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Causal associations between intermediate very-low-density lipoprotein cholesterol-to-total lipids ratio and peptic ulcer:A bidirectional Mendelian randomization study

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World Journal of Clinical Cases 2024年第25期12卷 5729-5738页

作者： Chun-Mei lin Qian Meng ying-jun li Shuang-Xi Zhang Qiong-Xi Luo Zhen-Yu Dai Postgraduate Student Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Gastroenterology Guangzhou University of Chinese Medicine Shunde HospitalFoshan 528300Guangdong ProvinceChina

BACKGROUND Previous epidemiologic investigations have consistently demonstrated a strong association between the ratio of cholesterol to total lipids in medium very-lowdensity lipoprotein(VLDL)and the occurrence of peptic ulcers(PU).However,the precise causal relationship between these factors remains ***,this study aims to elucidate the potential correlation between the ratio of cholesterol to total lipids in medium VLDL and the incidence of peptic *** To investigate the ratio of cholesterol to total lipids in medium very-low-density lipoprotein(VLDL)association with PU via genetic methods,guiding future clinical *** Genome-wide association study(GWAS)datasets for the ratio of cholesterol to total lipids in intermediate VLDL and peptic ulcer were retrieved from the IEU OpenGWAS project(https://***).For the forward Mendelian randomization(MR)analysis,72 single nucleotide polymorphisms(SNPs)were identified as instrumental *** SNPs were selected based on their association with the ratio of cholesterol to total lipids in intermediate VLDL,with peptic ulcer as the outcome ***,for the inverse MR analysis,no SNPs were identified with peptic ulcer as the exposure variable and the ratio of cholesterol to total lipids in intermediate VLDL as the *** MR analyses utilized inverse variance weighted(IVW)as the primary analytical ***,weighted median and MR-Egger methods were employed as supplementary analytical approaches to assess causal *** regression was used as a supplementary method to evaluate potential directional *** and multiplicity tests were conducted using the leave-one-out method to evaluate result stability and mitigate biases associated with multiple *** The genetically predicted ratio of cholesterol to total lipids in medium VLDL was significantly associated with an elevated risk of peptic ulcer(IVW:OR=2.557,95%CI=1.274

关键词： Ratio of cholesterol to total lipids in medium VLDL Peptic ulcer Mendelian randomization Casual effect Single nucleotide polymorphism

Velocity analysis of supersonic jet flow in double-cone ignition scheme

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Chinese Physics B 2024年第6期33卷 460-465页

作者：朱仲源张成龙李英骏 School of Science China University of Mining and TechnologyBeijing 100083China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyBeijing 100083China Double-cone ignition(DCI)joint team State Key Laboratory for Geomechanics and Deep Underground EngineeringChina University of Mining and TechnologyBeijing 100083China

In the double-cone ignition schemes(DCIS), the deuterium–tritium target shell is ablated and compressed by a highpower nanosecond laser in Au-cones to generate plasmas. Under the actions of spherically symmetric compression and acceleration along the Au cone, they will be ejected out of the cone mouth and collide with each other. The plasmas experience conversion from kinetic energy to internal energy at the vertex of the geometric center of two Au cones that are symmetric to each other, because of which high-density fusion plasmas are preheated. This key physical process has undergone experimental verification on the Shenguang-II upgraded facility in China. Apparently, the improvement and optimization of the velocity of plasmas in hypersonic jet flow at the cone mouth are crucial for the success of the DCIS. In the DCIR7 experiment of the Shenguang-II upgraded facility, a velocity yield of approximately 130–260 km/s was achieved for the plasmas at the cone mouth, with a result of nearly 300 km/s based on numerical simulation. In this paper, theoretical analysis is performed as regards the process, in which target shells are ablated and compressed by laser to generate highvelocity plasmas ejected through jet flow. Based on this analysis, the formula for the velocity of plasmas in supersonic jet flow at the cone mouth is proposed. This study also provides measures that are more effective for improving the kinetic energy of plasmas and optimizing energy conversion efficiency, which can serve as theoretical references for the adjustment and optimization of processes in subsequent experiments.

关键词： double-cone ignition(DCI) plasma hydrodynamics laser fusion

A concise synthetic approach to dihydrochalcone:First total syntheses of bipinnatone A and B

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Chinese Chemical Letters 2011年第10期22卷 1135-1138页

作者： Shi jun Da ying li State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 China

The first total syntheses of bipinnatone A and B have been achieved starting from commercially available phloroglucinol,p-hydroxybenzaldehyde in ten *** features of the syntheses include Aldol reaction,aryl-alkylation... 详细信息

关键词： Bipinnatone A Bipinnatone B Aldol reaction InCl_3-NaBH_4 reduction

Effect of initial phase on the Rayleigh–Taylor instability of a finite-thickness fluid shell

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Chinese Physics B 2022年第3期31卷 406-411页

作者： Hong-Yu Guo Tao Cheng Jing li ying-jun li State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyBeijing 100083China School of Science China University of Mining and TechnologyBeijing 10083China Beijing Aeronautical Technology Research Center Beijing 100076China

Rayleigh–Taylor instability(RTI) of finite-thickness shell plays an important role in deep understanding the characteristics of shell deformation and material mixing. The RTI of a finite-thickness fluid layer is studied analytically considering an arbitrary perturbation phase difference on the two interfaces of the shell. The third-order weakly nonlinear(WN) solutions for RTI are derived. It is found the main feature(bubble-spike structure) of the interface is not affected by phase difference. However, the positions of bubble and spike are sensitive to the initial phase difference, especially for a thin shell(kd lications where the interface coupling and perturbation phase effects are important, such as inertial confinement fusion.

关键词： Rayleigh–Taylor instability interface coupling effect inertial confinement fusion

Weakly nonlinear multi-mode Bell-Plesset growth in cylindrical geometry

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Chinese Physics B 2020年第11期29卷 406-411页

作者： Hong-Yu Guo Tao Cheng ying-jun li State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyBeijing 100083China School of Science China University of Mining and TechnologyBeijing 100083China

Bell-Plesset(BP)effect caused perturbation growth plays an important role in better understanding of characteristics of the convergence *** equations for multi-mode perturbation growth on a cylindrically convergent interface are *** second-order weakly nonlinear(WN)solutions for two-mode perturbations at the interface which is subject to uniformly radical motion are *** WN theory is consistent with the numerical result in terms of mode-coupling effect in converging Richtmyer-Meshkov *** mode-coupling effects will cause irregular deformation of the convergent *** mode-coupling behavior in convergent geometry depends on the mode number,Atwood number A and convergence ratio *** A=-1.0 at the interface results in larger perturbation growth than A=*** growth of generated perturbation modes from two similar modes at the initial stage are smaller than that from two dissimilar modes.

关键词： Bell-Plesset effect Rayleigh-Taylor instability inertial confinement fusion

Synthesis of granulated li_(1.33)Mn_(1.67)O_(4) via two antisolvent methods for lithium adsorption from gas-produced water

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Chinese Journal of Chemical Engineering 2024年第5期69卷 34-46页

作者： jun Qiu Lu-Ri Bao Wei Guo ying Yang Shu-ying Sun National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China

Gas-produced water is an accompanying wastewater in the natural gas extraction process,and it is a potential liquid lithium resource that contains a considerable amount of *** study investigated the feasibility of using manganese-based ion sieves to adsorb and extract lithium from gas-produced *** we focused on the applicability of two different granulation methods,extrusion and droplet,in gas-produced water *** types of H_(1.33)Mn_(1.67)O_(4) particles were prepared by the extrusion method(EHMO)and the droplet method(DHMO).The porosity of DHMO was much higher than that of EHMO,and the adsorption performance of DHMO increased with the decrease of binder *** prepared with a binder concentration of 0.14 g·ml^(-1)exhibited the best adsorption performance in gas-produced water,and the li^(+)adsorption capacity could reach 25.14 mg·g^(-1).In gas-produced water,the adsorption equilibrium of DHMO only took 9 h,and the adsorption process conformed to the Langmuir model and pseudo-second-order kinetic *** pore diffusion model(PDM)could well describe its adsorption ***,DHMO showed a great selectivity to li^(+),and the selectivity order of DHMO in gas-produced water was li^(+)>Ba^(2+)>>Mg^(2+),Ca^(2+),Sr^(2+)>>Na^(+)>>K^(+).After 20 cycles,the li^(+)adsorption capacity was still higher than 17.30 mg·g^(-1),and the rate of manganese dissolution was less than 1%.

关键词： Gas-produced water Granulation li_(1.33)Mn_(1.67)O_(4)

~1H NMR analysis of the tolylene-2,4-diisocyanate-methanol reaction

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Chinese Chemical Letters 2010年第7期21卷 853-855页

作者： Peng Fei Yang Yong De Han Tian Duo li jun ying li Key Laboratory of Fine Chemicals(Shandong Province) Shandong Institute of Light IndustryJinan 250353China Science and Technology Office Shandong Institute of Light IndustryJinan 250353China School of Chemical Engineering Shandong Institute of Light IndustryJinan 250353China

Tolylene-2,4-diisocyanate（2,4-TDI） 1 reacts with methanol through two simultaneous paths in the polyurethane reaction,which involve two different intermediates-tolylene-4-carbamatic-2-isocyanate 2 and tolylene-2-carbamatic-4-isocyanate 3,and the final product is tolylene-2,4-dicarbamate ***-CH_3 chemical shifts in benzene ring in compounds 1,2,3 and 4 can be easily tested and well distinguished,through which those four compounds are quantified and their kinetics are *** shows that four rate constants for the tolylene-2,4-diisocyanate-methanol reaction in CCl_4 at 50℃are k_1=9.6×10^（-2）h^（-2）mol^（-2）min^（-1）, k_2=1.4×10^（-2）h^（-2）mol^（-2）min^（-1）,k_3=4.0×10^（-3）h^（-2）mol^（-2）min^（-1）,k_4=1.4×10^（-3）h^（-2）mol^（-2）min^（-1）.（k_1 is the reaction rate constant from compounds 1 to 2;k_2 is the reaction rate constant from compounds 1 to 3;k_3 is the reaction rate constant from compounds 3 to 4;k_4 is the reaction rate constant from compounds 2 to 4）.

关键词： Tolylene-2 4-diisocyanate Polyurethane reaction Kinetics

Physical modeling of multiphase flow via lattice Boltzmann method： Numerical effects, equation of state and boundary conditions

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Frontiers of physics 2012年第4期7卷 481-490页

作者： Yan-Biao Gan Ai-Guo Xu Guang-Cai Zhang ying-jun li North China Institute of Aerospace Engineering Langfang 065000 China National Key Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics P. O. Box 8009-26 Beijing 100088 China State Key Laboratory for GeoMechanics and Deep Underground Engineering SMCEChina University of Mining and Technology (Beijing) Beijing 100083 China

The aims of the present paper are threefold. First, we further study the fast Fourier transform thermal lattice Boltzmann （FFT-TLB） model for van der Waals （VDW） fluids proposed in Phys. Rev. E, 2011, 84（4）： 046715. We analyze the merits of the FFT approach over the traditional finite difference scheme and investigate the effects of smoothing factors on accuracy and stability in detail. Second, we incorporate the VDW equation of state with flexible parameters into the FFT- TLB model. As a result, the revised model may be used to handle multiphase flows with various critical densities and temperatures. Third, we design appropriate boundary conditions for systems with solid walls. These improvements, from the views of numerics and physics, significantly extend the application scope of the model in science and engineering.

关键词： van der Waals fluids lattice Boltzmann method FFT equation of state

Low-protein diet supplemented with 1% L-glutamine improves growth performance, serum biochemistry, redox status, plasma amino acids, and alters fecal microbiota in weaned piglets

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Animal Nutrition 2024年第2期17卷 144-154页

作者： jun li jun Bai ying Yang Zhenlong Wu State Key Laboratory of Animal Nutrition and Feeding Department of Companion Animal Science China Agricultural University

Glutamine, one of the most abundant amino acids in the body, has been shown to exert various beneficial effects in pigs. However, knowledge regarding the role of dietary glutamine in low-protein diet-fed piglets remains scarce. The present study aimed to investigate the effects of different levels of L-glutamine on growth performance, serum biochemistry parameters, redox status, amino acids, and fecal microbiota in low-protein diet-fed piglets. A total of 128 healthy crossbred piglets(Landrace × Yorkshire)were randomly allocated into 4 groups of 4 replicate pens, with 8 piglets per pen. Piglets in the 4 groups were fed with corn and soybean meal-based low-protein diets(crude protein level, 17%) that contained0%, 1%, 2%, and 3% L-glutamine, respectively, for 28 d. Pigs administered 1% L-glutamine had greater body weight on d 28 and average daily gain(ADG, P line content(P < 0.05). Additionally, 1% Lglutamine upregulated the abundance of p＿75＿a5, Clostridium, Lactobacillus, Prevotellaceae＿Prevotella,and Gemmiger in the stool of piglets on d 14, with the Streptococcus lev

关键词： Glutamine Low protein diet Pig Redox status Amino acid Microbiota