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Chinese Journal of Integrative Medicine 2022年第1期28卷 88-95页

作者： Muhammad Atif Farrah Naz junaid akhtar Muhammad Imran Sidrah Saleem Javed Akram Muhammad Imran Muhammad Ikram Ullah Department of Clinical Laboratory Sciences College of Applied Medical SciencesJouf UniversitySakaka(75471)Saudi Arabia Department of Microbiology Government College UniversityFaisalabad(38000)Pakistan Department of Microbiology University of Health SciencesLahore(54600)Pakistan Department of Allied Health Sciences Sargodha Medical CollegeUniversity of SargodhaSargodha(40100)Pakistan University of Health Sciences Lahore(54600)Pakistan University Institute of Diet and Nutritional Sciences Faculty of Allied Health SciencesThe University of LahoreLahore(54590)Pakistan

COVID-19 virus is a causative agent of viral pandemic in human beings which specifically targets respiratory system of humans and causes viral *** unusual viral pneumonia is rapidly spreading to all parts of the world,currently affecting about 105 million people with 2.3 million *** review described history,genomic characteristics,replication,and pathogenesis of COVID-19 with special emphasis on Nigella sativum(***)as a treatment *** seeds are historically and religiously used over the centuries,both for prevention and treatment of different *** review summarizes the potential role of *** seeds against COVID-19 infection at levels of in silico,cell lines and animal models.

关键词： coronavirus nCoV-19 COVID-19 Nigella sativum review

Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad junaid Eun Jeong Lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

Retracing Realistic Disaster Scenarios from Archival Sources:A Key Tool for Disaster Risk Reduction

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International Journal of Disaster Risk Science 2021年第5期12卷 635-648页

作者： Bashir Ahmad akhtar Alam M.Sultan Bhat Khurshid Ahmad Bhat Jeelani Inaam ul Haq Hakim Farooq Ahmad junaid Qadir Department of Geology Nawakadal SchoolSrinagar 190002India Institute for Risk and Disaster Reduction University College LondonWCIE 6BTUK Department of Geography and Regional Development University of KashmirSrinagar 190006India Department of Statistics Chanapora SchoolSrinagar 190015India Department of Geology Aligarh Muslim UniversityAligarh 202002India

Disaster scenarios are constructed by integrating natural hazard phenomena and social science sources of *** profiled 51 natural hazard events of nineteenth century Kashmir that provide insights into the impacts of varying degree of severity that spread through the socioeconomic and political systems,influenced adaptation,and increased the consequences of the resulting *** root cause of these disasters was embedded in the social,natural,and political economic systems of their time,where vulnerabilities overlapped and interacted periodically with successive colonial regimes and acted as tipping *** combined effect of successive colonial regimes,inept administration,rigid political economy,and natural hazards made the situation go from bad to worse and reduced Kashmir to the depths of distress and *** the arc of the nineteenth century,a series of disasters led the Kashmiri population to learn how to live with disasters and minimize risk,bringing about the evolution of social and environmental *** the natural hazard vulnerability of the Kashmir Valley through archival narratives can help in scenario building to translate findings into formats that reduce related risk now as it did *** resulting information can be useful for regional design,planning,and policy responses to promote disaster risk reduction.

关键词： Disaster risk reduction Historical disasters Kashmir Nineteenth-century disasters Socioeconomic vulnerability

Sagbi-Gröbner Bases Under Composition

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Journal of Systems Science & Complexity 2023年第5期36卷 2214-2224页

作者： KANWAL Nazish KHAN junaid Alam Department of Sciences&Humanities FAST-National University of Computer&Emerging SciencesKarachicampusPakistan Department of Mathematical Sciences School of Mathematics and Computer ScienceInstitute of Business AdministrationKarachiPakistan

The process of substituting variables in a polynomial with other polynomials is dubbed polynomial *** behaviour of Gröbner bases and Sagbi bases under composition is well *** this paper,the authors provide a sufficient and necessary condition on a setΘof polynomials under which the Sagbi-Gröbner basis computation commutes with *** has natural applications to the computations of Sagbi-Gröbner bases for subsets of composed polynomials of subalgebra.

关键词： Polynomial composition sagbi bases Sagbi-Gr?bner bases

CRISPRing the hypertrophic cardiomyopathy:correcting one pathogenic variant at a time

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3206-3208页

作者： junaid Afzal Kshitiz Department of Medicine Division of CardiologyUniversity of California San FranciscoSan FranciscoCA 94158USA Department of Biomedical Engineering University of Connecticut HealthFarmingtonCT 06032USA

In recent paired Nature Medicine publications,Reichert et al.1 and Chai et al.,2 adopted the Crispr/Cas9-adenine base editing(ABE)approach to base correct one of the most common pathogenic variant of hypertrophic cardiomyopathy(HCM)—Myh7 gene(c.1208 G>A:***403Gln).They delivered1,2 ABE-Cas9 with single guide RNA(sgRNA)via intra-thoracic injection of dualAAV9 virus which resulted in the dramatic reduction of the hypertrophy and fibrosis in the adult mice model of HCM.

关键词： al. cardiomyopathy injection

A higher prediction accuracy–based alpha–beta filter algorithm using the feedforward artificial neural network

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CAAI Transactions on Intelligence Technology 2023年第4期8卷 1124-1139页

作者： junaid Khan Eunkyu Lee Kyungsup Kim Department of Environmental&IT Engineering Chungnam National UniversityDaejeonRepublic of Korea Research and Development Department SafeTech ResearchIncDaejeonRepublic of Korea Department of Computer Engineering Chungnam National UniversityDaejeonRepublic of Korea

The alpha–beta filter algorithm has been widely researched for various applications,for example,navigation and target tracking *** improve the dynamic performance of the alpha–beta filter algorithm,a new prediction learning model is proposed in this *** proposed model has two main components:(1)the alpha–beta filter algorithm is the main prediction module,and(2)the learning module is a feedforward artificial neural network(FF‐ANN).Furthermore,the model uses two inputs,temperature sensor and humidity sensor data,and a prediction algorithm is used to predict actual sensor readings from noisy sensor *** the novel proposed technique,prediction accuracy is significantly improved while adding the feed‐forward backpropagation neural network,and also reduces the root mean square error(RMSE)and mean absolute error(MAE).We carried out different experiments with different experimental *** proposed model performance was evaluated with the traditional alpha–beta filter algorithm and other algorithms such as the Kalman filter.A higher prediction accuracy was achieved,and the MAE and RMSE were 35.1%–38.2%*** final proposed model results show increased performance when compared to traditional methods.

关键词： alpha beta filter artificial neural network navigation prediction accuracy target tracking problems

An Automatic Intrusion Diagnosis Approach for Clouds

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International Journal of Automation and computing 2011年第3期8卷 286-296页

作者： junaid Arshad Paul Townend School of Computing University of Leeds

Virtual machines have attracted significant attention especially within the high performance computing community. How- ever, there remain problems with respect to security in general and intrusion detection and diagnosis in particular which underpin the realization of the potential offered by this emerging technology. In this paper, one such problem has been highlighted, i.e., intrusion severity analysis for large-scMe virtual machine based systems, such as clouds. Furthermore, the paper proposes a solution to this prob- lem for the first time for clouds. The proposed solution achieves virtual machine specific intrusion severity analysis while preserving isolation between the security module and the monitored virtual machine. Furthermore, an automated approach is adopted to signif- icantly reduce the overall intrusion response time. The paper includes a detailed description of the solution and an evaluation of our approach with the objective to determine the effectiveness and potential of this approach. The evaluation includes both architectural and experimentM evaluation thereby enabling us to strengthen our approach at an architectural level as well. Finally, open problems and challenges that need to be addressed in order to make further improvements to the proposed approach have been highlighted.

关键词： Intrusion severity virtualization cloud computing intrusion diagnosis intrusion tolerance.

Quality of Life after Functional Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis

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International Journal of Otolaryngology and Head & Neck Surgery 2018年第4期7卷 189-198页

作者： Sadaf Qadeer Shabbir akhtar Montasir junaid Muhammad Sohail Halim Department of Otolaryngology-Head & Neck Surgery Sir Syed College of Medical Sciences Karachi Pakistan Department of Otolaryngology-Head & Neck Surgery Aga Khan University & Hospital Karachi Pakistan Department of Otolaryngology-Head & Neck Surgery Armed Forces Hospital Southern Region Khamis Mushayt KSA Stanford University Palo Alto USA

Chronic Rhinosinusitis (CRS) is a group of disorders characterized by the inflammation of mucosa of the nasal passages and paranasal sinuses. It includes chronic rhinosinusitis with polyps, CRS without polyps and Allergic Fungal Sinusitis (AFS). This debilitating disease causes negative impact on quality of life (QOL) of patients. Functional endoscopic sinus surgery (FESS) is the mainstay of surgical treatment for patients and improves QOL of patients. This subjective assessment of QOL can be measured by disease specific questionnaires. SNOT-22 questionnaire is widely used and validated questionnaire for this purpose. Prospective study was done on 54 patients. Data were collected using SNOT-22 questionnaire and filled in pre-operative period then in post-operative follow-up visits on 1st, 3rd, 6th and 12th months. Paired sample t-test was used to compare pre-operative and post-operative SNOT scores and multivariate generalized linear model was used to estimate regression parameters for SNOT scores in CRS with polyp and AFS in comparison of CRS without polyps. Out of 54 patients, 59.3% were males, mean age was 35.98, 29.6% were in CRS without polyp group, 44.4% and 25.9% were in CRS with polyps and AFS group. Recurrence occurred in 7.4%, revision surgery required in 3.7% while 22.2% had history of asthma. Paired sample t-test showed statistical significant reduction in post-operative SNOT scores. Linear model results showed SNOT scores in CRS with polyp group was significantly reduced. Thus FESS provides significant improvement in QOL of patients in chronic rhinosinusitis.

关键词： Quality of Life Chronic Rhinosinusitis Surgery

ROBO-SPOT:Detecting Robocalls by Understanding User Engagement and Connectivity Graph

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Big Data Mining and Analytics 2024年第2期7卷 340-356页

作者： Muhammad Ajmal Azad junaid Arshad Farhan Riaz College of Comnputer Science Birmingham City UniversityBirminghamB55JUUK School of Computer Science University of LincolnLincolnLN67TSUK

Robo or unsolicited calls have become a persistent issue in telecommunication networks,posing significant challenges to individuals,businesses,and regulatory *** calls not only trick users into disclosing their private and financial information,but also affect their productivity through unwanted phone ringing.A proactive approach to identify and block such unsolicited calls is essential to protect users and service providers from potential ***,this paper proposes a solution to identify robo-callers in the telephony network utilising a set of novel features to evaluate the trustworthiness of callers in a *** trust score of the callers is then used along with machine learning models to classify them as legitimate or *** use a large anonymized dataset(call detailed records)from a large telecommunication provider containing more than 1 billion records collected over 10 *** have conducted extensive evaluation demonstrating that the proposed approach achieves high accuracy and detection rate whilst minimizing the error ***,the proposed features when used collectively achieve a true-positive rate of around 97%with a false-positive rate of less than 0.01%.

关键词： social network analysis reputation unwanted calls robo-callers telephone network Spam Over Internet Technology(SPIT)

Food intake regulation by leptin:Mechanisms mediating gluconeogenesis and energy expenditure

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Asian Pacific Journal of Tropical Medicine 2017年第10期10卷 940-944页

作者： Zulfia Hussain junaid Ali Khan Institute of Pharmacy Physiology and PharmacologyUniversity of AgricultureFaisalabad38040Pakistan

Regulation of blood glucose levels and body fat is critical for *** circulates freely in blood and controls body weight and food intake mainly through hypothalamic receptors and regulates glucose metabolism in the liver both directly through leptin receptors and indirectly via the hypothalamic receptors of central nervous *** affects food intake regulation and eventually glucose metabolism, lipometabolism,endocrine and immune functions, reproductive function, adipose tissue metabolism and energy *** also exerts peripheral effects directly on glucose metabolism and *** of obese human subjects have elevated plasma levels of leptin associated to the size of their total adipose tissue *** gluconeogenic function may be an essential factor in the regulation of nutritional intake and weight *** aim of this review is therefore to identify and module the possible effects of leptin with special application in *** addition, this review includes the study of fat consumption and energy expenditure in the *** modulation of leptin receptors and adipose tissues functioning could have important inference on therapeutic strategies.

关键词： Leptin Adipocyte Glycogen breakdown Gluconeogenesis Homeostasis Energy expenditure