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The prognosis of trabeculectomy in primary angleclosure glaucoma patients

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 66-72页

作者： jun-Dong Zhu Li-Lian Xie Zhi-yuan Li Xiao-He Lu Department of Ophthalmology Zhujiang Hospital of Southern Medical University Department of Ophthalmology the First People’s Hospital of Chenzhou CitySouthern Medical University

AIM: To evaluate whether the level of thrombospondin-1(TSP-1) in aqueous humor can predict the prognosis of trabeculectomy in patients with primary angle-closure glaucoma(PACG). METHODS: This case-control study involved 26 patients with PACG who experienced a failed trabeculectomy(case group) and 78 age-and sex-matched patients with PACG who underwent successful trabeculectomy(control group). Aqueous humor was collected at the time of trabeculectomy and tested for TSP-1 and TGF-β2 levels with an enzyme-linked immunosorbent assay method. Logistic regression modeling was used to assess the risk factors for failed trabeculectomy. RESULTS: The mean TSP-1 aqueous concentrations were significantly higher in the case group(20.67±9.79 ng/mL) than the control group(5.17±2.29 ng/mL)(P<0.001). The transforming growth factor-β2(TGF-β2) aqueous concentrations were significantly different between the case and control group, at 3633.25 and 1090.24 pg/mL, respectively(P<0.001). Logistic regression analysis revealed TSP-1 level as an independent risk factor for a failed trabeculectomy(OR=3.540; 95%CI=1.092-11.482). CONCLUSION: The aqueous humor TSP-1 and TGF-β2 levels are higher in PACG eyes with failed trabeculectomy than with successful trabeculectomy at one year. The aqueous humor TSP-1 level is an independent risk factor associated with failed trabeculectomy.

关键词： thrombospondin-1 prognosis primary angleclosure glaucoma

Energy Transfer in Er:CeF_(3) Crystals

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Chinese Physics Letters 1998年第8期15卷 603-604页

作者： LEI Ning FENG Xi-qi HU Guan-qin YIN Zhi-wen yuan Shuai XUE Shan-hua HOU Xiao-yuan Laboratory of Functional Inorganic Materials Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050 State Key Laboratory of Surface Physics Fudan UniversityShanghai 200433

Two Er:CeF3 crystals doped with 1.0 and 1.2 wt.%Er_(2)O_(3)and one pure CeF_(3) crystal were grown,their absorption and fluorescence spectra at room temperature were *** with pure crystal,the emission intensity of Ce^(3+)in Er:CeF3 decreased obviously,it is the sign of energy transfer from 5d state of lattice Ce^(3+)to 4f state of Er3+ions which improves the stimulation emission efficiency of Er^(3+)ions.

关键词： pure crystal absorption

Effects of Sm addition on microstructural evolution of Mg-6Zn-0.4Zr alloy during semi-solid isothermal heat treatment

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China Foundry 2017年第2期14卷 85-92页

作者： Yu Zhang Xiao-feng huang Ying Ma Ti-jun Chen yuan Hao State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of Technology Lanzhou 730050 China

The application of segmental semi-solid thixoforming of magnesium alloys is confined due to the dimensional distinction existing in solid particles of the alloy billet from edge to center zones. In the present study, the effects of Sm addition on the microstructural evolution of Mg-6Zn-0.4Zr and Mg-6Zn-4Sm-0.4Zr alloys by semi-solid isothermal heat treatment were investigated, to obtain optimum semi-solid microstructures for the subsequently thixoforming. The results indicate that the grains of the Sm-bearing alloy are evidently refined and gradually evolve from dendritic to globular and elliptic particles. In addition, the distinctly dimensional effect of the Mg-6Zn-0.4Zr alloy is eliminated with 4% Sm addition; the particle sizes in all zones from center to the edge of the billet are almost identical. With the increment of isothermal heat treatment temperature, the dendritic microstructures completely disappear, and meanwhile, the irregular and globular particles gradually form. The size, morphology and the distribution of solid particles mainly depend on the formation and permeation of the liquid phase in the process of isothermal heat treatment. As the isothermal temperature increases from 570 °C to 610 °C, the average size and shape factor of solid particles of both the alloys with and without Sm addition gradually decrease while the liquid fraction gradually increases.

关键词： Mg-Zn-Zr magnesium alloy dimensional effect Sm semi-solid isothermal heat treatment non-dendritic microstructure

SOX5 Regulates Cell Proliferation, Apoptosis, Migration and Invasion in KSHV-Infected Cells

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Virologica Sinica 2021年第3期36卷 449-457页

作者： Wu-Mei yuan Ya-Ge Fan Meng Cui Ting Luo Ya-E Wang Zhan-jun Shu Juan Zhao jun Zheng Yan Zeng Department of Stomatology The First Affiliated HospitalSchool of MedicineShihezi UniversityShihezi 832000China Key Laboratory of Xinjiang Endemic and Ethnic Disease and Department of Biochemistry School of MedicineShihezi UniversityShihezi 832000China AIDS Research Office National Traditional Chinese Medicine Research Base in Xinjiang and the Sixth People's Hospital of Xinjiang Uygur Autonomous RegionUriimqi 830000China

Kaposi's sarcoma(KS) originates from vascular endothelial cells, with KS-associated herpesvirus(KSHV) as the etiological agent. SRY-box transcription factor 5(SOX5) plays different roles in various types of cancer, although its role in KS remains poorly understood. In this study, we identified the role of SOX5 in KS tissues and KSHV-infected cells and elucidated the molecular mechanism. Thirty-two KS patients were enrolled in this study. Measurement of SOX5 m RNA and protein levels in human KS tissues and adjacent control tissues revealed lower levels in KS tissues, with KS patients having higher SOX5 level in the early stages of the disease compared to the later stages. And SOX5 m RNA and protein was also lower in KSHV-infected cells(iSLK-219 and iSLK-BAC) than normal cells(iSLK-Puro). Additionally, SOX5 overexpression inhibited cell proliferation and promoted apoptosis and decreased KSHV-infected cell migration and invasion. Moreover, we found that SOX5 overexpression suppressed the epithelial-to-mesenchymal transition of KSHV-infected cells. These results suggest SOX5 is a suppressor factor during KS development and a potential target for KS treatment.

关键词： SRY-box transcription factor 5(SOX5) Kaposi sarcoma(KS) Proliferation Apoptosis Epithelial-to-mesenchymal transition(EMT)

Advances in Radical Oxidative C--H Alkylation of N-Heteroarenes

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Chinese Journal of Chemistry 2017年第3期35卷 271-279页

作者： jun-Rong Zhang Li Xu Yan-Yan Liao Jian-Chao Deng Ri-yuan Tang Department of Applied Chemistry College of Materials and Energy South China Agricultural University Guangzhou Guangdong 510642 China

This review summarizes recent development in C—H alkylation of N ‐heteroarenes via the radical oxidative coupling process. A variety of alkyl radical sources (including alkanes, ethers, alcohols, carboxylic acids, o... 详细信息

关键词： radical oxidative coupling C—H functionalization alkylation heteroarenes

气相色谱-四极杆/飞行时间质谱法快速测定化妆品中全氟和多氟化合物

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质谱学报 2024年第5期45卷 682-690页

作者：曾广丰谢建军王璐王志元侯颖烨蔡翠玲肖可茵董洁李扬杰广州海关技术中心广东广州510623 国家化妆品质量安全检测重点实验室(广州) 广东广州510623 广东省药品检验所广东广州510663

本研究建立了QuEChERS法净化,结合气相色谱-四极杆/飞行时间质谱(GC-Q-TOF MS)法快速检测化妆品中全氟和多氟化合物(PFASs)的含量。样品经乙酸乙酯提取,无水硫酸钠脱水,石墨化炭黑(GCB)和硅胶粉(Si)分散固相萃取净化。目标物经DB-5MS毛... 详细信息

本研究建立了QuEChERS法净化,结合气相色谱-四极杆/飞行时间质谱(GC-Q-TOF MS)法快速检测化妆品中全氟和多氟化合物(PFASs)的含量。样品经乙酸乙酯提取,无水硫酸钠脱水,石墨化炭黑(GCB)和硅胶粉(Si)分散固相萃取净化。目标物经DB-5MS毛细管色谱柱(30 m×0.25 mm×0.25μm)分离,在EI源全扫描模式下采集质谱信号,外标法定量。结果表明:在5.0~1000μg/L范围内,8种化合物呈现良好的线性关系,相关系数(R^(2))均大于0.9976,检出限为20.0、200.0μg/kg,定量限为50.0、500.0μg/kg;在定量限、2倍和10倍定量限3个添加水平下的平均回收率为81.4%~112%,相对标准偏差为1.09%~7.63%(n=6)。该方法快速、准确、灵敏度高,可为化妆品中全氟和多氟化合物的快速检测和质量控制提供依据。

关键词：气相色谱-四极杆/飞行时间质谱(GC-Q-TOF MS) 快速检测化妆品全氟和多氟化合物(PFASs)

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Prostacyclin decreases splanchnic vascular contractility in cirrhotic rats

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Hepatobiliary & Pancreatic Diseases International 2014年第4期13卷 416-422页

作者： De-jun Liu Wei Chen Yan-Miao Huo Wei Liu jun-Feng Zhang Rong hua Yong-Wei Sun Department of Biliary-Pancreatic Surgery Renji Hospital School of Medicine Shanghai Jiaotong University

BACKGROUND： Prostacyclin has been shown to increase portal hypertension, but the mechanism is unclear. This study aimed to investigate whether the overproduction of prostacyclin（PGI2） in cirrhosis participates in the splanchnic vascular hyporesponsiveness to vasoconstrictors in cirrhotic ***： Cirrhotic model was created by subcutaneous injection of 60% carbon tetrachloride（CCl4） corn oil solution combined with intermittent drinking of 5% alcohol, and agematched rats served as controls. The isolated third-generation mesenteric arterioles were used to examine the contractile response to norepinephrine. The changes in vascular diameter were observed under a microscope imaging device. The plasma concentration of 6-ketone-prostaglandin F1α（6-keto-PGF1α, a stable metabolite of PGI2） was tested via enzyme immunoassays and the expression of cyclooxygenase（COX） in mesenteric arteries was detected by Western ***： In parallel with the increase of plasma 6-ketoPGF1α, the contractile response of arterioles from cirrhotic rats to norepinephrine was significantly impaired compared with that from controls. Inhibition of PGI2 or protein kinase A with indomethacin or Rp-adenosine 3＇, 5＇-cyclic monophosphothioate（Rp-cAMPS） partially reversed the vascular hypo-contractile response to norepinephrine in arterioles from cirrhotic *** significantly decreased the plasma 6-keto-PGF1α.Furthermore, indomethacin significantly attenuated the effect of Rp-cAMPS on arterioles from cirrhotic rats. COX-1 expression was up-regulated in mesenteric arteries from cirrhotic rats,whereas COX-2 was not detectable in the mesenteric arteries from both cirrhotic and control ***： Enhanced COX-1 expression in cirrhotic rats resulted in elevated PGI2 production which partially contributedto the splanchnic vascular hyporesponsiveness to a vasoconstrictor via the protein kinase A pathway.

关键词： portal hypertension prostacyclin indomethacin protein kinase A vascular hyporesponsiveness

基于生物信息学分析FAM83H-AS1在乳腺癌中的表达及临床意义

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中国现代医生 2024年第9期62卷 1-6,21页

作者：李娜袁军张安志胡楚玲徐茂义嘉兴市妇幼保健院嘉兴大学附属妇儿医院病理科浙江嘉兴314051 嘉兴市妇幼保健院嘉兴大学附属妇儿医院药剂科浙江嘉兴314051 嘉兴市第一医院嘉兴大学附属医院肿瘤内科浙江嘉兴314001

目的通过生物信息学分析FAM83H-AS1在乳腺癌中的表达及其对临床治疗和预后评估的意义。方法下载癌症基因组图谱(the Cancer Genome Atlas,TCGA)数据库中多种肿瘤表达资料,采用R语言分析FAM83H-AS1在多种癌症中的表达情况。单独分析FAM83... 详细信息

目的通过生物信息学分析FAM83H-AS1在乳腺癌中的表达及其对临床治疗和预后评估的意义。方法下载癌症基因组图谱(the Cancer Genome Atlas,TCGA)数据库中多种肿瘤表达资料,采用R语言分析FAM83H-AS1在多种癌症中的表达情况。单独分析FAM83H-AS1在乳腺癌中的表达情况,并通过基于基因表达水平值的交互式分析平台(Gene Expression Profiling Interactive Analysis,GEPIA)在线数据库验证表达情况。利用TCGA数据库下载并分析生存资料,明确FAM83H-AS1表达水平与乳腺癌患者预后的关系,并利用GEPIA及Kaplan-Meier Plotter进行双重验证。同时利用TCGA临床信息分析FAM83H-AS1与临床病理分期的关系,运用R语言分析FAM83H-AS1与肿瘤微环境、免疫检测点相关基因及肿瘤突变负荷(tumor mutation burden,TMB)的相关性,并进行基因集富集分析(gene set enrichment analysis,GSEA)。结果FAM83H-AS1在多种癌症中表达异常,其中在乳腺癌中的表达显著升高,且高表达FAM83H-AS1的乳腺癌患者总生存率显著降低。此外,不同临床分期的乳腺癌患者FAM83H-AS1的表达水平不同。FAM83H-AS1与乳腺癌样本中的基质细胞评分及免疫细胞评分均呈负相关,与一些免疫检测点相关基因表达具有相关性,TMB雷达图结果提示FAM83H-AS1在乳腺癌中的表达与TMB存在正相关性,GSEA结果提示FAM83H-AS1的表达与错配修复功能呈正相关性。结论FAM83H-AS1基因在乳腺癌中高表达,与患者的不良预后、临床病理分期、肿瘤微环境及TMB均有相关性。同时FAM83H-AS1与免疫检测点相关的一些基因及错配修复基因存在相关性,以上可能为临床乳腺癌的治疗、预测预后及基因靶向药物的研制提供理论依据。

关键词： FAM83H-AS1 乳腺癌免疫检测点肿瘤微环境肿瘤突变负荷

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车辆发动机舱非金属零部件热老化寿命研究

汽车工程学报 2024年第5期14卷 888-897页

作者：欧阳俊袁侠义肖露彭家燕段炼广州汽车集团股份有限公司汽车工程研究院广州511434

热氧老化是发动机舱非金属零部件主要热失效模式之一,传统的整车热管理开发流程大多仅关注零部件的最高工作温度,不能有效地预测零部件生命周期内的热衰退表现。基于中国市场的气候条件和车辆道路行驶大数据,建立了一套整车热老化等效... 详细信息

热氧老化是发动机舱非金属零部件主要热失效模式之一,传统的整车热管理开发流程大多仅关注零部件的最高工作温度,不能有效地预测零部件生命周期内的热衰退表现。基于中国市场的气候条件和车辆道路行驶大数据,建立了一套整车热老化等效行驶工况和零部件热老化寿命评估方法。采用该方法对某车型发动机悬置橡胶衬套的热老化寿命进行了评估,发现改善橡胶材料的配方可以提高其热老化寿命至约3倍,悬置橡胶衬套的实际工作温度在原有基础上升高10℃,其热老化寿命减少约50.0%。对悬置橡胶衬套的传热路径进行了分析,发现可以通过优化冷却风扇尾流以及降低发动机本体与悬置橡胶衬套之间的热传导来改善橡胶衬套的实际工作温度,从而提高其热老化寿命。

关键词：发动机舱热老化寿命等效行驶工况温度分布热衰退