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Neuroscience Bulletin 2020年第6期36卷 667-681页

作者： Ying Liao junbao du Department of Pediatrics Peking University First HospitalBeijing 100034China

Vasovagal syncope(VVS) and postural tachycardia syndrome(POTS) are the main forms of orthostatic intolerance in pediatrics and both are underlying causes of neurally-mediated *** recent years,increasing attention has been paid to the management of VVS and POTS in children and adolescents.A number of potential mechanisms are involved in their pathophysiology,but the leading cause of symptoms varies among patients.A few studies thus have focused on the individualized treatment of VVS or POTS based on selected hemodynamic parameters or biomarkers that can predict the therapeutic effect of certain therapies and improve their *** review summarizes the latest developments in individualized treatment of VVS and POTS in children and indicates directions for further research in this field.

关键词： Vasovagal syncope Postural tachycardia syndrome Individualized management Pathophysiology Children Adolescents

儿童新型冠状病毒感染后体位性心动过速综合征的研究进展

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中华儿科杂志 2024年第2期62卷 186-189页

作者：张清友高雨萌杜军保金红芳北京大学第一医院儿科北京100034

新型冠状病毒感染对儿童健康的影响已成为突出的公共健康问题。新型冠状病毒感染后体位性心动过速综合征在儿童新型冠状病毒感染后遗症中较常见。本文针对儿童新型冠状病毒感染后体位性心动过速综合征的定义、流行病学、主要临床表现、... 详细信息

新型冠状病毒感染对儿童健康的影响已成为突出的公共健康问题。新型冠状病毒感染后体位性心动过速综合征在儿童新型冠状病毒感染后遗症中较常见。本文针对儿童新型冠状病毒感染后体位性心动过速综合征的定义、流行病学、主要临床表现、诊断及初步治疗方案进行综述。

关键词：公共健康问题体位性心动过速综合征冠状病毒感染流行病学儿童健康后遗症临床表现研究进展

Orthostatic Intolerance and Coagulation Abnormalities:An Update

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Neuroscience Bulletin 2019年第1期35卷 171-177页

作者： Wei Quan Yuchen Wang Selena Chen junbao du Department of Pediatrics Peking University First Hospital Department of Clinical Medicine Peking University Health Science Center Department of Biochemistry and Cellular Biology University of California at San Diego Key Laboratory of Molecular Cardiovascular Science of the Ministry of Education

Orthostatic intolerance(OI)is a series of clinical symptoms that develop during long-term standing in the upright position,with clinical manifestations of frequent,recurrent,or persistent dizziness,fatigue,and heart p... 详细信息

关键词： HUT Hg Orthostatic Intolerance and Coagulation Abnormalities:An Update vWF

Autonomic Nervous Function in Vasovagal Syncope of Children and Adolescents

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Neuroscience Bulletin 2019年第5期35卷 937-940页

作者： Chunyan Tao Chaoshu Tang Selena Chen Hongfang Jin junbao du Department of Pediatrics Peking University First Hospital Beijing 100034 China Department of Physiology and Pathophysiology Peking University Health Sciences Centre Beijing 100191 China Division of Biological Sciences University of California San Diego CA 92093 USA Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education of China Beijing 100191 China

Syncope is defined as a transient loss of consciousness due to global cerebral hypoperfusion, accompanied by loss of muscle tone and failure to maintain an active position. Vasovagal syncope (VVS) is the most common presentation of syncope, and its diagnostic criteria include:(1) absence of any other evident etiology for syncope or presyncope,(2) positive response to head-up tilt test with evident vasovagal reaction (hypotension and/or bradycardia), and (3) no concomitant chronic or acute disease [1, 2]. The onset of VVS peaks initially in childhood and adolescence, and accounts for 60%–70% of all syncopal cases. Clinicians pay great attention to syncope among children and adolescents, due to its high prevalence and its impact on patients’ quality of life. Affected individuals often experience mental stress, economic burdens, and accidental bodily injuries related to syncope [2]. While the pathogenesis of VVS is not fully understood, autonomic nervous dysfunction has been identified as a contributing mechanism. The examination of autonomic nervous function can provide important information about patients with syncope.

关键词： Autonomic Nervous Function Vasovagal Syncope Children Adolescents

Interaction between en- dogenous nitric oxide and carbon monoxide in the pathogenesis of hypoxic pulmonary hypertension

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Chinese Science Bulletin 2003年第1期48卷 86-90页

作者： SHI Yun, du junbao, GUO Zhiliang, ZENG Chaomei & TANG Chaoshu Department of Pediatrics, the First Hospital, Peking University, Beijing 100034, China Correspondence should be addressed to du junbao (e-mail: junbaodu@ ***) Department of Pediatrics First Hospital Peking University Beijing 100034 China

The aim of the study was to investigate the in-teraction between nitric oxygenase (NOS)/ nitric oxide (NO) and heme oxygenase (HO)/ carbon monoxide (CO) system in the pathogenesis of hypoxic pulmonary hypertension. On a rat model of hypoxic pulmonary hypertension, the pulmo-nary artery pressure was measured, and NO formation and expression of NOS in pulmonary tissues were examined after treatment with ZnPP-IX, an HO-1 inhibitor. The pulmonary artery pressure, CO formation and expression of HO-1 in pulmonary tissues were examined after treatment with L-NAME, a NOS inhibitor. We found that pulmonary hy-pertension developed after 2-week hypoxia, while the con-centration of NO in the pulmonary tissue homogenates and the expression of NOS in intrapulmonary artery endothelial cells decreased markedly. ZnPP-IX worsened pulmonary hypertension of hypoxic rats. However, it increased endoge-nous production of NO and the expression of NOS obviously. The concentration of CO in the pulmonary tissue homoge-nates and the expression of HO-1 in intrapulmonary artery smooth muscle cells increased markedly with hypoxic pul-monary hypertension. L-NAME worsened pulmonary hy-pertension of hypoxic rats, but inhibited CO formation and HO-1 expression (P < 0.01). The results of this study sug-gested that endogenous NOS/NO and HO/CO systems might interact with each other and therefore play an important regulating role in hypoxic pulmonary hypertension.

关键词：低氧肺源性高血压病理发生内源性NO CO 一氧化碳一氧化氮

Pediatric syncope： where are we now？

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Chinese Medical Journal 2014年第21期127卷 3681-3683页

作者： Jin Hongfang du junbao Department of Pediatrics Peking University First Hospital Beijing100034 China

Syncope is precisely defined as a temporary loss of consciousness due to global cerebral hypoperfusion,often accompanied with loss of muscular tension and the failure to maintain active position. Pre-syncope is a state consisting of transient lightheadedness, loss of or weaker muscle tension, but not accompanied with loss of consciousness. Syncope and pre-syncope are common symptoms occurring in children and adolescents. Girls present more morbidity than boys. And patients with syncope accounted for about 1%-2% of all pediatric patients in the emergency department.l＇2 Among medical students at an average age of 20 years, one survey found that about 20% of males and 50% of females reported to have syncope at least once.3 The onset of syncope greatly affects the physical and psychological health of children and adolescents, which is a research hotspot in the field of pediatric cardiology at home and abroad.

关键词： syncope child diagnosis management

Prognostic markers for idiopathic pulmonary arterial hypertension

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Chinese Medical Journal 2014年第21期127卷 3798-3802页

作者： Guo Xiaomin Jin Hongfang du junbao Department of Pediatrics Peking University First Hospital Beijing 100034 China

Objective The objective of this study is to review the research on the prognostic markers of idiopathic pulmonary arterial hypertension （IPAH）.Date sources We searched literature from PubMed and CNKI databases both in English and Chinese up to *** selection Data about mortality and cut-off value are from clinical trials and identified by *** IPAH is an unexplained,progressive,and rare disease characterized by increased pulmonary artery pressure and pulmonary vascular *** diagnosis is difficult,mortality of IPAH is high,and the survival periods are only 2-3 years after *** in recent years have identified a range of prognostic markers for IPAH,including the 6-minute walking test,red blood cell distribution width,and platelet levels,as well as imaging *** in these markers are important sources of information to predict the prognosis of patients with IPAH,which carries significant benefits for treatment *** Even though the prognosis of IPAH has been investigated,the mortality is also *** accurate and meaningful assessment for the prognosis of IPAH is required.

关键词： pulmonary arterial hypertension prognosis prognostic markers

Changes of atrial natriuretic peptide and antidiuretic hormone in children with postural tachycardia syndrome and orthostatic hypertension： a case control study

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Chinese Medical Journal 2014年第10期127卷 1853-1857页

作者： Zhao Juan Yang Jinyan du Shuxu Tang Chaoshu du junbao Jin Hongfang Department of Pediatrics Peking University First Hospital Beijing100034 China Department of Pediatrics. Capital Medical University ShijitanHospital Beijing 100038 China Department of Physiology and Pathophysiology Peking UniversityHealth Sciences Centre Beijing 100191 China

Background The abnormal blood volume regulation is one of the most important pathogenesis in postural tachycardia syndrome in *** study was designed to investigate the plasma atrial natriuretic peptide and antidiuretic hormone levels in postural tachycardia syndrome children,and their associations with the changes in heart rate and blood pressure in head-up *** Twenty-one postural tachycardia syndrome patients （（12±2） years） and 26 healthy children （（12±1） years） were *** to blood pressure changes in head-up test,the postural tachycardia syndrome patients were divided into two subgroups：postural tachycardia syndrome with orthostatic hypertension and postural tachycardia syndrome without orthostatic *** plasma atrial natriuretic peptide and antidiuretic hormone levels were measured using enzyme-linked immunosorbent *** The plasma atrial natriuretic peptide level in postural tachycardia syndrome patients was higher than the control （P=0.004）,whereas the difference in plasma antidiuretic hormone level between postural tachycardia syndrome and controls was not significant （P=0.222）.The plasma antidiuretic hormone level of patients suffering from postural tachycardia syndrome with orthostatic hypertension was much higher than that of children having postural tachycardia syndrome without orthostatic hypertension （P ＜0.05）.In postural tachycardia syndrome patients,the updght max heart rate was positively correlated with the plasma atrial natriuretic peptide level （r=0.490,P＜0.05） and the upright systolic blood pressure was positively correlated with the plasma antidiuretic hormone levels （r=0.472,P ＜0.05）.Conclusions There was a disturbance of plasma atrial natriuretic peptide and antidiuretic hormone in postural tachycardia syndrome children.

关键词： postural tachycardia syndrome atrial natriuretic peptide antidiuretic hormone orthostatic hypertension

Al/Hf ratio-dependent mechanisms of microstructure and mechanical property of nearly fully dense Al—Hf reactive material

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Defence Technology（防务技术） 2024年第1期31卷 230-241页

作者： junbao Li Weibing Li Xiaoming Wang ZNDY of Ministerial Key Laboratory Nanjing University of Science and TechnologyNanjing 210094China

This study proposed three types of Al—Hf reactive materials with particle size ratios(a),which were almost completely dense(porosity of<5.40%)owing to their preparation using hot-pressing *** characteristics and phas... 详细信息

This study proposed three types of Al—Hf reactive materials with particle size ratios(a),which were almost completely dense(porosity ofdually increased with increasing a,and a small amount of fine Hf appeared for the sample with a=*** reactive materials exhibited clear strain-rate sensitivity,with flow stressσ0.05and failure strainεfincreasing approximately linearly with increasing strain rate.ε.It is found that the plastic deformation of the material increased with increasing strain *** a increased from 0.1 to 1,the flow stress gradually *** failure of the material was dominated by ductile fracture with a large Al phase plastic deformation band for lower a,while brittle fracture with crushed Hf particles occurred at higher ***,a constitutive model based on BP neural network was proposed to describe the stress-strain relationships of the materials,with an average relative error of 2.22%.

关键词： Reactive material Particle size Split Hopkinson pressure bar test Stressestrain relationship Impact failure BP neural network

Clinical features and management of postural tachycardia syndrome in children： a single-center experience

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Chinese Medical Journal 2014年第21期127卷 3684-3689页

作者： Li Jiawei Zhang Qingyou Hao Hongjun Jin Hongfang du junbao Department of Pediatrics Peking University First Hospital Beijing 100034 China Department of Neurology Peking University First Hospital Beijing 100034 China

Background The incidence of postural tachycardia syndrome （POTS） has been increasing in children and adolescents,while clinical characteristics of POTS in the pediatric population are not fully *** An observational study was performed in 150 pediatric patients aged between 5 and 18 years who underwent head-up tilt test （HUTT） with the diagnosis of POTS at Peking University First Hospital from March 2008 to August *** data,clinical presentation,autonomic parameters,laboratory findings,and treatments were *** POTS in children commonly occurred in the age of 7-14 *** （84.00％） was the most common symptom,followed by weakness （72.00％） and orthostatic syncope （62.67％）.Positive family history of orthostatic intolerance （Ol） was found in 24.64％ of children with *** 33.09％ of them had preceding infection history as precipitating *** percent of them suffered from orthostatic *** status was documented in 51.28％ of 39 patients who were tested for the standing norepinephrine *** than half of POTS patients,with 24-hour urinary sodium level ＜124 mmol/24 hours,were suitable for treatment of salt *** least 25.74％ of POTS patients were of positive acetylcholine receptor （AChR） *** iron storage in children with POTS was relatively *** patients responded well to treatments,43.51％ of patients recovered,while 7.63％ of them had relapse after symptoms *** POTS is a relatively common condition with complex pathophysiology and heterogeneous clinical manifestation.A comprehensive therapeutic regimen is recommended for the treatment.

关键词： postural tachycardia syndrome children orthostatic intolerance