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Anti-lymphangiogenesis for boosting drug accumulation in tumors

Signal Transduction and Targeted Therapy 2024年第5期9卷 2161-2175页

作者： Chunling wang junchao Xu Xiaoyu Cheng Ge Sun Fenfen Li Guangjun Nie Yinlong Zhang CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Sino-Danish College University of Chinese Academy of SciencesBeijing 100190China Sino-Danish Center for Education and Research Beijing 100190China Department of Bioengineering University of PennsylvaniaPhiladelphiaPA 19104USA School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049China

The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant concern in the clinical prospects for *** strategies aiming at regulating the intratumoral permeability of therapeutic drugs have been explored in preclinical studies,with a primary focus on vascular regulation and stromal ***,these methods may trigger or facilitate tumor metastasis as a ***,there is an urgent need for innovative strategies that boost intratumoral drug accumulation without compromising treatment *** another important factor affecting drug tumor accumulation besides vasculature and stroma,the impact of tumor-associated lymphatic vessels(LVs)has not been widely *** the current research,we verified that anlotinib,a tyrosine kinase inhibitor with anti-lymphangiogenesis activity,and SAR131675,a selective VEGFR-3 inhibitor,effectively decreased the density of tumor lymphatic vessels in mouse cancer models,further enhancing drug accumulation in tumor *** combining anlotinib with therapeutic drugs,including doxorubicin(Dox),liposomal doxorubicin(Lip-Dox),and anti-PD-L1 antibody,we observed improved anti-tumor efficacy in comparison with monotherapy ***,this strategy significantly reduced tumor metastasis and elicited stronger anti-tumor immune *** work describes a new,clinically transferrable approach to augmenting intratumoral drug accumulation,w.ich shows great potential to address the current,unsatisfactory efficacies of therapeutic drugs without introducing metastatic risk.

关键词： drugs angiogenesis metastasis

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Superexchange and charge transfer in the nickelate superconductor La_(3)Ni_(2)O_(7) under pressure

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 1-8页

作者： w.i wú Zhihui Luo Dao-Xin Yao Meng wang Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSchool of PhysicsSun Yat-sen UniversityGuangzhou 510275China

Recently, a bulk nickelate superconductor La_(3)Ni_(2)O_(7) is discovered at pressures with a remarkable high transition temperature T_(c)~ 80 K. Here, we study a Hubbard model with tight-binding parameters derived from ab initio calculations of La_(3)Ni_(2)O_(7),by employing large scale determinant quantum Monte Carlo and cellular dynamical mean-field theory. Our result suggests that the superexchange couplings in this system are comparable to that of cuprates. The system is a charge transfer insulator as the hole concentration becomes four per site at large Hubbard U. Upon hole doping, two low-energy spin-singlet bands emerge in the system exhibiting distinct correlation properties: w.ile the one composed of the out-of-plane Ni-d_(3z^(2)-r^(2)) and O-p_(z) orbitals demonstrates strong antiferromagnetic correlations and narrow effective bandwidth, the in-plane singlet band consisting of the Ni-d_(x^(2)-y^(2)) and O-p_(x)/p_(y) orbitals is in general more itinerant. Over a broad range of hole doping, the doped holes occupy primarily the d_(x^(2)-y^(2)) and p_(x)/p_(y) orbitals, whereas the d_(3z^(2)-r^(2)) and p_(z) orbitals retain underdoped. we propose an effective t-J model to capture the relevant physics and discuss the implications of our result for comprehending the La_(3)Ni_(2)O_(7) superconductivity.

关键词： superconductivity nickelate superconductors Hubbard model superexchange charge transfer insulator quantum Monte Carlo

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Thermodynamics-directed bulk/grain-boundary engineering for superior electrochemical durability of Ni-rich cathode

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Journal of Energy Chemistry 2024年第10期97卷 321-331页

作者： Kangyu Zou Mingzhu Jiang Tianxiang Ning Lei Tan junchao Zheng Jiexi wang Xiaobo Ji Lingjun Li School of Materials Science and Engineering Changsha University of Science and Technology School of Metallurgy and Environment Central South University National Engineering Research Centre of Advanced Energy Storage Materials College of Chemistry and Chemical Engineering Central South University

introducing high-valence Ta element is an essential strategy for addressing the structu ral deterioration of the Ni-rich LiNi1-x-yCoxMnyO2（NCM） cathode,but the enlarged Li/Ni cation mixing leads to the inferior rate capability originating from the hindered Li+*** that the non-magnetic Ti4+ion can suppress Li/Ni disorder by removing the magnetic frustration in the transition metal ***,it is still challenging to directionally design expected Ta/Ti dual-modification,resulting from the complexity of the elemental distribution and the uncertainty of in-situ formed coating compounds by introducing foreign ***,a LiTaO3grain boundary（GB） coating and bulk Ti-doping have been successfully achieved in LiNi0.834Co0.11Mn0.056O2cathode by thermodynamic guidance,in w.ich the structural formation energy and interfacial binding energy are employed to predict the elemental diffusion discrepancy and thermodynamically stable coating *** to the coupling effect of strengthened structural/interfacial stability and improved Li+diffusion kinetics by simultaneous bulk/GB engineering,the Ta/Ti-NCM cathode exhibits outstanding capacity retention,reaching 91.1% after 400 cycles at 1 *** elaborate work contributes valuable insights into rational dual-modification engineering from a thermodynamic perspective for maximizing the electrochemical performances of NCM cathodes.

关键词： Bulk doping Dual-modification Grain boundary coating Ni-rich layered cathode Thermodynamic perspective

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Developing a two-decadal time-record of rice field maps using Landsat-derived multi-index image collections with a random forest classifier:A Google Earth Engine based approach

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information Processing in Agriculture 2024年第2期11卷 260-275页

作者： w.Ashane M.Fernando i.P.Senanayake Department of Nano Science Technology Wayamba University of Sri LankaKuliyapitiya 60200Sri Lanka Dchoolf Engineing CllegeoEngineeringSience and EnionmentThe UniversyewcastleCallaghanW2Austraia

Historic maps showing the temporal distribution of rice fields are important for precision agriculture,irrigation optimisation,forecasting crop yields,land use management and formulating ***,mapping rice felds using traditional ground surveys is impractical when high cost,time and labour requirements are considered,and the availability of such detailed records is *** satellite remote sensing appears to be a viable solution,conventional segmentation and classification methods with spectral bands are often unable to contrast the distinct characteristics between rice fields and other vegetation *** this end,we explored a novel,Google Earth Engine(GEE)based multiindex random forest(RF)classification approach to map rice fields over two *** images from 2000 to 2020 of two Sri Lankan rice cultivation districts were extracted from GEE and a multi-index RF classification algorithm was applied to distinguish the rice *** results showed above 80%accuracy for both training and validation,when compared against high spatial resolution Google Earth *** essence,multi-index sampling and RF together synergised the compelling classifcation accuracy by effectively capturing vegetation,water(ponding)and soil characteristics unique to the rice felds using a single-click *** maps developed in this study were further compared against the MODiS land cover type product(MCD12Q1)and the corresponding superior statistics on rice fields demonstrated the robustness of the proposed *** work seeking effective index combinations is recommended,and this approach can potentially be extended to other crop analyses elsewhere.

关键词： Google Earth Engine(GEE) image classification Random forest Mapping rice fields Time series analysis Vegetation index

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Exploration and Practice of Big Data introductory Courses for Big Data Management and Application Majors

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Journal of Contemporary Educational Research 2024年第2期8卷 131-137页

作者： Tinghui Huang junchao Dong Liang Min School of Computer Science and information Security Guilin University of Electronic TechnologyGuilin 541004Guangxi Zhuang Autonomous RegionChina School of Computer Engineering Guilin University of Electronic TechnologyBeihai 536000Guangxi Zhuang Autonomous RegionChina The Youth innovation Team of Shaanxi Universities Xi’an Jiaotong University City CollegeXi’an 710018Shaanxi ProvinceChina

As an introductory course for the emerging major of big data management and application,“introduction to Big Data”has not yet formed a curriculum standard and implementation plan that is widely accepted and used by *** this end,we discuss some of our explorations and attempts in the construction and teaching process of big data courses for the major of big data management and application from the perspective of course planning,course implementation,and course *** interviews with students and feedback from questionnaires,students are highly satisfied with some of the teaching measures and programs currently adopted.

关键词： Big data management and application “introduction to Big Data” Teaching reform Curriculum exploration

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Correction:Anti-lymphangiogenesis for boosting drug accumulation in tumors

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3141-3142页

作者： Chunling wang junchao Xu Xiaoyu Cheng Ge Sun Fenfen Li Guangjun Nie Yinlong Zhang CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China Sino-Danish College University of Chinese Academy of Sciences Beijing 100190 China Sino-Danish Center for Education and Research Beijing 100190 China Department of Bioengineering University of Pennsylvania Philadelphia PA 19104 USA School of Nanoscience and Engineering University of Chinese Academy of Sciences Beijing 100049 China

Correction to:Signal Transduction and Targeted Therapy https://***/10.1038/s41392-024-01794-4,published online 15 April 2024 After the article was published online,1 the authors noticed one inadvertent mistake in Supplementary *** image of lung H&E in the Lip-Dox group was repeatedly inserted as the image of Dox group by mistake during the preparation of the *** correct figure was provided as *** correction did not affect any of our results or discussion presented in the original *** apologize for this inadvertent *** original article has been corrected.

关键词： lung boosting repeatedly

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秩序重建:元末明初徽州防卫力量的变动

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安徽史学 2024年第2期 126-134页

作者：葛俊超安徽师范大学历史学院安徽芜湖241002

元末明初,徽州防卫力量经历了从宗族义兵到卫所军的变动。在此过程中,徽州义兵先被收编,继而被改造为卫所军;本地兵员被大量外调,外籍兵员调入补充。同时,朱元璋集团凭借不断聚集的政治军事资源,强化对徽州地方的控制,从而使双方由最初... 详细信息

元末明初,徽州防卫力量经历了从宗族义兵到卫所军的变动。在此过程中,徽州义兵先被收编,继而被改造为卫所军;本地兵员被大量外调,外籍兵员调入补充。同时,朱元璋集团凭借不断聚集的政治军事资源,强化对徽州地方的控制,从而使双方由最初的合作关系转变为中央对地方的管辖关系。在朱元璋集团“化家为国”过程中,徽州防卫力量从“本地化”的宗族武装被改造为“国家化”的卫所军队,体现了中央集权的重构;徽州地方势力从防卫力量的主导者重归于公共事务的参与者,则体现了新旧政权交替后地方秩序的重建。

关键词：元末明初徽州防卫义兵卫所

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Neuroprotective effect of Naochuxue prescription(脑出血方) on intracerebral hemorrhage:inhibition of autophagy via downregulating high mobility group box-1

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Journal of Traditional Chinese Medicine 2024年第5期44卷 944-953页

作者： JiN Hong wANG Xinna wANG Ruonan Li Jinjian YU junchao ZHAO Dexi ZHAi Lu College of Chinese medicine Changchun University of Chinese Medicine Department of Encephalopathy the Affiliated Hospital of Changchun University of Chinese Medicine College of nursing Changchun University of Chinese Medicine Research Center of Traditional Chinese Medicine the First Affiliated Hospital of Changchun University of Chinese Medicine

OBJECTiVE: To determine the molecular mechanisms underlying the neuroprotective effects of Naochuxue prescription(脑出血方,NCXP) in rats with intracerebral hemorrhage(iCH). METHODS: Sprague–Dawley rats were injected with collagenase to generate iCH models, w.ich were then randomly divided into six groups, including control, sham, model, and three intervention groups. The intervention groups received different doses of NCXP(0.13, 0.26, and 0.52 g/kg) daily for 10 d. High-performance liquid chromatography(HPLC) was used to analyze the chemical characteristics of NCXP. The neurobehavioral outcomes of the rats were evaluated using neurological deficit scores(Zea Longa 5) and the corner turn test. Pathomorphological changes in perihematomal tissues after iCH were observed using hematoxylin and eosin staining. immunohistochemistry(iHC) was used to detect the inflammation expression of interleukin 6(iL-6) and toll-like receptor 4(TLR4). High mobility group box-1(HMGB1), Beclin1, microtubule-associated protein 1 light chain 3 beta(LC3), and sequestosome 1(p62) were detected using real-time quantitative polymerase chain reaction and western blotting in perihematomal tissues. RESULTS: HPLC showed that the NCXP had good stability. Rats with iCH had severe neurological function deficits compared to the control group. iHC results showed that NCXP significantly downregulated the expression of the inflammatory proteins iL-6 and TLR4. iCH rats treated with NCXP showed less neurological injury than the model group, accompanied by a significantly decreased expression of HMGB1, Beclin1, and LC3 and an increased expression of p62. CONCLUSiONS: The neuroprotective effect of NCXP alleviated inflammation and autophagy possibly by downregulating HMGB1 expression. However, further research on the signaling pathways is required to verify this hypothesis.

关键词： HMGB proteins Naochuxue prescription autophagy inflammation intracerebral hemorrhage

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Generalized time-dependent generator coordinate method for induced fission dynamics

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Frontiers of physics 2024年第4期19卷 1-12页

作者： B.Li D.Vretenar T.Nikšić J.Zhao P.w.Zhao J.Meng State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Physics Department Faculty of ScienceUniversity of Zagreb10000 ZagrebCroatia Center for Circuits and Systems Peng Cheng LaboratoryShenzhen 518055China

The generalized time-dependent generator coordinate method(TD-GCM)is extended to include pairing *** correlated GCM nuclear wave function is expressed in terms of time-dependent generator states and w.ight *** particle–hole channel of the effective interaction is determined by a Hamiltonian derived from an energy density functional,w.ile pairing is treated dynamically in the standard BCS approximation with time-dependent pairing tensor and single-particle occupation *** the inclusion of pairing correlations,various time-dependent phenomena in open-shell nuclei can be described more *** model is applied to the description of saddle-to-scission dynamics of induced *** generalized TD-GCM charge yields and total kinetic energy distribution for the fission of 240Pu,are compared to those obtained using the standard time-dependent density functional theory(TD-DFT)approach,and with available data.

关键词： nuclear density functional theory generator coordinate method fission dynamics

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一种基于可达距离的模糊C均值聚类算法

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地球信息科学学报 2024年第9期26卷 2038-2051页

作者：崔俊超张琼冰李小龙湖南科技大学计算机科学与工程学院湘潭411100

设施选址对提高居民生活质量至关重要,利用地理可达相似性聚类对空间元素进行分类是求解此类问题的重要方法。然而,现有的应用于地理可达性分析的聚类算法存在地理可达性测度不准确、不涉及簇中心选取或簇中心不可达等缺陷,不能有效求... 详细信息

设施选址对提高居民生活质量至关重要,利用地理可达相似性聚类对空间元素进行分类是求解此类问题的重要方法。然而,现有的应用于地理可达性分析的聚类算法存在地理可达性测度不准确、不涉及簇中心选取或簇中心不可达等缺陷,不能有效求解真实场景下的设施选址问题。基于此,本文提出一种基于可达距离的模糊C均值聚类算法(Fuzzy C-Means based on Reachable Distance,FCM-RD)。FCM-RD算法改造了经典FCM算法的目标函数、隶属度函数和簇中心函数,使其适用基于可达距离的聚类分析。其次,以沿路网的最短路径距离作为可达距离衡量元素间的地理可达相似性,将聚类元素的二维地理坐标映射为路网坐标,并以此设计簇中心迭代机制,实现在聚类过程中以可达距离迭代不受约束的可达簇中心。同时,对所提簇中心迭代机制的有效性进行理论分析和实验验证,结果表明,FCM-RD算法在每次迭代中所选的各簇簇中心唯一且为当前簇类目标函数最小值点。最后,基于真实地理场景的仿真实验表明,相比基准算法,FCM-RD不仅能获得位置不受限的可达簇中心,而且能获得更好的聚类效果,为实际场景下的地理空间聚类方案提供了有效且精准的解决方案。

关键词：地理可达性空间聚类可达距离设施选址路网模糊C均值聚类簇中心迭代机制

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