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Topological超共形代数的Leibniz中心扩张

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数学年刊（A辑） 2010年第4期31卷 411-418页

作者：法焕霞李军波王伟中国科学技术大学数学系合肥230026 常熟理工学院数学与统计学院江苏常熟215500 宁夏大学数学计算机学院银川750021

通过计算得到了Topological N=2超共形代数T的Leibniz二上同调群,从而确定了此代数的Leibniz中心扩张.

关键词： Topological N=2超共形代数 Leibniz二上同调群 Leibniz中心扩张

TEA domain transcription factor 1(TEAD1)induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1209-1220页

作者： Shuai Song Xiaokai Zhang Zihang Huang Yongchao Zhao Shuyang Lu linqi Zeng Fengze Cai Tongyao Wang Zhiqiang Pei Xinyu Weng Wei Luo Hao Lu Zilun Wei Jian Wu Peng Yu li Shen Xiaochun Zhang Aijun Sun junbo Ge Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghaiChina State Key Laboratory of Cardiology Zhongshan HospitalFudan UniversityShanghaiChina Key Laboratory of Viral Heart Diseases National Health CommissionShanghaiChina Key Laboratory of Viral Heart Diseases Chinese Academy of Medical SciencesShanghaiChina National Clinical Research Center for Interventional Medicine ShanghaiChina Department of cardiac surgery Zhongshan HospitalFudan UniversityShanghaiChina Institutes of Biomedical Sciences Fudan UniversityShanghaiChina Shanghai Institute of Hypertension Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Cardiac fibroblasts(CFs)are the primary cells tasked with depositing and remodeling collagen and significantly associated with heart failure(HF).TEAD1 has been shown to be essential for heart development and ***,fibroblast endogenous TEAD1 in cardiac remodeling remains incompletely *** analyses revealed consistently upregulated cardiac TEAD1 expression in mice 4 weeks after transverse aortic constriction(TAC)and Ang-l *** investigation revealed that CFs were the primary cell type expressing elevated TEAD1 levels in response to pressure *** TEAD1 knockout was achieved by crossing TEAD1-floxed mice with CFs-and myofibroblasts-specific Cre *** and histological analyses demonstrated that CFs-and myofibroblasts-specific TEAD1 deficiency and treatment with TEAD1 inhibitor,VT103,ameliorated TAC-induced cardiac ***,RNA-seq and ChiP-seq analysis identified Wnt4 as a novel TEAD1 ***1 has been shown to promote the fibroblast-to-myofibroblast transition through the Wnt signalling pathway,and genetic Wnt4 knockdown inhibited the pro-transformation phenotype in CFs with TEAD1 ***,coimmunoprecipitation combined with mass spectrometry,chromatin immunoprecipitation,and luciferase assays demonstrated interaction between TEAD1 and BET protein BRD4,leading to the binding and activation of the Wnt4 *** conclusion,TEAD1 is an essential regulator of the pro-fibrotic CFs phenotype associated with pathological cardiac remodeling via the BRD4/Wnt4 signallingpathway.

关键词： TEAD1 expression Wnt4

Isolation of yellow catfish β-actin promoter and generation of transgenic yellow catfish expressing enhanced yellow fluorescent protein

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维普期刊数据库

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Isolation of yellow catfish β-actin promoter and generation...

基于DEA-Malmquist模型的四川省矿产资源开发效率评价

第十届中国实验动物科学年会

作者： Jiachun Ge Zhangji Dong Jingyun li Zhiqiang Xu Wei Song Jie Bao Dong liang junbo li Kui li Wenshuang Jia Muzi Zhao Yongxiang Cai Jiaxin Yang Jianlin Pan Qingshun Zhao College of life Sciences Nanjing Normal University Freshwater Fisheries Research Institute of Jiangsu Province MOE Key Laboratory of Model Animal for Disease Study Model Animal Research CenterNanjing University Zhejiang Provincial Key Lab for Technology & Application of Model Organisms School of Life SciencesWenzhou Medical College

Yellow catfish(Pelteobagrus fulvidraco Richardson) is one of the most important freshwater farmed species in ***,its small size and slow growth rate limit its commercial *** genetic engineering has been a powerful tool to develop and improve fish traits for aquaculture,we performed transgenic research on yellow catfish in order to increase its size and growth *** PCR with degenerate primers,we cloned a genomic fragment comprising 5’-flanking sequence upstream of the initiation codon ofβ-actin gene in yellow catfish. The sequence is 1,017 bp long,containing the core sequence of proximal promoter including CAAT box, CArG motif and TATA *** the transgene construct Tg(beta-actin:eYFP) of the proximal promoter fused to enhanced yellow fluorescent protein(eYFP) reporter gene into zebrafish and yellow catfish embryos,we found the promoter could drive the reporter to express transiently in both embryos at early *** the offspring of five transgenic zebrafish founders developed from the embryos microinjected with Tg(ycbeta-actin:mCherry) or 19 yellow catfish founders developed from the embryos microinjected with Tg(beta-actin:eYFP),we obtained three lines of transgenic zebrafish and one transgenic yellow catfish,*** the expression patterns of the reporter genes in transgenic zebrafish(Tg(ycbeta-actin:mCherry)nju8/+) and transgenic yellow catfish(Tg{beta-actin:eYFP)nju 11/ +),we found the reporters were broadly expressed in both *** summary,we have established a platform to make transgenic yellow catfish using the proximal promoter of its ownβ-actin *** results will help us to create transgenic yellow catfish using "all yellow catfish" transgene constructs.

关键词： β-actin promoter Transgene Transgenic yellow catfish Transgenic zebrafish

来源： cnki会议评论

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矿产综合利用 2022年第1期43卷 82-88页

作者：李俊波浦华吴昊王月奇成都理工大学数理学院四川成都610059 成都理工大学数学地质四川省重点实验室四川成都610059 成都理工大学管理科学学院四川成都610059

提高矿产资源开发效率有利于加强资源保障能力,对促进地区可持续发展有着重大现实意义。为探究四川省矿产资源开发效率提升路径,本文采用DEA-BCC模型和Malmquist指数模型对四川省2010~2018年21个市州的矿产资源开发效率分别从静态和动... 详细信息

提高矿产资源开发效率有利于加强资源保障能力,对促进地区可持续发展有着重大现实意义。为探究四川省矿产资源开发效率提升路径,本文采用DEA-BCC模型和Malmquist指数模型对四川省2010~2018年21个市州的矿产资源开发效率分别从静态和动态两个角度进行测度评价。结果表明,四川省矿产资源开发水平正在逐步提升,技术进步是效率提高的主要动力,但纯技术效率和规模效率仍具有较大提升空间。其次,区域之间矿产资源开发效率存在差异,成都平原以及攀西地区开发效率提升最为明显,川南、川东北等地区矿产资源开发效率提升则相对缓慢。本文最后根据评价结果提出对策建议为提高矿产资源开发效率提供参考。

关键词：开发效率 DEA-BCC模型 Malmquist指数

Highly-chlorinated inert and robust interphase without mineralization of oxide enhancing high-rate li metal batteries

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Chinese Chemical Letters 2024年第6期35卷 239-243页

作者： Long li Kang Yang Chenpeng Xi Mengchao li Borong li Gui Xu Yuanbin Xiao Xiancai Cui Zhiliang liu lingyun li Yan Yu Chengkai Yang Key Laboratory of Advanced Materials Technologies International(HongKong Macao and Taiwan)Joint Laboratory on Advanced Materials TechnologiesSchool of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China College of Material Sciences and Chemical Engineering Harbin Engineering UniversityHarbin 150001China

Side reactions and dendrite growth triggered by the unstable interface and inhomogeneous deposition have become the biggest obstacle to the commercialization for lithium metal *** this study,a highly-chlorinated organic-inorganic hybrid interfacial protective layer is developed by rationally tuning the interfacial passivation and robustness to achieve the convenient and efficient li metal *** polyvinyl chloride(PVC)can effectively resist water and oxygen,which is confirmed by density functional *** organic-dominant solid electrolyte interphases(SEI)with lithium chloride are investigated by the X-ray photoelectron spectroscopy(XPS)with little mineralization of oxide,such as li_(2)O and li_(2)CO_(3).With such artificial SEI,a uniform and dense lithium deposition morphology are formed and an ultra-long stable cycle of over 500 h are achieved even at an ultra-high current density of 10 m A/cm^(2).Moreover,the simple and convenient protected anode also exhibits excellent battery stability when paired with the liNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)and liFePO_(4)(LFP)cathode,showing great potential for the commercial application of lithium metal batteries.

关键词： Highly-chlorinated Water/oxygen resistance Stable interphase Dendrite-free lithium metal batteries High-rate

Accelerating lithium-sulfur battery reaction kinetics and inducing 3D deposition of li_(2)S using interactions between Fe_(3)Se_(4)and lithium polysulfides

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Journal of Energy Chemistry 2024年第8期95卷 540-553,I0012页

作者： Yihan lin liheng li Longjie Tan Yongliang li Xiangzhong Ren Peixin Zhang Chuanxin He lingna Sun College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060GuangdongChina

Although lithium-sulfur batteries(LSBs)exhibit high theoretical energy density,their practical application is hindered by poor conductivity of the sulfur cathode,the shuttle effect,and the irreversible deposition of li_(2)*** address these issues,a novel composite,using electrospinning technology,consisting of Fe_(3)Se_(4)and porous nitrogen-doped carbon nanofibers was designed for the interlayer of *** porous carbon nanofiber structure facilitates the transport of ions and electrons,while the Fe_(3)Se_(4)material adsorbs lithium polysulfides(liPSs)and accelerates its catalytic conversion ***,the Fe_(3)Se_(4)material interacts with soluble liPSs to generate a new polysulfide intermediate,li_(x)FeS_(y)complex,which changes the electrochemical reaction pathway and facilitates the three-dimensional deposition of li_(2)S,enhancing the reversibility of *** designed LSB demonstrates a high specific capacity of1529.6 mA h g^(-1)in the first cycle at 0.2 *** rate performance is also excellent,maintaining an ultra-high specific capacity of 779.7 mA h g^(-1)at a high rate of 8 *** investigation explores the mechanism of the interaction between the interlayer and liPSs,and provides a new strategy to regulate the reaction kinetics and li_(2)S deposition in LSBs.

关键词： lithium-sulfur batteries Polysulfide intermediates li_(2)S electrodeposition Interlayers Electrostatic spinning Adsorption Catalysis

基于磁共振影像层间插值的超分辨率及多视角融合

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计算机应用 2021年第11期41卷 3362-3367页

作者：李萌秦品乐曾建潮李俊伯山西省医学影像与数据分析工程研究中心(中北大学) 太原030051 中北大学大数据学院太原030051 山西省医学影像人工智能工程技术研究中心(中北大学) 太原030051

针对磁共振(MR)图像切片内分辨率高而切片间分辨率低,导致MR在冠状面和矢状面上缺乏医学诊断意义的问题,提出了一种基于层间插值及多视角融合网络的医学图像处理算法。首先,引入了层间插值模块,用来将MR体数据沿冠状和矢状方向从三维数... 详细信息

针对磁共振(MR)图像切片内分辨率高而切片间分辨率低,导致MR在冠状面和矢状面上缺乏医学诊断意义的问题,提出了一种基于层间插值及多视角融合网络的医学图像处理算法。首先,引入了层间插值模块,用来将MR体数据沿冠状和矢状方向从三维数据切割成二维图像;然后,在分别对冠状面和矢状面进行特征提取之后,通过空间矩阵滤波器动态计算权重用于任意大小的上采样因子放大图像;最后,将冠状图和矢状图在层间插值模块中得到的结果聚合成三维数据后再次沿轴状方向切割成二维图像,对得到的二维图像两两进行融合并通过轴状方向数据进行修正。实验结果表明,所提算法相较于其他超分辨率算法在×2、×3、×4尺度下的峰值信噪比(PSNR)均有1 dB左右的提升,可见所提算法有效提升了图像的重建质量。

关键词：超分辨率神经网络层间插值脑部磁共振影像多视角融合

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基于超分辨率网络的CT三维重建算法

计算机应用 2022年第2期42卷 584-591页

作者：李俊伯秦品乐曾建潮李萌山西省医学影像与数据分析工程研究中心(中北大学) 太原030051 中北大学大数据学院太原030051 山西省医学影像人工智能工程技术研究中心(中北大学) 太原030051

计算机断层扫描(CT)三维重建技术通过上采样体数据来提高三维模型质量,减轻模型中的锯齿状边缘、条纹状伪影和不连续表面等现象,从而提高临床医学中疾病诊断的准确率。针对以往CT三维重建后模型仍然不够清晰的问题,提出一种基于超分辨... 详细信息

计算机断层扫描(CT)三维重建技术通过上采样体数据来提高三维模型质量,减轻模型中的锯齿状边缘、条纹状伪影和不连续表面等现象,从而提高临床医学中疾病诊断的准确率。针对以往CT三维重建后模型仍然不够清晰的问题,提出一种基于超分辨率网络的CT三维重建算法。网络模型为具有双重损失的优化学习纵轴超分辨率重建网络(DLRNet),通过单轴超分辨率进行腹部CT三维重建。网络末端引入优化学习模块,且除计算基准图与超分辨率图像的损失外,还计算网络内部粗略重建图像与基准图的损失,这样一来,优化学习与双重损失能使网络产生更接近于基准图的结果。随后在特征提取模块引入空间特征金字塔池化和通道注意力机制,加权细化学习了不同粗细以及规模不一的血管组织的特征。最后使用动态生成卷积核组的方法进行上采样使得单一网络模型可应对不同缩放因子的上采样任务。实验结果表明,相较于通道注意力的方法RCAN(Residual Channel Attention Network),所提网络模型在2、3、4倍缩放因子下的峰值信噪比(PSNR)平均提高0.789 dB。可见所提网络模型有效提升了CT三维模型的质量,一定程度上恢复了血管组织的连续细节特征,同时具备了实用性。

关键词：深度学习三维重建超分辨率计算机断层扫描优化学习

乳胶免疫层析法定量检测猪尿液中的盐酸克伦特罗

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食品科学 2017年第12期38卷 273-277页

作者：管笛魏颖王旗李俊博武会娟北京市理化分析测试中心北京100089 北京市基因测序与功能分析工程技术研究中心北京100089

目的:建立以彩色乳胶微球为标记物的免疫层析技术检测猪尿液中的盐酸克伦特罗(clenbuterol,CLB)。方法:彩色乳胶微球标记CLB抗体并真空冷冻干燥,盐酸克伦特罗-牛血清白蛋白(CLB-bovine serum albumin,CLB-BSA)人工抗原与羊抗鼠抗体分别... 详细信息

目的:建立以彩色乳胶微球为标记物的免疫层析技术检测猪尿液中的盐酸克伦特罗(clenbuterol,CLB)。方法:彩色乳胶微球标记CLB抗体并真空冷冻干燥,盐酸克伦特罗-牛血清白蛋白(CLB-bovine serum albumin,CLB-BSA)人工抗原与羊抗鼠抗体分别喷到硝酸纤维素膜上作检测线和质控线,猪尿液样本与冻干微球混匀后,插入试纸条,通过读条仪进行测定。结果:通过理化参数的优化,吐温-20为最优表面活性剂,选用300 nm乳胶微球,层析时间为9 min。方法的检出限为0.013 ng/m L,回收率范围在97.8%~106.0%之间,相对标准偏差不高于9.6%。结论:本研究成功建立了一种灵敏、准确的检测猪尿液中CLB的彩色乳胶免疫层析方法。

关键词：免疫层析试纸彩色乳胶盐酸克伦特罗猪尿液定量检测