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Diversification of amphioxus and vertebrate Cerberus protein function in modulating Nodal,BMP and Wnt signals

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Marine Life Science & Technology 2020年第1期2卷 16-23页

作者： yan-jun zhang De-Li Shi School of Life Sciences Shandong UniversityQingdao 266237China IBPS-Develompental Biology Laboratory Sorbonne UniversiteUPMC Univ Paris 06CNRSUMR762275005 ParisFrance

Cerberus is a multifunctional antagonist implicated in embryonic patterning through modulation of Nodal,BMP and Wnt *** its function is largely conserved in chordates,certain activities have diverged,even among ***,the antagonistic action of Cerberus from the basal chordate amphioxus toward Nodal,BMP and Wnt signals remains ***,we compared the activity of amphioxus and Xenopus Cerberus proteins using cross-species *** found that amphioxus and Xenopus Cerberus proteins display similar activities in antagonizing Nodal-induced events,but they exhibit both shared and distinct activities in modulating BMP and Wnt *** Cerberus has reduced neuralizing activity that is dependent on inhibition of BMP signaling,and it modulates the signals of a restricted subset of Wnt ***,we revealed that Xenopus Cerberus interacts with Wnt4 and Wntl 1 to activate canonical Wnt signaling,whereas amphioxus Cerberus lacks this *** differences may be correlated with the divergence in the N-terminal region of Cerberus proteins between amphioxus and *** results indicate that chordate Cerberus proteins have evolved sub-functionalities that depend not only on their concentrations,but also on the properties of BMP and Wnt *** may account for their evolutionary distinct functions in different patterning processes.

关键词： Amphioxus BMP Cerberus Chordate Nodal Wnt Xenopus

A STUDY ON WETLAND CLASSIFICATION MODEL OF REMOTE SENSING IN THE SANGJIANG PLAIN

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Chinese Geographical Science 2000年第1期10卷 69-74页

作者： Shu-qing zhang Shi-kui zhang jun-yan zhang Changchun Jingyuetan Remote Sensing Test Site Changchun Institute of Geography the Chinese Academy of Sciences Changchun P. R. China Municipal Engineering Design & Research Institute of China Changchun P. R. China

The Sanjiang Plain, where nearly 20 kinds of wetlands exist now, is one of the largest wetlands distributed area of wetlands in China. To identify each of them and pick up them separately by means of automatic interpretation of remote sensing from TM Landsat images is extremely important. However, most of the types of wetlands can not be divided each other due to the similarity and the illegibility of the wetland spectrum shown in TM images. Special disposals to remote sensing images include the spectrum enhancement of wetland information, the pseudo color composite of TM images of different bands and the algebra enhancement of TM images. By this way some kinds of wetlands such as Sparganium stoloniferum and Bolboschoenus maritimus can be identified. But in many cases, these methods are still insufficient because of the noise brought from the atmosphere transportation and so on. The physical features of wetlands reflecting the diversification of spectrum information of wetlands, which include the spatial temporal characteristics of the wetlands distribution, the landscape differences of wetlands from season to season, the growing environment and the vertical structure of wetlands vegetation and so on, must be taken into consideration. Besides these, the artificial alteration to spatial structure of wetlands such as the exploitation of some types of them can be also used as important symbols of wetlands identification from remote sensing images. On the basis of the above geographics analysis, a set of wetlands classification models of remote sensing could be established, and many types of wetlands such as paddy field, reed swamp, peat mire, meadow, CAREX marsh and paludification meadow and so on, will be distinguished consequently. All the ways of geographical analysis and model establishment will be given in detail in this article.

关键词： wetlands in the Sanjiang Plain wetland classification model remote sensing classification image disposal

Neuroprotection of Cyperus esculentus L. orientin against cerebral ischemia/reperfusion induced brain injury

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Neural Regeneration Research 2020年第3期15卷 548-556页

作者： Si-Qun Jing Sai-Sai Wang Rui-Min Zhong jun-yan zhang Jin-Zi Wu Yi-Xian Tu yan Pu Liang-jun yan Yingdong College of Food Science and Engineering Shaoguan UniversityShaoguanGuangdong ProvinceChina School of Bioengineering Jiangnan UniversityWuxiJiangsu ProvinceChina Department of Pharmaceutical Sciences UNT System College of PharmacyUniversity of North Texas Health Science CenterFort WorthTXUSA College of Life Sciences and Technology Xinjiang UniversityUrumqiXinjiang Uygur Autonomous RegionChina

Orientin is a flavonoid *** recent years,its importance as a source of pharmacological active substance is growing rapidly due to its properties such as anti-myocardial ischemia,anti-apoptosis,anti-radiation,anti-tumor,and ***,the neuroprotective effects of Orientin on stroke injury have not been comprehensively *** aim of the present study was thus to investigate the neuroprotective capacity and the potential mechanisms of Cyperus esculentus ***(CLO)from Cyperus esculentus *** against ischemia/reperfusion(I/R)injury using standard orientin as *** in vitro studies,we treated HT22 cells with CoCl2 as an in vitro ischemic injury ***22 cells in the control group were treated with *** in vivo studies,we used rat models of middle cerebral artery occlusion,and animals that received sham surgery were used as *** found that CLO protected CoCl2-induced HT22 cells against ischemia/reperfusion injury by lowering lipid peroxidation and reactive oxygen species formation as well as decreasing protein ***,CLO did not reduce the release of lactate dehydrogenase nor increase the activity of superoxide *** showed that CLO could decrease neurological deficit score,attenuate brain water content,and reduce cerebral infarct volume,leading to neuroprotection during cerebral ischemia-reperfusion *** studies indicate that CLO flavonoids can be taken as a natural antioxidant and bacteriostastic substance in food and pharmaceutical *** molecular mechanisms of CLO could be at least partially attributed to the antioxidant properties and subsequently inhibiting activation of *** experimental procedures and protocols were approved on May 16,2016 by the Experimental Animal Ethics Committee of Xinjiang Medical University of China(approval ***20160516-57).

关键词： antioxidants caspase-3 cerebral ischemia/reperfusion injury cobalt chloride Cyperus esculentus L.orientin(CLO) lipid peroxidation nerve regeneration neurological deficits oxidative stress reactive oxygen species

Efficacy and safety of ranibizumab for wet age-related macular degeneration in Chinese patients

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 91-97页

作者： Hui-jun Qi Xiao-Xin Li jun-yan zhang Ming-Wei Zhao Department of Ophthalmology People's HospitalPeking UniversityBeijing 100044China Clinical Study Consultant Bothwin Pte.Ltd.Shanghai 200232China Branch of Clinical Epidemiology and Evidence-Based Medicine Shanghai Medical AssociationShanghai 200240China

AIM： To evaluate the clinical efficacy and safety of ranibizumab for wet age-related macular degeneration （wAMD） in Chinese patients and to determine the mean number of injections administered over one year of follow-up. METHODS： This single centre, retrospective observational case series study included data from 121 patients with wAMD （121 eyes） who were diagnosed by indirect ophthalmoscopy, fluorescence fundus angiography （FFA）, indocyanine green angiography, and optical coherence tomography. Ranibizumab was injected into the vitreous cavities once per month for 3mo and as needed afterwards. Changes in visual acuity and central foveal thickness （CFT） during the follow-up period were compared, and the mean number of injections over the year was calculated. Patients with one or more adverse events related to the drugs and injections were recorded for further adverse events ***： The study population included 70 males and 51 females aged between 50 and 87y （mean： 71.32±9.41y）. The mean number of injections over the first year was 5±1 （range： 3-9）. The mean best-corrected visual acuity by Early Treatment Diabetic Retinopathy Study increased from 43.2±19.3 （95%CI： 39.8-46.7） at baseline to 51.7±20.1 （95%CI： 48.1-55.3）, and central foveal thickness （CFT） decreased from 526.5±277.0 μm （95%CI： 476.6-576.4） to 258.2±161.6 μm （95%CI： 229.2-287.3） at 12mo. The differences were statistically significant （P〈0.001）. Visual acuity significantly improved in 34.1% of the patients （38 eyes）, stabilized in 66.1% of the patients （80 eyes）, and significantly decreased in 2.5% of the patients （3 eyes）. CFT at baseline was an independent risk factor of decreased CFT and increased visual acuity. None of the patients had severe adverse events during the follow-up ***： Ranibizumab can effectively control disease progression and improve visual acuity in patients with wAMD. The disease conditions of most patients stabilized after a one-year treatment with an average

关键词： antiangiogenic drug ranibizumab wet age-relatedmacular degeneration fluorescence fundus angiography indocyanine green angiography optical coherence tomography visual acuity central foveal thickness

Melatonin for the treatment of spinal cord injury

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Neural Regeneration Research 2018年第10期13卷 1685-1692页

作者： yan zhang Wen-Xiu zhang yan-jun zhang Ya-Dong Liu Zong-Jian Liu Qi-Chao Wu Yun Guan Xue-Ming Chen Central Laboratory Beijing Luhe HospitalCapital Medical University Department of Orthopedics Beijing Luhe HospitalCapital Medical University Department of Anesthesiology and Critical Care Medicine Johns Hopkins University Department of Neurological Surgery Johns Hopkins University

Spinal cord injury（SCI） from trauma or disease severely impairs sensory and motor function. Neurorehabilitation after SCI is a complex medical process that focuses on improving neurologic function and repairing damaged connections in the central nervous system. An increasing number of preclinical studies suggest that melatonin may be useful for the treatment of SCI. Melatonin is an indolamine that is primarily secreted by the pineal gland and known to be regulated by photoperiodicity. However, it is also a versatile hormone with antioxidative, antiapoptotic, neuroprotective, and anti-inflammatory properties. Here, we review the neuroprotective properties of melatonin and the potential mechanisms by which it might be beneficial in the treatment of SCI. We also describe therapies that combine melatonin with exercise, oxytetracycline, and dexamethasone to attenuate the secondary injury after SCI and limit potential side effects. Finally, we discuss how injury at different spinal levels may differentially affect the secretion of melatonin.

关键词： spinal cord injury melatonin secondary damage neuroprotection antioxidative antiapoptotic anti-inflammatory synergistic effects neural regeneration

Study on Aroma Components in Fruit From Three Different Satsuma Mandarin Varieties

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Agricultural Sciences in China 2007年第12期6卷 1487-1493页

作者： QIAO Yu XIE Bi-jun zhang yan ZHOU Hai-yan PAN Si-yi College of Food Science and Technology Huazhong Agricultural University Wuhan 430070 P.R.China

Fruit aroma of Guoqing 1, Miyagawa Wase, and Owari from three different Satsuma mandarin varieties were investigated by headspace solid phase microextraction （HS-SPME） combined with GC-MS. The results showed that there were 73, 71, and 66 aroma components in the three varieties, and the total contents were 584.67,505.29, and 494.63 μg g^-1, respectively. Total 29 constituents were common in the three varieties. It was also found that Guoqing 1, Miyagawa Wase, and Owari had 12, 5, and 2 unique components, respectively. The key aroma components were limonene, linalool, γ-terpinene, β- myrcene, α-pinene, and octanal in the three fruits. Guoqing 1 contained more key aroma compounds than Miyagawa Wase and Owari.

关键词： Satsuma mandarins fruit volatile compounds aroma

A quantitative colorimetric assay of H_2O_2 and glucose using silver nanoparticles induced by H_2O_2 and UV

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Chinese Chemical Letters 2013年第12期24卷 1053-1058页

作者： Yu zhang yan-jun zhang Xiao-Dong Xia Xiao-Qi Hou Cheng-Ting Feng Jian-Xiu Wang Liu Deng College of Chemistry and Chemical Engineering Central South University

A simple spectrophotometric assay of H2O2 and glucose using Ag nanoparticles has been carried out. Relying on the synergistic effect of H2O2 reduction and ultraviolet （UV） irradiation, Ag nanoparticles with enhanced absorption signals were synthesized. H2O2 served as a reducing agent in the Ag nanoparticles formation in which Ag＋ was reduced to Ago by O2- generated via the decomposition of H2O2 in alkaline media. On the other hand, photoreduction of Ag＋ to Ago under UV irradiations also contributed to the nanoparticles formation. The synthesized nanoparticles were characterized by TEM, XPS, and XRD. The proposed method could determine H2O2 with concentrations ranging from 5.0× 10^-7 to 6.0× 10^-5 tool/ L The detection limit was estimated to be 2.0 × 10^-7 mol/L. Since the conversion of glucose to gluconic acid catalyzed by glucose oxidase was companied with the formation of H2O2, the sensing protocol has been successfully utilized for the determination of glucose in human blood samples. The results were in good agreement with those determined by a local hospital. This colorimetric sensor thus holds great promises in clinical applications.

关键词： Silver nanoparticles Colorimetric assay H2O2 Glucose

Effect of intensity-modulated radiation therapy on sciatic nerve injury caused by echinococcosis

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Neural Regeneration Research 2021年第3期16卷 580-586页

作者： Wan-Long Xu Dilimulati·Aikeremu jun-Gang Sun yan-jun zhang Jiang-Bo Xu Wen-Zheng Zhou Xi-Bin Zhao Hao Wang Hong Yuan Department of Orthopedics Qilu Hospital of Shandong UniversityJinanShandong ProvinceChina Department of Orthopedics People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang Uygur Autonomous RegionChina

Conventional radiotherapy has a good killing effect on femoral ***,the sciatic nerve around the lesion is irreversibly damaged owing to bystander *** intensity-modulated radiation therapy shows great advantages for precise dose distribution into lesions,it is unknown whether intensity-modulated radiation therapy can perfectly protect the surrounding sciatic nerve on the basis of good killing of femoral echinococcosis ***,this study comparatively analyzed differences between intensity-modulated radiation therapy and conventional radiotherapy on the basis of safety to peripheral ***-breed Meriones meridiani with bilateral femoral echinococcosis were selected as the research ***-modulated radiation therapy was used to treat left femoral echinococcosis of Meriones meridianus,while conventional radiotherapy was used to treat right femoral echinococcosis of the same Meriones *** total radiation dose was 40 *** understand whether intensity-modulated radiation therapy and conventional radiotherapy can kill femoral echinococcosis,trypan blue staining was used to detect pathological changes of bone Echinococcus granulosus and protoscolex death after ***,enzyme histochemical staining was utilized to measure acid phosphatase activity in the protoscolex after *** week after radiotherapy,the overall structure of echinococcosis in bilateral femurs of Meriones meridiani treated by intensity-modulated radiation therapy *** was no significant difference in the mortality rate of protoscoleces of Echinococcus granulosus between the bilateral femurs of Meriones ***,there was no significant difference in acid phosphatase activity in the protoscolex of Echinococcus granulosus between bilateral *** understand the injury of sciatic nerve surrounding the foci of femoral echinococcosis caused by intensity-modulated radiation therapy and conventiona

关键词： apoptosis factor model neuron peripheral nerve plasticity protein recovery regeneration repair

Synthesis,Structural Characterization of Ferrocenyl Iminophosphines and Amidophosphines as Well as Their Application in the Suzuki Reaction

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Chemical Research in Chinese Universities 2007年第6期23卷 683-687页

作者： GONG jun-fang zhang yan-hui FAN Xin-heng WANG Da-wei SONG Mao-ping WU yang-jie Department of Chemistry Henan Key Laboratory of Chemical Biology and Organic Chemistry Key Laboratory of Applied Chemistry of Henan Universities Zhengzhou University Zhengzhou 450052 P. R. China

Ferrocenyliminophosphine 1 and 1,1′-bisferrocenyliminophosphine 2 were easily prepared from the condensation of formylferrocene or 1,1′-diformylferrocene with 2-（diphenylphosphino） aniline. The following reduction of imine group by LiAlH4 led to the formation of the corresponding ferrocenyl amidophosphines 3 and 4. The new ligands 2- 4 were well characterized by IR, ^1H NMR, ^31p NMR spectra, elemental analysis, and ESI-MS. The catalytic activity of all the ligands with palladium compounds in the Suzuki reaction was evaluated. Ligand 1, in combination with Pd （OAc）2, was found to be the most effective for the Suzuki reaction of aryl bromides with phenylboronic acid. Typically, the use of 0. 1% （molar fraction） of Pd（OAc）2/ligand 1 in the presence of two equivalents of K2CO3 as base in toluene at 110 ℃ provided good to excellent yields of the coupled products.

关键词： Ferrocenyl Iminophosphine Amidophosphine Synthesis Suzuki reaction