatment with SSM inhibited hMGB-1 expression in the pancreas during *** accordance with in vivo data,SSM inhibited the cerulein-induced acinar cell death,cytokine,and hMGB-1 *** also inhibited the activation of c-Jun Nh2-terminal kinase,p38 and nuclear factor(NF)-κ***:These results suggest that SSM plays a protective role during the development of AP and pancreatitis associated lung injury via deactivating c-Jun Nh2-terminal kinase,p38 and NF-κB.

关键词： Scolopendra subspinipes mutilans Cytokines Acute pancreatitis high-mobility group box protein-1

Three-dimensional kagome structures in a PCL/hA-based hydrogel scaffold to lead slow BMP-2 release for effective bone regeneration

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Bio-Design and Manufacturing 2023年第1期6卷 12-25页

作者： Se-hwan Lee Kang-Gon Lee Jaeyeon Lee Yong Sang Cho Min-Soo Ghim Soojin Kim Su-Jin heo Yongdoo park young-Sam Cho Bu-Kyu Lee McKay Orthopaedic Research Laboratory Department of Orthopaedic SurgeryPerelman School of MedicineUniversity of Pennsylvania36th Street and Hamilton WalkPhiladelphiaPA 19104USA Department of Biomedical Sciences College of MedicineKorea University73Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Medical Device Development Center Daegu-Gyeongbuk Medical Innovation Foundation(K-MEDI hub)80Cheombok-roDong-guDaegu 41061Republic of Korea Department of Mechanical Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea Biomedical Engineering Research Center Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea Department of Mechanical Design Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea MEChABIO Group Wonkwang University460Iksan-daeroIksan 54538Republic of Korea Department of Oral and Maxillofacial Surgery Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea

Osteoconductive function is remarkably low in bone disease in the absence of bone tissue surrounding the grafting site,or if the bone tissue is in poor ***,an effective bone graft in terms of both osteoconductivity and osteoinductivity is required for clinical ***,the three-dimensional(3D)kagome structure has been shown to be advantageous for bone tissue regeneration due to its mechanical *** this study,a polycaprolactone(PCL)kagome-structure scaffold containing a hyaluronic acid(hA)-based hydrogel was fabricated using a 3D printing *** retention capacity of the hydrogel in the scaffold was assessed in vivo with a rat calvaria subcutaneous model for 3 weeks,and the results were compared with those obtained with conventional 3D-printed PCL grid-structure scaffolds containing hA-based hydrogel and bulk-type hA-based *** retained hydrogel in the kagome-structure scaffold was further evaluated by in vivo imaging system *** further reinforce the osteoinductivity of the kagome-structure scaffold,a PCL kagome-structure scaffold with bone morphogenetic protein-2(BMP-2)containing hA hydrogel was fabricated and implanted in a calvarial defect model of rabbits for 16 *** bone regeneration characteristics were evaluated with hematoxylin and eosin(h&E),Masson’s trichrome staining,and micro-CT image analysis.

关键词： Kagome-structure scaffold Retention capacity Biomimetic hydrogel Bone morphogenetic protein-2(BMP-2)

Solar‑Driven Sustainability:Ⅲ–ⅤSemiconductor for Green Energy Production Technologies

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Nano-Micro Letters 2024年第11期16卷 445-478页

作者： Chandran Bagavath Jeong‑Kyun Oh Sang‑Wook Lee Dae‑young Um Sung‑Un Kim Veeramuthu Vignesh Jin‑Seo park Shuo han Cheul‑Ro Lee Yong‑ho Ra Division of Advanced Materials Engineering Engineering CollegeResearch Center for Advanced Materials Development(RCAMD)Jeonbuk National UniversityJeonju 54896Republic of Korea

Long-term societal prosperity depends on addressing the world’s energy and environmental problems,and photocatalysis has emerged as a viable *** the efficiency of photocatalytic processes is fundamentally achieved by optimizing the effective utilization of solar energy and enhancing the efficient separation of photogenerated *** has been demonstrated that the fabrication ofⅢ–Ⅴsemiconductor-based photocatalysts is effective in increasing solar light absorption,long-term stability,large-scale production and promoting charge *** focused review explores on the current developments inⅢ–Ⅴsemiconductor materials for solar-powered photocatalytic *** review explores on various subjects,including the advancement ofⅢ–Ⅴsemiconductors,photocatalytic mechanisms,and their uses in h2 conversion,CO_(2)reduction,environmental remediation,and photocatalytic oxidation and reduction *** order to design heterostructures,the review delves into basic concepts including solar light absorption and effective charge *** also highlights significant advancements in green energy systems for water splitting,emphasizing the significance of establishing eco-friendly systems for CO_(2)reduction and hydrogen *** main purpose is to produce hydrogen through sustainable and ecologically friendly energy *** review intends to foster the development of greener and more sustainable energy source by encouraging researchers and developers to focus on practical applications and advancements in solar-powered photocatalysis.

关键词： Green energy system hydrogen evolution CO_(2)reduction Ⅲ-Ⅴsemiconductors Photo electrochemical water splitting

Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways

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International Journal of Oral Science 2022年第2期14卷 192-200页

作者： Bongkun Choi Ji-Eun Kim Si-On park Eun-young Kim Soyoon Oh hyuksu Choi Dohee Yoon hyo-Jin Min hyung-Ryong Kim Eun-Ju Chang Department of Biomedical Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Stem Cell Immunomodulation Research Center Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Pharmacology College of DentistryJeonbuk National UniversityJeonjuKorea Department of Biochemistry and Molecular Biology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

Sphingosine-1-phosphate(S1P)is an important lipid mediator that regulates a diverse range of intracellular cell signaling pathways that are relevant to tissue engineering and regenerative ***,the precise function of S1P in dental pulp stem cells(DPSCs)and its osteogenic differentiation remains *** here investigated the function of S1P/S1P receptor(S1PR)-mediated cellular signaling in the osteogenic differentiation of DPSCs and clarified the fundamental signaling *** results showed that S1P-treated DPSCs exhibited a low rate of differentiation toward the osteogenic phenotype in association with a marked reduction in osteogenesis-related gene expression and AKT *** note,both S1PR1/S1PR3 and S1PR2 agonists significantly downregulated the expression of osteogenic genes and suppressed AKT activation,resulting in an attenuated osteogenic capacity of *** importantly,an AKT activator completely abrogated the S1P-mediated downregulation of osteoblastic markers and partially prevented S1P-mediated attenuation effects during ***,the pro-inflammatory TNF-αcytokine promoted the infiltration of macrophages toward DPSCs and induced S1P production in both DPSCs and *** findings indicate that the elevation of S1P under inflammatory conditions suppresses the osteogenic capacity of the DPSCs responsible for regenerative endodontics.

关键词： pulp hinder precise

Function-regeneration of non-porous hydrolyzed-MOF-derived materials

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Nano Research 2019年第8期12卷 1921-1930页

作者： Yo Chan Jeong Jin Weon Seo Jae ho Kim Seunghoon Nam Min Chang Shin young Shik Cho Jin Syul Byeon Chong Rae park Seung Jae Yang Carbon Nanomaterials Design Laboratory Research Institute of Advanced Materials and Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Advanced Nanohybrids Lab. Department of Chemical Engineering Inha UniversityIncheon 22212Republic of Korea School of Advanced Materials Engineering College of Engineering Andong National University Andong Gyeongsangbuk-do 36729Republic of Korea

A facile synthetic strategy based on a water-based process is developed for the preparation of metal-organic framework (MOF)-derived materials by revisiting the hydrolyzed non-porous metal-organic frameworks (h-MOF). The poor water stability of MOF has been recognized as key limitations for its commercialization and large-scale applications because the hydrolysis resulted in the complete loss of their functionalities. however, we found that the negative effect of hydrolysis on MOF can be nullified during the heat treatment. As similar to the intact MOF, h-MOF can be used as a precursor for the preparation of MOF-derived materials from porous MOF-derived carbons (MDCs) to MDC@ZnO composites. The property of h-MOF-derived materials is almost equivalent to that of MOF-derived materials. In addition, h-MOF turned the weakness of water instability to the strength of facile water-based process for hybridization. With the demonstration of the hybrid composite between h-MDC@ZnO and reduced graphene oxide (rGO) as a prototype example, it exhibited superior electrochemical performance when evaluated as an electrode material for lithium-ion batteries.

关键词： nanomaterials metal-organic framework (MOF) porous materials MOF-derived carbon hydrolyzed MOF

The photodynamic therapy on Streptococcus mutans biofilms using erythrosine and dental halogen curing unit

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International Journal of Oral Science 2012年第4期4卷 196-201页

作者： young-ho Lee ho-Won park Ju-hyun Lee hyun-Woo Seo Si-young Lee Department of Pediatric Dentistry Graduate SchoolCollege of DentistryGangneung-Wonju National University Department of Pediatric Dentistry College of DentistryGangneung-Wonju National University Department of Microbiology and Immunology College of DentistryGangneung-Wonju National University

The purpose of our study was to evaluate the effect of photodynamic therapy （PDT）, using erythrosine as a photosensitizing agent and a dental halogen curing unit as a light source, on Streptococcus mutans in a biofilm phase. The S. mutans biofilms were formed in a 24-well cell culture cluster. Test groups consisted of biofilms divided into four groups： group 1： no photosensitizer or light irradiation treatment （control group）; group 2： photosensitizer treatment alone; group 3： light irradiation alone; group 4： photosensitizer treatment and light irradiation. After treatments, the numbers of colony-forming unit （CFU） were counted and samples were examined by confocal laser scanning fluorescence microscopy （CLSM）. Only group 4 （combined treatment） resulted in significant increases in cell death, with rates of 75% and 55% after 8 h of incubation, and 74% and 42% at 12 h, for biofilms formed in brain-heart infusion （BhI） broth supplemented with 0% or O. 1% sucrose, respectively. Therefore, PDT of S. mutans biofilms using a combination of erythrosine and a dental halogen curing unit, both widely used in dental clinics, resulted in a significant increase in cell death. The PDT effects are decreased in biofilms that form in the presence of sucrose.

关键词： biofilms dental halogen curing unit erythrosine photodynamic therapy Streptococcus mutans

GnRh impairs diabetic wound healing through enhanced NETosis

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Cellular & Molecular Immunology 2020年第8期17卷 856-864页

作者： Yun Sang Lee Sung Un Kang Myung-hoon Lee haeng-Jun Kim Chang-hak han ho-Ryun Won young Uk park Chul-ho Kim Department of Otolaryngology School of MedicineAjou UniversitySuwonRepublic of Korea Department of Molecular Science and Technology Ajou UniversitySuwonRepublic of Korea Department of Otolaryngology School of MedicineChungnam National UniversityDaejeonRepublic of Korea Department of Orthopedic Surgery Ajou UniversitySuwonRepublic of Korea

It has been reported that neutrophil extracellular traps(NETs)impair wound healing in diabetes and that inhibiting NET generation(NETosis)improves wound healing in diabetic ***-releasing hormone(GnRh)agonists are associated with a greater risk of ***,the role of GnRh in diabetic wound healing is *** determined whether GnRh-promoted NETosis and induced more severe and delayed diabetic wound healing.A mouse model of diabetes was established using five injections with *** with blood glucose levels>250 mg/dL were then used in the *** agonist treatment induced delayed wound healing and increased NETosis at the skin wounds of diabetic *** contrast,GnRh antagonist treatment inhibited GnRh agonist-induced delayed wound *** expression of NETosis markers PAD4 and citrullinated histone h3 were increased in the GnRh-treated diabetic skin wounds in diabetic mice and *** vitro experiments also showed that neutrophils expressed a GnRh receptor and that GnRh agonist treatment increased NETosis markers and promoted phorbol myristate acetate(PMA)-induced NETosis in mouse and human ***,GnRh antagonist treatment suppressed the expression of NETosis markers and PMA-induced NETosis,which were increased by GnRh *** results indicated that GnRh-promoted NETosis and that increased NETosis induced delayed wound healing in diabetic skin ***,inhibition of GnRh might be a novel treatment of diabetic foot ulcers.

关键词： Neutrophils GnRh Diabetic wound healing NETosis