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The Potential of Commercial Pension Insurance to Develop into One of the Pillars of Rural Pension Insurance:A Study from the Demand Perspective

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Contemporary Social Sciences 2023年第2期8卷 1-20页

作者： hu junbo Li Wenda Wang Jianrui Rural Development Research Institute Sichuan Academy of Social SciencesChengduSichuan610071China

The development of a multi-pillar pension insurance system is an effective solution for an aging *** pension insurance,as the third pillar of pension insurance,is an integral part of this system in China and can play a critical and complementary role in rural areas where support for the elderly is a more pressing concern and a second pillar of pension insurance remains *** this end,we first elaborate on the theoretical logic that commercial pension insurance can develop into one of the pillars of rural pension *** then empirically test rural residents’willingness to participate in a commercial pension insurance plan(CPIP)in a probit model with household research data from rural areas in major labor-exporting provinces,such as Sichuan and Henan so as to explore whether commercial pension insurance has the potential to become one of the pillars of rural pension *** research findings can be synthesized in three ***,rural residents out of agricultural production for five consecutive years are more willing to participate in a CPIP than other rural residents,indicating that progress in industrialization and urbanization can significantly boost such ***,the younger rural residents are more inclined to participate in a CPIP than the older ***,income increases can significantly boost rural residents’willingness to participate in a ***,with progress in industrialization and urbanization and an increase in rural disposable income,commercial pension insurance has a promising potential in rural areas and can hopefully develop into one of the pillars of rural pension insurance.

关键词： the pillar of pension insurance commercial pension insurance willingness to participate(in a CPIP)

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Threonine 32 （Thr32） of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells

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Protein & Cell 2015年第2期6卷 127-138页

作者： Xiangxuan Zhao Yong Liu Lei Du Leya He Biyun Ni junbo hu Dahai Zhu Quan Chen The Joint Laboratory of Apoptosis and Cancer Biology The State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Department of Radiology Shengjing Hospital of China Medical University Shenyang 110004 China Cancer Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430032 China Institute of Basic Medical Sciences of Chinese Academy of Medical Sciences and School of Basic Medicine of Peking Union Medical College Beijing 100005 China College of Life Science Nankai University Tianjin 300071 China

Transforming growth factor-β （TGF-β） exerts apoptotic effects on various types of malignant ceils, including liver cancer cells. However, the precise mechanisms by which TGF-β induces apoptosis remain poorly known. In the present study, we have showed that threonine 32 （Thr32） residue of FoxO3 is critical for TGF-β to induce apoptosis via Bim in hepatocarcinoma Hep3B cells. Our data demonstrated that TGF-βinduced FoxO3 activation through specific de-phosphorylation at Thr32. TGF-β-activated FoxO3 cooperated with Smad2/ 3 to mediate Bim up-regulation and apoptosis. FoxO3 （de）phosphorylation at Thr32 was regulated by casein kinase I-ε （CKI-E）. CKI inhibition by small molecule D4476 could abrogate TGF-β-induced FoxO/Smad acti- vation, reverse Bim up-regulation, and block the sequential apoptosis. More importantly, the deregulated levels of CKI-ε and p32FoxO3 were found in human malignant liver tissues. Taken together, our findings suggest that there might be a CKI-FoxO/Smad-Bim engine in which Thr32 of FoxO3 is pivotal for TGF-β- induced apoptosis, making it a potential therapeutic target for liver cancer treatment.

关键词： apoptosis TGF-β FoxO3 casein kinasel-ε hepatocarcinoma

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Discrimination of cervical cancer cells via cognition-based features

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Journal of Innovative Optical Health Sciences 2020年第1期3卷 113-122页

作者： Yue Liu Jiabo Ma Xu Li Xiuli Liu Gong Rao Jing Tian Jingya Yu Shenghua Cheng Shaoqun Zeng Li Chen junbo hu Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-huazhong University of Science and Technology Wuhan Hubei 430074P.R.China MoE Key Laboratory for Biomedical Photonics School of Engineering Sciences huazhong University of Science and Technology Wuhan Hubei 430074P.R.China Department of Clinical Laboratory Tongji Hospital Huazhong University of Science and Technology WuhanHubei 430030P.R.China Department of Pathology Hubei Maternal and Child Health Hospital WuhanHubei 430072P.R.China

Computer-assisted cervical screening is an effective method to save the doctors'workload and improve their work ***,the correct classification of cervical cells depends on the nuclear segmentation effect and the extraction of nuclear ***,the precise nucleus segmentation remains a huge challenge,especially for densely distributed ***,previous cellular classification methods are mostly based on morphological features of nucleus size or *** individual features can make accurate classification for severe lesions,but not for mild *** this paper,we propose an accurate instance segmentation algorithm and propose cognition-based features to identify cervical cancer *** from previous individual nucleus features,we also propose population features and cognition-based features according to the Bethesda System(TBS)for reporting cervical cytology and the diagnostic experience of the *** results showed that the segmentation achieves better success in complex situa-tions than that by traditional segmentation ***,the cell classification via cog-nition-based features also help us find out more about less severe lesions'nuclei than that based on conventional features of individual nucleus,meaning an improvement of classification accu-racy for cervical screening.

关键词： Cervical cancer instance segmentation nucleus classification lesion cognition

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The role of CDK1 siRNA interference in cell cycle and cell apoptosis

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Frontiers of Medicine 2009年第4期3卷 384-389页

作者： hui XIAO Ming TIAN Junna GE Xin WEI Zhaoming LI Xiaolan LI Deding TAO junbo hu Jianping GONG Cancer Research Institute Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

In the present report,cyclin-dependent kinase1(CDK1)siRNA was transfected into cells to silence the CDK1 gene expression and study its role in the cell cycle and cell *** siRNA targeting CDK1 gene was chemically synthesized and transfected into Hela cells by lipofectamine *** expression levels of CDK1 gene and protein were examined by real-time quantitative polymerase chain reaction(PCR)and Western blot,*** cell cycle was analyzed by using DNA content analysis byﬂow *** apoptosis was detected by the Annexin V/PI *** morphological changes of transfected cells were examined under the microscopy by Wright-Giemsa ***1 gene was successfully silenced by its siRNA,and the CDK1 protein expression level was decreased signiﬁcantly,especially from 48th h to 60th h after *** DNA content analysis showed that transfection of CDK1 siRNA led to cells accumulating in G2/M *** was no signiﬁcant difference in the apoptotic rate between transfected cells and the control cells after transfection of CDK1 siRNA for 48 or 60 *** double nucleus or multinucleus cells could be seen under the microscopy among the transfected *** decreased CDK1 expression by siRNA silencing gave rise to cell cycle arrest in G2/M phase but did not induce apoptosis.

关键词： cyclin-dependent kinasel siRNA interference cell cycle apoptosis

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农民首创与政府引导:农村土地制度改革30年思考

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财经科学 2009年第2期 103-109页

作者：胡俊波四川省社会科学院农村发展研究所成都610072

回顾农村土地制度改革30年的历程,本文认为可以分成"因穷求变"和"为富求变"两个阶段,其中农民首创与政府引导结合所形成的合力是改革最重要的推动力。改革之所以能够成功就是因为我们坚持"解放思想,实事求是"的思想路线,尊重农民的主体... 详细信息

回顾农村土地制度改革30年的历程,本文认为可以分成"因穷求变"和"为富求变"两个阶段,其中农民首创与政府引导结合所形成的合力是改革最重要的推动力。改革之所以能够成功就是因为我们坚持"解放思想,实事求是"的思想路线,尊重农民的主体地位和首创精神,坚持政府的规范和引导,遵循市场经济的规律。

关键词：农民首创政府引导农村土地制度改革

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Epidermal growth factor enhances chemosensitivityof colon cancer by inducing cancer stem cells toenter the cell cycle

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Oncology and Translational Medicine 2017年第2期3卷 86-90页

作者： You Zou Xiaolan Li Deding Tao junbo hu Jianping Gong Department of General Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

Objective The aim of the study was to investigate whether colon cancer stem cells induced by epidermal growth factor(EGF) to enter the cell cycle enhanced the chemosensitivity of colon *** In vitro,EGF was used to stimulate the entry of human colon cancer HCT116 cells into the cell *** and after treatment with EGF,CD133+ HCT116 cells were collected and flow cytometry was conducted to determine the apoptosis rate based on the 5-Fu and Ki-67 expression *** cell cycle distribution of the two groups was also *** vivo,a subcutaneous xenograft model of HCT116 human colon cancer cell lines in nude mice was *** nude mice were divided into two groups and treated with EGF and 5-Fu,*** in the growth of implanted tumors revealed the efficiency of cycle-induction combined ***(1) After EGF stimulation,the S-G2/M proportion of CD133+ HCT116 cells and Ki67 expression were increased,indicating that more cancer stem cells entered the cell cycle and promoted proliferation;(2) After EGF stimulation,CD133+ HCT116 cells showed a higher apoptosis rate induced by 5-Fu.(3) Animal experiments showed that the group subjected to combined treatment with EGF and 5-Fu had smaller tumor sizes compared to the group treated with 5-Fu *** EGF enhanced tumor sensitivity to chemotherapeutic drugs,likely by promoting tumor stem cells to enter the cell cycle.

关键词： chemosensitivity tumor stem cell cell cycle

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Postoperative sequential chemotherapy and radiotherapy for locally advanced gastric cancer

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Oncology and Translational Medicine 2018年第3期4卷 85-92页

作者： Qiang Fu Shiying Yu Guoqing hu Yuan Chen junbo hu Lihong Zhang Hong Qiu Xianglin Yuan Department of Oncology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Gastrointestinal Surgery Tongji hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Objective The aim of the study was to evaluate the role of postoperative sequential chemotherapy and radiotherapy in patients with locally advanced gastric *** From January 2003 to December 2010, 146 gastric cancer patients at our institution(Department of Oncology, Tongji Hospital, Tongji Medical College, huazhong University of Science and Technology, Wuhan, China) received postoperative sequential chemotherapy and radiotherapy after radical surgery. Radiotherapy was administered as a dose of 4500 cGy in 25 fractions. For patients with positive margins, the dose was raised to 5040 cGy in 28 fractions. Three cycles of m FOLFOX or PF(cisplatin, 5-fluorouracil) chemotherapy regimen were applied before and after radiotherapy. Three-and 5-year survival rates were analyzed; any adverse effects with respect to hematology, hepatic and renal function, or the gastrointestinal tract that occurred during the treatment were *** This cohort consisted of non-metastatic patients: 104 men and 42 women with a median age of 51.0 years. The full course of sequential chemotherapy and radiotherapy(4500–5040 cGy) was completed by 129 patients(88.4%). Seventeen regional relapses(9.8%) and 46 distant relapses(23.8%) were recorded. Fifty patients(34.2%) died during follow-up. The 3-and 5-year overall survival rates(OS) were 60% and 54%, and disease-free survival rates(DFS) were 53% and 47%, respectively. There were no significant differences in survival rate with respect to age, sex, histopathology, N stage, site of the tumor, or margin status. Multivariate analysis showed that only the depth of tumor invasion(T stage) was an independent prognostic factor for OS(P = 0.009) and DFS(P = 0.006). The rates of grades 3 and 4 neutropenia and vomiting were 9.6% and 3.4%, respectively, during the *** Postoperative sequential chemotherapy with an m FOLFOX or PF regimen and radiotherapy were found to be an effective means of treating advanced gastric cancer p

关键词： advanced gastric cancer sequential chemotherapy radiotherapy survival rate

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Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer

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Frontiers of Medicine 2017年第2期11卷 214-222页

作者： Bo Zhou Hongbin Xu Meng Xia Chaoyang Sun Na Li Ensong Guo Lili Guo Wanying Shan Hao Lu Yifan Wu Yuan Li Degui Yang Danhui Weng Li Meng junbo hu Ding Ma Gang Chen Kezhen Li Cancer Biology Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Gynecological Oncology Zhongnan Hospital of Wuhan University Hubei Key Laboratory of Tumor Biological Behaviors Hubei Cancer Clinical Study Center Wuhan 430071 China Department of Gynecology and Obstetrics the People's Hospital of Shenzhen Shenzhen 518000 China

MicroRNAs （miRNAs） play critical roles in the development and progression in various cancers. Dysfunctional miR-9 expression remains ambiguous, and no consensus on the metastatic progression of ovarian cancer has been reached. In this study, results from the bioinformatics analysis show that the 3＇-UTR of the E- cadherin mRNA was directly regulated by miR-9. Luciferase reporter assay results confirmed that miR-9 could directly target this 3＇-UTR. miR-9 and E-cadherin expression in ovarian cancer tissue was quantified by qRT- PCR. Migration and invasion were detected by wound healing and Transwell system assay in SKOV3 and A2780. qRT-PCR and Western blot were performed to detect the epithelial-mesenchymal transition-associated mRNA and proteins. Immunofluorescence technique was used to analyze the expression and subcellular localization of E- cadherin, N-cadherin, and vimentin. The results showed that miR-9 was frequently upregulated in metastatic serous ovarian cancer tissue compared with paired primary ones. Upregulation of miR-9 could downregulate the expression of E-cadherin but upregulate the expression of mesenchymal markers （N-cadherin and vimentin）. Overexpression of miR-9 could promote the cell migration and invasion in ovarian cancer, and these processes could be effectively inhibited via miR-9 inhibitor. Thus, our study demonstrates that miR-9 may promote ovarian cancer metastasis via targeting E-cadherin and a novel potential therapeutic approach to control metastasis of ovarian cancer.

关键词： ovarian cancer metastasis miR-9 E-cadherin

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Stage II/III Rectal Cancer Patients Benefit from Extremely Early Initiation of Postoperative Adjuvant Chemotherapy: A Retrospective Study

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Journal of Cancer Therapy 2019年第1期10卷 36-52页

作者： Liuniu Xiao Li Zhu Yingming Chen Zhenlin Hou Lingwei Jia junbo hu Yongdong Feng Department of General Surgery of Tongji Hospital Affiliated to Tongji Medical College of huazhong University of Science and Technology Wuhan China Center for Experiment Medicine and Molecular Biology Tongji Hospital Affiliated to Tongji Medical College Wuhan China

Background: For Stage II/III rectal cancer patients, curative resection is the primary treatment, prescribing of postoperative adjuvant chemotherapy (PAC) is regarded as a standard therapy. The interval between surgery and the initiation of PAC is usually within 8 weeks. However, the optimal cut-off is still controversial. This study aimed to explore the impact of extremely early initiation of PAC for II/III rectal cancer. Methods: Patients with Stage II/III rectal cancer treated from January 2013 to December 2015 were retrospectively collected at the Department of Tongji Hospital. According to the starting point of PAC, patients were categorized into two groups: extremely early group (The interval of PAC ≤ 2 weeks) and normal group (The interval of PAC within 3 - 5 weeks). For the sake of evaluating the effectiveness of different intervals, Overall Survival rate (OS), Progress-Free Survival rate (PFS) and Recurrence or Metastasis Rate (RMR) were analyzed, as well as the Quality of Life Score. To estimate the safety of the extremely early PAC, we evaluated the first post chemotherapy adverse reactions and defecation ability, and analyzed the variance laboratory indexes around the first postoperative adjuvant chemotherapy. Results: A total of 267 patients were included in this study. Compared to normal group (192 cases), extremely early group (75 cases) of patients attained a better tendency of OS and PFS, although there were no significant statistical differences (OS: P = 0.0930;PFS: P = 0.1058). However, the RMR was significant lower (P = 0.0452) and the Quality of Life Score was significantly higher (P = 0.0090) in extremely early group. Multivariate analysis also showed that extremely early group had better defecation ability (P = 0.0149) and less side reactions of post chemotherapy, such as vomiting (P , got a higher level of inflammatory cells (P Conclusion: For Stage II/III rectal cancer patients, extremely early to start PAC not only might be effectively prol

关键词： Rectal Cancer Postoperative Adjuvant Chemotherapy Prognosis Quality of Life Chemotherapy-Associated Adverse Reaction

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困境与突破:扶持农民工返乡创业的理论分析框架

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农村经济 2009年第6期 113-116页

作者：胡俊波四川省社会科学院

在金融危机的背景下扶持返乡农民工创业具有重要的现实意义。但是,在危机中返乡农民工的创业意愿将进一步下降。要破解此困局就需要政府介入,出台扶持政策激励农民工创业。本文基于人力资本理论构建了一个分析农民工返乡创业行为的理论... 详细信息

在金融危机的背景下扶持返乡农民工创业具有重要的现实意义。但是,在危机中返乡农民工的创业意愿将进一步下降。要破解此困局就需要政府介入,出台扶持政策激励农民工创业。本文基于人力资本理论构建了一个分析农民工返乡创业行为的理论框架,对农民工创业的动力机制进行了研究,提出扶持农民工返乡创业的政策着力点在于:增加创业机会、提高创业收入和创业成功的概率。

关键词：农民工返乡创业人力资本

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