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GIGANTEA Shapes the Photoperiodic Rhythms of Thermomorphogenic Growth in Arabidopsis

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Molecular Plant 2020年第3期13卷 459-470页

作者： young-Joon park Jae young Kim june-hee Lee Byoung-Doo Lee Nam-Chon Paek Chung-Mo park Department of Chemistry Seoul National UniversitySeoul 08826Korea Department of Plant Science Seoul National UniversitySeoul 08826Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea These authors contributed equally to this article

Plants maintain their internal temperature under environments with fluctuating temperatures by adjusting their morphology and architecture,an adaptive process termed ***,the rhythmic patterns of plant thermomorphogenesis are governed by day-length ***,it remains elusive how thermomorphogenic rhythms are regulated by ***,we show that warm temperatures enhance the accumulation of the chaperone GIGANTEA(Gl),which thermostabilizes the DELLA protein,REPRESSOR OF ga1-3(RGA),under long days,thereby attenuating PhYTOChROME INTERACTING FACTOR 4(PIF4)-mediated *** contrast,under short days,when Gl accumulation is reduced,RGA is readily degraded through the gibberellic acid-mediated ubiquitination-proteasome pathway,promoting thermomorphogenic *** data indicate that the GI-RGA-PIF4 signaling module enables plant thermomorphogenic responses to occur in a day-length-dependent *** propose that the Gl-mediated integration of photoperiodic and temperature information shapes thermomorphogenic rhythms,which enable plants to adapt to diel fluctuations in day length and temperature during seasonal transitions.

关键词： thermomorphogenesis day length Gl RGA PIF4

Plasmid DNA-loaded asymmetrically porous membrane for guided bone regeneration

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Journal of Materials Science & Technology 2021年第4期63卷 161-171页

作者： Se heang Oh june-ho Byun So young Chun young-Joo Jang Jin ho Lee Department of Nanobiomedical Science Dankook UniversityCheonan 31116Republic of Korea Department of Oral and Maxillofacial Surgery Gyeongsang National University School of MedicineGyeongsang National University HospitalInstitute of Health SciencesGyeongsang National UniversityJinju 52727Republic of Korea BioMedical Research Institute Kyungpook National University HospitalDaegu 41404Republic of Korea Department of Advanced Materials Hannam UniversityDaejeon 34054Republic of Korea

Although bone defects can be restored spontaneously,bone reconstruction with sufficient strength and volume continues to be a challenge in clinical *** recent years,the use of a variety of biomaterials with bioactivity has been attempted to compensate for this ***,we fabricated a pDNA(encoding for BMP-2)-loaded asymmetrically porous polycaprolactone(PCL)/Pluronic F127 membrane as a bioactive guided bone regeneration(GBR)membrane,using a modified immersion-precipitation *** was observed that the GBR membrane allows continuous release of pDNA for more than20 *** pDNA was sufficiently transfected into human bone marrow stem cells(h BMSCs)without significant cytotoxicity and the gene-transfected cells showed prolonged synthesis of *** in vitro osteogenic differentiation and in vivo animal studies,the effective induction of osteogenic differentiation of h BMSCs and enhanced bone regeneration by the pDNA-loaded asymmetrically porous PCL/Pluronic F127 membrane was observed,suggesting that the pDNA-loaded membrane as a bioactive GBR membrane can be an alternative therapeutic technique for effective bone regeneration.

关键词： loaded porous attempted

Probing temperature-dependent interlayer coupling in a MoS2/h-BN heterostructure

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Nano Research 2020年第2期13卷 576-582页

作者： hamin park Gwang hyuk Shin Khang june Lee Sung-Yool Choi School of Electrical Engineering Centerfor Advanced Materials Discovery towards 3D Display KAISTDaejeon 34141Republic of Korea

Stacking of atomically thin layers of two-dimensional materials has revealed extraordinary physical phenomena owing to van der Waals(vdW)interaction at the ***,most of the studies focused on the transition metal dichalcogenide(TMD)/TMD heterostructure,while the interlayer coupling of the TMD/hexagonal boron nitride(h-BN)heterostructure has not been extensively explored despite its *** this study,the temperature-dependent interlayer coupling is demonstrated in a heterostructure of molybdenum disulfide(MoS2)and *** interface between MoS2 and the insulating substrate exerts a significant spectroscopic impact on MoS2 through substrate-induced local strain,charged impurity,and vdW *** non-resonant conditions,temperature-dependent peak shifts in Raman and photoluminescence(PL)spectra of MoS2 reveal the evolution of interlayer *** frequencies and PL peak energies at different temperatures demonstrate how substrate-induced strain,impurity,and vdW interactions at the interface influence phonon vibration and excitonic transition of *** resonant conditions at low temperature,anomalous Raman modes appear in the MoS2/h-BN heterostructure because of the enhanced electron-phonon coupling and vdW *** anomalous Raman modes are quantitatively investigated by the deconvolution of the resonance Raman spectra and described by interlayer coupling at low temperature,in agreement with complementary indications from the temperature-dependent evolution of non-resonant Raman and PL spectra.

关键词： van der Waals heterostructures interlayer coupling Raman spectroscopy excitonic resonance photoluminescence

Identifying Driver Genes Mutations with Clinical Significance in Thyroid Cancer

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Computers, Materials & Continua 2021年第4期67卷 1241-1251页

作者： hyeong Won Yu Muhammad Afzal Maqbool hussain hyungju Kwon young Joo park june young Choi Kyu Eun Lee Department of Surgery Seoul National University Bundang HospitalSeongnam-siKorea Department of Software Sejong UniversitySeoulKorea Department of Surgery College of MedicineEwha Womans UniversitySeoulKorea Department of Internal Medicine Seoul National University Hospital and College of MedicineSeoulKorea Department of Surgery Seoul National University Hospital and College of MedicineSeoulKorea

Advances in technology are enabling gene mutations in papillary thyroid carcinoma(PTC)to be analyzed and clinical outcomes,such as recurrence,to be *** date,the most common genetic mutation in PTC is in BRAF kinase(BRAF).however,whether mutations in other genes coincide with those in BRAF remains to be *** aim of this study was to find mutations in other genes that co-exist with mutated BRAF,and to analyze their frequency and clinical relevance in *** and genetic data were collected from 213 PTC patients with a total of 36,572 mutation sites in 735 *** matching with genes from PTC entries in a global database(NCBI Gene),69 genes with mutations in coding regions were chosen for further *** frequency-based analysis,we identified commonly mutated genes co-existing with mutated BRAF and,using the mutation count correlation matrix(MCCM)method,analyzed their incidence according to age and *** designed Chord diagrams to reveal gene relationships concerning age and gender,and found that mutations in ALK,ATM,COL1A1,MSTIR,PRKCA,and WNK1 most commonly coincide with mutated BRAF,followed by APC,AURKA,and *** findings provide further insight into the genetic profile of PTC.

关键词： Medical informatics papillary thyroid carcinoma cancer gene mutation analysis BRAF clinical significance

Segmented tomographic evaluation of structural degradation of carbon support in proton exchange membrane fuel cells

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Journal of Energy Chemistry 2022年第11期31卷 359-367,I0010页

作者： Jung A.hong Min-hyoung Jung Sung Yong Cho Eun-Byeol park Daehee Yang young-hoon Kim Sang-hyeok Yang Woo-Sung Jang Jae hyuck Jang hyo june Lee Sungchul Lee hu young Jeong young-Min Kim Department of Energy Science Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Fuel Cell Core Parts Development Cell Hyundai Mobis Co.Ltd.Uiwang 16082Republic of Korea Electron Microscopy&Spectroscopy Team Korea Basic Science Institute(KBSI)Daejeon 34133Republic of Korea Graduate School of Semiconductor Materials and Devices Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

The variation of the three-dimensional(3D)structure of the membrane electrode of a fuel cell during proton exchange cycling involves the corrosion/compaction of the carbon *** increasing degradation of the carbon structure continuously reduces the electrocatalytic performance of proton exchange membrane fuel cells(PEM-FCs).This phenomenon can be explained by performing 3D tomographic analysis at the ***,conventional tomographic approaches which present limited experimental feasibility,cannot perform such evaluation and have not provided sufficient structural information with statistical significance thus ***,a reliable methodology is required for the 3D geometrical evaluation of the carbon ***,we propose a segmented tomographic approach which employs pore network analysis that enables the visualization of the geometrical parameters corresponding to the porous carbon structure at a high *** approach can be utilized to evaluate the 3D structural degradation of the porous carbon structure after cycling in terms of local surface area,pore size distribution,and their 3D *** geometrical parameters of the carbon body were demonstrated to be substantially reduced owing to the cycling-induced *** information enables a deeper understanding of the degradation phenomenon of carbon supports and can contribute to the development of stable PEM-FC electrodes.

关键词： Electron tomography Fuel cell Proton exchange membrane Membrane electrode assembly Carbon corrosion

A Lookahead Read Cache： Improving Read Performance for Deduplication Backup Storage

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Journal of Computer Science & Technology 2017年第1期32卷 26-40页

作者： Dongchul park Ziqi Fan young Jin Nam David h. C. Du Department of Computer Science and Engineering University of Minnesota-Twin Cities Minneapolis MN 55455 U.S.A.

Data deduplication （dedupe for short） is a special data compression technique. It has been widely adopted to save backup time as well as storage space, particularly in backup storage systems. Therefore, most dedupe research has primarily focused on improving dedupe write performance. however, backup storage dedupe read performance is also a crucial problem for storage recovery. This paper designs a new dedupe storage read cache for backup applications that improves read performance by exploiting a special characteristic： the read sequence is the same as the write sequence. Consequently, for better cache utilization, by looking ahead for future references within a moving window, it evicts victims from the cache having the smallest future access. Moreover~ to further improve read cache performance. it maintains a small log buffer to judiciously cache future access data chunks. Extensive experiments with real-world backup workloads demonstrate that the proposed read cache scheme improves read performance by up to 64.3%

关键词： deduplication dedupe read cache backup

COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm

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Signal Transduction and Targeted Therapy 2020年第1期5卷 910-920页

作者： Wonhwa Lee june hong Ahn hee ho park hong Nam Kim hyelim Kim youngbum Yoo hyosoo Shin Kyung Soo hong Jong Geol Jang Chun Gwon park Eun young Choi Jong-Sup Bae young-Kyo Seo Aging Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Republic of Korea Division of Pulmonology and Allergy Department of Internal MedicineCollege of MedicineYeungnam University and Regional Center for Respiratory DiseasesYeungnam University Medical CenterDaegu 42415Republic of Korea Department of Biotechnology and Bioengineering Kangwon National UniversityChuncheonGangwon-do 24341Republic of Korea Center for BioMicrosystems Brain Science InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea Department of Biomedical Engineering SKKU Institute for ConvergenceSungkyunkwan University(SKKU)SuwonRepublic of Korea Biomedical Institute for Convergence at SKKU(BICS) Sungkyunkwan University2066 Seobu-roJangan-guSuwon 16419Republic of Korea College of Pharmacy CMRIResearch Institute of Pharmaceutical SciencesBK21 Plus KNU Multi-Omics based Creative Drug Research TeamKyungpook National UniversityDaegu 41566Republic of Korea

Sterol regulatory element binding protein-2(SREBP-2)is activated by cytokines or pathogen,such as virus or bacteria,but its association with diminished cholesterol levels in COVID-19 patients is ***,we evaluated SREBP-2 activation in peripheral blood mononuclear cells of COVID-19 patients and verified the function of SREBP-2 in ***,we report the first observation of SREBP-2 C-terminal fragment in COVID-19 patients’blood and propose SREBP-2 C-terminal fragment as an indicator for determining *** confirmed that SREBP-2-induced cholesterol biosynthesis was suppressed by Sestrin-1 and PCSK9 expression,while the SREBP-2-induced inflammatory responses was upregulated in COVID-19 ICU *** an infectious disease mouse model,inhibitors of SREBP-2 and NF-κB suppressed cytokine storms caused by viral infection and prevented pulmonary *** results collectively suggest that SREBP-2 can serve as an indicator for severity diagnosis and therapeutic target for preventing cytokine storm and lung damage in severe COVID-19 patients.

关键词： cytokine diagnosis damage

Determination of surgical priorities in appendicitis based on the probability of undetected appendiceal perforation

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World Journal of Gastroenterology 2015年第7期21卷 2131-2139页

作者： Sang Chul Lee Geon park Byung-Jo Choi Say-june Kim Department of Surgery Daejeon St. Mary’s Hospital the Catholic University of Korea Department of Radiology Daejeon St. Mary’s Hospital the Catholic University of Korea

AIM:To identify risk factors of actual appendiceal perforation when computed tomography(CT)scans suggest nonperforated appendicitis and accordingly determine surgical ***:We collected database of 1362 patients who underwent an appendectomy for acute appendicitis between 2006 and 2013.A single radiologist selected1236 patients whose CT scans were suggestive ofnonperforated *** were divided into 2 groups:actual nonperforation group and actual perforation group according to intraoperative and pathologic *** of the 2 groups were made using binary logistic ***:Of 1236 patients,90(7.3%)were found to have actual appendiceal *** risk factors related with actual appendiceal perforation were identified:body temperature≥37.6℃(hR=1.912,95%CI:1.161-3.149;P=0.011),out-ofhospital symptom duration≥72 h(hR=2.454,95%CI:1.292-4.662;P=0.006),age≥35 years(hR=3.358,95%CI:1.968-5.728;PhR=4.294,95%CI:1.034-17.832;P=0.045).Actual appendiceal perforation group showed longer operation time,later initiation of diet,longer use of parenteral narcotics,longer hospital stay,and higher incidence of postoperative complications(Phere new criteria to select patients with adverse clinical outcomes after appendectomy among the patients with radiologically nonperforated *** appendectomy outcomes could be improved by determining the surgical priority according to our criteria.

关键词： Appendicitis Appendiceal perforation Operative pri

Electrochemically Deposited CZTSSe Thin Films for Monolithic Perovskite Tandem Solar Cells with Efficiencies Over 17%

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Energy & Environmental Materials 2024年第1期7卷 147-152页

作者： Sun Kyung hwang Ik Jae park Se Won Seo Jae hyun park So Jeong park Jin young Kim Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Korea Department of Applied Physics Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials and Systems Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials(RIAM) Seoul National UniversitySeoul 08826Korea

In spite of the high potential economic feasibility of the tandem solar cells consisting of the halide perovskite and the kesterite Cu2ZnSn(S,Se)4(CZTSSe),they have rarely been demonstrated due to the difficulty in implementing solution-processed perovskite top cell on the rough surface of the bottom ***,we firstly demonstrate an efficient monolithic two-terminal perovskite/CZTSSe tandem solar cell by significantly reducing the surface roughness of the electrochemically deposited CZTSSe bottom *** surface roughness(R_(rms))of the CZTSSe thin film could be reduced from 424 to 86 nm by using the potentiostatic mode rather than using the conventional galvanostatic mode,which can be further reduced to 22 nm after the subsequent ion-milling *** perovskite top cell with a bandgap of 1.65 eV could be prepared using a solution process on the flattened CZTSSe bottom cell,resulting in the efficient perovskite/CZTSSe tandem solar *** the current matching between two subcells involving the thickness control of the perovskite layer,the best performing tandem device exhibited a high conversion efficiency of 17.5%without the hysteresis effect.

关键词： CZTSSe monolithic tandem solar cells perovskite solution process surface roughness control