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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru C.guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British Columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Practical approach for detecting k-nonseparability of multipartite quantum states

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 28-44页

作者： Jie guo Jinchuan Hou Xiaofei Qi Kan He College of Mathematics Taiyuan University of TechnologyTaiyuan 030006China School of Mathematics and Statistics Shanxi UniversityTaiyuan 030006China Key Laboratory of Complex Systems and Data Science of Ministry of Education Shanxi UniversityTaiyuan 030006China

The instantaneous detection of entanglement in quantum states poses a significant challenge in the fields of quantum computation and quantum information,and there are no practical methods or tools to complete this task satisfactorily so *** propose a sufficient and necessary criterion of k-nonseparability for any n-partite finite or infinite dimensional systems,2≤k≤*** criterion serves as the foundation for a practical scheme designed to detect entanglement and k-nonseparability across multipar-tite finite-dimensional *** exemplify the application of our scheme,we have developed a software tool that facilitates swift and precise identification of entanglement,k-nonseparability,and genuine entanglement within n-qubit systems,specifically tailored for systems with 2≤n≤4.

关键词： multipartite systems entanglement states entanglement witnesses k-nonseparability

A Multifunctional Hydrogel with Multimodal Self-Powered Sensing Capability and Stable Direct Current Output for Outdoor Plant Monitoring Systems

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Nano-Micro Letters 2025年第4期17卷 1-24页

作者： Xinge guo Luwei Wang Zhenyang Jin Chengkuo Lee Department of Electrical&Computer Engineering National University of Singapore4 Engineering Drive 3Singapore 117576Singapore Center for Intelligent Sensors and MEMS(CISM) National University of Singapore5 Engineering Drive 1Singapore 117608Singapore NUS Graduate School-Integrative Sciences and Engineering Program(ISEP) National University of SingaporeSingapore 119077Singapore Research Center for Sustainable Urban Farming(SUrF) National University of SingaporeSingapore 117558Singapore

Smart farming with outdoor monitoring systems is critical to address food shortages and sustainability *** systems facilitate informed decisions that enhance efficiency in broader environmental *** outdoor systems equipped with energy harvesters and self-powered sensors often struggle with fluctuating energy sources,low durability under harsh conditions,non-transparent or non-biocompatible materials,and complex ***,a multifunctional hydrogel is developed,which can fulfill all the above requirements and build selfsustainable outdoor monitoring systems solely by *** can serve as a stable energy harvester that continuously generates direct current output with an average power density of 1.9 W m^(-3)for nearly 60 days of operation in normal environments(24℃,60%RH),with an energy density of around 1.36×10^(7)J m^(-3).It also shows good self-recoverability in severe environments(45℃,30%RH)in nearly 40 days of continuous ***,this hydrogel enables noninvasive and self-powered monitoring of leaf relative water content,providing critical data on evaluating plant health,previously obtainable only through invasive or high-power consumption *** potential extends to acting as other self-powered environmental *** multifunctional hydrogel enables self-sustainable outdoor systems with scalable and low-cost production,paving the way for future agriculture.

关键词： Self-powered sensor Hydrogel Energy harvester Outdoor farming Self-sustainable IoT

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基于BERT的中文简历命名实体识别

计算机应用 2021年第S01期41卷 15-19页

作者：郭军成万刚胡欣杰魏展基航天工程大学航天信息学院北京101416

为了充分发掘中文简历数据中所蕴含的信息,提高构建社交网络知识图谱和档案知识图谱的实体丰富度,提出了基于BERT的中文简历命名实体识别技术。该技术模型首先通过BERT网络将大规模未标注文本生成具有语义特征的字符向量,接着通过嵌入... 详细信息

为了充分发掘中文简历数据中所蕴含的信息,提高构建社交网络知识图谱和档案知识图谱的实体丰富度,提出了基于BERT的中文简历命名实体识别技术。该技术模型首先通过BERT网络将大规模未标注文本生成具有语义特征的字符向量,接着通过嵌入条件随机场(CRF)的双向长短时记忆(BiLSTM)神经网络模型获取输入文本序列的上下文特征,解码标注提取出相应的8个实体类型。实验结果表明,该网络模型在个人中文简历数据集上取得了97.07%的平均F1值,可以运用于中文简历数据的实体识别任务。

关键词：条件随机场中文实体识别个人简历 BERT

红色旅游体验、集体记忆、国家认同形成机制研究--基于网络UGC数据分析

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旅游科学 2024年第5期38卷 80-95页

作者：钱莉莉郑春晖王金伟郭俊成浙大城市学院国际文化旅游学院浙江杭州310015 广州大学管理学院(旅游学院/中法旅游学院) 广东广州510006 北京第二外国语学院旅游科学学院北京100024 澳门旅游学院中国澳门999078

在国家政策导向及红色旅游快速发展背景下,文章针对红色旅游精神体验、传承集体记忆、促进国家认同等社会效益研究的薄弱环节与不足,以国内九大典型红色旅游地为例,运用扎根理论对网络UGC数据进行编码分析,使用Gephi软件进行编码节点分... 详细信息

在国家政策导向及红色旅游快速发展背景下,文章针对红色旅游精神体验、传承集体记忆、促进国家认同等社会效益研究的薄弱环节与不足,以国内九大典型红色旅游地为例,运用扎根理论对网络UGC数据进行编码分析,使用Gephi软件进行编码节点分析与可视化,以揭示红色旅游国家认同的形成机制。研究发现,红色旅游体验包含瞻仰圣地、纪念先辈、学习历史与知识、感受红色革命文化;集体记忆包含认知记忆、情感记忆、反思启示,兼具记忆的个体性与社会性;认同具有多尺度性,存在从地方认同到国家认同的地理跃迁。研究建构了“红色旅游体验-集体记忆-地方认同-国家认同”这一理论模型,明确了三种不同类型红色旅游地游客建构国家认同的路径差异,揭示了国家认同形成的多途径性。本研究对于指导红色旅游高质量发展,提升红色旅游社会效益具有重要借鉴意义。

关键词：红色旅游旅游体验集体记忆国家认同网络UGC

Polypropylene-based blend with enhanced breakdown strength under gamma-ray irradiation for cable insulation

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Nuclear Science and Techniques 2025年第1期36卷 35-48页

作者： Bai-Xin Liu Yu Gao Jing Li Chen-Yi guo Bo-Sen Si Jun-guo Gao Yu Chen Bo-Xue Du School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbin 150080China State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong UniversityXi’an 710049China

This study focuses on the electrical properties and microstructure of polypropylene(PP)-based blends used for cable insulation in nuclear power plants(NPPs).The PP-based blend,comprising isotactic PP and propylene-based elastomer(PBE)at concentrations ranging from 0 to 50 wt%,underwent a melt blending process and subsequent cobalt-60 gamma-ray irradiation with doses ranging from 0 to 250 *** conductivity,trap distribution,and alternating(AC)breakdown strength were chosen to assess the insulation *** results indicate that the addition of PBE significantly improves the electrical properties of PP under *** PP,the electrical conductivity increased with irradiation,whereas the trap depth and breakdown strength decreased ***,for the blend,these changes initially exhibit opposite *** the irradiation was increased to 250 kGy,the AC breakdown strength of the blend improved by more than 21%compared to that of *** physical and chemical structures of the samples were investigated to explore the improvement *** results offer insights into the design of new cable-insulation materials suitable for NPPs.

关键词： Nuclear power plant Cable insulation Polypropylene Electrical properties Gamma-ray irradiation

基于FY-4A LMI的贵州及周边区域闪电活动特征分析

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山地气象学报 2024年第4期48卷 49-55页

作者：吴安坤郭军成王强贵州省气象数据中心贵州贵阳550081 贵州省安顺市气象局贵州安顺561000

【目的】为开展星载闪电活动特征分析。【方法】采用FY-4A闪电成像仪资料,以贵州省及其周边区域为例,分析闪电频次分布及辐亮度分布特征。【结果】研究区域闪电频次集中分布在一年的中的4—8月,一天中的19时—次日05时,空间分布呈现显... 详细信息

【目的】为开展星载闪电活动特征分析。【方法】采用FY-4A闪电成像仪资料,以贵州省及其周边区域为例,分析闪电频次分布及辐亮度分布特征。【结果】研究区域闪电频次集中分布在一年的中的4—8月,一天中的19时—次日05时,空间分布呈现显著的地域性差异,整体南部高于北部;辐亮度日变化呈现与频次相反的单峰型变化,白天高于夜间,空间分布整体呈现西部高于东部、北部高于南部的特征;LMI闪电辐亮度值与雷电流强度密切相关,聚类后的LMI“组”数据一致性较好,“事件”与“组”频数比介于3~4之间,在空间尺度上与一次闪击或者K过程相符。【结论】研究结果为今后在业务中使用该资料提供参考。

关键词： FY-4A闪电成像仪闪电活动辐亮度

Zooplankton community composition in summers of 2021and 2022 in the northern East China Sea and Yellow Sea,and their linkage with abiotic and biotic factors

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Journal of Oceanology and Limnology 2025年第1期43卷 159-176页

作者： Dongjie guo Fang ZHANG Shuangyan ZHANG Song SUN CAS Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China College of Marine Science University of Chinese Academy of SciencesQingdao 266071China Jiaozhou Bay National Marine Ecosystem Research Station Institute of OceanologyChinese Academy of SciencesQingdao 266071China

The northern East China Sea and Yellow Sea are highly dynamic marginal seas,serving as important fishing grounds and primary areas for *** zooplankton community structure,including abundance,biovolume,and normalized biovolume size spectra(NBSS)within this ecosystem in summers 2021 and 2022 was assessed through ZooScan digital imaging *** abundances of zooplankton in summers 2021 and 2022 were 3364.22±2190.53 and 4435.52±2520.06 inds./m^(3),respectively,whereas the corresponding biovolumes were 649.10±519.63 and 1064.86±1254.87 mm^(3)/m^(3),*** copepods as the dominant zooplankton functional group in terms of abundance in both years,while chaetognath and medusae were the dominant groups in terms of *** dominance of medusae and chaetognath in terms of biovolume,along with the flatter slopes of NBSS compared to a stable community,indicated that more energy accumulated in gelatinous organisms within the study *** were significant positive relationships between temperature and tunicates or medusae,with a significantly higher population size observed in summer 2022 than in *** lower abundance and biovolume of zooplankton,mainly of small copepods,in summer 2021 may be related to the larger population size of the large jellyfish and the proliferation of green *** investigation provided basic data and fundamental insights for achieving a comprehensive understanding of zooplankton community structure and their long-term dynamics.

关键词： zooplankton community spatial distribution global warming Nemopilema nomurai Ulva prolifera

Sequence-activated chemiluminescence probes:programmable illumination for high-contrast in vivo sensing and imaging

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Science China Chemistry 2025年第1期68卷 26-34页

作者： Yutao Zhang Juan Li Wei-Hong Zhu Zhiqian guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular EngineeringInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science&TechnologyShanghai 200237China

Sequence-activated chemiluminescence(CL)technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial *** fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest,thus enabling high-contrast signals under complex physiological *** sequential activation could be triggered by enzymes,reactive oxygen species(ROS),biothiols or changes in the *** unique sequence-activated CL probes bestow several advantages,including minimal background,deep-tissue penetration,and the ability of non-invasive or minimally invasive *** sequence-activated CL techniques represent a significant advancement in molecular imaging and *** this mini-review,we focus on the latest developments in sequential CL probes,addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

关键词： chemiluminescnece sequence-activation in-vivo bioimaging cyclic peroxide