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Inflammation scores predict survival for hepatitis B virus-related hepatocellular carcinoma patients after transarterial chemoembolization

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World Journal of Gastroenterology 2015年第18期21卷 5582-5590页

作者： Dong-Sheng Zhou Li Xu yao-Ling Luo Feng-Ying He jun-Ting Huang yao-jun zhang Min-Shan Chen Department of Hepatobiliary Surgery Sun Yat-sen University Cancer Center Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Clinical Laboratory Sun Yatsen University Cancer Center

AIM:To compare the prognostic ability of inflammation scores for patients with hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)undergoing transarterial chemoembolization(TACE).METHODS:Data of 224 consecutive patients who underwent TACE for unresectable HBV-related HCC from September 2009 to November 2011 were retrieved from a prospective *** association of inflammation scores with clinicopathologic variables and overall survival(OS)were analyzed,and receiver operating characteristic curves were generated,and the area under the curve(AUC)was calculated to evaluate the discriminatory ability of each inflammation score and staging system,including tumor-node-metastasis,Barcelona Clinic Liver Cancer,and Cancer of the Liver Italian Program(CLIP)***:The median follow-up period was 390 d,the one-,two-,and three-year OS were 38.4%,18.3%,and 11.1%,respectively,and the median OS was *** Glasgow Prognostic Score(GPS),modifed GPS,neutrophil-lymphocyte ratio,and Prognostic Index were associated with *** GPS consistently had a higher AUC value at 6 mo(0.702),12 mo(0.676),and24 mo(0.687)in comparison with other inflammation *** consistently had a higher AUC value at6 mo(0.656),12 mo(0.711),and 24 mo(0.721)in comparison with tumor-node-metastasis and Barcelona Clinic Liver Cancer staging *** analysis revealed that alanine aminotransferase,GPS,and CLIP were independent prognostic factors for *** combination of GPS and CLIP(AUC=0.777)was superior to CLIP or GPS alone in prognostic ability for ***:The prognostic ability of GPS is superior to other inflammation scores for HCC patients undergoing *** GPS and CLIP improved the prognostic power for OS.

关键词： Hepatocellular carcinoma Inflammation-based prognostic score Prognostic index Staging system Transarterial chemoembolization

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Biogenesis of Rab14-positive Endosome Buds at Golgi-endosome Contacts by the RhoBTB3-SHIP164-Vps26B Complex

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Current Medical Science 2024年第4期44卷 864-866页

作者： Jing-ru WANG jun-yao zhang Wei-Ke JI Department of Biochemistry and Molecular Biology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Cell Architecture Research Center Huazhong University of Science and TechnologyWuhan430030China State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Huazhong University of Science and TechnologyWuhan430030China Shenzhen Bay Laboratory Shenzhen518132China

As one of the basic processes of cellular activity,endocytosis sorting determines the fate of many proteins on the endosomal membranes,thus affecting a variety of important cellular processes,such as nutrient uptake,c... 详细信息

关键词： homeostasis endo sorting

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A NOVEL SILACARBOCYANINE DYE

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Chinese Chemical Letters 1995年第1期6卷 17-18页

作者： yao jun zhang Ji Xiang HAO Zu Xun zhang Department of Chemistry, Northwest University, Xi’an, 710069 NW Univ Xian Dept Chem Xian 710069 Peoples R China

A new type of photographic spectral sensitizer containing silicon-carbon double. bond is reported. The application tests show that the dye has excellent sensitivity in silver iodobromide emulsion and that the sensitivity maximum (S-max) of emulsion sensitized by the dye gives a hypsochromic shift about 70nm as compared with the absorption maximum (lambda (max)) of the dye in methanol. This phenomenon differs entirely from typical photographic spectral sensitizing dye.

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Left jackknife position:a novel position for laparoscopic hepatectomy

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Chinese Journal of Cancer 2017年第8期36卷 380-383页

作者： Jian-Cong Chen Rong-Xin zhang Min-Shan Chen Li Xu Jin-Bin Chen Ke-Li Yang yao-jun zhang Zhong-Guo Zhou State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Hepatobiliary Oncology Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Department of Colorectal Cancer Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background: Laparoscopic hepatectomy for hepatocellular carcinoma(HCC) located in segment Ⅵ, Ⅶ, or Ⅷ of the liver is usually difficult because of poor operative exposure, due to the unique anatomical structure. In this study, we evaluated the practice of laparoscopic hepatectomy with the left jackknife position for patients with HCC located in segment Ⅵ, Ⅶ, or Ⅷ.Methods: A total of 10 patients were enrolled to undergo laparoscopic hepatectomy with the left jackknife *** located in segment Ⅵ, Ⅶ, or Ⅷ were assessed by preoperative dynamic computed tomography or magnetic resonance imaging. Operation time, intraoperative blood loss, postoperative fasting time, postoperative drainage time, major postoperative complications, and duration of postoperative hospital stay were ***: All surgeries were successfully completed. None of the patients required conversion to open surgery during the procedure, and no serious postoperative complications were *** median tumor size was 31 mm(range 23-41 mm) in diameter, the mean operation time was 166 ± 38 min, the mean intraoperative blood loss was220 ± 135 mL, and the median postoperative hospital stay was 4 days(range 2-7 days).Conclusions: For HCC located in segment Ⅵ, Ⅶ, or Ⅷ, laparoscopic hepatectomy with this novel position—the left jackknife position—is safe and effective during tumor resection by exposing a sufficient operating *** registration *** ID:

关键词： Laparoscopic hepatectomy Hepatocellular carcinoma Segment VI VII or VIII Left jackknife position

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Tescalcin is an unfavorable prognosis factor that regulats cell proliferation and survival in hepatocellular carcinoma patients

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Cancer Communications 2020年第8期40卷 355-369页

作者： Zhong-Guo Zhou Jin-Bin Chen Rong-Xin zhang Ling Ye jun-ChengWang Yang-Xun Pan Xiao-HuiWang Wen-Xuan Li yao-jun zhang Li Xu Min-Shan Chen State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Liver Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Colorectal Cancer Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Oncology The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong 510630P.R.China

Background:Hepatocellular carcinoma(HCC)is a major health problem and a primary cause of cancer-related death *** great advances have achieved recently by large-scale high-throughput analysis,the precise molecular mechanism underlying HCC progression remains to be clearly *** investigated the relationship between Tescalcin(TESC),a candidate oncogene,and clinicopathological features of HCC patients and explored the role of TECS in HCC ***:To identify new genes involved in HCC development,we analyzed The Cancer Genome Atlas liver cancer database,and TESC was selected for further *** tissue microarray analysis for TESC and its association with clinicopathological features were performed to investigate its clinical *** was knocked down by using short-hairpin *** proliferation was analyzed by WST-1 assay and cell *** apoptosis was tested by fluorescence-activated cell sorting.A subcutaneous xenograft tumor model in nude mice was established to determine the in vivo function of *** microarray was used to identify its molecular ***:TESC was significantly increased in HCC tissues compared with the adjacent normal liver *** expression of TESC was detected in 61 of 172 HCC patients by tissue *** tumor(>5 cm)and elevated total bilirubin were associated with high TESC expression(both P<0.050).In multivariate analysis,TESC was identified as an independent prognostic factor for short overall survival of HCC *** knockdown impaired HCC cell growth in vitro and in *** knockdown significantly increased cell apoptosis in HCC cell ***,Affymetrix microarray analysis revealed that TESC knockdown inhibited tumor proliferation-related pathways while activated cell death-related ***:TESC was identified as an independent prognostic factor for short overall survival of HCC patients,and was critical for HCC cell proli

关键词： Apoptosis Cell proliferation Hepatocellular carcinoma Oncogene Tescalcin

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Long-term survival of patients with hepatocellular carcinoma with inferior vena cava tumor thrombus treated with sorafenib combined with transarterial chemoembolization:report of two cases and literature review

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Chinese Journal of Cancer 2014年第5期33卷 259-264页

作者： Heng-jun Gao Li Xu yao-jun zhang Min-Shan Chen Department of Hepatobiliary Surgery Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine

The prognosis of hepatocellular carcinoma(HCC) with tumor thrombus formation in the main vasculature is extremely *** combined with transarterial chemoembolization is a novel treatment approach for advanced *** this study,we report two HCC patients with inferior vena cava tumor thrombus who underwent the combination *** overall survival times for these two patients were 44 months and 35 months,*** report suggests that sorafenib combined with transarterial chemoembolization may be a viable choice for patients with advanced HCC even with inferior vena cava tumor *** studies are required to verify the efficacy and safety of this combination therapy for patients with advanced HCC with inferior vena cava tumor thrombus.

关键词：综合治疗肝动脉肝癌静脉栓塞化疗患者复习

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Role of radiofrequency ablation in the treatment of small hepatocellular carcinoma

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World Journal of Hepatology 2010年第4期2卷 146-150页

作者： yao-jun zhang Min-Shan Chen yao-jun zhang Min-Shan Chen Department of Hepatobiliary Surgery Cancer Center Sun Yat-Sen University 651 Dongfeng Road East Guangzhou 510060 Guangdong Province China.

Radiofrequency ablation (RFA), one of the most advanced loco-regional ablative therapeutic methods, is widely utilized in the treatment of hepatocellular carcinoma (HCC). Because of its minimal invasiveness and high efficacy, RFA has been regarded as a curative therapy as alternative to surgical resection and liver transplantation. It brings new hope and a new treatment pattern for small HCC. In this article, we summarize the important role of RFA in the treatment of small HCC according to our clinical experience over six years. The prognosis of small HCC after RFA is comparable to that of surgical resection but with higher safety, less complications, wider applicability, and good long-term survival. RFA will play a more and more important role in the clinical treatment of small HCC.

关键词： Hepatocellular carcinoma Radiofrequencyablation Hepatectomy Prognosis Complication Recurrence Therapy

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Choline suppresses hepatocellular carcinoma progression by attenuating AMPK/mTOR-mediated autophagy via choline transporter SLC5A7 activation

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 393-411,I0001,I0002页

作者： Chen Wang Zhao-Yan Liu Wen-Ge Huang Zhi-jun Yang Qiu-Ye Lan Ai-Ping Fang Meng-jun Hou Xiao-Lin Luo yao-jun zhang Si Chen Hui-Lian Zhu Department of Nutrition School of Public HealthSun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Food Nutrition and HealthSchool of Public HealthSun Yat-sen UniversityGuangzhouChina Center of Experimental Animals Sun Yat-sen UniversityGuangzhouChina Experimental and Teaching Center for Public Health School of Public HealthSun Yat-sen UniversityGuangzhouChina Department of Hepatobiliary Oncology Sun Yat-sen University Cancer CenterGuangzhouChina

Background:Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-associated *** evidence suggests that autophagy plays a critical role in HCC tumorigenesis,metastasis,and *** is an essential nutrient related to prolonged survival and reduced risk of ***,it remains unclear whether this phenomenon is mediated by ***:Two HCC cell lines(HUH-7 and Hep3B)were used in the present *** growth was evaluated by cell counting kit 8(CCK-8),colony formation,and in vivo mouse xenografts *** motility was calculated by wound healing and transwell *** were measured by transmission electron microscope(TEM),and autophagy flux was detected by mRFP-GFP-labeled LC3 *** mRNA level of genes was measured by quantitative real-time polymerase chain reaction(qRT-PCR).The protein levels were detected by Western blotting(WB).Results:We found that choline inhibited the proliferation,migration,and invasion of HCC cells by downregulating autophagy in vitro and in *** expression of the solute carrier family 5 member 7(SLC5A7),a specific choline transporter,correlated with better HCC *** further discovered that choline could promote SLC5A7 expression,upregulate cytoplasm p53 expression to impair the AMPK/mTOR pathway,and attenuate ***,we found that choline acted synergistically with sorafenib to attenuate HCC development in vitro and in ***:Our findings provide novel insights into choline-mediated autophagy in HCC,providing the foothold for its future application in HCC treatment.

关键词： Hepatocellular carcinoma(HCC) autophagy choline solute carrier family 5 member 7(SLC5A7)

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Intravascular Ultrasound Classification of Plaque in Angiographic True Bifurcation Lesions of the Left Main Coronary Artery

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Chinese Medical Journal 2016年第13期129卷 1538-1543页

作者： Li Li Debabrata Dash Lu-Yue Gai Yun-Shan Cao Qiang Zhao Ya-Rong Wang yao-jun zhang jun-Xia zhang Department of Cardiology Guangzhou Red Cross Hospital Jinan University Guangzhou Guangdong 510020 China Department of Cardiology S. L. Raheja (A Fortis Associate) Hospital Mumbai Maharashtra India Oepartment of CardiologY'Chinese People's Liberation Army' General Hospital Beijing 100851 China Department of Cardiology Gansu Provincial People's Hospital Lanzhou Gansu 730000 China Department of Cardiology Nanjing First Hospital Nanjing Medical University Nanjing Jiangsu 210006 China

Background： Accurately, characterizing plaques is critical for selecting the optimal intervention strategy for the left main coronary artery （LMCA） bifurcation. Coronary angiography cannot precisely assess the location or nature of plaques in bifurcation lesions. Few intravascular ultrasound （IVUS） classification scheme has been reported for angiographic imaging of true bifurcation lesions of the unprotected LMCA thus far. In addition, the plaque composition at the bifurcation has not been elucidated. This study aimed to detect plaque composition at LMCA bifurcation lesions by IVUS. Methods： Fifty-eight patients were recruited. The location, concentricity or eccentricity, site of maximum thickness, and composition of plaques of the distal LMCA, ostial left anterior descending （LAD） coronary artery and, left circumflex （LCX） coronary artery were assessed using IVUS and described using illustrative diagrams. Results： True bifurcation lesions of the unprotected LMCA were classified into four types： Type A, with continuous involvement from the distal LMCA to the ostial LAD and the ostial LCX with eccentric plaques; Type B, with concentric plaques at the distal LMCA, eccentric plaques at the ostial LAD, and no plaques at the LCX; Type C, with continuous involvement from the distal LMCA to the ostial LCX, with eccentric plaques, and to the ostial LAD, with eccentric plaques; and Type D, with continuous involvement from the distal LMCA to the ostial LAD, with eccentric plaques, and to the ostial LCX, with concentric plaques. The carina was involved in only 3.5% of the plaques. A total of 51.7% of the plaques at the ostium of the LAD were soft, while 44.8% and 44.6% were fibrous in the distal LMCA and in the ostial LCX, respectively. Conclusions： We classified LMCA true bifurcation lesions into four types. The carina was always free from disease. Plaques at the ostial LAD tended to be soft, whereas those at the ostial LCX and the distal LMCA tended to be fibrous.

关键词： Intravascular Ultrasound Left Main True Bifurcation Lesion Plaque

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A nomogram predicting the recurrence of hepatocellular carcinoma in patients after laparoscopic hepatectomy

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Cancer Communications 2019年第1期39卷 499-509页

作者： Yang-Xun Pan Jian-Cong Chen Ai-Ping Fang Xiao-Hui Wang Jin-Bin Chen jun-Cheng Wang Wei He Yi-Zhen Fu Li Xu Min-Shan Chen yao-jun zhang Qi-Jiong Li Zhong-Guo Zhou State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Liver Surgery Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Department of Public Health Sun Yat-sen UniversityGuangzhou 510080GuangdongP.R.China Department of Molecular Medicine California Campus The Scripps Research Institute10550North Torrey Pines RoadLa JollaCA 92037USA

Background:Patients with hepatocellular carcinoma(HCC)undergoing surgical resection still have a high 5-year recurrence rate(~60%).With the development of laparoscopic hepatectomy(LH),few studies have compared the efficacy between LH and traditional surgical approach on *** objective of this study was to establish a nomo-gram to evaluate the risk of recurrence in HCC patients who underwent ***:The clinical data of 432 patients,pathologically diagnosed with HCC,underwent LH as initial treatment and had surgical margin>1 cm were *** significance of their clinicopathological features to recurrence-free survival(RFS)was assessed,based on which a nomogram was constructed using a training cohort(n=324)and was internally validated using a temporal validation cohort(n=108).Results:Hepatitis B surface antigen(hazard ratio[HR],1.838;P=0.044),tumor number(HR,1.774;P=0.003),tumor thrombus(HR,2.356;P=0.003),cancer cell differentiation(HR,0.745;P=0.080),and microvascular tumor invasion(HR,1.673;P=0.007)were found to be independent risk factors for RFS in the training cohort,and were used for con-structing the *** C-index for RFS prediction in the training cohort using the nomogram was 0.786,which was higher than that of the 8th edition of the American Joint Committee on Cancer TNM classification(C-index,0.698)and the Barcelona Clinic Liver Cancer staging system(C-index,0.632).A high consistency between the nomogram prediction and actual observation was also demonstrated by a calibration *** improved predictive benefit in RFS and higher threshold probability of the nomogram were determined by receiver operating characteristic curve analysis,which was also confirmed in the validation cohort compared to other ***:We constructed and validated a nomogram able to quantify the risk of recurrence after initial LH for HCC patients,which can be clinically implemented in assisting the planification of individual postoperative surveil-lance

关键词： Hepatocellular carcinoma Laparoscopic hepatectomy Recurrence Nomogram American Joint Committee on Cancer TNM classification Barcelona Clinic Liver Cancer staging system Hepatitis B surface antigen Tumor thrombus Tumor invasion

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